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celecoxib + tramadol HCl (MR308 / Velyntra / Seglentis)

✓ Approved

Kowa · OPRM1 · 小分子

什么是 celecoxib + tramadol HCl？

celecoxib + tramadol HCl 是一种小分子，由Kowa研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名MR308, Velyntra, Seglentis
公司Kowa
药物类别小分子
分子靶点OPRM1, PTGS2, SLC6A2, SLC6A4
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Kowa

作用机制

分子靶点

celecoxib + tramadol HCl 作用于 4 个分子靶点：

OPRM1opioid receptor mu 1 (MOP, M-OR-1)
PTGS2prostaglandin-endoperoxide synthase 2 (PHS-2, PGG/HS)
SLC6A2solute carrier family 6 member 2 (NAT1, NET)
SLC6A4solute carrier family 6 member 4 (SERT1, 5-HTTLPR)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

celecoxib + tramadol HCl 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Gastrointestinal disordersAbdominal pain✓ Approved
Injury, poisoning and procedural complicationsProcedural painPhase III

相关研究文献

PubMedChemistry of materials : a publication of the American Chemical Society2026-08-05

Structured Aluminum Phosphonate Metal-Organic Framework for Efficient Hydrogen Purification: Reversible HCl Adsorption and Water-Triggered Regeneration.

Sharma Ravi R, Padunnappattu Ajay A, Van der Stricht Max Phil MP, Stock Norbert N et al.

Efficient removal of acidic impurities such as hydrogen chloride (HCl) is essential for hydrogen purification, yet most conventional adsorbents are nonregenerable and require frequent replacement, underscoring the need for scalable, regenerable alternatives. This study evaluates the aluminum-based metal-organic framework (MOF) Al-CAU-60 as a regenerable HCl adsorbent. A reproducible, scalable reflux synthesis was developed for phosphonate-based Al-CAU-60·6HCl, enabling 10 L scale production with high yield (151 g, >96%) and preserved crystallinity. Following neutralization, the MOF was shaped into mechanically robust pellets (Al-CAU-60/PVF) using 10 wt % polyvinyl formal (PVF) as a binder. Structural and chemical integrity were confirmed through scanning electron microscopy-energy-dispersive X-ray spectroscopy (SEM-EDX), powder X-ray diffraction (PXRD), attenuated total reflectance-Fourier transform infrared (ATR-FTIR), and thermogravimetric (TGA) analyses. Under dynamic breakthrough tests (10 bar, 25 °C, 100 ppm of HCl), Al-CAU-60/PVF showed an average HCl uptake of 1.38 mmol/g at the 1 ppm breakthrough and 1.73 mmol/g at saturation. The material retained its performance over seven adsorption-regeneration cycles using only water-triggered desorption, demonstrating an exceptional example of fully regenerable, phosphonate-based MOF sorbents. In contrast, zeolite 13X, while initially more active, lost ∼90% capacity after the first cycle, confirming the superior cyclic stability of Al-CAU-60/PVF. Mechanistic analysis revealed that HCl adsorption proceeds via reversible protonation-deprotonation of phosphonate groups during water-based regeneration.

PMID 42553707
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PubMedSaudi journal of anaesthesia2026-08-05

Ultrasound-guided erector spinae plane block versus anterior quadratus lumborum block for postoperative analgesia after percutaneous nephrolithotomy: A randomized controlled study.

Arora Yamini Y, Singh Pooja P, Mandal Pranita P, Kumar Harish H et al.

Percutaneous nephrolithotomy (PCNL) is associated with significant postoperative pain. Ultrasound-guided erector spinae plane block (ESPB) and anterior quadratus lumborum block (QLB) are increasingly used for analgesia; however, direct comparative evidence in PCNL remains limited. This randomized controlled study compared their analgesic efficacy following unilateral PCNL. Eighty-four adult patients (American Society of Anaesthesiologists I-III) were randomized to receive ESPB or anterior QLB. Three patients in each group had block failure. The primary outcome was time to first rescue analgesia. Secondary outcomes included Numeric Rating Scale (NRS) pain scores at rest and during movement at 1, 2, 6, 12, and 24 h, total tramadol consumption, complications, time to ambulation, and length of hospital stay. Time to first rescue analgesia was significantly longer in Group E compared to Group Q (406.15 ± 161.97 min vs. 326.15 ± 155.61 min; mean difference 80 min; 95% CI 9-151; P = 0.022; Cohen's d = 0.50). At 2 h, fewer patients in Group E required rescue analgesia (7.7% vs. 25.6%; P = 0.033). NRS scores at rest and during movement were comparable at all time points. Total tramadol consumption over 24 h was similar; however, fewer patients in Group E required tramadol at 12 h (23.1 vs. 43.6%; P = 0.049). Complication rates, ambulation time, and length of hospital stay were comparable. Both ESPB and anterior QLB provide effective postoperative analgesia after PCNL. ESPB offers moderate effect size prolongation in time to first rescue analgesia, suggesting a modest early postoperative analgesic advantage without increased complications.

