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synth conjugated estrogens (Enjuvia)

✓ Approved

Teva Pharmaceutical Industries Ltd. · ESR1

什么是 synth conjugated estrogens?

synth conjugated estrogens 是一种治疗药物,由Teva Pharmaceutical Industries Ltd.研发。该药已获批,用于治疗相关适应症,给药途径:Oral (PO)。

药物档案

商品名Enjuvia
公司Teva Pharmaceutical Industries Ltd.
分子靶点ESR1
给药途径Oral (PO)
状态Approved

作用机制

分子靶点

synth conjugated estrogens 作用于 1 个分子靶点:

ESR1estrogen receptor 1 (ER, ESR)
需要更深入的分析?Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

synth conjugated estrogens 针对 3 个适应症,涉及 2 个治疗领域。

治疗领域疾病/病症分期
Reproductive system and breast disordersAtrophic vulvovaginitis✓ Approved
Surgical and medical proceduresHormone replacement therapy✓ Approved
Reproductive system and breast disordersMenopausal symptoms✓ Approved

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BN-embedded electron-deficient aromatics: from molecular engineering to multifunctional optoelectronic devices.

Jiang Zhen Z, Shen Tao T, Liu Di D, Wang Yang Y et al.

n-Type organic semiconductors are indispensable components of organic optoelectronic devices and are central to the advancement of flexible electronics, bioelectronics and integrated organic circuits. Despite substantial progress, the development of high-performance acceptor building blocks and their corresponding n-type polymers remains fundamentally challenged by the difficult balance among frontier molecular orbital energetics, charge-transport capability and synthetic accessibility. In this context, boron-nitrogen (BN) motifs, including three-coordinate B-N bonds and four-coordinate B ← N bonds, have emerged as versatile molecular design elements for engineering electron-deficient π-conjugated systems. Owing to their unique isoelectronic characteristics and intrinsic bond polarization, BN units can effectively lower lowest unoccupied molecular orbital energy levels, enhance electron deficiency, and modulate intermolecular interactions while preserving favourable backbone planarity. As a result, they offer broad opportunities for simultaneously tuning optical bandgaps, charge-transport properties and environmental stability. In this review, we provide a comprehensive overview of BN-embedded electron-deficient small molecules and conjugated polymers, with particular emphasis on molecular design principles, synthetic methodologies and emerging structure-property relationships. We further discuss representative applications of these materials in five major optoelectronic device platforms, highlighting how BN structural characteristics govern electronic structure, solid-state organization and device performance. Finally, we outline the key challenges that remain in this rapidly evolving field and present perspectives on the future development of BN-enabled n-type organic semiconductors. This review aims to offer a unified framework and practical guidance for the rational design of next-generation high-performance n-type organic electronic materials.

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PubMedChemical science2026-08-05

Selenium-induced curvature control enables polymorphism in borabuckybowls.

Ikeno Atsuhiro A, Hayakawa Masahiro M, Masunaga Nonoka N, Ueda Akira A et al.

Selenium, a heavier congener of sulfur, has a larger atomic radius and higher polarizability, leading to distinct chemical reactivity and bonding. While these differences have been exploited in biological redox chemistry and materials science, their structural implications for molecular geometry and conformational adaptability remain underexplored. Such effects are particularly important for tuning solid-state properties of curved π-conjugated systems. Here we report a selenium-embedded borabuckybowl with shallow bowl geometry and enhanced shape adaptability. This structural flexibility enhances the redox stability and enables three distinct polymorphs depending on crystallization temperature. Differential scanning calorimetry revealed clear thermodynamic differences among these polymorphs in enthalpic and entropic contributions. The influence of crystal polymorphism on microscopic charge-transport properties was investigated computationally, and the structural adaptability and stability toward oxidation enabled the formation of suitable single crystals under I2 doping conditions, allowing experimental evaluation of electrical conductivity. This study highlights sulfur-to-selenium substitution as an effective strategy for controlling molecular shape adaptability and solid-state properties of curved π-conjugated molecules.

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PubMedAngewandte Chemie (International ed. in English)2026-08-05

In Situ Tracking of Radical Evolution in a Conjugated Covalent Organic Framework for Reversible Sodium Storage.

Ma Chunrong C, Wang Ting T, Zhang Fengling F, Zhang Xin X et al.

Covalent organic frameworks (COFs) have emerged as promising platforms for sodium-ion storage owing to their tunable redox-active sites and ordered porous architectures. However, the role of radical intermediates in their electrochemical processes remains elusive due to the lack of direct experimental evidence. Herein, we report a highly crystalline β-ketoenamine-linked COF (BT-COF-AA) that delivers exceptional rate capability and ultralong cycling stability over 10 000 cycles at 5 A g- 1. More importantly, in situ electron paramagnetic resonance (EPR) spectroscopy provides time-resolved and direct observation of transient radical intermediates, enabling the elucidation of a sequential sodium-ion storage mechanism. Specifically, Na+ ions initially coordinate with nitrogen sites in benzothiadiazole units, triggering localized electron transfer and the formation of stabilized radicals. Subsequent sodiation occurs at carbonyl oxygen sites, generating ketyl radicals accompanied by dynamic electron delocalization across the conjugated framework. This reversible radical evolution establishes a framework-coupled redox pathway that underpins the outstanding electrochemical performance. Combined experimental and theoretical results reveal a radical-mediated charge storage mechanism and provide fundamental insights for the rational design of high-performance organic electrode materials.

