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carbocysteine lysine salt (Fluifort / Pectox Lisina)

✓ Approved

Dompe · 小分子 · 小分子

什么是 carbocysteine lysine salt？

carbocysteine lysine salt 是一种小分子，由Dompe研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Fluifort, Pectox Lisina
公司Dompe
药物类别小分子
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Dompe

治疗适应症

carbocysteine lysine salt 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Congenital, familial and genetic disordersCystic fibrosis✓ Approved
Respiratory, thoracic and mediastinal disordersBronchitis chronicPhase I

相关研究文献

PubMedPlant science : an international journal of experimental plant biology2026-08-04

Functional characterization of the transcription factors Gm/GsERF160 from G.max and G.soja in conferring salt tolerance.

Liu Xun X, Gao Peixiang P, Chen Yutin Y, Yu Bingjun B

Soil salinization is a major challenge for the sustainable development of global agriculture. Cl⁻-dominated anion toxicity is less studied than Na⁺ because its uptake and transport are more complex. Thus, it has become a key issue for understanding salt tolerance in soybean and other plants. Our previous studies attribute the superior salt tolerance of Glycine soja over Glycine max to greater root Cl⁻ retention, reduced shoot transport, and stronger root GsCLC-c2 expression under salt stress. However, the upstream transcriptional regulators governing CLC-c2 gene expression in G. max and G. soja remain unclear. Using G. max (cv. N23674) and G. soja (acc. BB52), we combined yeast one-hybrid (Y1H), subcellular localization, hairy-root transformation, and transgenic Arabidopsis assays to reveal how the ERF transcription factors Gm/GsERF160 regulate CLC-c2 expression to enhance salt tolerance. Phylogenetic analysis indicates that GsERF160 has five extra amino acids than GmERF160, with only one difference in the conserved domain and nearly identical three-dimensional structures. Both the GmERF160 and GsERF160 genes exhibited markedly salt stress-inducible expression. GmERF160 and GsERF160, which are localized in the nucleus, can bind to the promoter region of GmCLC-c2 and subsequently activate its expression. Compared with GmERF160-Cas9 or WT plants, overexpression of Gm/GsERF160 in soybean hairy-root composite plants and Arabidopsis seedlings under salt stress alleviated salt damage. This was reflected by increased chlorophyll and relative water content (RWC) in leaves or shoots, as well as reduced malondialdehyde (MDA), relative electrolyte leakage (REL), and Cl⁻/NO3⁻ and Na+/K+ ratios in both roots and shoots. Together, these results demonstrate that the conserved, salt-inducible Gm/GsERF160-CLC-c2 module positively regulate GmCLC-c2 expression, thereby mediating root Cl⁻ uptake and shoot transport to maintain shoot Cl⁻ homeostasis and confer salt tolerance in soybean. These findings provide valuable regulatory targets and candidate genes for breeding of salt-tolerant soybean cultivars.

PMID 42546932
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PubMedFrontiers in plant science2026-08-04

Comprehensive assessment of salt tolerance in nine spring maize hybrids across the entire growth period.

Li Yipu Y, Xu Zhenghan Z, Lin Yanan Y, Wang Shiyao S et al.

Salt-alkaline soils are one of the major abiotic factors limiting global crop production, and maize is a moderately salt-sensitive crop. With global warming and the widespread use of drip irrigation, maize cultivation faces severe challenges from saline-alkali stress in arid areas. We used nine spring maize hybrids as experimental materials to measure 24 agronomic and physiological traits at the seedling, flowering, and maturity stages in soil with a total salt content of 0.18%-0.61% and a pH of 9.0-9.2 by depth. Salt tolerance and yield evaluations of the tested maize hybrids were performed using principal component analysis, the membership function method, and GGE biplot analysis. The results identified root-to-shoot ratio, leaf Na+/K+ ratio, shoot dry weight and root Na+/K+ ratio as key traits for selecting hybrids with excellent productivity and stability under saline conditions. Additionally, GGE biplot analysis indicated Dika159 (H7) demonstrated superior productivity and stability in all test environments. These results facilitate the development of salt-tolerant maize germplasm and the breeding of stable and adaptable hybrids for saline-alkaline soils.

PMID 42548568
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PubMedPlant, cell & environment2026-08-04

Surface Charge Dependent Foliar Applied Silicon Quantum Dots Enhance Soybean Salt Tolerance Through Leaf-Root-Microbial Responses.

Chen Zhidi Z, Liu Yunqian Y, Shi Tianxing T, Sun Han H et al.

Here, we evaluated foliar-applied silicon quantum dots (SiQDs) with different surface charges on soybean salt tolerance. Positively charged SiQDs (P-SiQDs) exhibited stronger foliar retention and penetration than negatively charged SiQDs (N-SiQDs), resulting in a 35.3% higher silicon accumulation in leaves. Under 200 mM NaCl stress, foliar application of P-SiQDs increased shoot dry weight and reduced the Na+/K+ ratio. Compared with N-SiQDs, P-SiQDs more effectively alleviated salt-induced damage to thylakoid ultrastructure and improved photosynthetic performance. A life cycle field pot trial further showed that SiQDs increased the 100-seed weight by 20.1%-25.9% under salt stress. Leaf metabolomics showed significant alterations in lipid metabolite pathways associated with redox homeostasis, accompanied by shifts in the phyllosphere microbiome. P-SiQDs increased the abundance of Chloroflexota, Actinomycetota, and genera such as Paenarthrobacter, Variovorax, and Xanthobacter. Meanwhile, the phyllosphere microbiome shifted toward life-history strategies related to growth, resource acquisition, and salt stress tolerance. In addition, P-SiQDs promoted root growth, nodulation, and nitrogenase activity, leghemoglobin content, and total nitrogen accumulation, together with changes in root exudate composition and the enrichment of salt-tolerant rhizosphere bacteria, including Sphingomonas and Novosphingobium. These findings indicate that surface charge modification is an effective strategy to enhance the efficiency of foliar nano-fertilizer application.

