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calcitonin (Fortical Injection / Forcaltonin)

✓ Approved

Kyowa Kirin Co., Ltd. · CALCR · 重组蛋白

什么是 calcitonin？

calcitonin 是一种重组蛋白，由Kyowa Kirin Co., Ltd.研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Subcutaneous Injection。

药物档案

商品名Fortical Injection, Forcaltonin
公司Kyowa Kirin Co., Ltd.
药物类别重组蛋白
分子靶点CALCR
给药途径Injectable (Others), Subcutaneous Injection
状态Approved
来源： ClinicalTrials.gov, Kyowa Kirin Co., Ltd.

作用机制

分子靶点

calcitonin 作用于 1 个分子靶点：

CALCRcalcitonin receptor (CT-R, CTR)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

calcitonin 针对 3 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Endocrine disordersHypercalcaemia of malignancy✓ Approved
Musculoskeletal and connective tissue disordersOsteitis deformans✓ Approved
Musculoskeletal and connective tissue disordersOsteoporosis✓ Approved

相关研究文献

PubMedOdontology2026-08-04

Color stability of different aligner attachment composites following exposure to conventional and electronic cigarette smoke.

Atik Ezgi E, Şanlı Burak B, Erdogan Melek Almila MA, Erdemli Bengi Yilmaz BY et al.

The objective was to compare conventional and electronic cigarettes regarding the discoloration of three types of aligner composite resin attachments. Three composite resins were evaluated: Tokuyama Estelite Universal Flow, G-ænial Universal Injectable, and Filtek Z350 XT Universal Restorative. Attachments were bonded onto epoxy resin models (N = 28 teeth). Each composite group was divided into conventional and electronic cigarette subgroups (n = 14). Color measurements were performed before and after exposure with VITA Easyshade V, and ΔE00 and Whiteness Index for Dentistry (WID) values were calculated. The chemical composition of the attachments was assessed using FTIR-ATR. Statistical analyses included one-way ANOVA, paired and independent samples t-tests. After conventional cigarette exposure, WID significantly decreased in all composites. Tokuyama Estelite Universal Flow exhibited a significantly smaller reduction in WID (- 4.06 ± 4.03) compared with G-ænial Universal Injectable (- 8.28 ± 3.56) and Filtek Z350 XT (- 10.16 ± 4.63) (p < 0.05). Following electronic cigarette exposure, WID increased for G-ænial Universal Injectable (p = 0.031) but decreased for Filtek Z350 XT (p = 0.009). After electronic cigarette, ΔE00 was significantly higher in G-ænial Universal Injectable (4.07 ± 1.49) than in Filtek Z350 XT (2.94 ± 2.38) (p = 0.001). Significant differences between conventional and electronic cigarette exposure were observed for G-ænial Universal Injectable in ΔL, for all composites in Δb and ΔWID, and for Filtek Z350 XT in ΔE00. Irrespective of the smoking type, all composite resins exhibited ΔE00 values exceeding the clinically acceptable threshold after exposure. After conventional cigarette, whiteness index of Tokuyama Estelite Universal Flow was less affected than other resin types. Conventional cigarette induced more pronounced color changes than electronic cigarette aerosol.

PMID 42547722
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PubMedJournal of pharmaceutical and biomedical analysis2026-08-04

Rapid screening of physicochemical compatibility between co-administered injectable drugs using thermal and spectroscopic approaches.

Granados Pedro A PA, Santana Ingrid A IA, Lima Ana Luiza AL, Gross Idejan P IP et al.