PMID 42553861
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PubMedVeterinary medicine and science2026-08-05

Effects of Topical Administration of Bupivacaine HCl to the Ovarian Pedicle on Postoperative Pain, Antioxidant Enzyme Activity and Inflammatory Cytokines in Dogs Undergoing Laparoscopic Ovariectomy.

Çiplak Alper Yasin AY, Polat Bülent B

Laparoscopic ovariectomy (LOE) is a common procedure for elective sterilization in dogs and is associated with less tissue trauma than open techniques. However, manipulation of the ovarian pedicle may still induce nociceptive stimulation and contribute to perioperative inflammatory responses and changes in antioxidant enzyme activity. Topical administration of local anaesthetic to the ovarian pedicle may improve perioperative analgesia in minimally invasive surgery. To evaluate the effects of topical administration of bupivacaine HCl to the ovarian pedicle on postoperative pain, serum antioxidant enzyme activity and systemic pro-inflammatory cytokines in dogs undergoing LOE. Twenty-four clinically healthy, American Society of Anaesthesiologists (ASA) Class I female dogs were enrolled in a prospective, randomized, controlled trial. The dogs were allocated to receive either a total dose of bupivacaine HCl at 2.2 mg/kg (BPLOVE, n = 12), divided between the two ovarian pedicles, or an equivalent volume of isotonic saline (LOVE, n = 12), applied using the same topical technique. Standardized anaesthesia and surgical protocols were implemented. Postoperative pain was assessed using the University of Melbourne Pain Scale (UMPS) at 0, 2 and 4 h after surgery. Serum samples collected preoperatively, intraoperatively, and at 0, 2 and 4 h postoperatively were analysed for superoxide dismutase (SOD), catalase (CAT), interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α). Data were analysed using repeated-measures ANOVA and non-parametric tests (p < 0.05). All dogs completed the study without experiencing any major complications or requiring intraoperative rescue analgesia. UMPS scores were significantly lower in the BPLOVE group at all postoperative time points (p < 0.05). Significant group and time effects were observed in SOD and CAT activities, with higher antioxidant enzyme activity detected in bupivacaine-treated dogs (p < 0.05). Cytokine outcomes showed no consistent between-group differences; IL-6 was numerically lower in the BPLOVE group across time points, with a significant difference detected only at 4 h postoperatively. Topical administration of bupivacaine HCl to the ovarian pedicle during LOE was associated with improved early postoperative analgesia and higher serum SOD and CAT activities, without consistent short-term changes in systemic pro-inflammatory cytokine concentrations. These findings support the potential value of ovarian pedicle bupivacaine administration as part of multimodal analgesia in canine laparoscopic surgery and indicate changes in antioxidant enzyme activity during the early perioperative period.

PMID 42554136
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PubMedAngewandte Chemie (International ed. in English)2026-08-05

One-Step Synthesis of Sequence-Tailored Amphiphilic Block Copolymers at the Emulsion Interface.

Hou Wangmeng W, Xu Dong D, Zhang Haoyu H, Wang Ke K et al.

The synthesis of sequence-controlled block copolymers (BCPs) via one-step copolymerization has garnered significant interest, as it offers a highly accessible and reproducible route. Herein, we describe a one-step strategy utilizing ring-opening metathesis polymerization (ROMP) at the emulsion interface for synthesizing amphiphilic BCPs with tailored sequences. Briefly, two norbornenyl monomers with similar reactivities containing hydrophilic tertiary amino and hydrophobic group, respectively, were dissolved in a CH2Cl2/H2O emulsion, and the copolymerization was initiated by Grubbs' third-generation catalyst (G3). The hydrophobic monomer and G3 were localized within CH2Cl2 droplets, whereas the tertiary amine-bearing norbornene was distributed in both aqueous and CH2Cl2 phases, a partitioning that could be tuned by hydrochloric acid (HCl). Leveraging the partitioning effect of CH2Cl2/H2O emulsion, ROMP was initiated in CH2Cl2 droplet and then propagated at the CH2Cl2/H2O interface, enabling the one-step formation of well-defined amphiphilic BCPs. Notably, the unit sequence could be precisely tuned by HCl concentration, which governs the distribution of tertiary amine-bearing norbornene between the two phases. After polymerization, these amphiphilic BCPs at the CH2Cl2/H2O interface could further undergo emulsion-induced self-assembly to prepare functional hybrid nanomaterials. Overall, this work offers a straightforward and efficient one-step strategy for sequence-tailored amphiphilic BCPs and their derived nanostructures.

