若生智能
Drug Database
LE

levamlodipine maleate (Xuan Ning / Conjupri / Xuanning)

✓ Approved

CSPC Ouyi Pharmaceutical · CACNA1C · 小分子

什么是 levamlodipine maleate？

levamlodipine maleate 是一种小分子，由CSPC Ouyi Pharmaceutical研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Xuan Ning, Conjupri, Xuanning
公司CSPC Ouyi Pharmaceutical
药物类别小分子
分子靶点CACNA1C
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, CSPC Ouyi Pharmaceutical

作用机制

分子靶点

levamlodipine maleate 作用于 1 个分子靶点：

CACNA1Ccalcium voltage-gated channel subunit alpha1 C (CACNL1A1, CACNA1C-IT2)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

levamlodipine maleate 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Vascular disordersHypertension✓ Approved

相关研究文献

PubMedFrontiers in medicine2026-08-02

Sigmoid colon perforation presumed to be stercoral in origin in an elderly patient with chronic constipation: a case report.

Zuo Wenwei W, Bai Jiexin J, Yin Fengsheng F, Long Chuan C

Stercoral perforation (SP) is an uncommon but potentially life-threatening complication of chronic constipation that predominantly affects elderly individuals. Early diagnosis is challenging because of nonspecific clinical manifestations and the risk of rapid progression to feculent peritonitis and sepsis. We report the case of an 85-year-old woman who presented with severe acute lower abdominal pain, abdominal distension, nausea, vomiting, and absence of flatus or bowel movements. She had a 6-month history of chronic constipation and long-term antihypertensive therapy with levamlodipine besylate. Computed tomography (CT) demonstrated free intraperitoneal air, abdominal fluid, and fecal impaction within the sigmoid colon. Emergency laparoscopic exploration followed by limited open surgery revealed severe feculent peritonitis and a 2.5 cm × 2.0 cm perforation of the distal sigmoid colon. Necrotic tissue at the perforation margin was debrided, and the perforated sigmoid segment was exteriorized and matured as a colostomy. No bowel resection was performed because diffuse ischemia or necrosis was not identified intraoperatively and the patient was considered high risk because of advanced age and poor baseline condition. The diagnosis of probable stercoral perforation was based on the clinical presentation, radiological findings, and intraoperative observations. Postoperatively, the patient required intensive care monitoring and received broad-spectrum antimicrobial therapy, nutritional support, and electrolyte replacement. She was discharged in stable condition on postoperative day 14. At the 11-week follow-up, she tolerated a regular diet and reported regular bowel movements. At 1-year follow-up, she remained independent in daily activities, with no recurrent perforation, severe constipation, or rehospitalization. This case highlights the importance of early CT evaluation, individualized surgical decision-making, prompt source control, and comprehensive perioperative management in elderly patients with suspected stercoral perforation.

PMID 42539415
阅读全文 →
PubMedMaterials today. Bio2026-08-02

Engineering adaptive self-healing biomaterials from jammed microfluidic elastomeric particles.

Kieda Jennifer J, Ramsay Kaitlyn K, Jiang Richard R, Landau Shira S et al.

Biomaterials designed for implantation must accommodate the dynamic mechanical and structural environment of the human body. Yet, current strategies for creating materials capable of adapting their shape post-implantation remain limited. In this work, we introduced a remoldable, biodegradable, and biocompatible granular scaffold composed of monodisperse poly(octamethylene maleate (anhydride) citrate) (POMaC) particles. Monodisperse POMaC droplets with controlled diameters were generated using a droplet microfluidic platform, then subsequently jammed and UV-crosslinked to form interconnected, porous, and self-healing elastomeric scaffolds. The scaffold chemical composition and crosslinking parameters directly influenced mechanical properties, stability, and permeability, enabling tunability across a range of tissue engineering applications. The granular scaffold exhibited autonomous self-healing, enhanced molecular diffusivity, and robust cell infiltration, while remaining moldable into prescribed geometries under both in vitro and in vivo conditions. Notably, following implantation, the granular scaffolds could be remolded in vivo 24 h post-implantation, allowing adaptation to a desired geometry while preserving structural integrity, promoting the recruitment of pro-reparative macrophages, and facilitating vascular ingrowth. Collectively, this work established a versatile strategy for designing adaptive implantable biomaterials capable of responding to the body's dynamic environment, with broad potential applications in regenerative medicine and tissue engineering.

PMID 42540479
阅读全文 →
PubMedAnimals : an open access journal from MDPI2026-07-28

Multi-Omics Characterization of Peripheral Blood Molecular Profiles in Hypertensive Aging Ailuropoda melanoleuca with Levamlodipine Intervention: Exploratory Analysis of ACE2 and Time-Resolved Transcriptomic Patterns.

Zhu Yan Y, Tao Qian Q, Li Chengyao C, Ling Shanshan S et al.

