若生智能
Drug Database
DT

DTP-HBV-Hib vaccine (Comvac5)

✓ Approved

Bharat Biotech Ltd. · 疫苗 · 疫苗

什么是 DTP-HBV-Hib vaccine？

DTP-HBV-Hib vaccine 是一种疫苗，由Bharat Biotech Ltd.研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)。

药物档案

商品名Comvac5
公司Bharat Biotech Ltd.
药物类别疫苗
给药途径Injectable (Others), Intravenous (IV)
状态Approved
来源： ClinicalTrials.gov, Bharat Biotech Ltd.

治疗适应症

DTP-HBV-Hib vaccine 针对 4 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsDiphtheria✓ Approved
Infections and infestationsHepatitis B✓ Approved
Infections and infestationsPertussis✓ Approved
Infections and infestationsTetanus✓ Approved

相关研究文献

PubMedClinical kidney journal2026-08-05

Lipid parameters but not inflammatory indices predict hepatitis B vaccine responses in hemodialysis patients.

Ekici Hilal H, Mirza Arzu A, Baltacı Sevgi S, Eren Davut D et al.

Hepatitis B virus (HBV) vaccination is essential in hemodialysis (HD) populations, yet seroprotection remains suboptimal. Inflammation-related hematologic indices are frequently used in clinical practice, but their ability to predict HBV vaccine response in HD patients is uncertain. We evaluated clinical and laboratory determinants of HBV vaccine response, with a focus on lipid-derived indices and inflammatory ratios. In this multicenter retrospective study, adult HD patients followed between 2015 and 2025 who received at least three doses of HBV vaccine and had available anti-HBs measurements were included (n = 341). Vaccine response was defined as anti-HBs ≥10 IU/L; non-response as <10 IU/L. Neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR), monocyte-to-lymphocyte (MLR), neutrophil percentage-to-albumin ratio (NPAR), and lipid ratios (TG/HDL, TC/HDL, LDL/HDL) were calculated. Additional analyses using percentile-based categorization of NPAR confirmed the absence of a significant association with vaccine response. Multivariable logistic regression and receiver operating characteristic analyses were performed. After the primary vaccination series, seroprotection was 77.4% and increased to 88.6% after revaccination/boosters; it declined to 78.3% at 1 year and 69.2% at 2 years. Non-responders were older and had higher triglyceride levels and lower HDL cholesterol levels. In contrast, inflammatory indices (NLR, PLR, MLR, and NPAR) did not differ significantly between groups. These indices also demonstrated limited discriminative ability for predicting vaccine response. In multivariable analysis, HDL cholesterol remained positively associated with vaccine response [odds ratio (OR): 1.046, 95% confidence interval (CI): 1.006-1.086, P = .022], and triglyceride levels were negatively associated with vaccine response (OR: 0.992, 95% CI: 0.984-0.999, P = .024). The TG/HDL ratio showed borderline statistical significance (OR: 1.235, 95% CI: 0.983-1.551, P = .070), suggesting a potential but limited contribution to vaccine response prediction. In HD patients, hematologic inflammatory indices were not informative for HBV vaccine response, whereas an atherogenic lipid profile-particularly lower HDL and higher triglycerides-showed a consistent association. Lipid parameters may support risk stratification and tailored post-vaccination monitoring strategies.

PMID 42553896
阅读全文 →
PubMedJournal of viral hepatitis2026-08-05

Prevalence of Hepatitis B Virus Infection in Cameroon: A Systematic Review and Meta-Analysis.

Maliki Iya I, Webb Edward J D EJD, Ada Rose Armelle RA, Dawkins Bryony B et al.

Chronic hepatitis B virus (HBV) infection is a global public health problem, and many regions of Sub-Saharan Africa are disproportionately affected, including Cameroon, where prevalence has previously been shown to be high. This study aimed to provide up-to-date estimates of HBV prevalence in Cameroon. We searched Medline, Global Health, Embase, Web of Science, Cochrane Library, Africa Index Medicus and the Journal of Health Science and Disease at the University of Yaounde. We included studies reporting HBV surface antigen (HBsAg) prevalence in the general population and subpopulations. A random-effects meta-analysis was used to generate pooled estimates of HBsAg prevalence, overall and for population subgroups including those considered at relatively higher-risk and relatively lower-risk of HBV infection. Heterogeneity was assessed using the index of heterogeneity (I2). Quality was assessed using the Joanna Briggs Institute critical appraisal tool. Out of 1236 records, 92 papers with 100 studies were included in the meta-analysis. Overall prevalence of HBV in Cameroon was 9.98% (95% confidence interval [CI] 9.00-11.02) with high heterogeneity (I2 = 98.10%). The prevalences for relatively lower-risk and higher-risk populations were8.94% (95% CI 7.84-10.11) and 12.70% (95% CI 10.28-15.32), respectively. In subgroup analyses, we found that sex, geographical area (regions), population risk groups and study design were the main sources of heterogeneity. Overall, HBV prevalence remains high in Cameroon. Our findings suggest an urgent need for health interventions to halt the spread of the disease, with particular attention needed for males and regions with the highest prevalence.

