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PHN-021 (PCNH / PHN021)

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PhytoHealth · 小分子 · 小分子

什么是 PHN-021？

PHN-021 是一种小分子，由PhytoHealth研发。该药已获批，用于治疗相关适应症，给药途径：Unknown。

药物档案

商品名PCNH, PHN021
公司PhytoHealth
药物类别小分子
给药途径Unknown
状态Approved
来源： ClinicalTrials.gov, PhytoHealth

治疗适应症

PHN-021 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Gastrointestinal disordersAbdominal painPhase I

相关研究文献

PubMedInternational health2026-08-04

Post-intervention outcomes 4 years after a nationwide postpartum haemorrhage mortality reduction project in Niger's health facilities: a retrospective analysis.

Seim Anders A, Alassoum Zeidou Z, Ousmane Nassirou N, Hamidou Oumoulkair O et al.

Niger in West Africa reduced maternal mortality by 34.5% among 1 380 799 health-facility births over 72 months through 2020 by more than halving postpartum haemorrhage (PPH) mortality in health facilities nationwide, using low-cost obstetrics technologies and 11 public health disease-eradication tools. Monthly support ended in December 2020 because of a lack of funding. Sustainability of innovations is important, given declining external funding and expectations that even very poor countries fund health from domestic taxes. Therefore, the current study assessed for PPH mortality rebound, also because 2015-20 results had been better than expected. Routinely collected government maternal mortality data during the 2015-20 project period and the 2021-4 post-project period were tested using Poisson regression models, and the Cochran-Armitage test for trend. Among 2 158 021 health-facility births from 2021 to 2024, no significant change was seen in the proportion of maternal deaths caused by PPH, PPH case fatality, PPH cases per 100 000 births, or PPH deaths/1000 births compared with the preceding 4 years. Niger's >50% PPH mortality reduction was sustained for 4 years without external attention to its implementation. Given sustained success emanating from capacity-strengthening, the strategy should be tested in other settings where maternal mortality remains high.

PMID 42550144
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PubMedJournal of the National Cancer Institute2026-08-04

Electroacupuncture for acute gastrointestinal symptoms during chemotherapy for colorectal cancer: a randomized clinical trial.

Chen Ziwen Z, Xu Tao T, Sun Mingsheng M, Li Qifu Q et al.

Acute chemotherapy-related gastrointestinal symptoms can limit colorectal cancer treatment. We evaluated electroacupuncture as adjunctive care for acute gastrointestinal symptom burden during chemotherapy. This multicenter, randomized, patient- and assessor-blinded, sham-controlled trial was conducted at 6 tertiary hospitals in China from July 2022 to August 2025. Adults with colorectal cancer and chemotherapy-related gastrointestinal symptoms were randomly assigned 1 1:1 to electroacupuncture, nonpenetrating sham acupuncture, or usual care. Treatments were given once daily for 3 days during chemotherapy. The primary outcome was change in Gastrointestinal Symptom Rating Scale (GSRS) total score from baseline to day 3. Secondary outcomes included rescue medication use and adverse events. Among 230 randomized patients (mean age, 60.1 years; 54.3% men), 211 (91.7%) completed the 3-day intervention. At day 3, electroacupuncture reduced GSRS total scores more than sham acupuncture (mean difference [MD], -1.54; 95% CI, -2.35 to -0.74; P < .001) and usual care (MD, -1.30; 95% CI, -2.09 to -0.50; P = .001). These differences did not exceed the prespecified minimal clinically important difference of 2.15 points. Electroacupuncture was associated with higher odds of remaining rescue-free than sham acupuncture (adjusted OR, 2.86; 95% CI, 1.23 to 6.63; P = .015) and usual care (adjusted OR, 2.64; 95% CI, 1.16 to 6.01; P = .021). No serious adverse events occurred. Electroacupuncture was associated with statistically significant but modest short-term reductions in acute gastrointestinal symptom burden. The between-group differences did not exceed the prespecified clinical-importance threshold and should be interpreted cautiously. Chinese Clinical Trials Register identifier ChiCTR2200062317.

