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CSF-G

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Dong-A ST · CSF3R · 重组蛋白

什么是 CSF-G？

CSF-G 是一种重组蛋白，由Dong-A ST研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Subcutaneous Injection。

药物档案

公司Dong-A ST
药物类别重组蛋白
分子靶点CSF3R
给药途径Injectable (Others), Subcutaneous Injection
状态Approved
来源： ClinicalTrials.gov, Dong-A ST

作用机制

分子靶点

CSF-G 作用于 1 个分子靶点：

CSF3Rcolony stimulating factor 3 receptor (CD114, GCSFR)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

CSF-G 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Blood and lymphatic system disordersNeutropenia✓ Approved

相关研究文献

PubMedBrain tumor research and treatment2026-08-03

Isolated Maxillary Extracranial Metastasis of a Suprasellar Germinoma.

Lee Jun Hyun JH, Park Hyeon Jin HJ, Shin Sang-Hoon SH, Kim Joo-Young JY et al.

Intracranial germinomas are exquisitely radiosensitive, and a tissue diagnosis obtained by minimal biopsy followed by radiotherapy (with or without chemotherapy) provides excellent long-term control; aggressive resection adds morbidity without oncological benefit. We report a 20-year-old man whose sellar and suprasellar mass was preoperatively interpreted as a pituitary adenoma and was treated by aggressive endoscopic endonasal transsphenoidal resection after an intraoperative frozen section suggested adenoma; final histology demonstrated germinoma. The postoperative course was complicated by a persistent skull-base cerebrospinal fluid (CSF) leak, methicillin-resistant Staphylococcus aureus meningitis/ventriculitis, and CSF dissemination documented by repeatedly positive CSF cytology and elevated CSF β-human chorionic gonadotropin. The initial skull-base reconstruction failed, and the resulting persistent CSF rhinorrhea required revision dural repair on postoperative day (POD) 29; proton craniospinal irradiation was delivered from POD 52. The patient achieved remission but, approximately 21 months after completing radiotherapy, developed a destructive germinoma lesion in the midline maxilla, with no recurrence at the primary site and no leptomeningeal disease at that time. In light of the anterior maxillary location and the relatively long interval after radiotherapy, we interpret the lesion as an isolated extracranial metastasis rather than a proven operative-tract event. The principal lesson is that accurate initial diagnosis and approach selection-measurement of tumor markers and minimal or transventricular biopsy in preference to resection-remain essential in young patients with sellar/suprasellar masses in whom germinoma is a diagnostic possibility.

PMID 42543818
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PubMedCNS neuroscience & therapeutics2026-08-03

Glymphatic Dysfunction in Children With Type 2 and 3 Spinal Muscular Atrophy.

Lan Shasha S, Xiang Pei P, Yan Cui C, Nie Huirong H et al.

Spinal muscular atrophy (SMA) not only causes lower motor neuron degeneration but also affects brain development. Given the role of the glymphatic system in maintaining brain homeostasis during development, this study explores glymphatic changes in children with type 2 and 3 SMA. Forty-eight children with SMA and 53 age- and sex-matched typically developing (TD) controls were prospectively recruited. A subgroup of 22 patients received nusinersen for one year. Glymphatic function was measured using diffusion tensor image analysis along the perivascular space (DTI-ALPS) index, frequency of enlarged perivascular space (ePVS), and the coupling strength of global blood-oxygen-level-dependent (gBOLD) signals and cerebrospinal fluid (CSF) dynamics. Based on the data distribution, these parameters were compared using a two-sample t-test or Mann-Whitney U test, followed by False Discovery Rate (FDR) correction. Partial correlation analysis examined the associations between these parameters and clinical severity. Compared to TD children, SMA children exhibited increased CSF volume, higher ePVS frequency, and a lower ALPS index. CSF volume was negatively correlated with SMA severity. Post-treatment SMA patients showed increased CSF and a lower ALPS index. This study revealed glymphatic dysfunction in SMA and its correlation with clinical severity, highlighting a previously unrecognized feature of the disease.

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PubMedInfectious diseases & clinical microbiology2026-08-03

Epidemiological and Laboratory Evaluation of Central Nervous System Infections Using the BioFire FilmArray Meningitis/Encephalitis Panel in a Tertiary Care Hospital in İstanbul.

Çuğlan Serpil S SS, İrvem Arzu A, Aslan Mahmure M, Çakır-Erdoğan Derya D et al.