PMID 42554292
阅读全文 →
PubMedFrontiers in global women's health2026-08-05

Awareness, factual knowledge, attitudes, and acceptability of human papillomavirus vaccination among adult women in Palestine: a cross-sectional study.

Amro Alhareth M AM, Safadi Leen M LM, Fahoum Shahd R SR, Deeb Salahaldeen S et al.

Human papillomavirus (HPV) is a major preventable cause of cervical cancer, yet awareness and uptake of HPV vaccination remain suboptimal in many settings. Evidence regarding women's HPV-related awareness, factual knowledge, and vaccine acceptability in Palestine remains limited. This study assessed awareness, factual knowledge, attitudes, self-reported uptake, willingness, and perceived barriers related to HPV infection and HPV vaccination among adult women in Palestine. A cross-sectional online survey was conducted between October 2025 and February 2026 among women aged ≥18 years residing in Palestine. The questionnaire assessed sociodemographic characteristics, HPV and HPV vaccine awareness, factual knowledge, attitudes, vaccine uptake, willingness to receive or recommend vaccination, and perceived barriers. A 12-item factual knowledge score was calculated, and higher factual knowledge was defined as ≥7 correct responses. Descriptive statistics, subgroup analyses, and multivariable logistic regression were performed. Among 424 adult women included in the final analysis, 220 (51.9%) had heard of HPV and 146 (34.4%) had heard of the HPV vaccine. The mean factual knowledge score was 4.03 ± 2.72 out of 12, and 90 participants (21.2%) had higher factual knowledge. Self-reported HPV vaccine uptake was low (13.0%), whereas willingness to receive the vaccine was higher (55.2%). Lack of awareness (55.8%) and concern about vaccine safety (22.8%) were the most frequently reported barriers among unvaccinated women. In expanded adjusted analyses, prior HPV awareness, prior HPV vaccine awareness, and more supportive HPV-vaccination attitudes were independently associated with higher factual knowledge. Higher factual knowledge and supportive attitudes were associated with self-reported vaccine uptake, while willingness among unvaccinated women was most strongly associated with supportive vaccination attitudes. Adult women in Palestine demonstrated limited HPV-related awareness and low factual knowledge, together with low self-reported HPV vaccine uptake. The gap between willingness and uptake, combined with the predominance of awareness and safety concerns as reported barriers, suggests a need for culturally appropriate education, provider-led counseling, and improved access to reliable HPV vaccine information. Findings should be interpreted cautiously given the cross-sectional design and online convenience sampling.

PMID 42553322
阅读全文 →
PubMedBMJ public health2026-08-05

Longitudinal retrospective cohort study to examine liver, cardiovascular and metabolic factors as predictors of all-cause mortality in a rural population in South-West Uganda.

Campbell Cori C, Mugisha Joseph O JO, Kimono Beatrice B, Waddilove Elizabeth E et al.

