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aP vaccine (aP vaccine, NAVA)

✓ Approved

Baxter International, Inc. · 疫苗 · 疫苗

什么是 aP vaccine？

aP vaccine 是一种疫苗，由Baxter International, Inc.研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intramuscular (IM) Injection。

药物档案

商品名aP vaccine, NAVA
公司Baxter International, Inc.
药物类别疫苗
给药途径Injectable (Others), Intramuscular (IM) Injection
状态Approved
来源： ClinicalTrials.gov, Baxter International, Inc.

治疗适应症

aP vaccine 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsPertussis✓ Approved

相关研究文献

PubMedGeriatrics & gerontology international2026-08-04

Oral Frailty and Meal Positioning Associated With Aspiration Pneumonia in Long-Term Care Residents at High Risk of Malnutrition.

Wu Xinze X, Okazaki Tatsuma T, Okochi Jiro J, Ebihara Satoru S

Aspiration pneumonia (AP) remains a clinical problem in long-term care facilities. However, evidence regarding modifiable care-related factors influencing swallowing remains inconsistent. We used a nationwide survey of residents in Japanese long-term care facilities to examine associations between oral frailty-related conditions, meal positioning strategies, and AP. This cross-sectional study analyzed nationwide survey data from residents at high risk of malnutrition in Japanese long-term care facilities. AP status was determined based on facility medical records. Oral frailty-related conditions and meal positioning factors were assessed using routine records. Logistic regression analyses evaluated associations with AP. Cumulative analysis examined associations between abnormal oral condition item counts and AP prevalence. Among 1204 residents, 8.1% (n = 97) reported AP. After full adjustment, inability to gargle (OR = 1.991; 95% CI: 1.139-3.479) and unclear speech (OR = 1.752; 95% CI: 1.085-2.829) remained significantly associated with AP. During meals, reclining angles of 0°-30° (OR = 4.024; 95% CI: 1.006-16.106) and 30°-60° (OR = 1.890; 95% CI: 1.074-3.327) were associated with AP. AP prevalence increased from 2.9% in residents with 0-1 abnormal oral frailty-related items to 13.1% in those with ≥ 4 items. AP was associated with cumulative oral frailty-related conditions and meal positioning among residents at high risk of malnutrition in long-term care facilities. Monitoring routine oral signs and optimizing seating angles may help reduce AP occurrence.

PMID 42548261
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PubMedNursing open2026-08-04

The Mediating Effects of Psychological Capital Between Undergraduate Nursing Students' Professional Commitment and Academic Procrastination.

Chen Shilin S, Chen Yaqin Y, Peng Yanchun Y, Chen Liangwan L et al.

The purpose of this study was to clarify the relationship between professional commitment, psychological capital (PsyCap) and academic procrastination (AP), and to explore the mediating role of PsyCap between professional commitment and AP of undergraduate nursing students. A descriptive cross-sectional study. A convenience sampling method was used to select 405 undergraduate students enrolled in the four-year nursing and midwifery major at an institution in Fujian Province from December 31, 2023 to March 31, 2024 for the study. A self-administered general information collection form, Positive Psycap Questionnaire (PPQ), Professional Commitment of Undergraduates Scales (PCUS) and Procrastination Assessment Scale for Students (PASS) were utilized for online data collection to validate the mediating effect of PsyCap between professional commitment and AP among undergraduate nursing students. The AP score of undergraduate nursing students was (33.74 ± 7.77), with 49.63% of students experiencing AP. Significant differences in AP were observed across gender, grade, student cadre status and love of nursing major (p < 0.05). Higher anxiety levels in female students contributed to greater AP, and senior nursing students exhibited higher levels of AP. AP was negatively correlated with PsyCap (r = -0.551, p < 0.01) and professional commitment (r = -0.579, p < 0.01), while PsyCap was positively correlated with professional commitment (r = 0.625, p < 0.01). PsyCap played a partial mediating role in the relationship between professional commitment and AP among undergraduate nursing students, with a mediation effect value of -0.1950, accounting for 34.03% of the total effect. The incidence of AP among undergraduate nursing students is relatively high, with gender, grade, student cadre status and love of nursing major identified as influential factors. PsyCap plays a partial mediating role between professional commitment and AP. Nursing educators reduce AP behaviours in undergraduate nursing students through PsyCap interventions, helping them improve learning efficiency, guiding them in academic planning, and laying a foundation for their future career development and the advancement of the nursing profession. A total of 405 undergraduate nursing students were involved in this study.

