若生智能
Drug Database
AM

amphotericin B (Ampholip)

✓ Approved

Bharat Serums and Vaccines Limited · 小分子 · 小分子

什么是 amphotericin B？

amphotericin B 是一种小分子，由Bharat Serums and Vaccines Limited研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)。

药物档案

商品名Ampholip
公司Bharat Serums and Vaccines Limited
药物类别小分子
给药途径Injectable (Others), Intravenous (IV)
状态Approved
来源： ClinicalTrials.gov, Bharat Serums and Vaccines Limited

治疗适应症

amphotericin B 针对 3 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Cardiac disordersEndocardial disease✓ Approved
Infections and infestationsCandida infection✓ Approved
Infections and infestationsAspergillus infection✓ Approved

相关研究文献

PubMedBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2026-08-04

Duloxetine repositioning: Investigation of antifungal and antibiofilm activity against fluconazole-sensitive and resistant Candida Spp. strains.

Barbosa Sarah Alves SA, Pinheiro Dávylla Rênnia Saldanha DRS, de Oliveira Leilson Carvalho LC, de Almeida Moreira Lara Elloyse LE et al.

The increase in fungal infections, the limited therapeutic arsenal, and the emergence of resistance pose a global health problem. Candida spp. stand out as opportunistic pathogens that cause superficial and invasive diseases. Thus, the search for new therapeutic alternatives, such as drug repositioning, is necessary. Duloxetine (DUL), a serotonin-norepinephrine reuptake inhibitor antidepressant used to treat depression, has demonstrated antifungal activity and potentiates the effects of conventional antifungals in vitro. The objective of this study is to evaluate the in vitro activity of duloxetine (DUL) against resistant Candida spp. strains. To this end, the minimum inhibitory concentration (MIC) of DUL alone and in combination with conventional antifungals was determined in order to evaluate the type of interaction between them, as well as the minimum fungicidal concentration (MFC). The activity of DUL against mature and developing biofilms was evaluated, in addition to the possible antifungal mechanism of action. DUL showed MICs of 16 to 128 µg/mL with a fungicidal action profile, and when combined there was synergistic interaction with amphotericin B (AMB). In biofilms, DUL exhibited antibiofilm activity and enhanced AMB activity against developing, but not mature, biofilms. Mechanism of action analysis showed that DUL promoted oxidative stress, evidenced by increased reactive oxygen species (ROS) production, reduced GSH levels, mitochondrial depolarization, and phosphatidylserine externalization, suggesting the activation of the apoptotic pathway as a possible mechanism of cell death. The pro-oxidant effects of DUL were evident in C. albicans strains deficient in antioxidant defenses (cap1Δ and gpx3Δ) compared to the wild-type strain. DUL exhibited antibiofilm activity and enhanced AMB activity against developing, but not mature, biofilms.

PMID 42547693
阅读全文 →
PubMedMolecular biology reports2026-08-04

Pharmacological evaluation reveals distinct anti-proliferative and migration-associated effects of curcumin analogues B-143 and B-155 in ovarian cancer cells.

Murwanti Retno R, Diani Prima Anargya Rosalina R, Saputra Bakti Wahyu BW, Ozura Zuhra Nur Jauza ZNJ et al.

The elevated mortality associated with ovarian cancer arises from delayed detection, recurrent disease, and the rapid emergence of chemoresistance. This study assesses the anticancer efficacy of two synthetic curcumin analogues, B-143 and B-155, in comparison to natural curcumin, employing SKOV3 ovarian cancer cells as the experimental model. The aim of this study was to determine whether structural alterations to the analogues enhanced their functional performance. Through assays assessing cytotoxicity, cell-cycle distribution, apoptosis, and migration, the findings revealed that B-155 exhibited significantly greater cytotoxicity compared to curcumin and B-143, which was associated with G2/M cell-cycle arrest and increased apoptosis. Furthermore, both B-155 and curcumin effectively suppressed SKOV3 cell migration, whereas B-143 displayed minimal effects. Network pharmacology analyses predicted that B-143 and B-155 interact with overlapping yet distinct angiogenesis- and metastasis-associated signaling networks, suggesting potential associations with multiple signaling pathways relevant to ovarian cancer. Moreover, RT-qPCR reveals curcumin consistently downregulated the expression of genes linked to epithelial-mesenchymal transition (EMT) and cellular stress, whereas B-143 and B-155 displayed only partial adaptive responses in several angiogenesis and metastasis transcription markers. To further explore the molecular basis of B-155 activity, molecular docking and molecular dynamics simulations were performed using MAPK14 (p38α MAPK) as a candidate target. Computational analyses demonstrated favorable binding of B-155 within the MAPK14 ATP-binding pocket and stable protein-ligand complex formation throughout a 100 ns simulation. B-155 demonstrated more significant anticancer activity than B-143, suggesting superior structural change-enhanced effectiveness. This research highlights the influence of structural modifications on curcumin's biological activity, supports B-155 as a promising curcumin analogue for further investigation with anti-proliferative and migration suppressive properties, and emphasizes the need to incorporate both phenotypic and network-level assessments together with structural interaction analyses in curcumin-based drug development for ovarian cancer.

PMID 42550311
阅读全文 →
PubMedPlant science : an international journal of experimental plant biology2026-08-04

Biochemical and photochemical constraints to photosynthesis under boron excess: evidence from physiological and transcriptomic responses in Citrus macrophylla.

