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MV-130 (Bactek / MV130)

✓ Approved

Inmunotek · 细胞治疗 · 细胞治疗

什么是 MV-130？

MV-130 是一种细胞治疗，由Inmunotek研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)、Sublingual (SL)/Oral Transmucosal。

药物档案

商品名Bactek, MV130
公司Inmunotek
药物类别细胞治疗, 疫苗
给药途径Oral (PO), Sublingual (SL)/Oral Transmucosal
状态Approved
来源： ClinicalTrials.gov, Inmunotek

治疗适应症

MV-130 针对 11 个适应症，涉及 4 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsViral upper respiratory tract infection✓ Approved
Infections and infestationsLower respiratory tract infectionPhase III
Infections and infestationsOtitis mediaPhase II
Infections and infestationsPneumoniaPhase II
Infections and infestationsSinusitisPhase II

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相关研究文献

PubMedRSC advances2026-08-04

Hydrothermal fabrication of a CuCo2O4-decorated MXene hybrid electrode for overall water splitting and energy storage.

Ahmad Sohail S, Lei Cong C, Sami Abdus A, Tahir Hasnat H et al.

On nickel foam, a binder-free CuCo2O4/MXene electrode was created and thoroughly examined for use in supercapacitors, the oxygen evolution reaction (OER), and the hydrogen evolution reaction (HER) in alkaline media. When compared with pure CuCo2O4, the addition of MXene greatly enhances electrical conductivity, encourages effective charge transfer, and increases the accessibility of electrochemically active sites. Consequently, the CuCo2O4/MXene electrode shows a high specific capacitance (C sp) of 1851.61 F g-1 at 3.5 A g-1, along with a power density of 1085 W kg-1 and an energy density of 98.85 W h kg-1. At low overpotentials of 190 mV for the OER and 250 mV for the HER, the electrode reaches a current density of 10 mA cm-2, with matching Tafel slopes of 59 and 70 mV dec-1, respectively, showing good reaction kinetics and electrocatalytic performance. Furthermore, the electrode exhibits good endurance, sustaining consistent operation for more than 20 hours and keeping 95.68% of its initial capacitance after 1000 cycles. The high synergistic coupling and close interfacial contact between CuCo2O4 and MXene, which promote quick electron transit and effective redox activity, are responsible for the improved electrochemical performance. These findings demonstrate the potential of CuCo2O4/MXene as a sophisticated, binder-free, and three-dimensional electrode architecture for multipurpose energy conversion and storage applications.

PMID 42549052
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PubMedSmall science2026-08-04

Sustainable P3HB:ZnO Composite Piezoelectric Nanofibers for AI-Driven Gait Monitoring.

Razbin Milad M, Ruan Kexin K, Tahir Danish D, Li Xuan X et al.

Degrable, high-performance piezoelectric materials are critical for implantable and environmentally friendly devices capable of reliable sensing and energy harvesting while safely degrading after use. However, most degrable piezoelectric materials still suffer from limited electromechanical performance. Here, we report a high-performance poly(3-hydroxybutyrate):zinc oxide (P3HB:ZnO) composite piezoelectric nanofiber optimized using an integrated artificial neural network-genetic algorithm framework. The model identified an optimal ZnO content of 4.3 wt.%, resulting in significantly enhanced piezoelectric performance compared with pristine P3HB. The optimized nanofibers achieved a peak voltage sensitivity of 0.382 mV/kPa at 1 Hz and an effective piezoelectric voltage coefficient of 13.65 mV/m·N, with stable output over 1000 loading cycles and a response delay of 318 ms. Biodegradation studies showed approximately 38% mass loss after 6 weeks, while the nanofibers retained measurable piezoelectric functionality within this timeframe. Furthermore, integration with a multichannel sensing platform enabled a proof-of-concept AI-assisted gait-recognition demonstration. This work presents a scalable machine-learning-driven strategy for designing high-performance sustainable piezoelectric materials for self-powered transient bioelectronics.

