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ketoprofen (Ketopatch / ketoprofen, Pacific / Ketotop patch)

✓ Approved

Aestura · PTGS1 · 小分子

什么是 ketoprofen？

ketoprofen 是一种小分子，由Aestura研发。该药已获批，用于治疗相关适应症，给药途径：Transdermal。

药物档案

商品名Ketopatch, ketoprofen, Pacific, Ketotop patch
公司Aestura
药物类别小分子
分子靶点PTGS1, PTGS2
给药途径Transdermal
状态Approved
来源： ClinicalTrials.gov, Aestura

作用机制

分子靶点

ketoprofen 作用于 2 个分子靶点：

PTGS1prostaglandin-endoperoxide synthase 1 (COX3, PCOX1)
PTGS2prostaglandin-endoperoxide synthase 2 (GRIPGHS, hCox-2)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

ketoprofen 针对 6 个适应症，涉及 3 个治疗领域。

治疗领域疾病/病症分期
Injury, poisoning and procedural complicationsEpicondylitis✓ Approved
Hepatobiliary disordersHepatitis✓ Approved
Musculoskeletal and connective tissue disordersMusculoskeletal pain✓ Approved
Musculoskeletal and connective tissue disordersOsteoarthritis✓ Approved
Musculoskeletal and connective tissue disordersRheumatoid arthritis✓ Approved

注册免费账户还可查看另外 1 个适应症

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相关研究文献

PubMedJournal of genetics2026-08-04

Mitochondrial COI evidence of recent expansion and panmixia in Bangladesh Penaeus monodon, with distinct phylogeographic lineages in the Indo-Pacific.

Alam M M Mahbub MMM, Westfall Kristen K, Palsson Snaebjorn S

The Black Tiger Shrimp (Penaeus monodon) is one of the world's most valuable aquaculture resources, and its genetic diversity has been measured through the Indo-Pacific region. We examined variation in a 584 bp region of mtDNA Cytochrome Oxidase Subunit I (COI) sequence from three sample sites in the Bay of Bengal (total N = 46), to assess its genetic diversity, demographic history, and phylogeographic structure. There is high haplotype diversity in consequence of multiple singleton sequences (h = 0.73), but very low nucleotide diversity (π = 0.0030). Population structure across the three sites is negligible (AMOVA ΦST = 0.0, P > 0.05). Demographic analyses, based on mismatch Tau from ARLIQUIN, suggests a population expansion ~235 Kya (95% CI: 34 - 452 Kya). Negative Tajima's D and Fu's FS values suggest post-bottleneck population growth or a selective sweep. Bayesian skyline analysis estimates the effective population size as Ne > 6 × 106 individuals. The data indicate that P. monodon in the Bay of Bengal is a haplotypically diverse but genetically shallow panmictic population, possibly in consequence of recent expansion. The contrast with other Indo-Pacific populations is discussed. The phylogenetic analysis suggests that mitochondrial DNA (mtDNA) lineages in the Indian Ocean and Pacific lineages may be separate species, separated more than 4 Mya.

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PubMedFrontiers in psychology2026-08-04

Optimizing IELTS Writing Task 2 performance: effects of the WeCWI-Enabled Tencent Applications (WETA) intervention, UTAUT-validated user acceptance, and implied motivational-affective benefits.

Suo Changbao C, Yu Jiashun J, Li Boyi B, Mah Boon Yih BY

Though Technology Enhanced Language Learning (TELL) has advanced EFL writing instruction, existing work remains Western-centric, lacking validated, context-appropriate tools for Chinese learners' persistent IELTS Writing Task 2 challenges. Furthermore, studies have separated writing performance from user acceptance, while the motivational and affective impacts of such interventions remain underexplored in Asia-Pacific EFL settings. To meet the challenges, this study designed, implemented and assessed WeCWI-Enabled Tencent Applications (WETA)-a blended TELL tool designed to integrate WeChat, Tencent Meeting and Web-based Cognitive Writing Instruction (WeCWI), and analyzed its influence on user acceptance based on the IELTS Writing Task 2 performance and Unified Theory of Acceptance and Use of Technology (UTAUT) model. Using an explanatory sequential mixed-methods approach, 60 Chinese EFL undergraduates were divided for an 8-week quasi-experiment. The ANCOVA results showed that the intervention group's participants were associated with a significant and large effect gain in writing scores and also showed gains in its four IELTS scoring sub-criteria, especially in Lexical Resources. Thematic analysis of semi-structured interviews confirmed high user acceptance and strong sustained use intention, driven by all core UTAUT constructs. Qualitative reflections from participants implied that WETA's design suggests a potential for mitigating high-stakes writing anxiety and is associated with increased academic self-efficacy, providing hypothesis-generating motivational-affective insights for the Asia-Pacific EFL context. These findings demonstrate the feasibility of the proposed WeCWI-ADDIE-UTAUT integrated framework, and suggest WETA as a low-cost, context-appropriate, and equitable TELL solution outperforming conventional instruction for Chinese EFL undergraduates.

