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Factor VIIa (AryoSeven)

✓ Approved

AryoGen Pharmed · F7 · 重组蛋白

什么是 Factor VIIa？

Factor VIIa 是一种重组蛋白，由AryoGen Pharmed研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)。

药物档案

商品名AryoSeven
公司AryoGen Pharmed
药物类别重组蛋白, 细胞治疗
分子靶点F7
给药途径Injectable (Others), Intravenous (IV)
状态Approved
来源： ClinicalTrials.gov, AryoGen Pharmed

作用机制

分子靶点

Factor VIIa 作用于 1 个分子靶点：

F7coagulation factor VII (SPCA)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

Factor VIIa 针对 4 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Vascular disordersExtravasation blood✓ Approved
Congenital, familial and genetic disordersFactor IX deficiency✓ Approved
Congenital, familial and genetic disordersFactor VIII deficiency✓ Approved
Vascular disordersHaemorrhage✓ Approved

相关研究文献

PubMedInternational journal of biological macromolecules2026-08-06

The transcription factor DhDOF5 regulates mannose biosynthesis in Dendrobium huoshanense under low-temperature and water-deficit stress.

Wang Chun C, Wang Shuting S, Guan Junjie J, Hao Mengyao M et al.

Transcription factor proteins are important biological macromolecules that regulate plant metabolic pathways and stress responses. In Dendrobium huoshanense C. Z. Tang et S. J. Cheng, mannose biosynthesis is closely related to polysaccharide accumulation, however, the protein-level regulators involved in this process remain poorly understood. In this study, a Dof family transcription factor protein, DhDOF5, was identified as a candidate regulator of DhPMM, a key enzyme gene involved in mannose biosynthesis. Bioinformatic and structural analyses showed that DhDOF5 contains a highly conserved Dof DNA-binding domain, supporting its potential function as a transcription factor protein. Yeast one-hybrid and electrophoretic mobility shift assays further confirmed that DhDOF5 directly binds to the DhPMM promoter. Functional analysis in transgenic Arabidopsis thaliana showed that DhDof5 enhanced tolerance to low-temperature and water-deficit stress and promoted polysaccharide accumulation. These findings provide direct evidence that DhDOF5 functions as a DNA-binding transcription factor protein involved in the regulation of mannose biosynthesis under abiotic stress. This study highlights a functional biological macromolecule linking transcriptional regulation with polysaccharide metabolism in D. huoshanense. SIGNIFICANCE STATEMENT: This study characterizes DhDOF5 as a transcription factor protein macromolecule that binds to the DhPMM promoter and contributes to stress-associated polysaccharide accumulation in Dendrobium huoshanense.

PMID 42556679
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PubMedThe journal of pain2026-08-06

Development and Initial Validation of the Cannabis Pain Expectancies Scale.

Hooker Julia E JE, LaRowe Lisa R LR, Maisto Stephen A SA, Gewandter Jennifer S JS et al.

Although pain-related outcome expectancies are hypothesized to contribute to elevated rates of cannabis use among individuals with pain, research has been hindered by the absence of a psychometrically validated measure of expectancies regarding the effects of cannabis on pain. The goals of this study were to develop a Cannabis Pain Expectancies Scale (CPES; Study 1) and assess its psychometric properties (Study 2). An initial pool of 58 items was drafted; 32 items were retained after evaluation by a panel of subject-matter experts. Study 1: Items were administered to 277 cannabis users with chronic pain via online survey. Item properties were examined, and exploratory factor analysis (EFA) was used to evaluate factor structure. Study 2: The CPES developed in Study 1 was administered to a separate sample of 314 cannabis users with chronic pain to confirm the factor structure and evaluate reliability and validity. Study 1: EFA of proposed CPES items indicated a two-factor structure comprising 14 items. Study 2: Confirmatory factor analysis indicated that a parsimonious one-factor model provided comparable fit and was retained for the final scale. The CPES demonstrated excellent internal consistency, reliability, and evidence of convergent validity via positive covariation with measures of cannabis use and chronic pain. This study provides initial support for the factor structure, reliability, and validity of a new measure of expectancies regarding the effects of cannabis on pain. Future research is needed to corroborate these findings and evaluate the predictive utility of CPES scores in relation to pain and cannabis use trajectories. PERSPECTIVE: The article presents the psychometric properties of a novel measure of cannabis-related pain expectancies, the Cannabis Pain Expectancies Scale (CPES). The CPES may inform prevention and treatment efforts by identifying pain-related expectancies associated with continued or escalating cannabis use.

PMID 42556601
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PubMedJournal of education & teaching in emergency medicine2026-08-06

Hematoma, Hemarthrosis, and Hemotympanum: A Case Report of Acquired Hemophilia A.