PMID 42548063
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PubMedAmerican journal of physiology. Regulatory, integrative and comparative physiology2026-08-04

Sympathetic action potential synchronicity and blood pressure regulation in healthy young adults.

Iannarelli Nathaniel J NJ, Spafford Julia E JE, Lynn Cameron M CM, Cheung Stephen S SS et al.

This study investigated sympathetic neural blood pressure regulation in humans by quantifying synchronous and asynchronous action potential (AP) discharge. Muscle sympathetic AP discharge was measured (microneurography; continuous wavelet transform) in twenty-one healthy young adults. Baroreflex functions (central baroreflex component) and diastolic blood pressure (DBP) transduction (peripheral baroreflex component) were quantified for synchronous and asynchronous AP discharge. Analyses were stratified by falling and rising blood pressures to examine hysteresis. Medium-sized synchronous APs exhibited the greatest discharge frequencies (p<0.001) and baroreflex threshold gains (p<0.001). Asynchronous AP discharge exhibited weak baroreflex regulation (p=0.999). Central baroreflex regulation of medium-sized synchronous APs exhibited hysteresis. Medium-sized synchronous APs expressed stronger baroreflex threshold gains (Sympathetic AP Cluster 3: DBP Fall slope: -5.48±3.07%/mmHg, DBP Rise slope: -4.71±2.91%/mmHg; p<0.001) and greater discharge frequencies (Sympathetic AP Cluster 3: DBP Fall: 0.29±0.15Hz, DBP Rise: 0.25±0.13Hz; p<0.001) during falling compared to rising blood pressures. The peripheral baroreflex component exhibited hysteresis. Transduction responses to synchronous AP discharge were larger during rising compared to falling blood pressures (DBP Fall peak: 2.67±1.02mmHg, DBP Rise peak: 3.14±1.29mmHg; p=0.009). Asynchronous AP discharge was associated with attenuated blood pressure reductions compared to cardiac cycles with no AP activity, and more so during rising compared to falling blood pressures (DBP Fall nadir: -2.17±1.09mmHg, DBP Rise nadir: -1.43±0.68mmHg; p<0.001). These data suggest that homeostatic blood pressure regulation is achieved via distinct subpopulations of synchronous and asynchronous APs that receive different central baroreflex and non-baroreflex inputs. Central and peripheral baroreflex hysteresis may reflect a moment-to-moment compensatory strategy for blood pressure regulation.

PMID 42547860
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PubMedClinical nutrition ESPEN2026-08-04

Validation of GLIM Criteria and Nutrition Assessment Tools in Patients with Mild and Moderately Severe Acute Pancreatitis: A Prospective Cohort Study.

Lakananurak Narisorn N, Kittisuphat Nutchakorn N

The international guidelines recommend nutrition evaluation in all patients with mild and moderately severe acute pancreatitis (AP). The Global Leadership Initiative on Malnutrition (GLIM) criteria were developed for evaluating malnutrition. However, no prospective study has validated GLIM criteria in AP, and research on nutrition assessment tools in AP remains limited. This study aimed to validate GLIM criteria and evaluate nutrition assessment tools in patients with mild and moderately severe AP. This prospective study enrolled patients diagnosed with mild and moderately severe AP from July 2022 to April 2023. GLIM criteria and subjective global assessment (SGA) were assessed by different trained clinicians. SGA was used as a semi-gold standard for diagnosis of malnutrition according to GLIM validation guidance. Clinical outcomes, including mortality, complications, length of stay (LOS), and 90-day readmission, were evaluated. Sixty-five patients were enrolled. Mild and moderately severe AP were observed in 90.8% and 9.2% of patients, respectively. The prevalence of malnutrition, as assessed by GLIM criteria and SGA, was 21.5%. GLIM criteria showed a significant strong agreement (weighted κ = 0.817, 95% CI 0.57-1.00, p < 0.001) and strong diagnostic performance, with a sensitivity of 85.7%, specificity of 96.1%, positive predictive value of 85.7%, and negative predictive value of 96.1%. Only SGA was independently associated with LOS≥6 days (OR 4.67; 95% CI: 1.22-17.89, p = 0.025). GLIM criteria demonstrated strong validity in diagnosing malnutrition in mild and moderately severe AP. Only SGA was independently associated with longer LOS. Further multicenter studies with larger populations are warranted to confirm these findings.

