若生智能
Drug Database
QL

QL-1209 (QL1209 / QL 1209)

✓ Approved

Qilu Pharmaceutical · ERBB2 · 单克隆抗体

什么是 QL-1209？

QL-1209 是一种单克隆抗体，由Qilu Pharmaceutical研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)。

药物档案

商品名QL1209, QL 1209
公司Qilu Pharmaceutical
药物类别单克隆抗体, 抗体
分子靶点ERBB2
给药途径Injectable (Others), Intravenous (IV)
状态Approved
来源： ClinicalTrials.gov, Qilu Pharmaceutical

作用机制

分子靶点

QL-1209 作用于 1 个分子靶点：

ERBB2erb-b2 receptor tyrosine kinase 2 (NEU, CD340)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

QL-1209 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Breast cancer✓ Approved

相关研究文献

PubMedEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026-08-03

Auditory and cognitive outcomes in children with incomplete partition type II: A comparison with normal cochlear anatomy.

Yılmaz Beyza Demirtaş BD, Batuk Merve Özbal MÖ, D'Alessandro Hilal Dinçer HD, Sennaroğlu Gonca G

Children with inner ear malformations, particularlyIncomplete Partition Type II (IP-II), often exhibit variability in auditory and cognitive outcomes despite receiving appropriate rehabilitation. This study aimed to compare phoneme discrimination, executive functions, verbal memory, and hearing-related quality of life in children with IP-II using cochlear implants against peers with normal cochlear anatomy (using hearing aids or implants) and normal hearing. Fifty-eight children (aged 7-10 years) were divided into four groups: hearing aid users (HA), cochlear implant users with normal anatomy (CI), CI users with IP-II(CI), and normal-hearing controls. The test battery included the Auditory Speech Sound Evaluation (ASSE), Stroop Test, Working Memory Scale, and HEAR-QL-26. Regression analyses examined predictors of cognitive outcomes. Phoneme discrimination accuracy differed significantly among groups (p < 0.001), with the IP-II(CI) group demonstrating the lowest performance. Verbal memory levels also differed significantly (p = 0.014), with the HA group showing a notably higher proportion of "very low" performance. While no significant differences were found in Stroop performance, descriptively longer completion times were observed in hearing-impaired groups. Quality of life scores were significantly lower in all hearing-impaired groups (p < 0.01). Regression analyses indicated that duration of device use was a significant predictor of interference control (Stroop Level 5: β=-0.45,p = 0.002). Children with IP-II exhibit reduced phoneme discrimination and verbal memory vulnerabilities despite comparable aided thresholds. These findings highlight the necessity of incorporating phoneme-level and cognitive assessments into routine follow-up, as audiological measures alone may underestimate functional listening challenges.

PMID 42543434
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PubMedPloS one2026-07-30

An innovative quantum-fuzzy paradigm for time- and context-sensitive membership: Quantive logic.

Yerlikaya Mehmet Akif MA, Efe Ömer Faruk ÖF, Efe Burak B, Javadı Hatef H et al.

Uncertainty in real-world decision problems is rarely static or one-dimensional: the relevance of evidence changes over time, depends on context, and is shaped by interactions between multiple criteria. Classical fuzzy logic provides a flexible scalar notion of membership, but it typically treats each criterion in isolation and does not natively encode temporal or contextual dynamics. Quantum-inspired models, on the other hand, offer rich Hilbert-space representations but are often difficult to integrate with everyday decision-making tasks. This paper proposes Quantive Logic (QL), a quantum-inspired fuzzy framework for time- and context-sensitive membership. In QL, each element is assigned a quantive membership state, represented as a vector in a complex Hilbert space. Conventional fuzzy degrees are recovered as suitable projections of this state, while phase and superposition capture interactions and context effects between criteria. We formalize how quantive membership states are initialized from classical information and updated through linear operators that model temporal evolution and contextual shifts. To illustrate the framework, we outline a multi-criteria credit-risk assessment scenario in which applicant profiles are encoded as quantive membership states and updated under changing economic conditions. This example shows how QL can refine risk judgments when interactions between criteria and scenario-dependent effects are important. Rather than competing with existing fuzzy or probabilistic models, QL is intended as a complementary layer that enriches membership representation wherever time, context, and interaction effects cannot be ignored.