Wolff Andrea A, Dahlen Ivy I, Singavi Arun A

A 75-year-old female with no prior history of bleeding disorders presented to the emergency department with spontaneous sublingual hematoma, hemarthrosis, hemotympanum, and cutaneous ecchymoses. She denied anticoagulant use, recent trauma, or underlying systemic disease. Initial laboratory findings revealed an isolated prolonged activated partial thromboplastin time (aPTT) that failed to correct with mixing studies. Factor VIII activity was markedly reduced, and the presence of factor VIII inhibitors was confirmed, leading to a diagnosis of acquired hemophilia A (AHA). Management included recombinant activated factor VII (rFVIIa) for hemostatic control, corticosteroids for immunosuppression, and weekly rituximab for inhibitor eradication. During her hospital course, serial monitoring demonstrated a decreasing inhibitor titer and improving coagulation profile. She was discharged and completed four weeks of rituximab and a steroid taper, with complete normalization of coagulation profile and inhibitor eradication within four weeks. This case underscores the importance of recognizing AHA in patients with unexplained bleeding and prolonged aPTT. Prompt diagnosis and targeted therapy are critical in reducing morbidity and mortality associated with this rare but potentially life-threatening disorder.1,2. Acquired hemophilia A, spontaneous bleeding, factor VIII inhibitors, prolonged aPTT, Bethesda assay, recombinant activated factor VII (rFVIIa), immunosuppressive therapy.

PMID 42559514
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PubMedJournal of attention disorders2026-08-06

Depressed or Disengaged? Disentangling Cognitive Disengagement Syndrome, ADHD, and Depression in Adults.

Kafka Julian J, Ebener Deborah D, Bujtor Serena S, Nicholas Louis K LK

This study examined the associations between cognitive disengagement syndrome (CDS), ADHD, and depression in adults to clarify patterns of comorbidity and inform efforts to establish the nosological status of CDS. In addition, the latent structure of adult CDS symptoms was examined, and the clinical relevance of empirically derived CDS dimensions was evaluated. Clinically referred adults completed self-report measures of CDS and depressive symptoms and were assessed for ADHD, anxiety, and depression using multi-informant diagnostic procedures. Exploratory factor analysis was conducted to evaluate the dimensional structure of CDS symptoms. Group comparisons examined differences in depressive symptom severity across diagnostic groups, and correlational analyses evaluated associations between CDS factor scores and depression. Exploratory factor analysis supported a two-factor structure of CDS symptoms reflecting cognitive complaints and lethargy. Individuals with CDS reported significantly greater depressive symptom severity than individuals with ADHD. Both CDS factors were significantly associated with depressive symptoms, with lethargy demonstrating a stronger association than cognitive complaints. Findings support CDS as a multidimensional construct in adults that is closely linked to depressive symptomatology. The observed factor structure and its associations with depression suggest that CDS symptoms extend beyond attentional dysfunction alone and may reflect broader internalizing processes. Although CDS was rarely observed in isolation, its distinct symptom profile and pattern of associations differentiate it from ADHD. Further research is needed to clarify whether CDS is best conceptualized as a transdiagnostic process, a cross-diagnostic clinical syndrome, an internalizing disorder, or an attentional disorder.

PMID 42558063
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PubMedPlastic and reconstructive surgery. Global open2026-08-06

Measurement Properties of the Michigan Hand Outcomes Questionnaire in Patients With a Metacarpal or Phalangeal Fracture.

van de Lücht Veronique A P VAP, de Haas Louise L, de Wolf Gideon S GS, van Heijl Mark M

The Michigan Hand Outcomes Questionnaire (MHQ) is among the most frequently used patient-reported outcome measures to evaluate hand disorder-specific outcomes. However, despite its frequent use in patients with hand trauma, its measurement properties have mainly been evaluated in nontraumatic hand conditions. Consequently, although the MHQ is often described as a validated questionnaire, its measurement properties in patients with acute hand trauma remain unclear. In addition, the MHQ is frequently summarized as a single overall score derived from the 6 domains, often interpreted as representing "hand function." However, it is unclear whether combining these domains into a single score is appropriate. Three months postinjury data of the MHQ from 442 adult patients with metacarpal and phalangeal fractures were analyzed. Structural validity was evaluated using exploratory and confirmatory factor analysis. Construct validity was assessed through known-group comparisons based on a priori hypotheses. Internal consistency was evaluated using Cronbach alpha. Exploratory factor analysis identified 6 factors corresponding to the original MHQ domains. Confirmatory factor analysis showed poor fit for a unidimensional model. In contrast, the 6-factor model showed better fit. Known-group comparisons confirmed 83% of the hypotheses. Domain scores showed clearer differences between clinical subgroups than the overall score. Internal consistency ranged from 0.79 to 0.95 across domains. The MHQ demonstrated sufficient construct validity and internal consistency for its continued use as a 6-domain instrument in patients with metacarpal and phalangeal fractures. We recommend reporting the individual domain scores, as a summarized overall score may mask clinically relevant differences between domains.

PMID 42559349
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PubMedUrology annals2026-08-06

Erratum: Prevalence and management of testicular incidentaloma in men with male factor infertility: Experience of a high-volume tertiary center.

[This corrects the article DOI: 10.4103/ua.ua_97_25.].

PMID 42559551
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