PMID 42547029
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PubMedPancreas2026-08-04

Primary Hyperparathyroidism-Induced Acute Pancreatitis: Case Report and Systematic Review.

Che Fei F, Lv Dongfeng D, Liu YaDong Y, Wu Yangpeng Y

Primary hyperparathyroidism (PHPT) is a rare but notable metabolic cause of acute pancreatitis (AP). Early diagnosis and surgical intervention are crucial to prevent recurrence and improve prognosis. We retrospectively analyzed the clinical data of a 61-year-old male presenting with AP and severe hypercalcemia (3.54 mmol/L) as the initial manifestation of PHPT. Additionally, a systematic review of 83 studies published between 1958 and May 2026 was performed in accordance with PRISMA guidelines. Individual patient data (IPD) on demographics, total serum calcium levels, treatment modalities, and clinical outcomes were extracted. The patient's total serum calcium was 3.54 mmol/L (14.16 mg/dL) with a parathyroid hormone (PTH) of 640.5 pg/mL. Unenhanced abdominal computed tomography (CT) confirmed acute pancreatitis (AP; moderately severe acute pancreatitis according to the Revised Atlanta 2012 classification), and a left inferior parathyroid adenoma was identified via cervical ultrasonography and 99mTc-MIBI scintigraphy. Total serum calcium normalized following parathyroidectomy (PTX), with resolution of symptoms. A systematic review of 107 patients with primary hyperparathyroidism-associated pancreatitis (PHPT-AP) showed the median age was 38 years (IQR 26-56, range 11-88), 41.1% male, and the median peak total calcium was 3.25 mmol/L (IQR 2.98-3.82, range 2.55-5.36). PTX was performed in 88.8% of the cases. PHPT is a treatable cause of acute pancreatitis and should be considered in cases of idiopathic or recurrent pancreatitis. Routine screening of total serum calcium and PTH levels is recommended for idiopathic or recurrent AP. For PHPT-AP patients with hypercalcemic crisis (>3.75 mmol/L or >15 mg/dL), early parathyroidectomy after medical stabilization (traditionally recommended within 72 hours, although modern evidence supports optimization over 48 hours up to 1 week) is safe and curative. For severe but non-crisis PHPT-AP (such as our index case with peak calcium 3.54 mmol/L), definitive parathyroidectomy should be scheduled during the same hospitalization or within 2-4 weeks after pancreatitis resolution. Among 99 survivors, 75 had explicit follow-up records with no pancreatitis recurrence reported; quantifiable follow-up duration was available for 36 of these patients (median 18 months, IQR 6-36).

PMID 42549662
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PubMedInfection and immunity2026-08-04

Subunits of adaptor protein complex-1 make distinct contributions to the virulence of Cryptococcus neoformans.

Bhalla Kabir K, Sánchez-León Eddy E, Huang Yu-Hsuan Y-H, Hu Guanggan G et al.

Cryptococcal meningoencephalitis is among the most prevalent invasive fungal diseases, posing a threat to immunocompromised individuals and representing a growing global health concern. The mechanisms of cryptococcal trafficking of virulence factors during disease are incompletely understood. Adaptor protein (AP) complexes play crucial roles in intracellular trafficking by orchestrating the sorting of macromolecular cargo and serving as essential components of the endocytic and secretory pathways. In a recent study, we demonstrated that Cryptococcus neoformans cells lacking the AP-1 complex subunits exhibit impaired elaboration of virulence factors and fail to survive in the harsh conditions of the macrophage phagolysosome. Although we characterized the phenotypes of AP-1 deficient cells in vitro, the contribution of this complex to pathogenesis remains unexplored. In this study, we show that mutants deficient in AP-1 complex subunits are either avirulent or exhibit attenuated virulence in a murine inhalational model. Loss of the small subunit resulted in the formation of granuloma-like lesions in mouse lungs with early containment of infection but eventual mortality, whereas mutants lacking the large subunits were rapidly cleared by mice. The delayed onset of disease in mice caused by mutants lacking the small subunit was marked by delayed weight loss and increased respiration rate, yet the mutant exhibited enhanced dissemination during late-stage infection, coinciding with waning immune responses and elevated collagen deposition. These findings demonstrate that deficiencies in the AP-1 complex impair C. neoformans virulence, reveal distinct roles for individual subunits, and identify the complex as a potential target for therapeutic intervention in cryptococcosis.

PMID 42550076
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