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immunoglobulin (Bivigam)

✓ Approved

ADMA Biologics, Inc. · 多克隆抗体 · 多克隆抗体

什么是 immunoglobulin？

immunoglobulin 是一种多克隆抗体，由ADMA Biologics, Inc.研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)。

药物档案

商品名Bivigam
公司ADMA Biologics, Inc.
药物类别多克隆抗体, 抗体
给药途径Injectable (Others), Intravenous (IV)
状态Approved
来源： ClinicalTrials.gov, ADMA Biologics, Inc.

治疗适应症

immunoglobulin 针对 5 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Congenital, familial and genetic disordersCombined immunodeficiency✓ Approved
Congenital, familial and genetic disordersWiskott-Aldrich syndrome✓ Approved
Immune system disordersSelective IgG subclass deficiency✓ Approved
Congenital, familial and genetic disordersBruton's agammaglobulinaemia✓ Approved
Immune system disordersImmunodeficiency✓ Approved

相关研究文献

PubMedCell2026-08-04

Co-option of retrotransposons promotes antibody diversification.

Lauring Max C MC, Yang Ming M, Sarode Aditya A, Wang Jianhua J et al.

Activation-induced cytidine deaminase (AID) accomplishes somatic hypermutation (SHM) of VH(D)JH genes in germinal center B cells for antibody diversification and affinity maturation. How AID specifically targets VH(D)JH remains unclear. We report the discovery of LINE-1 (L1) retrotransposons upstream to many VH genes in the immunoglobulin locus. These L1s are evolutionarily old, truncated, and retrotransposition dead. Recombined VH promoters generate long, strong antisense RNAs encoding upstream L1s, triggering the human silencing hub (HUSH) complex and AID recruitment, which we term L1-driven SHM. We show that L1-driven SHM occurs in vivo using HUSH conditional knockout mice and engineered mice with VH genes devoid of upstream L1s. Insertion of transcriptionally active L1s at non-immunoglobulin loci endogenously lacking upstream L1s promotes off-target SHM. We demonstrate that old retrotransposons serve physiological roles, and our findings reveal how B cells co-opted an anti-retrotransposon silencing mechanism to promote antibody diversity. In doing so, we established a new link between cell-intrinsic innate and adaptive immunity.

PMID 42546688
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PubMedFrontiers in immunology2026-08-04

Case Report: Overlapping multiple sclerosis and neuropsychiatric systemic lupus erythematosus with positive MOG-IgG: a case initially misdiagnosed as depression.

Wei Wan W, Jin Tao T, Zhang Liuhai L, Sun Yumeng Y et al.

We present a 69-year-old female patient who initially manifested with depression and anhedonia, initially misdiagnosed as primary psychiatric illness. She subsequently developed progressive gait instability and cognitive decline. After comprehensive clinical and laboratory evaluation, she was finally diagnosed with multiple sclerosis (MS) complicated by neuropsychiatric systemic lupus erythematosus (NPSLE). Brain magnetic resonance imaging (MRI) revealed multifocal white matter lesions consistent with demyelination. Serologic testing demonstrated positivity for antinuclear antibody (ANA), anti-double-stranded DNA (dsDNA), anti-SS-A/Ro, anti-histone, anti-nucleosome, and anti-centromere antibodies. Cerebrospinal fluid (CSF) examination confirmed intrathecal synthesis of immunoglobulin G (IgG), as evidenced by CSF-restricted oligoclonal bands (OCBs). Serum myelin oligodendrocyte glycoprotein immunoglobulin G (MOG-IgG) was positive at a titer of 1:32, whereas aquaporin-4 (AQP4) antibodies were negative. Based on the clinical manifestations, laboratory results and disease progression, the final diagnosis was established as coexisting MS and NPSLE. The patient achieved clinical improvement after treatment with glucocorticoids and hydroxychloroquine. This case highlights the diagnostic challenges posed by overlapping autoimmune central nervous system (CNS) disorders and underscores the importance of longitudinal assessment in differentiating MS from MOG-IgG-associated disorder (MOGAD) and NPSLE.

PMID 42548805
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PubMedIndian journal of medical microbiology2026-08-04

HSV-2 Reactivation Following Influenza A H3N2 Infection in an Adolescent with Transverse Myelitis: A Case Report and Literature Review.

Padhi Abhishek A, Parmar Prashant P, Rajyaguru Bhoomika B, Modasiya Ishita I et al.

Herpes simplex virus type 2 (HSV-2) reactivation following influenza infection is rare but clinically significant. Influenza-induced immunosuppression may trigger reactivation of latent herpesviruses. A 17-year-old male with transverse myelitis developed HSV-2 myelitis after influenza A (H3N2) infection, presenting with fever, cough, and acute quadriparesis requiring ventilation. Cerebrospinal fluid tested positive for HSV-2, while nasopharyngeal and oropharyngeal swabs tested positive for Influenza A (H3N2), and MRI showed extensive cervicothoracic gray matter involvement. Treatment with antivirals, corticosteroids, and immunoglobulin led to marked neurological recovery. Influenza-related immunosuppression can precipitate HSV-2 reactivation; early diagnosis and antiviral therapy are essential for favorable outcomes.

