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clomipramine hydrochloride + sildenafil citrate (Gusejeong / DKB22002 / DKB 22002)

✓ Approved

DongKoo Bio & Pharma · PDE5A · 小分子

什么是 clomipramine hydrochloride + sildenafil citrate？

clomipramine hydrochloride + sildenafil citrate 是一种小分子，由DongKoo Bio & Pharma研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Gusejeong, DKB22002, DKB 22002
公司DongKoo Bio & Pharma
药物类别小分子
分子靶点PDE5A
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, DongKoo Bio & Pharma

作用机制

分子靶点

clomipramine hydrochloride + sildenafil citrate 作用于 1 个分子靶点：

PDE5Aphosphodiesterase 5A (PDE5, CGB-PDE)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

clomipramine hydrochloride + sildenafil citrate 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Psychiatric disordersPremature ejaculation✓ Approved
Reproductive system and breast disordersErectile dysfunction✓ Approved

相关研究文献

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Surface Chemistry-Driven Surface-Enhanced Raman Scattering Fingerprinting of Aptamers on Silver Colloids.

Pandolfi Sara S, Venuti Elisabetta E, Locatelli Erica E, Mateos Xavier X et al.

The surface-enhanced Raman scattering (SERS) spectra of nucleic acids (NAs) often vary substantially across plasmonic substrates. However, systematic comparative studies across the most commonly employed plasmonic platforms remain limited, particularly for structurally complex NAs, such as aptamers. Herein, we investigate the direct SERS fingerprinting of a thiolated aptamer across three representative silver colloidal systems widely used in nucleic-acid SERS studies: intrinsically cationic spermine-modified nanoparticles, post-synthetically spermine-modified citrate colloids, and chloride-modified citrate colloids. The results show that, under the investigated conditions, the surface chemistry appears to primarily determine the dominant adsorption regime, modulating the balance between the backbone electrostatics and nucleobase-metal interactions. Intrinsically cationic nanoparticles preserve folding-dependent spectral differences, whereas negatively charged systems exhibit pronounced coverage-dependent spectral variability, highlighting the sensitivity of the interfacial SERS response to surface coverage and preparation history. These findings highlight that the SERS fingerprint of the aptamer in colloidal suspension largely emerges from the interplay between the structural complexity of the NA and the adsorption regime imposed by the nanoparticle surface chemistry. Therefore, different colloidal substrates can provide complementary spectroscopic information.

PMID 42553731
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PubMedEnergy & fuels : an American Chemical Society journal2026-08-05

Hydrothermal Liquefaction of Digestate and Copyrolysis of Hydrochar-Straw Blends: An Integrated Approach for Bio-crude and Biochar Production.

Grottola Corinna Maria CM, Marotta Giusy G, Amato Davide D, Di Lauro Francesca F et al.

Anaerobic digestion converts wet biogenic wastes into biogas and a byproduct, the digestate, which is a wet material rich in carbon and nutrients widely used in agriculture. However, the large amount produced determines some limitations in this exploitation, thus different thermochemical processes are under investigation. The hydrothermal liquefaction (HTL) process is considered a viable thermochemical route to convert high-water-content biomasses into a liquid energy vector, the bio-crude. However, considerable uncertainties remain regarding the use of the HTL solid residue, the hydrochar (HC), which is not regulated as soil amendment. Thus, its transformation into biochar, already recognized by law as soil improver, could be a promising valorization route. In this context, copyrolysis of HC with abundant agricultural residues may represent an effective strategy to further improve resources' valorization. This study proposes an integrated approach that combines the conversion of digestate through HTL into bio-crude and copyrolysis of hydrochar and straw (S), an abundant agricultural waste to produce biochar. HTL of digestate has been performed in a 500 mL batch autoclave reactor and optimized, based on the biocrude yield and properties, investigating different temperatures (300 and 350 °C) and isothermal reaction times (0-30 min). HC produced under the optimal operating conditions for bio-crude production and S have been pyrolyzed individually and in blends with varying compositions (10-50 wt % S) under slow pyrolysis conditions at a final temperature of 450 °C. Pyrolysis products' yields and properties of biochars have been investigated to assess the compliance of biochar with EU Fertilizing Products Regulation (EU 2019/1009) and to identify possible nonlinear effects arising from the combination of the two feedstocks. Results show high biochar yields in the range of 42.8-62.9 wt % and high H/C ratios in the range of 0.68 to 0.61 which comply with the threshold limits imposed by the EU regulations.

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PubMedChemistry (Weinheim an der Bergstrasse, Germany)2026-08-05

An Integrated Bio-Based Film With Dynamic Covalent Networks for Coupled pH-Responsive Release and Colorimetric Reporting.

