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CTC-111 (Anact C)

✓ Approved

Meiji Holdings · PROC

什么是 CTC-111？

CTC-111 是一种治疗药物，由Meiji Holdings研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)。

药物档案

商品名Anact C
公司Meiji Holdings
分子靶点PROC
给药途径Injectable (Others), Intravenous (IV)
状态Approved
来源： ClinicalTrials.gov, Meiji Holdings

作用机制

分子靶点

CTC-111 作用于 1 个分子靶点：

PROCprotein C, inactivator of coagulation factors Va and VIIIa (APC, PROC1)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

CTC-111 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Vascular disordersThrombosis✓ Approved
Skin and subcutaneous tissue disordersPurpura fulminans✓ Approved

相关研究文献

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Draft genome sequence of Bacillus thuringiensis GIFSPR-111, a putative probiotic isolated from shrimp farm soil in Bangladesh.

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Bacillus thuringiensis GIFSPR-111, isolated from shrimp farm soil in Shamnagar, Bangladesh, inhibits Vibrio parahaemolyticus, the causative agent of acute hepatopancreatic necrosis disease in shrimp and exhibits probiotic potential. The 5,608,442 bp draft genome contains multiple biosynthetic gene clusters, with potential to synthesize diverse bioactive metabolites.

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Coupling of Kondo resonance with RF signal injected in a scanning tunneling microscope junction.

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We injected an RF signal into the scanning tunneling microscope (STM) junction. A radical molecule of 1,3,5-triphenyl-6-oxoverdazyl (TOV) adsorbed on the Au(111) surface was used as a sample, in which the Kondo resonance, which arises when the substrate's itinerant electrons screen the isolated spin of the molecule, was observed. With increased injected RF power, the Kondo peak undergoes energy splitting and intensity suppression, with the latter accompanied by an intriguing beat-like oscillation. The peak suppression is accounted for by the Kondo resonance's decoherence due to the flip of the unpaired spin. Unlike previous works reported for the suppression by RF power (energy ℏω), we demonstrated that this phenomenon occurs when ℏω is smaller than the Kondo resonance energy; this suggests that multiple photons can induce the spin-flip process, which appears as a beat in the Kondo intensity decay as a function of RF power. This finding should benefit Kondo resonance control in systems with stronger spin-substrate coupling.

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Perceived Enablers and Barriers to HIV Testing Service Uptake Among Adolescent Girls and Young Women in Kilimanjaro, Tanzania: A Contextual Analysis.

Njau Bernard B, Fadhili Nasrath N, Gamassa Editruda E, Jeremia Damian D

Adolescent girls and young women (AGYW) are among the high-risk groups for new HIV infection, particularly in Sub-Saharan Africa (SSA). HIV testing is an entry path to HIV care and treatment and is crucial in ending the HIV epidemic by 2023. Despite the availability of HIV Testing Services (HTS) in most SSA countries, including Tanzania, most AGYW are undiagnosed HIV or have ongoing HIV exposure. This study explored the enablers for and barriers to the uptake of HTS among AGYW aged 15-24 in northern Tanzania. This qualitative study was conducted between 4th October and 30th November 2024 in the Kilimanjaro Region, northern Tanzania. We included AGYW attending four purposively selected Care and Treatment (CTC) sites. Four Focused Group Discussions (FGDs) (two for 15-19 years and 20-24 years, respectively) were conducted using a semi-structured interview guide to explore perceived enablers for and barriers to the uptake of HTS among AGYW. Data were analyzed using thematic content analysis, and findings were presented narratively, using verbatim quotes. A total of 32 AGYW participated in the FGDs, more than half (53%) were aged 20- 24 years old and had primary education, and 63% (n = 20/32) were still in school. Perceived enablers that may facilitate the uptake of HTS include small blood samples collected, trust of a sexual partner, confidentiality of HIV test results, and existing social support. Other perceived enablers were the provider-centred HIV approach, comprehensive HIV education, health benefits of ARV use, and antenatal care as an entry point to HTS. Perceived barriers to HTS uptake include lack of HTS knowledge, being asymptomatic, fear of HIV test results, spiritual healing beliefs, being visible at the health facility, and anticipated stigma. Other perceived barriers were the provider's negative attitudes, long waiting times, lack of confidentiality of HIV test results, and transport costs. This calls for a multifaceted, client-centred intervention that strengthens the perceived enablers and simultaneously addresses the perceived barriers to create an enabling environment for uptake of HTS among AGYW.