PMID 42554433
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PubMedPain medicine case reports2026-08-04

Ultrasound-Guided Stellate Ganglion and Interscalene Blocks for Refractory Pediatric Parsonage-Turner Syndrome: A Case Report and Clinical Implications.

Laraib Warda W, Abbas Adeel A, Habib Insha I, Fareh Zohad Z et al.

Parsonage-Turner syndrome (PTS) is an uncommon inflammatory brachial plexopathy; pediatric and bilateral cases are rare, and evidence for managing refractory pediatric pain is limited. A previously healthy 6-year-old girl developed sudden severe left upper-limb pain with progressive wrist-drop in August 2023; by October, the right arm was affected. Nerve conduction studies/electromyography confirmed brachial plexopathy and magnetic resonance imaging showed diffuse thickening of left C5-C7. Laboratory tests were unremarkable, except for an isolated anti-glycosphingolipid monosialo-2 antibody. Oral corticosteroids, tramadol, and 2 intravenous immunoglobulin doses produced limited benefit, and corticosteroids caused mood disturbance. In October 2023, ultrasound-guided stellate ganglion (C6) and interscalene (C5-C6) blocks with 4-6 mL of 0.25% bupivacaine under general anesthesia were performed. At one week, she reported ~85% pain relief; analgesics were reduced to paracetamol. In refractory pediatric bilateral PTS, regional stellate ganglion and interscalene blocks provided rapid, substantial analgesia; prospective studies should define indications and long-term outcomes.

PMID 42550561
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PubMedFrontiers in medicine2026-08-04

Pragmatic evaluation of prescription glucosamine sulfate (pGS) in knee osteoarthritis: insights from a Filipino cohort.

Yu Julie J, Lichauco Juan Javier JJ, Navarra Sandra S, Chiaese Raffaella Maria Rita RMR et al.

The real-world effectiveness and tolerability of prescription glucosamine sulfate (pGS) in reducing knee osteoarthritis (KOA) symptoms in a Filipino cohort was evaluated. This 8-week, pragmatic, open-label, multicenter study enrolled 281 Filipino adults with mild-to-moderate (Kellgren-Lawrence grade 2-3) KOA. Participants received pGS 1,500 mg once daily. Outcomes included changes from baseline assessed with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Visual Analog Scale (VAS) for pain at Weeks 4, 6, and 8. Tolerability was evaluated through adverse event monitoring. Among 281 treated patients, 277 (98.6%) completed the study, and 245 (~88.0%) received pGS alone for the full period. These patients demonstrated rapid, sustained symptom improvement, with knee pain decreasing by Week 4 and continuing through Week 8. After 4 weeks, 132 patients (~47.0%) had already achieved ≥50.0% pain reduction. By Week 8, WOMAC pain showed a least squares (LS) mean change of -11.96 (95% CI: -12.26 to -11.67), with marked improvements in stiffness, physical function, and total score. VAS pain decreased from 68.4 mm at baseline to 11.9 mm at Week 8, consistent with meaningful clinical benefit. Treatment satisfaction was high, with 98.78% satisfied at Week 8 and a mean psychometric VAS score of 9.0. Patients with more advanced KOA requiring add-on therapy (n = 34) also demonstrated pain improvement, with an LS mean change in WOMAC pain of -8.81 (95% CI: -9.62 to -7.99). Overall, adverse events occurred in 4.6% of patients, were mostly mild, and led to only one withdrawal, confirming good tolerability of pGS as monotherapy and in multimodal treatment. Prescription glucosamine sulfate improved pain, stiffness, and function in Filipino patients with mild-to-moderate KOA as early as Week 4, sustained through Week 8. Treatment was well tolerated, with high satisfaction and one discontinuation. Most patients (~88%) were effectively managed with pGS monotherapy, while add-on celecoxib benefited those with insufficient response, supporting a multimodal approach for KOA symptom control in routine care.

PMID 42549386
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