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PubMedPloS one2026-08-03

Analysis of the genotyping of circulating strains and characteristics of Glycoprotein E of Varicella-Zoster Virus in Shanxi Province, China.

Liu Hongye H, Lv Peiyao P, Ma Runmeng R, Guo Shuping S et al.

Varicella-zoster virus (VZV), a neurotropic and epidermotropic herpesvirus, causes varicella (chickenpox) upon primary infection and reactivates later in life to cause herpes zoster (HZ), which is associated with significant morbidity, particularly postherpetic neuralgia (PHN). VZV genotyping and characterization of key viral proteins, such as glycoprotein E (gE), are critical for understanding viral circulation, distinguishing vaccine from wild-type strains, and optimizing vaccine strategies. In China, clade 2 is the predominant VZV genotype, but data from Shanxi Province remain limited. Forty herpes fluid specimens from clinically diagnosed herpes zoster (HZ) patients in Shanxi Province were collected. Quantitative polymerase chain reaction (qPCR) was used to detect viral DNA for definitive diagnosis. Six single-nucleotide polymorphisms (SNPs) in the open reading frame (ORF) 22 and ORF 38 fragments of positive specimens were analyzed by PCR and Sanger sequencing to determine viral genotypes. Four SNPs in ORF 38 and ORF 62 were analyzed to distinguish between vaccine and wild-type strains. The full-length nucleotide sequences of the gE gene in VZV-positive clinical specimens were determined. Sequence analysis was performed using Sequencher 5.4.6 and MEGA 11.0.11 software, with comparative reference to VZV strains retrieved from GenBank, to analyze the genetic characteristics of the VZV gE in Shanxi Province. The potential impact of amino acid substitutions caused by nucleotide mutations on the function of the gE protein was predicted using PROVEAN. Mutations in the gE protein were visualized using AlphaFold2 and PyMOL 2.6.0. All 40 specimens tested positive for VZV and were identified as wild-type clade 2 strains. Strain SX-17 exhibited a T → C mutation at position 107252. Notably, two strains (SX-01 and SX-04) lacked the 69424 SNP locus in ORF 38. gE gene sequencing revealed amino acid substitutions compared to the Dumas reference strain, including T40I (39 strains), H98P (SX-18), V489L (SX-04 and SX-05), and N529S (SX-08). PROVEAN analysis classified all mutations as neutral (scores > -2.5), with no impact on critical gE functional domains. The dominant VZV genotype in Shanxi Province is wild-type clade 2. A T → C mutation at position 107252 exists in clade 2 strains. The mutation sites of gE identified so far have not exerted a significant impact on the VZV functions, suggesting that VZV vaccination can serve as a critical measure for herpes zoster prevention in Shanxi Province.

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PubMedEnfermedades infecciosas y microbiologia clinica (English ed.)2026-08-02

Herpes Zoster recurrence and its associated risk factors: A population-based study in primary care in Madrid region (central Spain).

Reques Laura L, Humanes-Navarro Ana Maria AM, Jiménez-Bueno Susana S, García-Comas Luis L

Although Herpes Zoster (HZ) recurrence rates seem to be increasing, there are few studies exploring them in the general population. We aimed to investigate the HZ recurrence rates and associated risk factors in a large population-based study. The Primary Care Electronic Health Records from the Community of Madrid were used to identify initial HZ episodes from January 1, 2016 to December 31, 2024. These cases were followed through December 31, 2024 to identify recurrences. Recurrence cumulative incidence rate was calculated. The association of multiple risk factors with recurrence was estimated by Cox regression, including multivariate analysis. There were 10,470 recurrences out of 290,170 initial episodes with a mean of 4.23 years of follow-up. The recurrence rate was 8.81 per 1000 person-years (3.6%). Risk factors significantly associated with recurrence were post herpetic neuralgia (PHN) [hazard ratio [HR]=2.94; 95% confidence interval [CI], 2.69-3.36], other complications arising from HZ [HR=1.71; 1.38-1.96], cardiovascular disease [HR=1.20; 1.03-1.40], age over 60 years-old (1.20; 1.10-1.32) and sex (women) [HR=1.08; 1.03-1.12]. Our results suggest that HZ recurrence is relatively frequent and multicausal. Complications of the first episode, specially PHN, play an important role in predicting recurrence.