PMID 42546927
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PubMedPain medicine case reports2026-08-04

Ultrasound-Guided Stellate Ganglion and Interscalene Blocks for Refractory Pediatric Parsonage-Turner Syndrome: A Case Report and Clinical Implications.

Laraib Warda W, Abbas Adeel A, Habib Insha I, Fareh Zohad Z et al.

Parsonage-Turner syndrome (PTS) is an uncommon inflammatory brachial plexopathy; pediatric and bilateral cases are rare, and evidence for managing refractory pediatric pain is limited. A previously healthy 6-year-old girl developed sudden severe left upper-limb pain with progressive wrist-drop in August 2023; by October, the right arm was affected. Nerve conduction studies/electromyography confirmed brachial plexopathy and magnetic resonance imaging showed diffuse thickening of left C5-C7. Laboratory tests were unremarkable, except for an isolated anti-glycosphingolipid monosialo-2 antibody. Oral corticosteroids, tramadol, and 2 intravenous immunoglobulin doses produced limited benefit, and corticosteroids caused mood disturbance. In October 2023, ultrasound-guided stellate ganglion (C6) and interscalene (C5-C6) blocks with 4-6 mL of 0.25% bupivacaine under general anesthesia were performed. At one week, she reported ~85% pain relief; analgesics were reduced to paracetamol. In refractory pediatric bilateral PTS, regional stellate ganglion and interscalene blocks provided rapid, substantial analgesia; prospective studies should define indications and long-term outcomes.

PMID 42550561
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PubMedVeterinary immunology and immunopathology2026-08-04

Efficacy of intraperitoneal and oral administration of a lectin-adjuvanted microencapsulated scaffold vaccine on immune response in Nile tilapia (Oreochromis niloticus) infected with Streptococcus iniae.

Nandhakumar, Jimsha E E, Wangkahart Eakapol E, Elumalai Preetham P

Streptococcus iniae, an emerging pathogen, significantly impacts the productivity of marine and freshwater aquaculture by causing streptococcosis. Vaccination is a promising strategy to address this challenge. This study investigates an innovative vaccination approach utilizing a biomaterial-based scaffold encapsulated with a lectin adjuvant to combat S. iniae in Nile tilapia (Oreochromis niloticus). The scaffold was prepared via ion gelation using chitosan and alginate, and it was adjuvanted with lectin. The fish were administered with both injection and oral routes, by the formulated vaccine. Both the i.p. and oral vaccinated groups exhibited significantly higher levels of lysozyme, myeloperoxidase, and superoxide dismutase compared to the control group (P < 0.05). Furthermore, increased levels of specific antibody Immunoglobulin M (IgM) were observed, along with notable fold changes in adaptive immune genes in the spleen and head kidney. The treatment group vaccinated with the encapsulated vaccine adjuvanted with lectin demonstrated high survival rates in both routes. These findings highlight the potential of this scaffold-based vaccine delivery and adjuvant for its long-term efficacy both i.p. and oral administration as a novel and effective approach for aquaculture. This strategy could also be applied for the delivery of other vaccines and therapeutics in aquatic species.

PMID 42546425
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PubMedFujita medical journal2026-08-04

A case of anti-N-methyl-D-aspartate receptor antibody encephalitis associated with immature ovarian teratoma.

Ohwaki Akiko A, Isomura Kurumi K, Takada Kyohei K, Ito Mayuko M et al.

Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is typically associated with mature cystic teratomas. We report a case of anti-NMDA receptor encephalitis associated with an immature ovarian teratoma, which is a malignant tumor. A 16-year-old girl who presented with impaired consciousness and abnormal behavior was referred to our hospital. After evaluation upon admission, she was diagnosed with anti-NMDA receptor encephalitis associated with an ovarian mature cystic teratoma, and laparoscopic right salpingo-oophorectomy was performed. The postoperative pathological diagnosis confirmed the presence of an immature ovarian teratoma. The patient subsequently underwent immunoglobulin therapy, steroid pulse therapy, and plasma exchange for the treatment of encephalitis. Bleomycin, etoposide, and cisplatin chemotherapy was administered after her symptoms improved. In this case, early collaboration among the departments of neurology, obstetrics and gynecology, and emergency medicine enabled a prompt diagnosis and effective treatment. The patient's symptoms were successfully ameliorated through early removal of the tumor and pharmacotherapy. Although anti-NMDA receptor encephalitis generally has a favorable prognosis, early diagnosis and initiation of treatment considerably affect the outcome. Clinicians should suspect anti-NMDA receptor encephalitis when a young patient presents with impaired consciousness or abnormal behavior and consider the possibility of underlying malignant tumors.

PMID 42549471
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