The concomitant administration of injectable drugs in hospital settings frequently involves extemporaneous combinations within the same infusion line, often without compatibility evaluation. This practice may compromise drug stability and patient safety, particularly in intensive care units characterized by complex polypharmacy regimens. In this study, a rapid screening protocol based on complementary thermal, spectroscopic, and morphological techniques was applied to investigate potential physicochemical interactions between injectable drugs under accelerated stress conditions. Dopamine, ondansetron, rocuronium, and fluconazole were combined pairwise as binary physical mixtures and subjected to controlled thermal and photonic stress. Differential scanning calorimetry, thermogravimetric analysis, FTIR spectroscopy, and stereomicroscopy were employed to detect early physicochemical interactions and stress-induced instability. Thermal analysis revealed melting point shifts, enthalpy reduction, amorphization, and premature degradation events for several combinations, indicating different levels of intermolecular interaction. FTIR and morphological analyses demonstrated that some changes in thermal profile were accompanied by chemically relevant alterations and progressive discoloration, particularly after combined thermal and light exposure. Dopamine/fluconazole and dopamine/ondansetron mixtures showed evidence of moderate solid-state interaction, while ondansetron/fluconazole exhibited increased susceptibility to stress-induced instability. Mixtures containing rocuronium exhibited greater sensitivity to combined thermal and photonic stress, especially ondansetron/rocuronium, which showed marked light-dependent instability. Overall, the proposed approach proved useful as a rapid preliminary risk-ranking strategy to identify injectable drug combinations requiring further compatibility investigation under clinically relevant conditions.

PMID 42546540
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PubMedSmall science2026-08-04

Injectable Artificial Photoreceptors: STEM Cell Functional Integration and in vivo Electrophysiological Validation in Retinal Degeneration Models.

Izadian Afshin A, Torkashvand Ali A, McCall Benjamin Allan BA, Gao Yong Y et al.

In this study, an injectable artificial photoreceptor (APR) is engineered to transduce visible light into cell-level electrical stimulation via localized surface plasmon resonance to restore vision in patients with vision loss. APRs comprise gold nanoparticles (AuNPs) with poly (vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) dielectric coating and are integrated onto a high-permittivity barium titanate core. This yields a stable nanocomposite with maximum absorbance in the green band at around 525 nm. APRs were evaluated in vitro using human pluripotent stem cell-derived retinal ganglion cells (hRGCs) exposed to light stimulation. In vivo efficacy was assessed following intravitreal injection of APRs in the rd1 mouse model, and functional outcomes were evaluated using visual evoked potentials (VEPs) and pupillary light reflex (PLR) testing. In vitro, optical stimulation of hRGCs in the presence of APRs increased multielectrode-array (MEA) firing. This shifted cellular metabolism toward mitochondrial oxidative phosphorylation without inducing apoptosis. In rd1 mice, intravitreal APR delivery produced robust restoration of light-evoked retinal activity in explant MEAs and improved functional readouts in vivo, validated by enhanced PLR and increased N1 amplitudes on flash VEPs. This study demonstrates that a fully injectable nanophotonic prosthesis can restore light responsiveness in a retinal degeneration model without the need for implanted electronics or genetic modification.

PMID 42549431
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PubMedDrug and alcohol review2026-08-04

Long-Acting Injectable Buprenorphine in Prison: Insights From a Short-Answer Survey of People in the Criminal Justice System Commencing Long-Acting Injectable Buprenorphine During a Non-Randomised Clinical Trial.

Woods Amelia A, Foley Catherine C, Dunlop Adrian A, White Bethany B et al.

Long-acting injectable buprenorphine (LAIB) is increasingly used in the Criminal Justice System (CJS) for treating people with opioid use disorder; however, little is known about these patients' experiences. We aimed to understand the perspectives of participants commenced on LAIB in prison as a part of the Understanding NSW Long-Active Opioids in Custody-Treatment (UNLOC-T) study. Results of an open-ended survey administered by UNLOC-T researchers underwent analysis. Participants were adults, recruited November 2018-July 2019, with moderate-severe opioid use disorder and ≥ 6 months remaining on their sentence. We conducted a thematic analysis using a pragmatic, descriptive coding approach. Sixty-seven participants were included, of which 82% were male. Five primary themes were identified that described participants' experiences and highlighted issues that can directly inform service delivery: medication effectiveness, social and relational considerations, dosing frequency, financial aspects, and health and wellbeing. There was considerable variation in participant perspectives within themes. Perspectives on LAIB are diverse, suggesting a need to individualise treatment and ensure person-centered care. While LAIB offers benefits to warrant including it as a treatment option, challenges remain. Future research into LAIB in the CJS would allow for triangulation, as well as further exploration of ongoing acceptability in the post-release period. Our findings could help to improve the way LAIB is offered as a treatment option or delivered to people in the CJS. There are also lessons for prescribers in counselling and tailoring treatment, and broader policy considerations around access to treatment formulations and patient autonomy.

