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collagen (Gelfix / Biopad / Condress)

✓ Approved

Merck & Co. · 治疗药物

什么是 collagen？

collagen 是一种治疗药物，由Merck & Co.研发。该药已获批，用于治疗相关适应症，给药途径：Topical。

药物档案

商品名Gelfix, Biopad, Condress
公司Merck & Co.
给药途径Topical
状态Approved
来源： ClinicalTrials.gov, Merck & Co.

治疗适应症

collagen 针对 4 个适应症，涉及 3 个治疗领域。

治疗领域疾病/病症分期
General disorders and administration site conditionsImpaired healing✓ Approved
Skin and subcutaneous tissue disordersDiabetic foot✓ Approved
Skin and subcutaneous tissue disordersDecubitus ulcer✓ Approved
Vascular disordersPeripheral venous disease✓ Approved

相关研究文献

PubMedSoft matter2026-08-04

Collagen type II dynamics and assembly in anisotropic porous polyacrylamide hydrogels.

Tsai Mario M, Adedeji Adediwura Deborah AD, Suresh Sneha S, Morozova Svetlana S

Inspired by liquid crystallinity and hierarchical organization in natural systems, we fabricate anisotropic polyacrylamide (PAAm) networks by templating polymerization around disodium cromoglycate (DSCG) liquid crystal phases. These anisotropic porous networks act as scaffolds that guide collagen fiber alignment, recapitulating key aspects of extracellular matrix (ECM) organization in biological tissues. The pore morphology and characteristic length scales are tuned by varying the modulus of the PAAm network, while polymerization at different temperatures induces distinct DSCG phases and corresponding pore anisotropies. Network architecture is characterized by confocal microscopy. The hydrogels are subsequently swollen in 1 mg mL-1 collagen solutions prepared in 0.012 M HCl, followed by fibril formation triggered in a neutral pH buffer. Collagen localization within the pore walls and voids is visualized, and collagen dynamics are quantified using confocal microscopy and differential dynamic microscopy (DDM), respectively. As the gel concentration increases, collagen mobility is progressively slowed and the distribution within the gel depends on the morphology and the local acrylamide concentration in pores. In networks polymerized at 30 °C, collagen localizes exclusively within the pore walls. In contrast, in gels polymerized at -20 °C collagen freely diffuses and assembles within the anisotropic pores, yielding highly aligned structures at higher collagen concentrations. Together, these results provide insight into self-assembly within crowded, elastic environments and establish a strategy for engineering biomimetic ECM scaffolds.

PMID 42549499
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PubMedWound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society2026-08-04

Evaluation of a Micronized Collagen Wound Matrix for Advanced Wound Management: Physical, Structural and Biochemical Properties.

Nasrallah Rami A RA, Alhamdi Jumana R JR, Ngo Thuan-Ethan TE, Avery Justin T JT et al.

Wounds affect millions worldwide and non-healing wounds are characterised by excessive protease activity, impaired extracellular matrix remodelling and persistent inflammation, highlighting the need for innovative extracellular matrix-based therapies. This study evaluated a micronized collagen wound matrix (Collagen Wound Matrix-Micronized; CWM-MZ), a biomaterial derived from porcine small intestinal submucosa and processed into a micronized form. Physical and structural properties of CWM-MZ were characterised using collagen content and structure, sulphated glycosaminoglycan content, deoxyribonucleic acid removal, particle size and its ability to inhibit protease activity. Functional in vitro assays were used to assess biochemical responses using dermal fibroblasts and endothelial cells under conditions simulating wound fluid to evaluate effects on cell viability, migration, sulphated glycosaminoglycan production, collagen type I deposition and tube formation. Physically and structurally, CWM-MZ preserved the native collagen architecture, was robustly decellularized and exhibited dose-dependent inhibition of multiple proteases, achieving over 80% inhibition of matrix metalloproteinases. Using in vitro cell-based assays, CWM-MZ resulted in enhanced fibroblast viability, supported fibroblast migration, increased sulphated glycosaminoglycan and collagen type I production and led to more robust formation of capillary-like structures by endothelial cells. These results highlight how CWM-MZ may support an environment for wound healing and its continued evaluation as a novel extracellular matrix-based biomaterial for wound management.

PMID 42548020
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PubMedAdvanced healthcare materials2026-08-04

Hierarchical Collagen Nanofiber Gels Recapitulate a Physiologically Relevant Tumor Stromal Microenvironment.

Sasaki Naoko N, Suezawa Tomoyuki T, Kitano Shiro S, Katayama Ryohei R et al.

Cancer tissue forms cancer stroma with a high elastic modulus due to increased type I collagen (Col I) production from fibroblasts and cross-linking of Col I fibers. Stiffened cancer stroma acts on cancer cells as a mechanical stress and promotes cancer progression. This highlights the need for culture scaffolds that recapitulate the structural, mechanical, and biological characteristics of the tumor stromal microenvironment. In this study, we attempted to create a scaffold material that mimics the fibrous structure and elastic modulus of in vivo cancer tissue using Col I. By gelation with collagen microfibers (CMFs) and collagen nanofibers (CNFs) at various concentrations, we were able to produce collagen gels with elastic moduli ranging from 1 to 18 kPa and 2 to 80 kPa, respectively. When cultured on CNF gels with a similar elasticity to in vivo colorectal cancer tissue, JC-011 exhibited proliferation comparable to that on Matrigel. Furthermore, JC-011 cells cultured on CNF gels exhibited cancer-related protein expression patterns highly similar to those observed on Matrigel. Together, these findings demonstrate that hierarchical CNF gels recapitulate a physiologically relevant tumor stromal microenvironment and provide a promising collagen-based platform for investigating cancer cell-matrix interactions.

