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immunoglobulin G

✓ Approved

Quimbiotec · 多克隆抗体 · 多克隆抗体

什么是 immunoglobulin G？

immunoglobulin G 是一种多克隆抗体，由Quimbiotec研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)。

药物档案

公司Quimbiotec
药物类别多克隆抗体, 抗体
给药途径Injectable (Others), Intravenous (IV)
状态Approved
来源： ClinicalTrials.gov, Quimbiotec

治疗适应症

immunoglobulin G 针对 4 个适应症，涉及 4 个治疗领域。

治疗领域疾病/病症分期
Nervous system disordersGuillain-Barre syndrome✓ Approved
Skin and subcutaneous tissue disordersPurpura✓ Approved
Immune system disordersImmunodeficiency✓ Approved
Infections and infestationsBorna virus infection✓ Approved

相关研究文献

PubMedFrontiers in immunology2026-08-04

Case Report: Overlapping multiple sclerosis and neuropsychiatric systemic lupus erythematosus with positive MOG-IgG: a case initially misdiagnosed as depression.

Wei Wan W, Jin Tao T, Zhang Liuhai L, Sun Yumeng Y et al.

We present a 69-year-old female patient who initially manifested with depression and anhedonia, initially misdiagnosed as primary psychiatric illness. She subsequently developed progressive gait instability and cognitive decline. After comprehensive clinical and laboratory evaluation, she was finally diagnosed with multiple sclerosis (MS) complicated by neuropsychiatric systemic lupus erythematosus (NPSLE). Brain magnetic resonance imaging (MRI) revealed multifocal white matter lesions consistent with demyelination. Serologic testing demonstrated positivity for antinuclear antibody (ANA), anti-double-stranded DNA (dsDNA), anti-SS-A/Ro, anti-histone, anti-nucleosome, and anti-centromere antibodies. Cerebrospinal fluid (CSF) examination confirmed intrathecal synthesis of immunoglobulin G (IgG), as evidenced by CSF-restricted oligoclonal bands (OCBs). Serum myelin oligodendrocyte glycoprotein immunoglobulin G (MOG-IgG) was positive at a titer of 1:32, whereas aquaporin-4 (AQP4) antibodies were negative. Based on the clinical manifestations, laboratory results and disease progression, the final diagnosis was established as coexisting MS and NPSLE. The patient achieved clinical improvement after treatment with glucocorticoids and hydroxychloroquine. This case highlights the diagnostic challenges posed by overlapping autoimmune central nervous system (CNS) disorders and underscores the importance of longitudinal assessment in differentiating MS from MOG-IgG-associated disorder (MOGAD) and NPSLE.

PMID 42548805
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PubMedCell2026-08-04

Co-option of retrotransposons promotes antibody diversification.

Lauring Max C MC, Yang Ming M, Sarode Aditya A, Wang Jianhua J et al.

Activation-induced cytidine deaminase (AID) accomplishes somatic hypermutation (SHM) of VH(D)JH genes in germinal center B cells for antibody diversification and affinity maturation. How AID specifically targets VH(D)JH remains unclear. We report the discovery of LINE-1 (L1) retrotransposons upstream to many VH genes in the immunoglobulin locus. These L1s are evolutionarily old, truncated, and retrotransposition dead. Recombined VH promoters generate long, strong antisense RNAs encoding upstream L1s, triggering the human silencing hub (HUSH) complex and AID recruitment, which we term L1-driven SHM. We show that L1-driven SHM occurs in vivo using HUSH conditional knockout mice and engineered mice with VH genes devoid of upstream L1s. Insertion of transcriptionally active L1s at non-immunoglobulin loci endogenously lacking upstream L1s promotes off-target SHM. We demonstrate that old retrotransposons serve physiological roles, and our findings reveal how B cells co-opted an anti-retrotransposon silencing mechanism to promote antibody diversity. In doing so, we established a new link between cell-intrinsic innate and adaptive immunity.

PMID 42546688
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PubMedMetabolic engineering2026-08-04

Systematic Metabolic Engineering of Escherichia coli for High-Level Production of trans-4-Hydroxy-L-proline.

Wang Kai K, Tian Shu-Ping SP, Wan Shuo S, Chen Xiu-Lai XL et al.

As a high-value-added amino acid derivative, trans-4-hydroxy-L-proline (T-4-Hyp) faces key bottlenecks in its microbial production from glucose, including insufficient precursor supply and an imbalance between cell growth and product biosynthesis. In this study, we successfully constructed an engineered Escherichia coli strain QF-27 for efficient T-4-Hyp production. First, the L-proline (L-Pro) biosynthetic pathway was enhanced by overexpressing the feedback-resistant γ-glutamyl kinase, glutamate-γ-semialdehyde dehydrogenase, and pyrroline-5-carboxylate reductase, and by knocking out the L-proline dehydrogenase. The resulting strain QF-9 produced 15.75 ± 0.56 g/L of L-Pro. Subsequently, the expression level of proline-4-hydroxylase from Dactylosporangium sp. RH1 was optimized in strain QF-9, and the resulting strain QF-14 produced 5.32 ± 0.26 g/L of T-4-Hyp. To address the insufficient supply of α-ketoglutarate (α-KG), a multi-modular synergistic strategy (i.e., blocking byproduct pathways, enhancing α-KG flux, and relieving global transcriptional repression) increased T-4-Hyp production to 11.02 ± 0.27 g/L. Moreover, a dynamic switch combining PrpsT promoter and DAS+4 degradation tag was designed to repress expression and promote degradation of the α-ketoglutarate dehydrogenase complex during the stationary phase, thereby balancing cell growth and T-4-Hyp production. Consequently, T-4-Hyp production reached 14.37 ± 0.46 g/L, and residual L-Pro fell to 0.38 ± 0.17 g/L. In fed-batch fermentation, the final strain QF-27 produced 105.72 ± 0.84 g/L of T-4-Hyp with productivity of 2.20 g/L/h and carbon yield of 0.364 g/g glucose. To our knowledge, this is the best performance reported for T-4-Hyp production by microbial fermentation, and the first study to enhance it via systematic modification of central carbon metabolism.