Markers of liver and metabolic disease have not been well described for many populations in Africa, but could be important to inform individual and public health interventions that reduce morbidity and mortality. We studied longitudinal data from a population in rural Uganda, aiming (1) to describe trends in liver function tests and (2) to investigate how liver, metabolic and cardiovascular parameters are associated with all-cause mortality. Demographic and laboratory data were collected through the General Population Cohort in South-Western Uganda. We summarised cohort characteristics at baseline using descriptive statistics and used univariable and multivariable Cox proportional hazards models to investigate factors associated with adjusted HR (aHR) for death over a 12-year period (between 2011 and 2023). Our dataset includes 7896 individuals, of whom 4441/7896 (56%) were female and 5722/7896 (72%) were aged under 45 years. Prevalence of hepatitis B virus (HBV) was 216/7896 (2.74%; 95% CI 2.38% to 3.10%) and HIV was 582/7896 (7.37%; 95% CI 6.79% to 7.94%). Alanine aminotransferase (ALT) was elevated in 2020/7896 (25.58%; 95% CI 24.62% to 26.55%). During the period observed, all-cause death was associated with older age (p<0.001), male sex (aHR 1.56, 95% CI 1.30 to 1.86) and HIV infection (aHR 1.67, 95% CI 1.25 to 2.22). Mortality was associated with an increase in aspartate aminotransferase:ALT ratio (aHR 1.17, 95% CI 1.08 to 1.26), a marker of alcoholic hepatitis. Increases in systolic blood pressure and haemoglobin A1c were also associated with significantly elevated hazards of death. Under sensitivity analysis restricted to participants with longitudinal follow-up data (n=871), HBV infection was associated with death (aHR 5.38, 95% CI 2.01 to 14.42). Simple interventions to prevent, diagnose and treat hypertension, diabetes, alcohol excess, and HIV and HBV infection could have an important impact on mortality in this setting.

PMID 42553754
阅读全文 →
PubMedInternal medicine journal2026-08-05

Critical role of vaccination in preventing severe coronavirus disease 2019: perspectives from clinical outcomes in an Australian kidney transplant recipient cohort.

Tharmaraj Dhakshayini D, Naidu Paayal P, Baptista Mohana M, McBride Sarah S et al.

Kidney transplant recipients (KTRs) disproportionately experience severe COVID-19 infections. We previously identified concern regarding vaccine-induced rejection as a barrier to vaccine uptake. This study assesses COVID-19 vaccine uptake, infection outcomes and allograft rejection in KTRs during the delta and omicron waves (BA.1/BA.2). This cohort study included all adult KTRs with a functioning allograft at 22 March 2021 at our centre. KTR and vaccination-related risk factors for the primary outcome of severe COVID-19 infection (requiring hospitalisation) and the secondary outcomes of death and all COVID-19 infections were assessed using Cox proportional hazards models. Rejection risk following infection/vaccination was also assessed. Of the 986 included KTRs, there were 333 (33.8%) COVID-19 infections, 79 (23.7%) severe infections and 13 deaths (n = 13/333, 3.9%). Vaccine number was the most significant modifiable predictor of severe infection (adjusted hazards ratio, per additional dose, 0.5; 95% confidence interval, 0.40-0.65, P < 0.001) and death. While older age also predicted severe infection and death, lower estimated glomerular filtration rate, history of diabetes and previous allograft rejection predicted severe infection. Male gender was the only predictor of all infections. Mycophenolate dose, prednisolone use and vaccine type did not predict infection or severe disease. Infections and vaccinations did not increase the risk of rejection. KTRs should be encouraged to be optimally vaccinated to prevent severe disease and can be reassured about the low risk of allograft rejection. Risk factors that compound the state of immunocompromise and severe COVID-19 infections should prompt vigilance and targeted interventions to mitigate these risks.

PMID 42554002
阅读全文 →
PubMedPLoS computational biology2026-08-05

Quantifying the impact of vaccination on pertussis dynamics in Sweden.

Brett Tobias S TS, Tredennick Andrew A, Briga Michael M, Coudeville Laurent L et al.

The last few decades have witnessed a resurgence in pertussis notifications in a number of countries with high vaccine coverage, including Sweden. The underlying causes of the resurgence have been the subject of much scientific debate. To arbitrate among the putative drivers of the resurgence in Sweden, we formulated a mechanistic transmission model which we fit to age-structured time-series notifications data via likelihood maximisation. Given our model, we find the data are best explained by the combined effects of a low basic reproductive number, incomplete (leaky) DTaP-derived immunity, a much lower reporting probability of infections in older individuals and waning of vaccine-derived immunity. In addition, our modelling explains the post-2014 resurgence as a combination of two factors. First, a dynamical transient known as the honeymoon effect, in which a rebound in transmission follows after a rapid decrease in the average population susceptibility. Second, an increase in the infection reporting probability from 2014 onwards, likely due to the use of new laboratory testing methods. Additionally, we used our fitted transmission model to reconstruct indirect protective effects of vaccination. Our results suggest immunization prevents about 50% of potential infections in individuals too young to receive vaccination. However, our statistical inference demonstrates that pertussis elimination is not possible with routine immunization using acellular vaccines due to the combined effects of vaccine leakiness and waning immunity.

PMID 42550879
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多DTP-HBV-Hib vaccine