PMID 42531285
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PubMedThe Eurasian journal of medicine2026-07-30

Nuclear and Mitochondrial DNA Variants in Chiari Malformation Type 1: Insights from an East Coast Malaysian Cohort.

Rosdi Siti Nornazihah Mohd SNM, Yusoff Abdul Aziz Mohamed AAM

Chiari malformation type 1 (CM1) is a neurological disorder characterized by cerebellar tonsil herniation. While nuclear DNA has been associated with craniovertebral development, the role of mitochondrial DNA (mtDNA) remains unclear. This study investigated nuclear DNA variants (PAX1, EPAS1, DKK1, GDF6) and mtDNA D-loop mutations in CM1 patients from East Coast Malaysia. Sixty-eight participants were enrolled, comprising 38 CM1 patients and 30 controls. Genomic DNA from peripheral blood was analyzed by polymerase chain reaction amplification and Sanger sequencing. Associations between genetic variants and clinicopathological parameters (age, sex, tonsillar herniation, syringomyelia) were assessed using chi-square or Fisher's exact test. Four nuclear DNA variants were identified, comprising a synonymous PAX1 mutation (c.555G>A, p.K185K) and intronic changes in EPAS1 (c.1035-7C>G), DKK1 (c.548-3T>C), and GDF6 (c.406+112T>C), none of which exhibited significant associations with clinicopathological characteristics. In contrast, mtDNA analysis revealed that 50% of CM1 patients (n = 30) harbored D-loop mutations, predominantly T>C or G>A transitions, including 18 novel variants. Mutation frequency was significantly higher in patients with more severe tonsillar herniation (>10 mm) (OR = 28.570; 95% CI: 3.080-250.000; P < .001) and in those with syringomyelia (OR = 7.792; 95% CI: 1.782-34.060; P = .007), while no significant associations were observed with age or sex. Nuclear DNA variants may function as genetic modifiers without significant clinical impact. Conversely, mtDNA D-loop mutations were prevalent and correlated with disease severity, suggesting a contributory role in CM1 pathogenesis and warranting further investigation of mitochondrial genetic factors. Cite this article as: Rosdi SNM, Mohamed Yusoff AA. Nuclear and mitochondrial DNA variants in Chiari malformation type 1: insights from an east coast Malaysian cohort. Eurasian J Med. 2026, 58(4), 1209, doi: 10.5152/eurasianjmed.2026.251209.

PMID 42528056
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PubMedSensors (Basel, Switzerland)2026-07-28

A Pulsatile Flow-Modulation Microfluidic Sensor for Simultaneous Monitoring of Red Blood Cell Aggregation and Viscosity-Sensitive Time Constant.

Kang Yang Jun YJ

Red blood cell (RBC) aggregation and viscosity-related flow resistance are important hemorheological parameters for assessing blood flow abnormalities, but their simultaneous measurement often requires multiple pumps or intermittent flow stoppage. In this study, we propose a single syringe pump microfluidic sensing method for simultaneous evaluation of RBC aggregation and transient flow response under continuous pulsatile blood delivery. The device consists of a single inlet, a main straight channel, a bifurcated test channel, and a big outlet. An optimized pulsatile-flow profile was applied by periodically switching the flow rate between high flow rate (Qh = 6 mL/h for 2 min) and low flow rate (Ql = 1 mL/h for 4 min), and the transient velocity response was analyzed to extract the time constant (λ1) as a viscosity-related indicator. After optimization, the selected flow profile provides stable and reproducible measurements of both λ1 and the RBC aggregation index (AI) while reducing unnecessary blood consumption. The λ1 shows a strong correlation with viscosity and is significantly affected by syringe air compliance. The proposed AI exhibits consistent trends when compared with conventional aggregation indices. Furthermore, it exhibits temporal stability under continuous blood flow. Finally, the method is adopted to detect time-dependent changes in blood during continuous blood infusion, which demonstrates its potential as a simple, sensitive, and practical microfluidic sensor for real-time hemorheological monitoring.

PMID 42515425
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PubMedClinical epidemiology2026-07-28

The Danish Lymphoid Cancer Research (DALY-CARE): Genetic Cohort Profile.

Dietz Jojo Biel-Nielsen JB, Kadlec Tereza Fait TF, Rotbain Emelie Curovic EC, Werling Mikkel M et al.