PMID 42547008
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PubMedEnvironmental microbiology reports2026-08-04

Texture and Neonicotinoid Exposure Shape Bacterial Assemblages and Functions in Agricultural Soils: Responses Over Prolonged Exposure.

Akter Sharmin S, Jasonsmith Julia J, Hulugalle Nilantha R NR, Strong Craig L CL et al.

The physical and chemical properties of soil fundamentally shape its microbial communities. In a controlled 28-day microcosm experiment, we assessed bacterial community responses to imidacloprid in three soils with differing textures and classifications: a loamy sand (11 g/100 g clay; red Luvisol), a sandy loam (16 g/100 g clay; red Luvisol) and a clay soil (56 g/100 g clay, Vertisol). Analyses included 16S rRNA gene amplicon sequencing, indicator species analysis, co-occurrence network analysis and PICRUSt2-based functional prediction. Imidacloprid exposure elicited soil-specific shifts in bacterial community structure, primarily altering evenness rather than richness; however, overall diversity patterns were more strongly governed by soil texture and sampling time. Indicator species analysis identified distinct sensitive and tolerant taxa in each soil texture, with a core set of taxa remaining largely unchanged. Co-occurrence network analysis showed decreased network complexity and increased modularity under imidacloprid, particularly in loamy sand and clay soils, suggesting altered bacterial interaction patterns. Predicted functional profiles showed upregulation of stress-response pathways and downregulation of energy/nutrient metabolism pathways, implying a community-level shift toward stress adaptation. Although taxonomic richness remained relatively stable, these reorganisations of community interactions and functional potential suggest changes in bacterial resilience and biogeochemical cycling, which may have implications for long-term soil health.

PMID 42547035
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PubMedSmall (Weinheim an der Bergstrasse, Germany)2026-08-04

Regulating MXene Functionalization and Oxidation for High-Rate, High Mass-Loading Supercapacitors.

Zheng Wei W, Guo Miaoxi M, Zhang Mutian M, Liu Xiang X et al.

Unlocking the commercial potential of MXene electrodes in high-energy supercapacitors requires overcoming a fundamental limitation: severe performance decay at increased electrode thickness and mass loading. This work resolves the intrinsic trade-off between surface functionalization and oxidation in MXene chemistry regulation by constructing a controlled redox environment. A urea-assisted hydrothermal process effectively removes inert -F terminations while inducing the formation of a 3D MXene hydrogel enriched with -N active sites. Concurrently, L-ascorbic acid is introduced as an antioxidant to suppress structural oxidation and enhance stability. As a result, the optimized MXene exhibits superior rate capability and long-term cycling stability under high mass loadings. Specifically, at 10.97 mg cm-2, a high specific capacitance of 597 F g-1 is achieved at 1 A g-1, with 69.66% retention at 50 A g-1, significantly outperforming that of pristine MXene (23.44%) and N-doped MXene (59.03%). Even at an ultrahigh loading of 108.64 mg cm-2, 44.50% of the capacitance is retained (from 564 F g-1 to 251 F g-1) over the current density range of 1 to 20 A g-1. This work establishes an effective strategy for designing high-performance MXene-based electrodes via reaction pathway regulation, enabling practical operation at commercially relevant mass loadings.

PMID 42549626
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PubMedDalton transactions (Cambridge, England : 2003)2026-08-04

Ligand-defective Ni-MOF-74/g-C3N4 heterojunction via in situ growth for boosted photocatalytic CO2 reduction.

Yang Ting-Yu TY, Jiang Yu Y, Xing Zhong-Lei ZL, Hou Si-Yu SY et al.

Solar-driven photocatalytic reduction of CO2 into value-added fuels offers a promising route to address greenhouse gas emissions and energy shortages. Herein, we report the in situ growth of ligand-defective Ni-MOF-74 (Ni-DMOF) on graphitic carbon nitride (g-C3N4) to construct a series of heterojunction photocatalysts (denoted as XCNN, X = 100, 200, 300 mg of g-C3N4). Ligand defects in Ni-DMOF expose abundant unsaturated Ni active sites and optimize charge transfer behavior, while the in situ heterojunction with g-C3N4 promotes interfacial contact and efficient spatial separation of photogenerated electron-hole pairs. The optimized 300CNN catalyst exhibits a remarkable CO production rate of 3.52 mmol g-1 h-1 with a high CO selectivity of 96.77%, which is 2.66 times higher than that of pure Ni-DMOF. Moreover, 300CNN exhibits good stability over six consecutive catalytic cycles. Comprehensive characterization studies reveal that the enhanced performance originates from the synergistic effects of defect engineering in Ni-DMOF and the charge transfer pathway in the Ni-DMOF/g-C3N4 heterojunction, which accelerates charge separation, suppresses carrier recombination, and retains strong redox capability. This work provides a feasible strategy for designing high-efficiency MOF/semiconductor heterojunction photocatalysts for CO2 conversion.

PMID 42549814
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