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PubMedSmall (Weinheim an der Bergstrasse, Germany)2026-08-05

Bioinspired Neuron-Like Conjugated Polymer Chains@MXene of Polymer-Based Anode for High-Rate Potassium-Ion Batteries.

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Polymer electrode materials (PEMs), characterized by tunable and flexible molecular structures, hold great promise for potassium storage. However, their practical implementation is hindered by inherently low electrical conductivity. Herein, we synthesize a novel bioinspired neuron-like networks by controllably grafting conjugated polymer nanofilaments onto MXene nanosheets (denoted as CMP@BrMXene). This distinctive neuron-like architecture, along with the resulting cytoplast-like MXene junctions, not only creates abundant continuous pathways in multiple directions to facilitate rapid and uniform electron transport, but also exposes additional active sites for K+ coordination within the polymer-based anode. Leveraging these unique structures, the CMP@BrMXene electrodes deliver a high reversible specific capacity of 525 mAh g-1 at 30 mA g-1 and exhibit outstanding rate capability, retaining 119.8 mAh g-1 at 3000 mA g-1. Impressively, a durable capacity retention of 88.4% is maintained after 3000 cycles at 1 A g-1. Furthermore, operando XPS and theoretical analysis provide new insights into the redox reaction mechanism, confirming that MXene can streamline the multi-electron redox process and enhance the utilization of redox-active sites. These findings underscore that the all-integrated CMP@BrMXene electrodes, with MXene serving as multifunctional junctions, establish a new paradigm for developing high-performance potassium storage anodes.

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PubMedSmall (Weinheim an der Bergstrasse, Germany)2026-08-05

Tunable Electron-Hole Distribution in π-Conjugated Porous Organic Polymers for Unified Light-Driven Au(III) Photoreduction, Fluorescence Detection, and Efficient Gold Recovery.

Zhang Naizhong N, Liu Runle R, Pak Yen Leng YL, Wang Zhao Z et al.

The development of materials that integrate fluorescence sensing with light-promoted adsorption is essential for the selective detection and efficient recovery of gold. However, most previously reported materials address either detection or recovery alone, thereby restricting their potential application as multifunctional probes, photocatalysts, or adsorbents. Herein, we introduce two multifunctional porous organic polymers (POPs), TBE-S-POP and TBE-O-POP, that combine detection and recovery functions in a single platform. Both materials feature a π-conjugated 1,1,2,2-tetra(biphenyl-4-yl)ethene core, while differ in their electron-accepting units, dithiobiurea in TBE-S-POP and biurea in TBE-O-POP. By strategically modulating their electron-hole distribution, we achieved complementary functions within a single platform. TBE-S-POP, featuring a more separated electron-hole distribution, exhibits superior photocatalytic activity and achieves a remarkable gold adsorption capacity of 2267.7 mg g- 1 under light irradiation. In contrast, TBE-O-POP, which exhibits a more overlapped charge distribution, displays stronger fluorescence and provides a reliable response to Au3 + in the 0-50 µM range. Density functional theory calculations elucidate the underlying mechanism of their divergent photophysical behaviors. This work pioneers a design strategy by modulating electron-hole separation to unify detection, photoreduction, and adsorption in a single POP platform, offering a novel insight into the construction of advanced materials for gold sensing and recovery.

PMID 42553004
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PubMedJournal of inherited metabolic disease2026-08-05

Baat-Deficient Mice Recapitulate Elevated 7α-Hydroxy-3-Oxo-4-Cholestenoic Acid Observed in a Japanese Patient With BAAT Deficiency.

Koga Soma S, Takei Hajime H, Tamura Ryutaro R, Takaki Yugo Y et al.

Bile acid Coenzyme A: amino acid N-acyltransferase (BAAT) catalyzes the conjugation of bile acids with taurine or glycine, a process essential for bile acid solubility and intestinal lipid absorption. Mutations in BAAT cause an inborn error of bile acid metabolism, typically characterized by reduced conjugated bile acids and fat-soluble vitamin deficiency. However, several clinical features of BAAT deficiency cannot be fully explained by impaired conjugation alone, suggesting the presence of broader metabolic disturbances. In this study, we analyzed serum bile acid and intermediate profiles in a Japanese patient with genetically confirmed BAAT deficiency and identified a marked elevation of 7α-hydroxy-3-oxo-4-cholestenoic acid (7-HOCA), a key intermediate in bile acid synthesis. To investigate the metabolic consequences of BAAT loss, we generated a hepatic Baat knockdown mouse model using adeno-associated virus serotype 8-mediated delivery of Nme2Cas9 and Baat-targeting sgRNA. This model faithfully recapitulated the accumulation of 7-HOCA observed in the patient, together with a significant reduction in amino acid-conjugated bile acids. Integrated analyses combining bile acid profiling, quantitative PCR, and stable-isotope tracing of cholesterol demonstrated enhanced cholesterol flux toward bile acid biosynthetic pathways and upregulation of bile acid synthetic enzymes in Baat-deficient livers. These findings indicate that BAAT deficiency leads to dysregulated bile acid synthesis in addition to defective conjugation. Together, our results reveal a previously unrecognized metabolic phenotype of BAAT deficiency and provide mechanistic insight into its pathophysiology, establishing a novel in vivo model for studying bile acid metabolism beyond simple conjugation defects.

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