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ior-t3 (IORt3)

✓ Approved

Center of Molecular Immunology · CD3E · 单克隆抗体

什么是 ior-t3？

ior-t3 是一种单克隆抗体，由Center of Molecular Immunology研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)。

药物档案

商品名IORt3
公司Center of Molecular Immunology
药物类别单克隆抗体, 抗体
分子靶点CD3E
给药途径Injectable (Others)
状态Approved
来源： ClinicalTrials.gov, Center of Molecular Immunology

作用机制

分子靶点

ior-t3 作用于 1 个分子靶点：

CD3ECD3 epsilon subunit of T-cell receptor complex (TCRE, CD3epsilon)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

ior-t3 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Immune system disordersSolid organ transplant rejection✓ Approved

相关研究文献

PubMedJournal of the science of food and agriculture2026-08-04

Dietary cinnamon essential oil improves the amino acids, lipid quality, long-chain polyunsaturated fatty acid biosynthesis, and gut microbiota of Nile tilapia.

Li Huiyi H, Liu Xiaoli X, Yang Fawei F, He Dong D et al.

Cinnamon essential oil (EO) exhibits high antioxidant and antibacterial activities; however, its effects on nutrient deposition and gut microbiota in Nile tilapia remain unclear. This study investigated the effect of dietary cinnamon EO on amino acid (AA) and fatty acid (FA) composition, long-chain polyunsaturated fatty acid (LC-PUFA) metabolism, and gut microbiota of Nile tilapia (Oreochromis niloticus). Nile tilapia were fed diets supplemented with 0 (control), 2 (T1), 3.5 (T2) and 5 (T3) g kg-1 cinnamon EO for 30 days. Supplementation linearly increased taste-active AAs and essential AAs (P < 0.05). The T3 group exhibited the highest aspartate and serine contents, with 2.3-fold and 5-fold increases compared to the control, respectively. The EO significantly improved the FA composition, with the greatest increase observed for C22:6n3 in the T3 group. Cinnamon EO supplementation improved lipid quality indices (atherogenicity index, thrombogenicity index, hypocholesterolemic index, and nutritive value index; P < 0.05). T3 supplementation significantly upregulated key LC-PUFA biosynthesis genes, including Δ6Δ5 fads2, Δ4 fads2 and elovl5 (P < 0.05). Δ6Δ5 fads2 and Δ4 fads2 mRNA levels were increased 3- and 8-fold, respectively, compared with the control group (P < 0.05). T3 supplementation increased the relative abundance of Firmicutes and Proteobacteria at the phylum level. The unclassified_Planctomycetaceae and unclassified_Rhizobiales abundances were positively correlated with the mRNA levels of Δ4 fads2 and elovl5 (0.997, 0.994. P < 0.01). Dietary cinnamon EO improved AA and FA composition and enhanced LC-PUFA biosynthesis, which was associated with alterations in gut microbiota. © 2026 Society of Chemical Industry.

PMID 42547943
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PubMedFrontiers in psychiatry2026-08-04

Anxiety symptoms following conception through assisted reproductive technology: a systematic review.

Davies Nicole L NL, Carson Lauren L, Keynejad Roxanne C RC

The use of assisted reproductive technology (ART) to aid conception is increasing worldwide, yet little research has explored psychological outcomes following ART conception. To systematically review the prevalence and mean anxiety symptom scores among women who conceived following ART, from confirmed pregnancy until 12 months postpartum, compared to women who conceived without ART (spontaneous conception, SC). We searched MEDLINE, PsycINFO, and EMBASE from their start dates to 3rd June 2024 using a piloted search combining keywords related to ART, anxiety symptoms, pregnancy or the postnatal period, using Boolean operators. We extracted data on prevalence and mean anxiety symptom scores in the ART and SC groups, along with study characteristics. Twenty studies met inclusion criteria, comprising cohort (n=15), case-control (n=1), and cross-sectional (n=4) designs. Most studies measuring symptoms during the first (n=3) and second trimester (n=8) reported non-significant differences, apart from one second trimester study which reported elevated pregnancy-specific anxiety symptoms in the ART group. Studies measuring symptoms during the third trimester (T3) (n=16) and postnatal period (n=8) reported mixed findings of higher (T3:n=4; postnatal:n=2), lower (T3:n=1; postnatal:n=2), and no significant differences (T3:n=9; postnatal:n=4) anxiety in the ART group relative to SC. Two third trimester studies reported higher pregnancy-specific anxiety but lower or equivalent generalized anxiety symptoms in the ART group. While some studies reported elevated anxiety symptoms following ART, particularly in late pregnancy and postpartum, findings remain mixed, with others indicating no differences or lower symptom levels. Further longitudinal research is warranted to better understand the postpartum experiences of women with fertility difficulties.