Hypertension threatens the health of aging captive giant pandas, yet its molecular signatures remain poorly characterized. Here, multi-omics sequencing was applied to explore the molecular regulatory process of hypertension and the pharmacodynamic effect of levamlodipine on this endangered species. Six aged giant pandas were divided into hypertensive and normotensive groups (three hypertensive and three normotensive pandas) based on clinical phenotypes and blood pressure measurements. A multi-omics approach was employed, including blood RNA-seq, Assay for Transposase-Accessible Chromatin with high-throughput sequencing (ATAC-seq), single-cell RNA-seq (scRNA-seq) of peripheral blood mononuclear cells, and time-series RNA-seq following levamlodipine administration. Our transcriptomic analysis revealed a statistically significant decline in ACE2 transcript abundance (Padj < 0.05), which suggests a possible shift in renin-angiotensin system signaling linked to hypertensive status in giant pandas. Single-cell analysis of 88,693 cells revealed that hypertension-associated genes were predominantly enriched in monocytes and T cells, implicating immune cell activation. Time-dependent transcriptional changes after levamlodipine administration. Temporal gene dynamics showed early activation of metabolic pathways followed by delayed inhibition of ion channels and calcium signaling. This study provides a transcriptional molecular perspective into the pathogenesis of hypertension in giant pandas, which is conducive to developing more effective antihypertensive treatment strategies, thereby protecting the health of this endangered species.

PMID 42510995
阅读全文 →
PubMedBulletin of experimental biology and medicine2026-07-28

Comparative Analysis of Novel Derivatives of Pyridoxine and Dicarboxylic Acids as Activators of Transcription Factor Nrf2.

Balakina A A AA, Podgurskaya A D AD, Amozova V I VI, Stupina T S TS et al.

We performed a structure-activity relationship analysis of novel maleic acid and pyridoxine derivatives, as well as epigid and morpholine fumarates, as potential inducers of Nrf2 transcription factor. A reduction in the number of hydroxyl groups in the structure of the compounds was shown to decrease their cytoprotective activity. The effectiveness of the compounds as Nrf2 activators depends not only on the presence of maleate or fumarate moieties, but also on the structure of the hydroxyaromatic fragment of the molecule. A derivative of pyridoxine and maleic acid, 3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridin-1-ium hydromaleate, is an effective activator of Nrf2 transcription factor and exhibits cytoprotective and antioxidant activity in vitro, which suggests its further evaluation in in vivo models and its potential for novel drug development.

PMID 42509432
阅读全文 →
PubMedThe Journal of organic chemistry2026-07-27

Catalytic Hydrosulfenylation of Maleic Anhydride and Its Derivatives Enabled by Proton-Coupled Electron Transfer.

Peng Dong D, Sun Jiayi J, Huang Yun Y, Zeng Xianghua X

We herein report a practical method for the efficient hydrosulfenylation of maleic anhydride and its derivatives by decavanadate-induced proton-coupled electron transfer. Preliminary mechanistic studies suggest that a thiyl radical is generated from the decavanadate polyanion and thiol through an oxidative PCET process. This method utilizes readily available thiols as a sulfur source and air as an oxidant and is capable of hydrosulfenylating a variety of maleic anhydrides and maleate esters with good diastereoselectivity.

PMID 42503765
阅读全文 →
PubMedGels (Basel, Switzerland)2026-07-27

Construction of PEGMC Copolymerized Modified Hydrogel and Its Mechanism for Salt Retardation and Nutrient Immobilization in Dryland Soil.

Cheng Jianwei J, Xiang Rui R, Liu Jingcai J, Yang Baocun B et al.

Aiming at severe soil secondary salinization, poor water retention and insufficient salt tolerance of conventional acrylic-based modifiers in arid and semi-arid regions of China, a poly(ethylene glycol) maleate citrate (PEGMC) crosslinking monomer was synthesized through esterification, and a dual covalent-hydrogen crosslinked P(PEGMC/AA) hydrogel was fabricated via free radical copolymerization with acrylic acid (AA). The hydrogel was characterized by NMR, FTIR, SEM, TGA and elemental mapping, while its binding mechanism with saline-alkali ions was elucidated through DFT calculations and molecular dynamics simulations. Its amelioration performance was evaluated through swelling, soil water retention, desalination and pot germination experiments. The hydrogel exhibited outstanding water absorbency, salt resistance and dry-wet cycling stability, with swelling ratios of 712 g/g in deionized water and 285 g/g in 0.9% NaCl solution, and remained 200 g/g after four dry-wet cycles. It enhanced soil water retention remarkably (over 93% after 72 h). At 0.30% dosage, soil salt content declined from 7.1 g/kg to 1.3 g/kg with desalination efficiency exceeding 80%, owing to porous physical adsorption and chemical chelation toward Na+, Ca2+ and Mg2+, with a binding energy of -136.936 kJ/mol. Pot tests revealed that crop germination rate rose from 19% (blank) to 75% under severe saline-alkali stress. Meanwhile, the hydrogel inhibited nutrient leaching and favored soil-water conservation. This work first incorporated PEGMC monomer into agricultural hydrogels to construct a stable dual crosslinked network, clarifying its synergistic mechanisms for salt fixation and water retention macroscopically and microscopically. It provides a promising functional material and theoretical basis for green, efficient in situ amelioration of dryland saline-alkali soil.

PMID 42505278
阅读全文 →

注册免费账户还可查看另外 7296 篇文献

免费注册查看全部文献 →

了解更多levamlodipine maleate