若生智能
Drug Database
YY

YY-3130 (YY 3130 / YY3130)

✓ Approved

YuYu Pharma · 小分子 · 小分子

什么是 YY-3130？

YY-3130 是一种小分子，由YuYu Pharma研发。该药已获批，用于治疗相关适应症，给药途径：Unknown。

药物档案

商品名YY 3130, YY3130
公司YuYu Pharma
药物类别小分子
给药途径Unknown
状态Approved
来源： ClinicalTrials.gov, YuYu Pharma

治疗适应症

YY-3130 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Metabolism and nutrition disordersHypercholesterolaemia✓ Approved

相关研究文献

PubMedEuropean review for medical and pharmacological sciences2026-07-31

Retraction Note.

No Authors Listed

The Editor-in-Chief, in accordance with the Publisher, has retracted the following articles published between 2017 and 2019 on the grounds of figure duplication and manipulation, subsequent to concerns raised on PubPeer. The corresponding authors of all articles have been contacted several times and were asked to provide the original data, but no responses were received. This retraction notice pertains to the following articles and is carried out in accordance with the recommendations of the Committee on Publication Ethics (COPE): 1.  Mani J, Fleger J, Rutz J, Maxeiner S, Bernd A, Kippenberger S, Zöller N, Chun FK, Relja B, Juengel E, Blaheta RA. Curcumin combined with exposure to visible light blocks bladder cancer cell adhesion and migration by an integrin dependent mechanism. Eur Rev Med Pharmacol Sci 2019; 23(23): 10564-10574-DOI: 10.26355/eurrev_201912_19698-PMID: 31841214. 2.  Ma JB, Hu SL, Zang RK, Su Y, Liang YC, Wang Y. MicroRNA-487a promotes proliferation of esophageal cancer cells by inhibiting p62 expression. Eur Rev Med Pharmacol Sci 2019; 23(4): 1502-1512-DOI: 10.26355/eurrev_201902_17108-PMID: 30840272. 3.  Ma YX, Zhang H, Li XH, Liu YH. MiR-30e-5p inhibits proliferation and metastasis of nasopharyngeal carcinoma cells by target-ing USP22. Eur Rev Med Pharmacol Sci 2018; 22(19): 6342-6349-DOI: 10.26355/eurrev_201810_16045-PMID: 30338802. 4.  Gao AG, Zhou YC, Hu ZJ, Lu BB. Ipriflavone promotes osteogenesis of MSCs derived from osteoporotic rats. Eur Rev Med Pharmacol Sci 2018; 22(14): 4669-4676-DOI: 10.26355/eurrev_201807_15527-PMID: 30058710. 5.  Du XY, Liu X, Wang ZJ, Wang YY. SLPI promotes the gastric cancer growth and metastasis by regulating the expression of P53, Bcl-2 and Caspase-8. Eur Rev Med Pharmacol Sci 2017; 21(7): 1495-1501-PMID: 28429358. The authors have been informed about the retraction but remained unresponsive. These articles have been retracted. The Publisher apologizes for any inconvenience this may cause.

PMID 42535751
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PubMedPharmaceuticals (Basel, Switzerland)2026-07-28

Ylang Ylang Essential Oil in Malignant and Non-Malignant Cells: Comparative Mitophagy-Related Transcriptional Responses.

Kasarci-Kavsara Goksu G, Barak Timur Hakan TH, Ertugrul Baris B, Senturk Tugba Buse TB et al.

Background: Mitophagy is a mitochondrial quality-control pathway whose contribution to cancer stress tolerance may vary by cellular context. For essential oils, mechanistic interpretation is often limited by compositional variability and the limited number of studies addressing malignant and non-malignant comparisons under matched exposure conditions. Methods: Ylang Ylang essential oil (YY EO) was characterized by GC-MS-FID. Lung cancer cells (A549) and a salivary gland carcinoma model (HTB-41), together with non-malignant lung-related cells (BEAS-2B, MRC-5), were exposed to YY EO. Functional outcomes were assessed by WST-1 and LDH assays. Mitophagy-related and mitochondrial quality-control-associated genes were quantified by RT-qPCR (2-ΔΔCt). Results: GC-MS-FID identified a terpenoid-rich mixture (99.31%), with germacrene D and β-caryophyllene among the major constituents. YY EO was associated with dose- and cell-type-dependent functional responses, with malignant cells showing reductions in WST-1 signal and stronger LDH-associated responses under the tested conditions, while non-malignant cells showed less pronounced functional changes. Transcriptional responses were context-dependent, with differential changes in mitophagy-related genes across cell lines. Conclusions: These findings provide comparative evidence of greater functional sensitivity in malignant cells, alongside cell-context-dependent mitophagy-related transcriptional responses. These observations are hypothesis-generating and remain limited to functional readouts and mRNA-level data. Within these limits, the present study provides a composition-anchored comparative dataset that may support future mechanistic studies in this area.