The Danish Lymphoid Cancer Research (DALY-CARE) Genetic Cohort was established to support research into how genetic factors influence clinical outcomes in lymphoid cancers (LCs), including disease progression, treatment response, toxicity, and survival. Individual-level genetic data were combined with detailed clinical information from national health registers, hospital-based electronic health records (EHR), laboratory data, and pathology reports. The cohort enables large-scale studies of genetic susceptibility, disease course, and therapy-related outcomes in LCs and provides a platform for genetic epidemiology and future multi-omics research within a unified data infrastructure. The genetic cohort includes 8675 genotyped individuals drawn from the broader DALY-CARE population (n=74,251, as of April 2025), including individuals diagnosed with LCs such as diffuse large B-cell lymphoma (DLBCL, n=1349), chronic lymphocytic leukemia (CLL, n=1245), multiple myeloma (MM, n=1209), follicular lymphoma (FL, n=704), Hodgkin lymphoma (HL, n=407), Waldenström macroglobulinemia and lymphoplasmacytic lymphoma (WM/LPL, n=368), marginal zone lymphoma (MZL, n=287), and precursor states such as monoclonal gammopathy of undetermined significance (MGUS, n=1299). Hematologic malignancy was the most frequent cause of death (30%), followed by infections (27%) and other cancers (15%). Polypharmacy, as a more sensitive proxy for comorbidity than hospital diagnosis codes, was substantial (median 7-8 drugs pre-diagnosis). Frequently observed comorbidities were hypertension (47%), cardiovascular disease (16%), cerebrovascular disease (11%) and type 2 diabetes (10%). Kinship analysis identified limited relatedness (41 parent-offspring, 51 siblings), while ancestry inference confirmed predominantly Northwestern European descent (97%). The DALY-CARE Genetic Cohort provides a foundation for studying genetic and clinical determinants of LC outcomes. Integration of genotype data with EHR and national health registers enables exploration of germline risk and protective variants. Future expansions will integrate additional omics data types, such as whole-genome sequencing, transcriptomics, proteomics, and immunophenotyping, positioning the cohort as a national platform for multi-omics research in LC.

PMID 42518861
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PubMedAIDS care2026-07-23

Beyond viral suppression: determinants of health-related quality of life in a national HIV cohort in Turkiye.

Karacaer Zehra Z, Bozdag Merve M, Asar Erdogan E, Bastug Aliye A et al.

This multicentre study evaluated Health-related Quality of Life (HRQoL) and identified sociodemographic and clinical determinants of physical and mental health outcomes in a large national HIV cohort in Turkiye. This cross-sectional study included 1303 adults across 23 centres. HRQoL was assessed using the Turkish MOS-HIV Health Survey, yielding Physical Health Summary (PHSS) and Mental Health Summary (MHSS) scores. HRQoL scores were dichotomised into "higher" (>50) and "lower" (≤50) groups. Data were analysed via univariate tests and multivariable logistic regression. Participants (88.6% male; median age: 38) were primarily single, employed, and university graduates. The median CD4+ T-cell count and HIV RNA level were 627 cells/mm3 and <50 copy/mL, respectively. Median PHSS and MHSS were 57.25 and 50.57, respectively. While social/role functioning scored highest, health transition scored lowest. Lower PHSS was identified in 22.7% of participants, whereas 47.9% reported lower MHSS. Low education and high daily pill burden significantly increased the risk of lower HRQoL. Interestingly, lower income was independently associated with better HRQoL, while older age and psychiatric treatment correlated with better MHSS. Despite robust physical HRQoL, mental health remains a significant challenge. To achieve "Fourth 90" targets, interventions should prioritise health literacy and integrated mental health services within HIV care.​​Abbreviations: ART: antiretroviral therapy; CF: cognitive functioning; CI: confidence interval; EF: energy/fatigue; GH: general health perception; HAART: highly active antiretroviral therapy; HD: health distress; HIV: human immunodeficiency virus; HL: Hosmer-Lemeshow; HRQoL: health-related quality of life; HT: health transition; MHS: mental health summary; MHSS: mental health summary score; MOS-HIV: medical outcomes study HIV health survey; OR: odds ratio; P: pain; PF: physical functioning; PHS: physical health summary; PHSS: physical health summary score; PLWH: people living with HIV; QL: quality of life; RF: role function; RNA: ribonucleic acid; SF: social function; UNAIDS: joint United Nations programme on HIV/AIDS.

PMID 42492089
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