PMID 42548846
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PubMedSante mentale au Quebec2026-08-04

[Allostatic Load and Transdiagnostic Dimensions in Patients Admitted to the Psychiatric Emergency Department: A Research Protocol Using the Signature Biobank].

Juster Robert-Paul RP, Le Page Cécile C, Chuntova Nevena N, Cipriani Enzo E et al.

Objective People in acute crisis who seek psychiatric emergency services are clearly in great distress and likely already show signs of chronic stress. But how can we best measure chronic stress physiologically? Our study aims to assess allostatic load (AL), the "wear and tear" on biological systems that we can measure using different biological marker called biomarkers. Method We aim to assess biological and psychosocial dimensions related to psychiatric symptom changes among psychiatric emergency patients repeatedly evaluated at four-time points: (T1) 48-hours upon admission, (T2) end of hospitalization (about 2 weeks later), (T3) external follow-up (about 2 months), and (T4) 1 year later. We expect that (1) AL at T1 will distinguish psychiatric conditions, (2) higher AL will predict symptom trajectories over time, and (3) that combinations of modifiable risk and protective factors (e.g. health-related behaviors, psychosocial experiences) will boost or buffer these associations. We acquired funding in order analyze hair, saliva, and blood samples that have already been collected as part of the Signature Biobank that offers measures at T1 (N=1,984; 40% women; mean age 41 with a range from 18-81) as well as at T2 (n=685), T3 (n=606), & T4 (n=370). Results In the proposed project, we acquired funding to analyze biobanked tissues to index AL among all PEP and 149 healthy controls. Among subsamples with T2, T3, and T4 measures, we will assess prospectively changes in AL and psychiatric symptoms trajectories simultaneously. Conclusion From admission to remission, the study of psychiatric emergency patients is a unique opportunity to assess extreme profiles that can help refine precision medicine. The Signature Biobank will provide unique insights on the biological signatures of psychiatric conditions and changes over time while also providing unique knowledge and training opportunities for years to come supported by a transdisciplinary team.

PMID 42550439
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PubMedOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2026-08-04

Is Bilateral Neck Dissection Always Necessary for Hypopharyngeal Squamous Cell Carcinoma? Risk Factors for Occult Contralateral Metastasis.

Wen Jiamei J, Liu Chuan C, Wang Zhihai Z, Pan Min M et al.

This study aimed to analyze risk factors for occult contralateral lymph node metastasis (LNM) in hypopharyngeal squamous cell carcinoma (HSCC) patients and provide evidence-based recommendations for neck dissection. Retrospective analysis. Tertiary general hospital. We retrospectively analyzed 145 patients with HSCC who underwent primary tumor resection and neck dissection. Clinical and pathological data were collected, including tumor characteristics and lymph node status. Univariate and multivariate logistic regression analyses were conducted to identify risk factors for occult contralateral LNM. The overall occult contralateral LNM rate was 13.24% (n = 18/136). In cN0 patients with Type A & B(unilateral) tumors, occult contralateral LNM occurred in 9.30% (4/43), specifically 12.90% (4/31) for Type A and 0% (0/12) for Type B. In cN+ patients with Type A & B(unilateral) tumors, the rate was 15.05% (14/93), with Type A(unilateral without midline involvement) at 12.5% (9/72) and Type B(unilateral with midline involvement) at 23.81% (5/21). Macroscopic extranodal extension (ENE) in the ipsilateral neck significantly affected contralateral occult metastasis. In contralateral clinically negative necks, occult metastases were primarily concentrated in levels II and III. Central type tumors require bilateral neck dissection. For lateral lesions, contralateral levels II to III are dissected only if ipsilateral cN+, T3-4, or midline crossing is present. Macroscopic ENE in the ipsilateral neck significantly increases the risk of contralateral occult metastasis; intra-operative identification warrants contralateral neck dissection.

PMID 42549690
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PubMedJournal of medical screening2026-08-03

Ecological analysis of breast screening uptake and coverage in East London.

Blake Helen A HA, Li Shuping Joy SJ, Derksen Christina C, Bijdiguen Loubna L et al.