PMID 42549290
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PubMedNeurocritical care2026-08-04

Value of Sympathetic Skin Response for Identifying Paroxysmal Sympathetic Hyperactivity in Patients with Prolonged Disorders of Consciousness.

Fu Juanjuan J, Wu Yongli Y, Liu Lizhi L, Chen Fangyu F et al.

This study aimed to explore the value of sympathetic skin response (SSR) for identifying paroxysmal sympathetic hyperactivity (PSH) in patients with prolonged disorders of consciousness (PDOC). This retrospective observational study included 124 consecutive patients with PDOC from March 2022 to March 2024. On the basis of the PSH Assessment Method (PSH-AM), the patients were classified into the PSH-positive (PSH + , n = 43) and PSH-negative (PSH - , n = 81) groups. Among them, 75 patients (PSH - , n = 44; PSH + , n = 31) with elicitable SSR were included in the final analysis. There were no significant differences between groups in the SSR elicitation rate (P = 0.08) or in SSR latency (P > 0.05). By contrast, both SSR amplitude and SSR amplitude difference were significantly elevated in the PSH + group compared with the PSH- group (P < 0.001). In patients with elicitable SSR (n = 75), multivariable logistic regression analysis including age, CRS-R score, right SSR amplitude, left SSR amplitude, and SSR amplitude difference simultaneously (with no significant multicollinearity) demonstrated that only the SSR amplitude difference was independently associated with PSH (OR per 0.1 mV = 2.08; 95% CI: 1.49-3.45, P = 0.004). ROC analysis showed that the SSR amplitude difference had excellent diagnostic accuracy (AUC = 0.96; 95% CI: 0.93-0.998). The sensitivity analysis, including 124 patients (with absent SSR coded as 0 mV), indicated that age (OR = 0.96; 95% CI: 0.92-0.999, P = 0.05), CRS-R score (OR = 0.77; 95% CI: 0.65-0.89, P = 0.001), and SSR amplitude difference (OR per 0.1 mV = 1.47; 95% CI: 1.22-1.86, P < 0.001) were independently associated with PSH. ROC analysis demonstrated that the SSR amplitude difference alone had good diagnostic accuracy (AUC = 0.77; 95% CI: 0.666-0.875), and the combination of age, CRS-R score, and SSR amplitude difference achieved the highest diagnostic accuracy (AUC = 0.888; 95% CI: 0.826-0.951). The SSR amplitude difference is independently associated with PSH in patients with PDOC and demonstrates high diagnostic accuracy, both alone and in combination with age and CRS-R score. It may serve as a valuable, noninvasive electrophysiological marker to aid in identifying PSH in this patient population.

PMID 42547672
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PubMedInternational journal of sports physical therapy2026-08-04

Rapid Re-activation of Functionally Inhibited Hamstring Muscles via Real-Time EMG Visual Feedback in an Asymptomatic Masters Sprinter: A Case Report.

Kinugasa Ryuta R, Kubo Shimpei S

Masters athletes inevitably face age-related neuromuscular alterations, such as dynapenia, where the loss of muscle strength and power exceeds the loss of muscle mass. In sprinters, the selective loss of neural drive to the posterior chain impairs performance and increases injury risk. This condition often resembles a functional analogue of arthrogenic muscle inhibition, occurring even without structural damage. This case report highlights the application of real-time visual feedback (VFB) to overcome functional neuromuscular inhibition in a masters sprinter. The 41-year-old participant had struggled with hamstring activation failure during Romanian deadlifts for two decades, a phenomenon resembling learned non-use despite the absence of structural injury. A wireless electromyography (EMG) system was used to provide real-time visual feedback of hamstring muscle activity. Following VFB intervention, the participant exhibited a dramatic increase in hamstring EMG amplitude compared to the control condition (without VFB). The muscle activity demonstrated a dramatic surge, rising from a negligible baseline (~ 0.014 mV) to ~0.574 mV. This 40-fold increase suggests that VFB can facilitate higher EMG output and re-recruit high-threshold motor units. These findings underscore the potential of VFB as a neuro-cognitive intervention to facilitate higher EMG output in aging athletes exhibiting functional inhibition. 4.