PMID 42515686
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PubMedBiomedicines2026-07-28

Genetic Diversity Analysis of Risk Variants Associated with Bone and Cartilage Metabolism in Nine Mexican Subpopulations.

Nuño-Arana Ismael I, Villagómez Vega Alejandra A, Martínez Cortés Gabriela G

Backgrounds/Objectives: Allele frequencies of genetic variants associated with complex diseases can contribute to varying degrees to predisposition depending on the population's genetic profile. The aim of this study was to analyze the genetic diversity of 15 relevant SNVs that could modulate bone and cartilage metabolism in underrepresented structured populations. Methods: In a sample of 130 Mestizos and 304 natives from 8 native Mexican populations, SNVs related to multifactorial diseases were genotyped using a SNaPShot Multiplex kit and analyzed via capillary electrophoresis using an ABI PrismTM 3130 Genetic Analyzer (Applied Biosystems, Waltham, MA, USA.), and genetic profiles for 15 SNVs were obtained using GeneMapper software v. 3.2. Allele frequencies were calculated by locus and population using Power Stats and Arlequin v.3.1 software, for which the EM algorithm was used to compare reference populations obtained from the dbSNV database of the International HapMap project. Population structure, paired comparisons, and genetic differentiation between native, admixed, and reference populations (p value) were estimated through Fst tests using the STRUCTURE v.2.3.2 and Arlequin v.3.1 software. Results: Haplotype frequency combinations grouped as profiles showed higher predominance in the allelic combination A/A/G for rs9340799 (ESR1), rs700518 (CYP19A1), and rs1800795 (IL6) genes, respectively. Conclusions: Allelic profiles could be useful as medical tools for preventing and managing individuals or populations. Mexican populations showed high genetic variability among allelic risk profiles for estrogen control and response, as well as high frequencies of variant combinations associated with an increased inflammatory response, potentially resulting in high osteoclastogenesis. This analysis advances our understanding of the complexity of bone and cartilage metabolism in highly stratified populations.

PMID 42511945
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PubMedPharmaceuticals (Basel, Switzerland)2026-07-28

Peptide Hormones in Appetite Regulation: A Complex Network.

Abdollahi Sara S, Adam Hussan H, Al Musaimi Othman O

Background: Appetite regulation is governed by a complex neuroendocrine network that integrates peripheral peptide signals with hypothalamic and brainstem circuits to coordinate energy intake and maintain energy homeostasis. Disruption of these pathways contributes to obesity and other disorders characterised by dysregulated feeding behaviour. Objective: To map and synthesise the current evidence on the role of appetite-regulating peptide hormones and central neural pathways in appetite control, obesity pathophysiology, and emerging therapeutic approaches. Methods: A scoping review of the literature was conducted to identify and synthesise evidence relating to the physiological and pathological mechanisms of appetite regulation. The review examined the actions of key peptide hormones, including ghrelin, glucagon-like peptide-1 (GLP-1), peptide YY (PYY), leptin, and insulin, their interactions within the gut-brain axis, and their effects on central appetite-regulating circuits. Results: The evidence highlights the central role of the arcuate nucleus in integrating peripheral hormonal signals with neural pathways controlling feeding behaviour. Appetite regulation is mediated by the balance between orexigenic neuropeptide Y/agouti-related peptide (NPY/AgRP) neurons and anorexigenic pro-opiomelanocortin/cocaine- and amphetamine-regulated transcript (POMC/CART) neurons, with further modulation by the paraventricular, lateral, and ventromedial hypothalamic nuclei. The literature identifies hormone resistance, impaired satiety signalling, and altered neuroendocrine feedback as major contributors to obesity. Evidence on therapeutic interventions demonstrates the potential of GLP-1 receptor agonists, including liraglutide and semaglutide, and the dual incretin agonist tirzepatide, while also highlighting challenges related to treatment durability, adverse effects, and weight regain following discontinuation. Conclusions: Current evidence demonstrates that appetite regulation involves highly interconnected peripheral and central signalling pathways. The reviewed literature supports the development of multi-target and precision-based therapeutic strategies for obesity and identifies important areas for future research, including mechanisms of treatment resistance, long-term efficacy, and inter-individual variability in neuroendocrine responses.

