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erythromycin (Erymin / erythromycin, Elan)

✓ Approved

Takeda · 小分子 · 小分子

什么是 erythromycin？

erythromycin 是一种小分子，由Takeda研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Erymin, erythromycin, Elan
公司Takeda
药物类别小分子
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Takeda

治疗适应症

erythromycin 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsSalmonellosis✓ Approved

相关研究文献

PubMedThe Journal of dairy research2026-08-04

Pathogen profiles and antimicrobial resistance in mastitis cases from Algerian dairy she-camels in semi-intensive production.

Mebarki Mounir M, Besbaci Mohamed M

This study aimed to assess the prevalence, aetiology and antimicrobial susceptibility profiles of mastitis in lactating she-camels on semi-intensive dromedary dairy farms. A total of 179 lactating camels from nine farms across five key regions were examined, with 716 udder quarters analysed. Mastitis was identified in 17.9% of animals and 9.4% of udder quarters (95% confidence intervals [CI]: 7.4-11.7), comprising clinical (7.3% of animals; 3.5% of quarters) and subclinical (10.6% of animals; 5.9% of quarters) forms. Bacteriological analysis revealed Staphylococcus aureus as the most frequently isolated pathogen (a combined prevalence 34.3%; 95% CI: 23.2-46.9), followed by Streptococcus spp. and Escherichia coli. Antimicrobial susceptibility testing of 43 isolates showed high susceptibility to trimethoprim-sulfamethoxazole in both S. aureus (100%; 95% CI: 80.5-100) and Streptococcus spp. (100%; 95% CI: 78.2-100). For erythromycin, susceptibility was 100% (95% CI: 78.2-100) in Streptococcus spp. and 76.5% (95% CI: 50.1-93.2) in S. aureus. Conversely, E. coli exhibited high rates of resistance to tetracycline (72.7%; 95% CI: 39.0-94.0) and ampicillin (54.5%; 95% CI: 23.4-83.3), highlighting concerns about the efficacy of empirical treatment and the emergence of antimicrobial resistance in this production context. These findings underscore the need for systematic udder health monitoring, evidence-based antimicrobial stewardship and improved biosecurity on semi-intensive camel dairy farms. This study contributes to the understanding of the microbial landscape and resistance profiles in camel dairy production, with implications for animal productivity, milk safety and public health within a One Health framework.

PMID 42549492
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PubMedMicrobiology spectrum2026-08-04

Markerless gene deletion in Porphyromonas gingivalis using a pheS*-based counterselection system.

Kim Hey-Min H-M, Davey Mary Ellen ME, Yu Manda M

Porphyromonas gingivalis is an oral pathobiont implicated in periodontitis and several systemic diseases and serves as an important model organism. However, the routine generation of markerless mutants in P. gingivalis has remained challenging due to the lack of an efficient counterselection system for the double cross-over approach. Markerless gene deletion is crucial for bacterial genetic manipulations, in particular for generating multiple gene deletions or introducing point mutations. In this study, a counterselection system for P. gingivalis was established by placing the pheS* gene under the control of a P. gingivalis promoter enabling efficient expression. The construct was delivered to P. gingivalis via a suicide plasmid by conjugation. Using PG0719 as a representative target gene, first cross-over recombinants were selected using erythromycin resistance encoded on the suicide plasmid. Cells were then subjected to counterselection in the presence of p-chloro-phenylalanine (p-Cl-Phe). Retention of pheS* in the genome reduced viability, thereby enriching recombinants that had undergone a second recombination event and loss of the plasmid sequence. Candidate clones were screened by colony PCR analysis to confirm the loss of the gene of interest. A markerless PG0719 mutant was generated and further validated by Sanger sequencing, demonstrating a practical approach for markerless gene deletion in P. gingivalis and providing a framework for further genome modifications in the organism.IMPORTANCEAlthough Porphyromonas gingivalis is a widely studied model organism, the genetic manipulation of this bacterium has remained limited by the lack of efficient tools for markerless genome editing. Here, we established a counterselection system based on pheS∗ that enables markerless gene deletion in P. gingivalis. This approach addresses a technical limitation in the field and provides a practical and broadly applicable framework for advanced genetic manipulation in this important oral pathobiont.

PMID 42549931
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PubMedJapanese journal of infectious diseases2026-08-03

Antimicrobial Resistance and Molecular Epidemiology of Campylobacter Isolates from Foodborne Illness Cases in Saitama, Japan.

Koyama Yuki Y, Yoshida Risa R, Arashima Asami A, Doi Rie R et al.

Campylobacter jejuni and C. coli are major causes of foodborne illness worldwide. Increasing antimicrobial resistance (AMR) and the implication of C. jejuni in Guillain-Barré syndrome (GBS), a post-infectious complication, are serious public health concerns. In this study, we characterized Campylobacter isolates from foodborne illness cases in Saitama Prefecture, Japan, focusing on AMR profiles, CPS (Penner) genotypes, multilocus sequence types (STs), and GBS-associated LOS biosynthesis genes. High resistance rates to quinolones and tetracycline were observed in C. jejuni (46.6%, 26.4%) and C. coli (50.0%, 60.0%), and C. coli also showed erythromycin resistance (25.0%), whereas C. jejuni remained susceptible. CPS genotyping of 148 C. jejuni isolates showed a high typeability rate (97.3%), supporting its utility for molecular surveillance. In a 40-isolate C. jejuni subset, MLST revealed that clonal complex 21 (CC21) predominated and ST-4526 was the most common ST. All ST-4526 isolates were quinolone-resistant and carried the GBS-associated genes cst-II (Thr51 variant), cgtA, and cgtB. The ST distribution of C. jejuni overlapped with that of chicken-derived strains, suggesting poultry as a major source of infection. These findings highlight the utility of CPS genotyping and the public health importance of the quinolone-resistant ST-4526 lineage carrying GBS-associated LOS biosynthesis genes.