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Stage-Survival Paradox in Young-Onset Lung Adenocarcinoma Patients Among Asian and Pacific Islander Women: A Population-Based Analysis.

Samaan Hnada H, Alomari Sohaib A SA, Fakeh Sara S, Awidi Muhammad M

Lung adenocarcinoma (LUAD) in young adults may represent a distinct entity with sex and ancestry-related differences. Population-level data on incidence and survival remain limited. We assessed age- and stage-specific trends in early-onset LUAD and evaluated racial and sex disparities in presentation and outcomes. We used the Surveillance, Epidemiology, and End Results (SEER) database to identify patients aged 15-49 years diagnosed with LUAD. Age-adjusted incidence and stage-specific trends were assessed using joinpoint regression. Cause-specific survival was analyzed using Kaplan-Meier methods and multivariable Cox regression, focusing on non-Hispanic Asian or Pacific Islander (NHAPI) females. Among 14,109 patients, 1,149 (8.1%) were NHAPI females. Incidence trends were heterogeneous across groups, with relatively stable patterns in NHAPI females and variable trends in other populations. NHAPI females more frequently presented with distant-stage disease than non-Hispanic White patients (73.6% vs. 68.0%; p = 0.001). Despite this, they demonstrated superior survival. Five-year cause-specific survival was higher in NHAPI females, with a median survival of 38.0 versus 24.0 months in non-Hispanic White patients (log-rank p < 0.001). In multivariable analysis, non-Hispanic White patients had increased mortality risk compared with NHAPI females (HR 1.25, 95% CI 1.12-1.41). Stage remained the strongest prognostic factor, with higher risk in regional (HR 3.51) and distant disease (HR 12.41) versus localized disease (both p < 0.001). Young NHAPI females represent a distinct LUAD subgroup characterized by a paradox of advanced-stage presentation but improved survival. These findings highlight clinically meaningful heterogeneity and support targeted strategies for early detection and prevention.

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Epidemiology of Health-Related Social Needs Screening and Positivity in a Multistate Health System.

Patel Bhavik P BP, Bayes Brian B, Madden Vanessa V, Lu Yingying Y et al.

Health systems increasingly screen for health-related social needs (HRSNs), which are modifiable social factors associated with health outcomes. However, screening selection biases and HRSN burdens are poorly characterized. To evaluate patient characteristics associated with HRSN screening completion, positivity, and assistance requests. This retrospective cohort study of adults with screening-eligible outpatient or inpatient encounters in a 22-state, 92-hospital system was performed from January 1, 2020, to November 30, 2024. Data were analyzed from June 7, 2025, to February 4, 2026. Patient sociodemographic characteristics. Unadjusted standardized mean differences and adjusted logistic regression were used to identify characteristics associated with screening completion. Multivariable regression and marginal standardization were used to identify characteristics associated with positivity for any HRSN, total HRSN burden, and assistance requests. Among 1 893 331 eligible adults, 696 925 (36.8%) were 65 years or older (median age, 57 [IQR, 38-71] years), 1 138 792 (60.1%) were female, 8437 (0.4%) were American Indian or Alaska Native, 60 884 (3.2%) were Asian, 257 391 (13.6%) were Black, 4193 (0.2%) were Native Hawaiian or Other Pacific Islander, and 1 561 702 (82.5%) were White; 87 641 (4.6%) were of Hispanic or Latino ethnicity, and 916 449 (48.4%) had Medicare or Medicaid coverage. A total of 1 135 136 participants (60.0%) completed screening and 334 399 (29.5%) reported at least 1 HRSN. Unadjusted differences between screened and unscreened patients were not significant (standardized mean difference, ≤0.20). In adjusted analyses, Black patients (odds ratio [OR], 0.85; 95% CI, 0.79-0.91) and Medicaid beneficiaries (OR, 0.87; 95% CI, 0.80-0.95) had lower odds of being screened, and Hispanic or Latino patients had higher odds (OR, 1.11; 95% CI, 1.01-1.23). Outpatient underscreening was attenuated in inpatient settings for Black patients and Medicaid beneficiaries. The adjusted probabilities of any positive screen were higher among Black (absolute risk difference [ARD], 12.6%; 95% CI, 9.5%-15.7%), American Indian or Alaska Native (ARD, 10.6%; 95% CI, 9.2%-11.9%), and Native Hawaiian or Other Pacific Islander (ARD, 7.2%; 95% CI, 2.1%-12.2%) patients and among Medicare (ARD, 13.1%; 95% CI, 9.7%-16.5%) and Medicaid (ARD, 18.7%; 95% CI, 16.1%-21.2%) beneficiaries compared with White and commercially insured patients. Black patients (ARD, 9.4%; 95% CI, 6.5%-12.3%) and Medicaid beneficiaries (ARD, 16.9%; 95% CI, 16.0%-17.9%) had higher adjusted probabilities of at least 3 positive domains. Among those with at least 3 positive domains, Black patients (ARD, 21.9%; 95% CI, 16.5%-27.2%), Medicare (ARD, 7.0%; 95% CI, 5.1%-8.8%), and Medicaid (ARD, 12.2%; 95% CI, 10.9%-13.6%) beneficiaries had higher assistance requests. In this cohort study across inpatient and outpatient settings, HRSN screening had a substantial reach largely free of selection. Nearly 30% of screened patients demonstrated needs, with higher rates among patients who were members of racial and ethnic minority groups and publicly insured. This study provides support for inpatient HRSN screening workflows, even as policy mandates evolve, to preserve equitable reach for patient groups with disproportionately high social needs.

