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Hoe-285 (Hoe 285 / Brainorm / Albex 285)

✓ Approved

Sanofi S.A · 小分子 · 小分子

什么是 Hoe-285？

Hoe-285 是一种小分子，由Sanofi S.A研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)、Oral (PO)。

药物档案

商品名Hoe 285, Brainorm, Albex 285
公司Sanofi S.A
药物类别小分子
给药途径Injectable (Others), Intravenous (IV), Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Sanofi S.A

治疗适应症

Hoe-285 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Nervous system disordersDelayed ischaemic neurological deficit✓ Approved

相关研究文献

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Translation, cross-cultural adaptation, reliability, and validity of the Chinese version of the Nursing Handoff Competency Scale.

Gao Jie J, Zhao Yingying Y, Yang Meng M, Jiang Yao Y et al.

Nursing handoff is critical for patient safety but faces challenges like unstructured communication. While standardized assessment tools exist internationally, China lacks such a tool for evaluating handoff competency. This study aimed to translate and validate the Nursing Handoff Competency Scale (NHCS) for use in China. A methodological study comprising cross-cultural adaptation and psychometric validation. Following the Brislin model, the NHCS was translated and cross-culturally adapted via Delphi expert consultation (18 experts) and pilot testing (10 nurses). Psychometric evaluation involved 285 nurses from tertiary hospitals. Content validity, construct validity, internal consistency (Cronbach alpha and McDonald omega), and split-half reliability were assessed. The final 23-item, four-dimensional scale showed acceptable content validity (S-CVI = 0.961, modified kappa = 0.833-1.000), internal consistency (Cronbach's α = 0.977, McDonald's ω = 0.979), and a four-factor structure explaining 84.639% of variance. CFA indicated acceptable fit (χ2/df = 2.666, RMSEA = 0.077, CFI = 0.958, TLI = 0.952). The Chinese NHCS demonstrated satisfactory psychometric properties, providing initial evidence for assessing nursing handoff competency in China. Further validation in diverse settings is recommended.

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Prognostic Value of the P16/P53 Immunohistochemical Association in Oropharyngeal Squamous Cell Carcinomas.

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Accurate HPV status diagnosis is essential for managing oropharyngeal squamous cell carcinoma. We aimed to refine HPV status determination using a cost-effective and reliable approach by integrating the p53 immunohistochemical marker with the conventional p16 marker. We assessed the association between HPV status and the p16/p53 tumor immunohistochemical status and analyzed patient survival based on p16/p53 expression.Design, Setting, Participants, and Exposures:This retrospective, single-center study included 285 patients with oropharyngeal squamous cell carcinoma (2017-2022) with known p16/p53 immunohistochemical profiles. In a subset of 92 patients, HPV status was formally determined using polymerase chain reaction or in situ hybridization. The p16/p53 test was an excellent predictor of HPV status (specificity: 100%, sensitivity: 98.48%), significantly outperforming p16 alone (P < .01). Patients with a p16+/p53WT profile had superior 5-year overall survival (82.2%; 108/131) and recurrence-free survival (79.4%; 104/131). Patients with discordant profiles (p16+/p53MT, p16-/p53WT) had survival outcomes similar to HPV-independent oropharyngeal squamous cell carcinomas. The p16/p53 immunohistochemical profile appears to be a reliable surrogate marker for HPV status and a strong predictor of survival. It could help identify discordant cases, helping prevent inappropriate therapeutic de-escalation. With the advancement of artificial intelligence, integrating additional markers into an algorithmic analysis could further refine patient classification and enable more personalized therapeutic approaches.

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Agreement and measurement properties of the interviewer-administered, self-completed and proxy-reported versions of the Tigrinya EQ-5D-Y-5L in Ethiopia.