PMID 42550469
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PubMedPlant science : an international journal of experimental plant biology2026-08-04

Functional characterization of the MdFLZ2 gene in drought and salt stress tolerance in apple.

Liu Yaqi Y, Su Jingyi J, Li Xiaowen X, Wang Xue X et al.

Drought and salt stress are significant environmental limitations that severely constrain plant growth and productivity, therefore, enhancing stress tolerance is a key goal in crop improvement. The plant-specific FCS-like zinc finger (FLZ) proteins have been identified as important regulators of stress adaptation. In this study, we conducted a genome-wide characterization of the FLZ gene family in apple and functionally characterized MdFLZ2. qRT-PCR analysis revealed that MdFLZ2 was differentially expressed across various tissues and transcriptionally induced by both drought and salt stress. Subcellular localization assays demonstrated that the MdFLZ2 protein is localized to both the nucleus and the cytoplasm. The overexpression of MdFLZ2 in apple calli, Arabidopsis and tomato conferred increased resistance to drought and salt stress. In addition, yeast two-hybrid (Y2H) assays confirmed that MdFLZ2 interacted with MdSnRK1.1, and similar interactions were also detected between other MdFLZ family members and MdSnRK1.1. Collectively, our findings suggest MdFLZ2 as a positive regulator of drought and salt tolerance and highlight its potential to serve as a genetic resource for abiotic stress improvement.

PMID 42546931
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PubMedERJ open research2026-08-04

Urinary sodium, table salt use and incidence of late-onset asthma in females and males: evidence from a large prospective cohort.

Kronsteiner-Gicevic Selma S, Thompson Alysha S AS, Gaggl Martina M, Cassidy Aedín A et al.

The contribution of dietary sodium to asthma development remains unclear, particularly for adult-onset disease. We examined associations between estimated 24-h urinary sodium excretion, table salt use and incident asthma in a large prospective cohort. We analysed 420 041 adults aged 40-69 years without prior asthma. Incident asthma was ascertained through linked health records. Urinary sodium was estimated using the INTERSALT equation from spot urine samples. Frequency of adding salt at the table was self-reported. Associations were evaluated using multivariable Cox proportional hazards models with adjustment for sociodemographic, lifestyle and clinical factors. Over a median 10.9-year follow-up, 11 927 participants developed asthma. Compared with the lowest quintile, the highest quintile of estimated urinary sodium was associated with increased asthma incidence (hazard ratio (HR) 1.50, 95% CI 1.41-1.59). Associations were stronger in females (HR 1.55, 95% CI 1.44-1.68) than males (HR 1.28, 95% CI 1.17-1.39; p-heterogeneity=0.0011) and in individuals with low eosinophil counts <300 cells·µL-1 (HR 1.55, 95% CI 1.43-1.66) compared with those ≥300 cells·µL-1 (HR 1.24, 95% CI 1.10-1.40; p-heterogeneity=0.0017). Associations were also stronger in never-smokers (HR 1.64, 95% CI 1.51-1.79) than former (HR 1.46, 95% CI 1.33-1.60) or current smokers (HR 1.16, 95% CI 1.00-1.36; p-heterogeneity=0.0008). Frequent table salt use ("always" versus "never/rarely") was associated with higher asthma incidence (HR 1.28, 95% CI 1.19-1.37), with no meaningful subgroup differences. Higher estimated urinary sodium excretion and frequent table salt use were associated with greater asthma incidence. Stronger associations in women and individuals with low eosinophil counts suggest potential phenotype-specific susceptibility. Randomised studies are warranted to test whether sodium reduction lowers asthma risk in these subgroups.

PMID 42549459
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PubMedChemical engineering journal (Lausanne, Switzerland : 1996)2026-08-04

CRISPR-Programmable Nanoparticle Transport in Salt-Gated Porous Media for Visual DNA Detection.

Schalper Kurt T KT, Yang Rui R, Guan Xin X, Zhang Jiongyu J et al.

Paper-based diagnostics typically treat porous cellulose as a passive capillary medium, with nanoparticle transport governed by channel geometry and capture chemistry. Here we show that CRISPR-programmable nanoparticle surface chemistry can actively regulate transport in paper through a salt-activated adhesion mechanism. Gold nanoparticles functionalized with hydrophobic Cy5-labeled DNA exhibit strong adhesion to cellulose fibers at elevated ionic strength (~1.5 M local NaCl generated upon rehydration of preloaded salt), whereas particles lacking hydrophobic domains migrate freely. This phenomenon enables a distance-based visual readout, in which the length of the colored nanoparticle front provides a semi-quantitative measure of DNA target concentration. Optical and electron microscopy reveal that nanoparticle immobilization arises from extensive fiber adhesion rather than pore occlusion or particle aggregation. As a proof of concept, coupling Cas12a-mediated cleavage of Cy5-labeled DNA probes to this salt-gated transport system enabled naked-eye, distance-based detection of Herpes simplex virus 1 (HSV-1) DNA with a limit of detection of 100 aM in ~45-60 min. Evaluation of 40 clinical samples showed excellent agreement with qPCR, achieving 96.2% sensitivity and 100% specificity. More broadly, this work establishes a general strategy for programming nanoparticle transport in porous media by encoding functionality directly into nanoparticle surface chemistry.

PMID 42549190
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