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Gold nanoparticles (Au NPs) supported on ordered mesoporous silica have attracted significant attention as robust nanocatalysts. In this study, high-gold-content three-dimensional (3D) mesoporous silica (KIT-6-Au NPs) was synthesized, which exhibited a 3D cubic Ia3d mesostructure with uniformly dispersed Au NPs (∼8 nm) predominantly exposing the (111) facets. Structural analyses were conducted by Brunauer-Emmett-Teller surface area measurement, Raman spectroscopy, solid-state Si29 NMR spectroscopy, Transmission electron microscopy, x-ray diffraction, x-ray photoelectron spectroscopy, and inductively coupled plasma optical emission spectroscopy, confirming high gold loading 15.5 wt% and strong metal-support interaction. Catalytic performance was evaluated through the reduction of 4-nitrophenol (4-NP) with NaBH4 as a model reaction, exhibiting a maximum apparent rate constant of 0.0086 ± 0.0002 s- 1 at 25°C. It surpasses comparable Au-mesoporous silica systems and is competitive with other silica-supported metallic nanocatalysts. The findings further confirm that the reduction of 4-NP by NaBH4 in the presence of the KIT-6-Au NP catalyst proceeds via a heterogeneous catalytic pathway and that the catalyst is structurally robust under the reaction conditions. This work highlights the potential of facet-engineered, high-loading Au NPs integrated within a 3D mesoporous silica framework as an efficient catalyst capable of promoting diverse reactions under mild conditions.

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Stable core-encapsulation of indium-111 in crosslinked polyionic complex micelles and assessment of its biodistribution.

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Radioactive isotopes, such as Indium-111 (111In), are pivotal for highly sensitive noninvasive imaging and targeted radiotherapy. However, achieving stable in vivo retention remains a critical barrier. Conventional nanocarriers typically rely on surface-bound chelators, exposing the isotopes to biological transchelation and detachment, while potentially altering the carrier's surface properties and pharmacokinetics. To address these limitations, this study evaluates a polyionic complex micelle (PICm) platform designed to encapsulate 111In within a crosslinked core using DOTA chelation. This approach aims to enhance radiochemical stability while preserving the micelle's native, engineered surface characteristics. DOTA-functionalized PICm were fabricated through electrostatic self-assembly of PEG-based polymers and subsequent core crosslinking. The resulting micelles exhibited a highly uniform size (32.6 ± 6.3 nm) and a modestly negative surface charge (- 4.9 ± 1.0 mV). Stability assays demonstrated that under the acidic conditions required for 111In chelation (pH 5.5), the micelles undergo reversible size swelling driven by polymer protonation without aggregating or collapsing, confirming that core crosslinking successfully maintains micellar integrity. In vivo biodistribution in CT26 tumor-bearing mice revealed that 111In-loaded PICm displayed prolonged systemic presence, with tumor accumulation peaking at 2.3 ± 0.4%ID/g at 24 h post-injection via the enhanced permeability and retention effect. Hepatic and splenic uptakes aligned with typical nanoparticle clearance pathways. The core-loading of PICm may offer advantages over surface-chelated nanocarriers. By maintaining structural integrity during radiolabeling and extending systemic circulation in vivo, these results validate the platform's robustness and passive tumor accumulation, highlighting its potential as a versatile vehicle for the delivery of diagnostic radionuclides.

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On-surface photochemistry provides a non-thermal strategy that can circumvent the side reactions and structural defects associated with thermal activation, enabling enhanced control over surface reactions. Among these, Ullmann coupling serves as a representative on-surface reaction for fundamental studies of reaction mechanisms and controllability. However, how the aromatic core of molecular precursors governs photoinduced C-Br activation on metal surfaces remains insufficiently understood. In this work, we investigated photoinduced Ullmann coupling on Au(111) using three dibromo molecular precursors with distinct aromatic cores. The three precursors show markedly different photoreactivities under 405 and 532 nm irradiation. Time-dependent density functional theory calculations reveal a photoinduced surface-to-molecule charge-transfer process. Combined with calculations of potential energy surfaces for C-Br bond dissociations, these results provide a qualitative rationale for comparing the relative tendency of photo-triggered C-Br cleavage at the surface. The results establish a direct correlation between photo-selectivity and the molecular aromatic core, providing mechanistic insight into light-controlled on-surface synthesis and offering design principles for tailoring light-responsive precursors toward desired carbon nanostructures.

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