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Maharaj Jayishni N JN, Woodburn Jim J, McLaren-Kennedy Annette A, Kola Mohamed A MA et al.

Diabetic foot ulcers (DFU) continue to occur despite established prevention guidelines, yet consumer perspectives, particularly from socioeconomically disadvantaged and culturally and linguistically diverse (CALD) communities, have been underrepresented in shaping prevention. To address this gap, we aimed to co-design a consumer-derived prevention research agenda by identifying barriers and enablers, establishing research priorities, prioritising implementation strategies, and defining meaningful outcome measures. Four sequential workshops were conducted with 11 consumers with a history of DFU in South East Queensland, including Aboriginal and Pacific Islander participants (n = 4) and those from areas of socioeconomic disadvantage (n = 8). Rapid qualitative analysis informed iterative refinement across workshops, with priorities, implementation strategies, and outcome measures ranked by participants. Participants identified barriers across clinical, self-care, psychosocial, social, and financial domains, including feeling unsupported when trying to prevent DFU, the cognitive burden of constant vigilance, conflicting guidance, and the financial and travel costs of care. The highest-ranked research priorities were better ways to predict problems before they happen (median 2, IQR 1-4.5), formal education support (median 4, IQR 3-9), and tools to support regular foot checks (median 5, IQR 3-6). Across all three priorities, consumers consistently selected technology enabled implementation strategies, including wearable sensors, AI powered personalised learning, and smart interventions. Participants defined prevention success through quality of life, function, and confidence outcome measures rather than clinical endpoints alone. For socioeconomically disadvantaged and CALD populations, effective DFU prevention must be technology enabled, personalised, and developed in partnership with the consumer.

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PubMedAllergy, asthma & immunology research2026-08-04

Real-World Performance of Non-Allergist-Led Penicillin Allergy Delabeling: Prospective Head-to-Head Comparison of APAAACI vs. PENFAST.

Chung Freya Kl FK, Shi Weihong W, Chong Man Yui MY, Lee Elaine E et al.

Although around 90% of penicillin allergies are mislabelled, delabeling initiatives have been hindered by limited access to drug allergy services. Asia Pacific Association of Allergy, Asthma, and Clinical Immunology (APAAACI) and PENFAST risk-stratification tools can facilitate non-allergist delabeling, but their comparative real-world performance remains unknown. The purpose of this study was to prospectively evaluate APAAACI and PENFAST against allergist assessment and drug provocation testing (DPT) outcomes. In a blinded, head-to-head study, 103 adults with penicillin allergy labels underwent independent risk stratification using both APAAACI and PENFAST tools, followed by allergist evaluation and allergy testing (skin tests, in vitro tests, and DPT). We assessed diagnostic performance (area under the curve [AUC]-receiver operating characteristic, accuracy, sensitivity, specificity, positive and negative predictive values [NPVs]) and agreement (Cohen's κ) of these tools. Overall, allergist assessment demonstrated the highest AUC of 0.82 (95% confidence interval [CI], 0.69-0.95), outperforming APAAACI (AUC, 0.79; 95% CI, 0.66-0.92; P = 0.012) and PENFAST (AUC, 0.75; 95% CI, 0.62-0.89; P = 0.010). Both APAAACI and PENFAST demonstrated high sensitivity (0.88) and NPV (APAAACI, 0.99; PENFAST, 0.98), missing only one non-severe DPT-positive case. APAAACI showed excellent agreement with allergist assessment (κ = 0.96, P < 0.001) versus moderate agreement for PENFAST (κ = 0.43). Allergist evaluation had superior specificity (0.77 vs. 0.71 [APAAACI] and 0.63 [PENFAST]) and overall accuracy (0.78 vs. 0.72 and 0.65). APAAACI and PENFAST can both effectively identify low-risk patients labelled with penicillin allergy when used by non-allergists, with comparable sensitivity to allergist assessment. APAAACI's stronger agreement with allergist assessment may suggest particular utility in Asian populations. These tools can significantly improve access to delabeling in settings lacking specialist allergy services.

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