PMID 42549260
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PubMedPacing and clinical electrophysiology : PACE2026-08-04

Islands of Fractionation for Automated Fractionation Mapping in Epicardial Brugada Syndrome Substrate Ablation.

Chan Cheng-Han CH, Chang Ting Yung TY, Chang Shih Lin SL, Lin Chin-Yu CY et al.

Brugada syndrome epicardial RVOT ablation reduces VF, but procedural endpoints remain debated. Automated fractionation maps are often interpreted as scattered points, which may reflect artifacts. We propose Islands of Fractionation (IOF), a framework comparing EnSite X fractionation count settings against voltage-defined lesion-effect reference region. This case series included six Brugada syndrome patients undergoing epicardial substrate ablation. Mapping was performed in sinus rhythm using EnSite X with an Advisor HD Grid catheter. Automated fractionation maps were generated with the EnSite X CFE-count algorithm using refractory settings of 14 and 20 ms. Abnormal points were defined as fractionation count ≥3; lesion-effect reference region was defined by voltage change (pre >0.5 mV, post <0.3 mV). Island overlap was quantified using DBSCAN clustering and mesh-based area estimation. IOF revealed a consistent coverage-parsimony trade-off between refractory settings. The 14-ms setting produced broader islands with higher reference-region coverage (median overlap 84.6% [IQR 80.8-93.7]) but larger extraneous mapped area (up to 72.9 cm2). The 20-ms setting produced more compact islands with markedly reduced extraneous area (0.0-34.8 cm2) but lower coverage (59.9% [IQR 37.2-74.7]). In parallel, fractionation burden within the ablated region decreased substantially after ablation in both settings (median total burden reduction 86% vs 93%), supporting lesion-effect concordance of automated fractionation metrics. IOF provides an island-based framework for interpreting automated fractionation mapping and describing its spatial concordance with lesion-effect regions. In this retrospective series, 14 ms favored broader coverage, whereas 20 ms favored greater parsimony.

PMID 42548079
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PubMedFrontiers in sports and active living2026-08-04

Effect of BPM music on post-exercise heart rate variability in male collegiate sprinters.

Bao Chen C, Li Jiayi J, Gao Ran R, Zhang Shixiang S et al.

Sudden cardiac death (SCD) during or immediately after intense exercise remains a major concern in sports medicine. Heart rate variability (HRV) is a key indicator of autonomic regulation, and music tempo may influence post-exercise autonomic recovery. This study investigated the effects of different music tempo conditions, expressed as beats per minute (BPM), on heart rate (HR) and HRV recovery in collegiate sprinters following high-intensity exercise. Among 300 initially selected male collegiate sprinters, 265 eligible participants were included in the final analysis and randomly allocated to either a no-music control group or one of nine music intervention groups listening to music ranging from 50 to 130 BPM during recovery. Participants completed a high-intensity Wingate-style anaerobic cycling test. HR and HRV were assessed at baseline and during recovery at 0-1, 5-6, and 15-16 min after exercise. Data were analyzed using two-way repeated-measures analysis of variance with Bonferroni post hoc correction. No significant between-group differences were observed in baseline HRV indices or anaerobic performance variables (p > 0.05). Significant time × group interactions were identified for HR, low-frequency (LF) power, and high-frequency (HF) power. The 120 BPM condition demonstrated comparatively favorable recovery responses, including lower HR values and beneficial autonomic modulation during recovery. However, 120 BPM was not consistently superior across all HRV parameters or recovery time points, and the 130 BPM condition showed comparable effects for several HRV indices. Under the present experimental conditions, music at 120 BPM was associated with relatively favorable autonomic recovery following high-intensity exercise. Nevertheless, this tempo should not be considered universally optimal. The potential role of BPM-specific music interventions in reducing SCD risk requires further investigation.

PMID 42548702
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