PMID 42548035
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PubMedZhonghua shao shang yu chuang mian xiu fu za zhi2026-08-04

[Research progress on the role of calcitonin gene-related peptide in the repair of diabetic wounds].

Wang X Y XY, Tan Q Q

Diabetic wounds are a severe complication of diabetes, which can lead to amputation or even mortality in severe cases. While normal wound healing consists of four phases: hemostasis, inflammation, proliferation, and remodeling, diabetic wounds tend to become chronic and refractory primarily due to a prolonged inflammatory phase. In diabetic wounds, insufficient synthesis and release of endogenous calcitonin gene-related peptide (CGRP) is a critical upstream mechanism underlying the disrupted neuro-immune communication, the persistent inflammation, and the arrested wound healing process. In contrast to pure skin defect wounds, where CGRP is rapidly upregulated after injury, CGRP remains persistently low in diabetic wound tissue, consequently failing to drive macrophage polarization towards the M2 phenotype or promote vascular maturation and collagen fiber deposition in the later phase of inflammation. In the early inflammatory phase, CGRP exerts pro-inflammatory effects by enhancing angiogenesis and modulating macrophage polarization. In the late inflammatory phase, CGRP upregulates thrombospondin-1, promotes neutrophil apoptosis and phagocytic clearance, thereby inhibiting excessive inflammatory response and shifting the wound microenvironment from a pro-inflammatory state to a pro-reparative state. Restoring CGRP signaling reconstructs the neuroimmunomodulation axis and improves wound repair while relieving diabetic neuropathic pain. Engineered CGRP combined with intelligent delivery systems offers promising prospects for diabetic wound therapy. However, large-scale clinical trials are still required to validate its clinical efficacy and safety. This paper systematically analyzes the mechanisms and application strategies of CGRP in facilitating diabetic wound repair, which can provide a theoretical basis and innovative strategies for clinical management.

PMID 42547443
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PubMedFrontiers in oncology2026-08-04

Modern brachytherapy in glioblastoma: overcoming clinical barriers to improve local control.

Schneller Perrine P, Daouk Joël J, Pierson Julien J, Rech Fabien F et al.

Glioblastoma almost invariably recurs at the margin of the resection cavity despite maximal treatment combining surgery, external beam radiotherapy, and chemotherapy. More than 80% of recurrences arise locally, underscoring a persistent unmet need for improved locoregional control. Despite major advances in conformal external beam radiotherapy techniques, durable local control remains challenging because of diffuse tumor infiltration, biological resistance, and the need to preserve surrounding healthy brain tissue. Although internal radiotherapy has existed for decades and is supported by a compelling radiobiological rationale, its integration into routine neuro-oncological practice remains limited. In this narrative review, we examine why a technically established approach, based on a sound biological rationale, continues to play a limited role in glioblastoma management. We focus on dosimetric standardization as a major challenge specific to internal radiotherapy. Unlike external beam radiotherapy, which prescribes absorbed dose within a standardized planning framework, internal radiotherapy delivers radioactive activity, resulting in spatially and temporally evolving dose distributions that are difficult to reconstruct, compare, and biologically interpret. Recent advances in intracavitary implantable and injectable platforms, patient-specific modeling, and improved understanding of glioblastoma radiobiology may enable a shift toward biologically informed treatment planning. By integrating radiation physics, tumor biology, and clinical decision-making, modern brachytherapy may emerge as a structured complement to multimodal glioblastoma care aimed at achieving improved local control.

PMID 42548479
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