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To assess measurement properties of self-complete (SC), interviewer-administered (IA), and proxy-report versions of EQ-5D-Y-5L and to assess the degree of agreement in response between these versions. SC, IA, and proxy-report were administered to children and adolescents with and without health conditions on two occasions, separated by either a 10-day interval (to assess test-retest reliability) or a one-month interval (to assess responsiveness). The SC and IA versions were administered in randomized order. Agreement and test-retest reliability assessed using Gwet's agreement coefficient (Gwet's AC2) and intraclass correlation coefficient (ICC) and, interpreted based on predefined thresholds. Feasibility, known-group validity, and responsiveness were assessed using missing values, Kruskal-Wallis test, and standardized effect size (SES), respectively. A total of 644 child/parent dyads participated. Missing values were higher for SC, particularly among younger children aged 8-12 years (4.65%-11.63%). Agreement between EQ-5D-Y-5L versions ranged from moderate to almost perfect, with excellent test-retest reliability across all dimensions and EQ-VAS. The EQ-5D-Y-5L level sum score (LSS) significantly differentiated between known disease groups across all versions (SC: χ² = 285; IA: χ² = 273; Proxy-report: χ² = 232; all p < 0.01). Both SC and IA versions were responsive to change in health with a moderate SES (SC: 0.74, - 0.61; IA: 0.36, - 0.66) in "worsened" and "improved" groups, respectively. The substantial agreement and similar measurement properties between SC and IA versions suggest that IA could be used as an alternative approach for data collection when self-complete is not an option. Although the proxy-report version had acceptable measurement properties, they were inferior to the SC and IA versions.

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Hao Xu X, Simiao Chen C, Han Zhang Z, Linyou Zhang Z

Periareolar incisions improve cosmesis in video-assisted thoracoscopic surgery, but their use as an assistant port in robotic-assisted thoracoscopic surgery (RATS) has not been formally described. We characterized the learning curve of this approach and compared perioperative outcomes with conventional-portal RATS. We retrospectively analyzed 117 consecutive malignant RATS resections performed with a periareolar assistant port (December 2025-June 2026) and 285 conventional-portal cases (January 2024-September 2025) at a single center. Learning curve analysis used cumulative sum analysis, moving-average smoothing, and case-sequence quartile comparison. Outcomes were compared using 1:1 propensity-score matching (100 pairs) and multivariable regression. No monotonic improvement in unadjusted operative time was detected (r = 0.099, P = 0.287), and operative time did not differ between matched groups (80.0 vs. 75.0 min, P = 0.503). The periareolar approach had less blood loss (20.0 vs. 30.0 mL, P < 0.001) but fewer lymph node stations (6.0 vs. 7.0, P < 0.001) and nodes dissected (10.0 vs. 12.5, P = 0.025), and a higher complication rate (15.0% vs. 0.0%, P < 0.001), driven mainly by prolonged air leak. Multivariable regression confirmed these findings (lymph node stations: β = -0.824, P < 0.001; complications: OR = 6.65, P < 0.001). No conversions or positive margins occurred. RATS with a periareolar assistant port was technically feasible; no monotonic improvement in unadjusted operative time was detected across the case series, and operative time was comparable to the conventional approach. However, comparative safety and oncologic adequacy remain uncertain given the higher complication rate and lower lymph-node yield observed, warranting prospective, randomized, multicenter validation.

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Faith and access: The role of religion in formal mental health service utilization among Black adolescents.

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Despite growing concerns about mental health in Black adolescents, cultural factors influencing their help-seeking behaviors remain largely understudied. Pathways to formal mental health help-seeking and the influence of religion remain underexplored in Black adolescents. This study investigated the relationship between religious affiliation and formal mental health service utilization in Black adolescents using a mixed-methods sequential explanatory approach. Quantitative analysis (n=285) revealed that religious Black adolescents are more likely to seek mental health services from school-based professionals and less likely to use phone or text lines compared to their nonreligious counterparts. Using inductive thematic analysis, three themes were identified from qualitative interviews (n=6): Cultural and Community Emphasis on Religious Coping, Stigma and Dismissiveness, and Awareness of the Need for Additional Help. Findings underscore the need for culturally responsive mental health interventions and collaborations with community organizations to improve formal service access and utilization for Black teens. Implications for clinicians, educators, and community leaders focus on strategies to promote health equity and address systemic barriers to care in Black communities.

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