PMID 42543572
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PubMedBioresource technology2026-08-02

Treatment of erythromycin fermentation residues by anaerobic fermentation coupled with ionizing radiation: Degradation of erythromycin and erythromycin resistance genes.

Song Yuening Y, Yin Yanan Y, He Shijun S, Wang Jianlong J

Erythromycin fermentation residues (EFR) constitute a major pharmaceutical waste stream in China, which contains residual erythromycin (Ery) and antibiotic resistance genes (ARGs), it poses environmental and biosafety risks. In this study, a two-stage treatment strategy combining anaerobic fermentation with ionizing radiation was developed to simultaneously achieve Ery degradation, ARG elimination, and biogas production. During anaerobic fermentation, thermal pretreatment of EFR enhanced substrate solubilization and promoted Ery removal, with raw sludge inoculation yielding the highest Ery removal efficiency (>85 %). In the subsequent ionizing radiation stage, Ery was completely degraded at 50-100 kGy in optimally fermented systems. Thermal or ionizing radiation pretreatment of the inoculum suppressed methanogenic activity, leading to excessive volatile fatty acid (VFA) accumulation, which competitively scavenged reactive radical species and reduced radiolytic efficiency during ionizing radiation treatment. Regarding ARGs, fermentation enriched ereA, ermB, and mefA, while mphB was degraded. Subsequent radiation substantially reduced all targeted ARGs, with all four ARGs falling below the qPCR detection limit at 150 kGy. This study demonstrates that coupling moderate anaerobic fermentation with ionizing radiation provides a feasible approach for the effective disposal of EFR.

PMID 42542143
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PubMedTropical medicine & international health : TM & IH2026-07-31

Vaccine Targets and Antimicrobial Resistance of Streptococcus agalactiae Recovered From Pregnant Women in Brazil.

Barros Clarissa Campos CC, Kegele Fabíola C Oliveira FCO, Soares Maria Francisca da S N MFDSN, Ferreira Douglas Guedes DG et al.

The available measure to prevent Streptococcus agalactiae (Group B Streptococcus, GBS) neonatal infection is intrapartum antibiotic prophylaxis (IAP), but it is threatened by bacterial resistance. Therefore, this study aimed to investigate antimicrobial resistance and bacterial targets of vaccines at the most advanced stage of development. GBS isolates (n = 222) recovered from pregnant women between 2019 and 2024 were subjected to capsular polysaccharides and alpha-like proteins investigation and antimicrobial susceptibility testing. Macrolide and fluoroquinolone resistance determinants and genetic diversity of multidrug-resistant (MDR) isolates were also investigated. The main capsular types were Ia (78, 35.1%), III (42, 18.9%), V (39, 17.6%) and II (32, 14.4%). Vaccines based on hexavalent capsular polysaccharides and alpha-like proteins would have 97.3% and 87.5% of predicted efficacy, respectively. Isolates were categorized as not susceptible (NS), that is, intermediate and resistant, to levofloxacin (5, 2.3%), clindamycin (11, 5%), erythromycin (58, 26.1%) and tetracycline (171, 77%). Among erythromycin NS isolates, the M phenotype/mef(A) gene predominated (47, 81%). All levofloxacin-resistant isolates showed amino acid substitutions in both GyrA (S81L) and ParC (S79F). MDR isolates (10, 4.5%) had distinct genetic backgrounds. Both immunization approaches would be effective in the population. Although the elevated erythromycin resistance rate, one of the highest reported in the country, clindamycin remains an efficient option in IAP. MDR isolates have not resulted from the dissemination of a single clone, but instead showed a polyclonal origin.

PMID 42532504
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PubMedJournal of the Royal Society of New Zealand2026-07-31

Detection of Antibiotic-Resistant Campylobacter on Retail Chicken in New Zealand: A Sentinel Survey.

Sircombe Kathleen J KJ, Pletzer Daniel D, Hook Sarah S

Antibiotics are relied upon to treat and prevent infections in humans, animals, and plants. However, antimicrobial use, particularly when unnecessary or inappropriate, has contributed to the emergence and dissemination of antimicrobial resistance (AMR). Foodborne transmission of antibiotic-resistant bacteria is an increasing public health concern, particularly through poultry contaminated with Campylobacter jejuni. In this study, the prevalence of Campylobacter contamination and associated antimicrobial resistance in fresh retail chicken purchased around New Zealand was investigated. Campylobacter was detected in 50% (12/24; 95% CI: 31.3%-68.7%) of samples using selective culture, PCR, and sequencing. Among confirmed isolates, high levels of resistance were observed to tetracycline (92%) and ciprofloxacin (83%), while 83% were susceptible to erythromycin. No isolate was fully susceptible to all interpreted antibiotics. These preliminary findings indicate that antimicrobial-resistant Campylobacter can be detected in fresh retail chicken in New Zealand and support the need for larger, probabilistic surveillance studies to generate national prevalence and resistance estimates. Continued surveillance, stricter policies on contaminated poultry products, and development of alternatives to traditional antibiotics are recommended to protect public health.

PMID 42535175
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