ObjectiveTo provide descriptive analysis of observational data on breast screening uptake and coverage in North East London with a focus on health inequalities.SettingAreas in North East London with amongst the lowest breast screening uptake, coverage and breast cancer survival in England.MethodsWe investigated screening uptake and coverage for 163 general practices (GPs) served by the NHS Central & East London Breast Screening Service retrieved from Public Health England's Fingertips resource. The 10 highest and 10 lowest GPs by uptake and by coverage were identified. We summarised pre-treatment T-stage (tumour size) over time and by age group.ResultsOverall, uptake and coverage were lowest in City & Hackney, Newham and Tower Hamlets, with uptake of 7-26%, 13-26% and 24-28% respectively. GPs with the highest uptake and coverage rates tended to be in Waltham Forest (uptake 56-65%). The maximum uptake observed in 2022 was 72%, above the national uptake target of 70%, for one practice.For women receiving a breast cancer diagnosis, the proportion of larger-sized tumours seemed to increase during the 2020-2021 Covid-19 pandemic period (implying later diagnoses), eventually returning to pre-pandemic levels. Smaller tumours were identified at the screening ages 50-70 (<20% T3/T4, implying earlier diagnoses) compared to younger (∼25% T3/T4) and older (∼30% T3/T4) women.ConclusionsBreast screening uptake varied between areas and GPs. City & Hackney, Tower Hamlets and Newham were identified as areas with low screening uptake and coverage.

PMID 42545180
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PubMedZhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica2026-08-03

[Study on mechanism of Zhenwu Decoction against heart-kidney Yang deficiency-induced heart failure via cAMP/PKA signaling pathway].

Li Ya-Shu YS, Zhao Jing J, Li Jian-Bei JB, Zhang Xin-Ting XT et al.

This study aimed to investigate the effects of Zhenwu Decoction(ZWT) on cardiac fibrosis in mice with heart-kidney Yang deficiency-induced chronic heart failure(CHF). The research further explored the therapeutic mechanisms of ZWT in CHF treatment in the hope of providing novel insights for TCM approaches to managing heart-kidney Yang deficiency-induced heart failure. Sixty C57BL/6 mice were randomly divided into the following groups: the control group(normal untreated mice),the DOX group(doxorubicin-induced CHF model),the low-dose ZWT group(ZWT-L,4.7 g·kg~(-1)),the medium-dose ZWT group(ZWT-M,9.3 g·kg~(-1)),the high-dose ZWT group(ZWT-H,18.6 g·kg~(-1)),and the dopamine group(DA,positive control). The CHF mouse model was established over a 4-week period, which was followed by an additional 4-week treatment regimen. After 8 weeks, the spontaneous locomotor activity of mice was assessed, and TCM syndrome scoring was performed. Mouse serum samples were collected and analyzed to measure the levels of cardiac-specific biomarkers including cardiac troponin Ⅰ(cTn-Ⅰ),brain natriuretic peptide(BNP), creatine kinase-MB isoenzyme(CK-MB), creatine kinase(CK),lactate dehydrogenase(LDH),triiodothyronine(T3),succinate dehydrogenase(SDH) and myocardial cyclic adenosine monophosphate(cAMP). Cardiac tissue was collected for pathological examination. Western blot and real-time quantitative polymerase chain reaction(RT-PCR) were used to detect the expression of myocardial cAMP-dependent protein kinase catalytic subunit(PKA C),protein kinase A(PKA),ryanodine receptor 2(RyR2),phospholamban(PLB),B-cell lymphoma-2(Bcl-2),caspase-3,cleaved caspase-3 and Bcl-2-associated X protein(Bax). The experimental results indicated that, compared with the control group, the DOX group exhibited significantly elevated TCM syndrome scores accompanied by decreased heart rate, reduced body weight, and increased cardiac index(P<0.05); serum levels of CK, CK-MB, BNP, cTn-Ⅰ, LDH and myocardial cAMP were significantly increased(P<0.05), while SDH and T3 levels were decreased(P<0.05); meanwhile, myocardial interstitial fibrosis was aggravated and myocardial hypertrophy appeared; the expression of PKA C, PKA, caspase-3, cleaved caspase-3, Bax and phosphorylation of RyR2 were increased(P<0.05), the expression of Bcl-2 and phosphorylation of PLB were decreased compared with the DOX group, the ZWT treated groups demonstrated reduced TCM syndrome scores, increased heart rate, improved body weight, and decreased cardiac index. Additionally, serum levels of CK, CK-MB, BNP, cTn-Ⅰ, LDH and myocardial cAMP were decreased(P<0.05), while SDH and T3 levels were increased(P<0.05); myocardial hypertrophy and fibrosis were also improved; the expression of PKA C, PKA, Bax, caspase-3, cleaved caspase-3 and phosphorylation of RyR2 was reduced(P<0.05), and the expression of Bcl-2 and phosphorylation of PLB were increased(P<0.05). These findings suggested that ZWT may exert therapeutic effects on CHF by regulating sarcoplasmic reticulum calcium-related proteins, reducing apoptosis, and improving cardiac function.

PMID 42543375
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