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PubMedExperimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation2026-08-02

Progression of Liver Transplant Outcomes From Donors After Circulatory Death in the United States: A 23-Year Comparative Analysis With Donors After Brain Death.

Jamshidi Abolfazl A, Kunam Suhani S, Patale Tara T, Langman Dean D et al.

We evaluated outcomes of liver transplant from donors after cardiac death versus transplants from donors after brain death, assessing trends over time. Using the Scientific Registry of Transplant Recipients, we retrospectively analyzed liver transplants in the United States from January 2000 through May 2023. We categorized patients by donor type and transplant period. After inclusion and exclusion criteria were considered, 99 014 patients were evaluated (32 498 patients in the 2000 -2010 group and 66 516 patients in the 2011 -2023 group ). From the first to the second time period, liver transplants from donors after cardiac death increased from 4 -% to 8.5 -%. For both time periods, liver transplant recipients from donors after cardiac death had lower Model for End-Stage Liver Disease scores than recipients from donors after brain death (18.61 ± 8.39 vs 20.32 ± 8.91 in 2000-2010 {P < .001 } and 17.31 ± 7.24 vs 22.49 ± 10.45 in 2011-2023 {P < .001 } ). Compared with transplants with donors after cardiac death, transplants with donors after brain death had higher 5 -year graft survival (72.36 % vs 68.56 % in 2000-2010 {P < .001 }; 80.22 % vs 78.06 % in 2011 -2023 {P = .021 } ) and patient survival rates (72.09 % vs 68.56 % in 2000 -2010 {P < .001 }; 79.65 % vs 77.32 % in 2011 -2023 {P = .016 } ). Of note, the survival difference decreased in the second time period. Regarding graft failure, more transplant recipients from donors after cardiac death (vs donors after brain death ) had biliary tract complications (9.7 % vs 4.9 %; P < .001 ). Outcomes of liver transplants from donations after cardiac death have significantly improved, potentially partly as a result of allocation of donation after cardiac death livers to patients with lower Model for End -Stage Liver Disease scores in recent years.

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Construction of an entry-to-practice competency evaluation index system for public health nurses in China: A Delphi study.

Gao Yunyun Y, Liu Weiwei W

Public health nurses (PHNs) play a key role in health promotion, infectious disease control, policy development, and emergency response. In China, specialized PHN training has not yet been established, highlighting the need for a competency evaluation system. To construct a competency evaluation index system for PHNs to guide future training and assessment in China. A two-round Delphi study based on the Iceberg Competency Model. A panel of 27 experts (associate senior level or above) in community nursing practice, management, education, or public health was recruited from seven cities across China. A preliminary indicator system was developed through literature review and semi-structured interviews with 17 community nurses and 15 public health physicians. Two Delphi rounds were then conducted with the 27 experts, who rated indicator importance and provided revision suggestions. Indicators were retained if importance mean > 3.5 and coefficient of variation <0.25. Both rounds achieved a 100% effective response rate, with an expert authority coefficient of 0.90. Kendall's W coefficients were 0.518 for the first round and 0.628 for the second (both P < 0.001). The final system comprised 4 first-level, 19 second-level, and 80 third-level indicators. The PHN competency evaluation index system is structured around four overarching domains, namely professional knowledge, professional skills, professional competence, and professional qualities. It demonstrates methodological rigor, thereby offering a standardized and actionable framework for competency assessment, personnel training, and workforce development in China, and ultimately contributing to enhanced public health service quality.

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