PMID 42548008
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PubMedMagma (New York, N.Y.)2026-08-04

Machine learning assisted prediction of cartilage histology using MR fingerprinting - a preliminary study.

Kantola Ville V, Nykänen Olli O, Casula Victor V, Karjalainen Ville-Pauli VP et al.

Prediction of cartilage structural properties through MRI could allow earlier detection of joint pathologies, such as osteoarthritis. Bovine patellar cartilage samples (n = 12) were imaged using magnetic resonance fingerprinting, followed by histological examination of proteoglycan content and collagen fiber anisotropy. The relaxation time maps and raw signal data were then used for training Gaussian process regression (GPR) models to predict the histology results. Proteoglycan content was predicted by the GPR models with high accuracy (median r = 0.81, σ = 0.08 and NRMSE = 11.7%). Predictions performed using raw MRF data outperformed those done using qMRI maps. Collagen fiber anisotropy predictions found only weak correlation (median r = 0.40, σ = 0.25 & NRMSE = 26.4%) and no significant difference was seen between models trained on raw MRF or relaxation time maps. These findings indicate that noninvasive prediction of proteoglycan content in cartilage from MRF measurements using a 3 T clinical scanner is feasible, holding promise for future clinical applications. Collagen fiber anisotropy could not be reliably estimated with the current setup. GPR-based prediction models were found to outperform reference linear models using the same prediction data.

PMID 42550347
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PubMedBeyoglu eye journal2026-08-04

One-Year Visual, Refractive, Tomographic, and Aberrometric Outcomes of Repeat Corneal Collagen Crosslinking in Eyes with Progressive Keratoconus.

Buyuktepe Tuna Celik TC, Kılıç Burcu B, Ucakhan-Gunduz Omur O OO

To evaluate visual, refractive, tomographic and aberrometic outcomes of repeat corneal collagen crosslinking (CXL) using Dresden protocol in the management of keratoconus progression at 1-year follow-up. Charts of consecutive progressive keratoconus patients who underwent repeat corneal collagen CXL using Dresden protocol and had at least 1 year follow-up were retrospectively evaluated. Best spectacle-corrected distance visual acuity (CDVA), manifest refraction, slit lamp biomicroscopy, corneal tomography, corneal aberrometry and endothelial cell counts were evaluated before repeat CXL and at postoperative year-1. At postoperative 1-month, corneal demarcation line depth were evaluated using anterior segment optic coherence tomography. Overall, seven eyes of seven patients with the mean age of 23 (ranged 19 to 27) years were included. The interval between the initial and repeat CXL procedures was 60 (ranged 28 to 89) months. At postoperative month-1, a clear demarcation line could be observed in all patient eyes. The mean demarcation line depth was 250 (ranged 220 to 360) µm. At postoperative month-12, mean CDVA, manifest refraction, topographic indices, and aberrometric outcomes remained stable (p>0.05). Maximum keratometry was reduced more than 1D in two (28.6%) eyes, and remained stable in the remaining five (71.4%) eyes. No significant endothelial cell loss or any other sight-threatening complication was encountered in any patient eye. Repeat corneal CXL seems to be safe and effective in halting keratoconus progression at 1-year follow-up.

PMID 42549180
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PubMedJournal of diabetes investigation2026-08-04

Liraglutide reprograms vascular smooth muscle cell metabolism to suppress extracellular matrix remodeling in diabetic atherosclerosis.

Zhu Kun K, Liu Hanxiu H, He Ni N, Wang Haoyang H et al.

Metabolic reprogramming contributes to vascular dysfunction in diabetic atherosclerosis, but the mechanisms linking hyperglycemia-induced metabolic alterations to extracellular matrix remodeling in vascular smooth muscle cells remain incompletely understood. This study investigated whether liraglutide modulates vascular smooth muscle cell metabolism and plaque remodeling under diabetic conditions. Primary vascular smooth muscle cells were exposed to normal glucose, high glucose, or high glucose plus liraglutide. Cellular bioenergetics, mitochondrial function, oxidative stress, extracellular matrix remodeling, and AMPK/PGC-1α, mTOR, and HIF-1α signaling were assessed. In vivo, diabetic ApoE-/- mice were treated with liraglutide for 12 weeks, followed by evaluation of metabolic parameters, aortic root plaque burden, lipid deposition, collagen content, and plaque-associated signaling markers. High glucose impaired mitochondrial respiration, enhanced glycolysis, reduced mitochondrial membrane potential, increased mitochondrial reactive oxygen species, and promoted mitochondrial fragmentation and extracellular matrix remodeling in vascular smooth muscle cells. Liraglutide restored mitochondrial function, activated AMPK/PGC-1α signaling, suppressed mTOR activation and HIF-1α accumulation, reduced collagen I, MMP-2, and MMP-9 expression, and partially restored elastin levels. In diabetic ApoE-/- mice, liraglutide improved systemic metabolic parameters, reduced atherosclerotic plaque burden and lipid accumulation, increased plaque collagen content, restored plaque p-AMPK expression, and reduced HIF-1α and MMP-9 expression. Liraglutide attenuates hyperglycemia-induced metabolic reprogramming and extracellular matrix remodeling in vascular smooth muscle cells and improves plaque stability in diabetic atherosclerosis. These effects are associated with restoration of AMPK/PGC-1α signaling, inhibition of mTOR activation, suppression of HIF-1α accumulation, and improved mitochondrial homeostasis.

PMID 42549609
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