Wang Tongtong T, Sun Hui H, Weng Yunxuan Y

A multifunctional smart film was fabricated via dynamic Schiff base cross-linking between quaternary ammonium chitosan (HACC) and dialdehyde cellulose (DAC), enabling the integrated encapsulation, controlled release, and visual indication of curcumin within a single matrix without external sensors. Structural analyses (FTIR, XPS) confirmed the formation of the pH-responsive dynamic network. Curcumin incorporation significantly enhanced the film's performance, increasing tensile strength (TS) by ∼60%, improving barrier properties, and providing potent antioxidant activity (DPPH scavenging efficiency approaching 90%). The swelling behavior and release kinetics of the films were highly pH-dependent. Rapid burst release dominated by nonFickian diffusion was observed under acidic conditions (pH 4.0), whereas slow, sustained Fickian diffusion-controlled release occurred in neutral and alkaline environments (pH 7.0 and 9.0). Owing to the intrinsic chromophoric properties of curcumin, the films displayed distinct and reversible pH-dependent color changes, transitioning from bright yellow in acidic media to reddish-brown in alkaline conditions, enabling intuitive visual monitoring of environmental changes. This work demonstrates an effective strategy for designing bio-based innovative packaging materials that integrate sensing, protection, and controlled release functions within a unified, dynamically responsive polysaccharide network.

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PubMedSmall methods2026-08-05

Multidimensional Protein Corona Analysis Toward Predictive Nano-Bio Interface Design.

Hou Mingxuan M, Chen Minglong M, Liu Shiyong S

Nanoparticles entering biological fluids are rapidly coated by proteins and other biomolecules, converting their synthetic surfaces into biologically active nano-bio interfaces. These coronas regulate colloidal stability, immune recognition, cellular uptake, biodistribution, pharmacokinetics, cargo delivery, and toxicity. Yet a protein list obtained by mass spectrometry captures only part of this interface. Corona identity and function are also shaped by protein organization, binding stability, exchange dynamics, conformational changes, and molecular accessibility. Here, we discuss recent progress in protein corona isolation and analysis from a question-oriented analytical perspective, with emphasis on how centrifugation, magnetic recovery, affinity- or chemistry-enabled capture, chromatography, filtration, and field-flow fractionation (FFF) influence the fidelity, integrity, and comparability of recovered coronas. We then examine how proteomic profiling can be integrated with binding measurements, interfacial structural analysis and functional validation to distinguish descriptive corona signatures from biologically meaningful mechanisms. We further consider how biofluid composition, disease state, tissue interfaces and cellular environments remodel corona identity, presentation, and bioactivity. Finally, we argue that standardized reporting, computational modeling, and AI-enabled approaches are essential for converting protein corona datasets into reproducible and predictive knowledge that can guide the design of drug delivery systems and precision nanomedicines.

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PubMedFrontiers in medicine2026-08-05

Case Report: Mitochondrial insufficiency underlies cholinergic failure in post-vaccination long COVID: a candidate treatment protocol.

Goulding Tom T

An 80-year-old male with severe long COVID developed acute deterioration following COVID-19 vaccination despite ongoing cholinergic therapy (Mestinon 90 mg daily). A comprehensive mitochondrial support protocol targeting NAD+ repletion, electron transport chain function, and oxidative stress was initiated, with all components delivered in fresh-squeezed orange juice. Clinical response was dramatic within 48 h, with sustained functional recovery over 6 weeks. Challenge-rechallenge testing demonstrated rapid symptom recurrence and resolution with three key observations: missed doses, wrong component sequence, and substitution of water for orange juice. This final observation suggests citric acid may function as a rate-limiting Krebs cycle substrate, consistent with impaired endogenous citrate synthesis in severe long COVID. This case suggests that cholinergic support may require concurrent metabolic foundation including direct substrate supplementation, and some long COVID manifestations may be metabolically reversible with multi-pathway intervention. As a single self-case report, these findings generate hypotheses for systematic investigation rather than establishing treatment guidelines.

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Green carbon quantum dots as eco-friendly nano-additives for tribological enhancement of Pongamia oil.

Khan Mohammed Ali MA, Shetty Akshatha R AR, Aroor Ganesha G, Navada Meghana K MK

Carbon quantum dots (CQDs) offer various advantages - biodegradability, non-toxicity, lower cost and are used as a replacement for various metal oxide-based nanoparticles. Despite these advantages, the use of CQDs remains limited. This study investigates the synthesis of CQDs using cowpea seeds and their application as nano-additives in bio-based Pongamia oil as a lubricant. The addition of CQDs enhanced the lubricating properties of Pongamia oil. At a concentration of 0.15 wt% CQDs, the nanofluid improved the viscosity and anti-wear properties while reducing the friction compared to the base oil. The enhancement in tribological properties of Pongamia oil after the addition of CQDs was rationalised based on the correlation among viscosity, activation energy, wear, friction, thermal conductivity, flash point, and fire point. The analysis of the wear scar surface revealed lower wear and fewer grooves on the metal surface lubricated with CQD-modified Pongamia oil compared to the base oil. The results offer a simple and effective strategy for using CQDs in base oil as nanoadditives, thereby increasing the tribological properties.

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