Tasa Maria M, Penella Consuelo C, Arbona Vicent V, Gonzalez-Guzmán Miguel M et al.

This study investigated the effects of high boron (B) concentrations on photosynthetic performance in Citrus macrophylla. Six-month-old plants were grown under controlled conditions and irrigated for 30 days with nutrient solutions containing 0.11mg·L⁻¹ (control), 5mg·L⁻¹ (B5), and 10mg·L⁻¹ (B10) B. Excess B reduced stomatal conductance (gs) and net CO2 assimilation (ACO2). However, the stronger decline in ACO2 relative to gs, together with stable intercellular CO2 concentration (Ci), indicated that photosynthetic inhibition was not exclusively driven by stomatal closure. Instead, non-stomatal limitations played a key role. Chlorophyll fluorescence analysis showed progressive declines in Fv/Fm and ΦPSII with increasing B accumulation, indicating PSII photoinhibition and impaired electron transport. At moderate B levels (B5), regulated non-photochemical energy dissipation (ΦNPQ) was activated. However, at excessive B accumulation (B10), photoprotective mechanisms became insufficient, resulting in increased lipid peroxidation. Photosynthetic capacity analysis revealed a significant decrease in Vcmax under high B, while Jmax and TPU remained unaffected. Total soluble sugars and starch concentrations were also not significantly affected by B supply, indicating that the decline in apparent carboxylation capacity occurred without detectable changes in bulk leaf carbohydrate pools. These results are consistent with a predominant biochemical limitation involving reduced apparent Rubisco carboxylation capacity. Additionally, chlorophyll concentration decreased under excess B, further compromising photosynthetic efficiency. At the gene expression level, processes related to cellular functions aiming to maintain the structural cell integrity and plant defence responses are modified, which may take precedence over the preservation of photosynthetic efficiency. Overall, B toxicity in C. macrophylla induced a shift from stomatal to dominant non-stomatal limitations in photosynthesis, involving Rubisco impairment and PSII photochemistry. These findings provide new insights into the mechanisms underlying B-induced photosynthetic decline and highlight the vulnerability of citrus to B toxicity.

PMID 42546930
阅读全文 →
PubMedHLA2026-08-04

Discovery of the Novel HLA-B*38:136 Allele in a Brazilian Volunteer Donor.

Machado Emerson Fernando Garcia EFG, Linhares Josiane Aparecida JA, Dugonski Maria Eduarda ME, Cazarote Helena Bianchi HB et al.

HLA-B*38:136 differs from HLA-B*38:01:01:01 by a non-synonymous substitution in exon 3.

PMID 42550061
阅读全文 →
PubMedPlant physiology and biochemistry : PPB2026-08-04

In planta storage of boron and calcium affects clubroot severity in Brassica napus.

Tu Jiangying J, Gossen Bruce D BD, Tu Kaiyang K, Stobbs Jarvis J et al.

Boron (B) and calcium (Ca) are essential nutrients for plant growth that have also been reported to reduce clubroot disease caused by Plasmodiophora brassicae. This study evaluated the effects of soil-applied B (0, 8 or 16 kg B ha-1) and Ca (0, 500 or 1000 kg Ca ha-1) on clubroot development in Brassica napus lines differing in B sensitivity, and investigated underlying mechanisms. Ca consistently reduced clubroot severity, whereas B had a weaker, inconsistent effect and caused phytotoxicity at higher rates. Ca also alleviated B toxicity and increased shoot biomass under high B conditions. Fourier transform mid-infrared spectroscopy revealed that Ca promoted pectin demethylation and Ca-mediated crosslinking, enhancing cell wall rigidity and reducing porosity. Infection by P. brassicae induced lignification, remodeling of matrix polysaccharides, and changes in protein composition and nitrate signatures, indicating coordinated cell wall modification and metabolic reprogramming. Boron K-edge X-ray absorption near-edge structure spectra showed shifts in B speciation between healthy and infected roots, suggesting that infection alters B coordination and localization through modifications to cell wall structure and intracellular binding. Micro X-ray fluorescence mapping showed that Ca accumulation at infection sites was consistent with cell wall reinforcement, while infection also triggered zinc (Zn) accumulation, indicating altered Zn homeostasis. These results provide mechanistic insight into nutrient-mediated cell wall modification and element redistribution. These results also demonstrate that Ca is more effective and reliable than B for reducing clubroot severity, which has a practical application in nutrient strategies for clubroot management.

PMID 42546605
阅读全文 →
PubMedBioorganic chemistry2026-08-04

One-step gram-scale synthesis of striasteroid B inspired by its nonenzymatic formation.

Cheng Shan S, Chen Chunmei C, Chen Yi Y, Cai Jian J et al.

Striasteroids A and B are fungus-derived hybrid steroids with novel skeletons and promising biological activities. Our investigation suggests that both compounds are likely generated from ergosterol and pyrone derivatives via a nonenzymatic pathway during silica gel chromatography. Based on this finding, we developed an efficient one-step synthesis enabling gram-scale production of striasteroid B. In vitro activity evaluation showed that striasteroid B exhibited anti-renal fibrosis activity comparable to that of the clinical drug pirfenidone (PFD) at a concentration of 10 μM. In addition, preliminary pharmacokinetic studies indicated that this compound possesses favorable drug-like properties. Taken together, these results suggest that striasteroid B holds potential for further development as an anti-renal fibrosis agent.

PMID 42546463
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多amphotericin B