PMID 42515672
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PubMedMolecular nutrition & food research2026-07-27

Intermittent Fasting Amplifies Gut-Endocrine Axis Responses to Senna alexandrina Supplementation in Obese Rats.

Fulyani Faizah F, Widayanti Iftitan Setya IS, Bestari Salwa Alifa SA, Batubara Lusiana L et al.

Obesity induced by high‑fat, high‑sucrose diets (HFSD) remains a major global health challenge, disrupting lipid metabolism, glucose homeostasis, and gut microbial balance. These disturbances underscore the need for safe interventions capable of restoring metabolic regulation. Senna alexandrina (SA), traditionally used for weight reduction, has recently been shown to modulate the gut microbiota beyond its laxative effects. To enhance efficacy while minimizing adverse outcomes, this study investigated the effects of a low and safe dose of SA combined with intermittent fasting (IF), a strategy that reshapes nutrient availability and microbial dynamics. HFSD‑induced obese rats were treated for four weeks with SA leaf powder (300 mg/kg/day), IF, or both. Bioactive constituents of SA were characterized using LC‑HRMS, alongside systematic evaluation of physiological and metabolic parameters-including adiposity, morphometry, lipid profiles, insulin sensitivity markers, and gut-endocrine axis indicators. SA supplementation showed improvements across all parameters, surpassing those achieved with IF alone. Importantly, the combined intervention (SA+IF) yielded complementary benefits, notably enhancing GLUT4 expression, short‑chain fatty acid (SCFA) production, peptide YY (PYY) secretion, and reducing the Firmicutes/Bacteroidetes ratio. These findings highlight the complementary roles of SA and IF in metabolic regulation, providing experimental evidence for a potential dietary approach to mitigate obesity‑related dysfunction.

PMID 42504494
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PubMedJournal of neurogastroenterology and motility2026-07-27

Possible Mechanisms Underlying the Effects of Fecal Microbiota Transplantation in Patients With Irritable Bowel Syndrome.

El-Salhy Magdy M, Skarvatun Tora T, Hoff Dag Arne Lihaug DAL, Lunding Johan J et al.

: This study aims to identify the mechanisms underlying the effects of fecal microbiota transplantation (FMT). : This study investigated 93 patients included in our previous clinical trial: 24 received 30 g of their own feces (placebo group), while 47 and 22 received 30 g and 60 g of donor feces, respectively. The patients underwent sigmoidoscopy with biopsies, provided fecal samples, and completed questionnaires to assess irritable bowel syndrome (IBS) symptoms, fatigue, and quality of life at the baseline and at 1 month following FMT. The biopsy samples were immunostained for Musashi-1, neurogenin-3, and enteroendocrine and immune cells. The cell densities were quantified by computerized image analysis. Fecal short-chain fatty acids (SCFAs) were measured by gas chromatography, and fecal bacteria were measured by 16S ribosomal RNA polymerase chain reaction DNA amplification. : The densities of stem cells, enteroendocrine cell progenitors, serotonin, glucagon-like peptide 1, and peptide YY (PYY) cells increased following FMT in the 30-g and 60-g treated groups but not in the placebo group, and they were inversely correlated with both IBS symptoms and fatigue. The densities of submucosal immune cells and mast cells decreased following FMT in the 30-g and 60-g treated groups but not in the placebo group, and they were correlated with IBS symptoms and fatigue. The fecal level of butyric acid increased in patients treated with donor feces, and this was inversely correlated with IBS symptoms and fatigue. : Stem cells, enteroendocrine progenitors, serotonin, and glucagon-like peptide 1 as well as low-grade inflammation may play roles in IBS symptom manifestations. The effects of FMT are probably due to the amelioration of these abnormalities.

PMID 42504661
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