Rapid and accurate identification of central nervous system (CNS) pathogens is essential for appropriate antimicrobial management. This study aimed to evaluate the performance of the BioFire FilmArray Meningitis/Encephalitis (ME) Panel compared with conventional cerebrospinal fluid (CSF) analysis. This retrospective study was conducted at a tertiary care hospital over a three-year period. Cerebrospinal fluid samples were analyzed using routine microbiological methods (culture and Gram staining), cytological examination, biochemical testing, and multiplex PCR with the BioFire FilmArray ME Panel. A total of 1470 CSF samples were analyzed, and pathogens were detected in 104 samples (7.1%), including 57 viral pathogens, 39 bacterial pathogens, one fungal pathogen, and six co-infections. Culture positivity was observed in one case each of Streptococcus pneumoniae and Cryptococcus neoformans, both concordant with PCR findings. Bacterial infections were associated with significantly lower CSF glucose levels (42.57 ± 26.07 mg/dL) and higher lactate dehydrogenase (LDH) levels (320.33 ± 455.76 IU/L) than viral infections (60.38 ± 18.88 mg/dL and 53.08 ± 26.85 IU/L, respectively). The proportion of polymorphonuclear leukocytes (PMNLs) was significantly higher in bacterial cases. Receiver operating characteristic (ROC) analysis demonstrated good discriminatory performance for LDH (area under the receiver operating characteristic curve [AUC] = 0.917) and PMNL percentage (AUC = 0.834). Viral pathogens were more frequent in the 0-2-year age group, whereas bacterial infections predominated in older children. The BioFire FilmArray ME Panel, when interpreted in conjunction with routine CSF biochemical and cytological parameters, provides a rapid and reliable diagnostic approach for differentiating bacterial from viral CNS infections. Graphical Abstract.

PMID 42544351
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PubMedThe Journal of the Association of Physicians of India2026-08-03

Atypical Presentations of Central Nervous System Tuberculosis at a Tertiary Care Center: Case Series.

Shrivastava Anubha A, Dhaneshry Deepanshu D, Sahoo Mrityunjay M

This case series highlights three patients with unusual central nervous system (CNS) tuberculosis (TB) manifestations, diagnosed at the Department of Medicine and Neurology, Moti Lal Nehru Medical College, Prayagraj, India, between January and November 2024. The cases underscore the diagnostic challenges of atypical CNS TB and the importance of an integrated diagnostic approach combining clinical, radiological, and laboratory findings. A 35-year-old male presented with sudden-onset right-sided weakness. Imaging revealed intracranial hemorrhage (ICH) in the left parietal region without vascular anomalies. Cerebrospinal fluid (CSF) analysis showed lymphocytic pleocytosis, elevated protein, and adenosine deaminase (ADA), while the interferon-gamma release assay was positive. He was diagnosed with CNS TB presenting as ICH secondary to vasculitis. A 49-year-old male developed left-hand weakness. Imaging showed a left parietal infarct. CSF analysis revealed lymphocytic pleocytosis with elevated protein and ADA. Pulmonary TB was suspected based on a chest X-ray. He was diagnosed with stroke secondary to tubercular CNS vasculitis presenting as pseudomedian nerve palsy. A 32-year-old male presented with sudden-onset bilateral lower limb weakness and sensory loss. Magnetic resonance imaging (MRI) spine findings were suggestive of a normal spine but with paraspinal muscle hyperintensity. CSF analysis was normal, and the interferon-gamma release assay was positive. Antitubercular therapy and steroids improved motor function, leading to a diagnosis of MRI-negative paraplegia secondary to tubercular myeloradiculitis. These cases demonstrate the varied and atypical manifestations of CNS TB, including ICH, stroke mimicking nerve palsy, and MRI-negative paraplegia. Prompt recognition and treatment are crucial to improve outcomes in such rare presentations.

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PubMedChemical communications (Cambridge, England)2026-08-03

Practical and direct synthesis of α-aminonitriles using N-Boc-O-tosyl alkylhydroxylamines and TMSCN.

Zhang Yu-Heng YH, Jiao Fang-Na FN, Cao Fei-Yang FY, Zhao Ming-Zhu MZ et al.

Herein, we report a practical and direct method for the synthesis of α-aminonitriles from easily accessible N-Boc-O-tosyl alkylhydroxylamines. The transformation proceeds under mild, transition-metal-free, and redox-neutral conditions using readily available reagents and is readily scalable to the gram scale. Mechanistic studies indicate that the reaction proceeds via in situ imine formation enabled by CsF, followed by nucleophilic cyanation. Furthermore, the synthetic utility of the products is demonstrated through diverse downstream transformations.

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PubMedNeurosurgical review2026-08-03

Intrawound vancomycin powder for infection prevention in neurosurgical patients: a retrospective cohort study.

Tejada-Pineda Maria Fernanda MF, Ortega-Porcayo Luis Alberto LA, Reyes-Madrigal Francisco F, Romano-Feinholz Samuel S et al.

Surgical site infections (SSIs) are the most frequent healthcare-associated infections in surgical patients and are largely preventable. Neurosurgical procedures are particularly vulnerable due to inherent risk factors. While intrawound vancomycin has been extensively studied in spinal surgery, evidence in cranial procedures remains limited. We performed a retrospective cohort study of 741 patients undergoing cranial or spinal neurosurgery between November 2014 and February 2024. The primary outcome was the 90-day SSI rate, defined in accordance with CDC surveillance criteria for neurosurgical procedures. Secondary analysis evaluated associations between infection and operative duration, cerebrospinal fluid (CSF) leaks, reintervention, use of surgical drains, emergency surgery, and hospital stay. After applying exclusion criteria, 548 patients were included: 291 received topical vancomycin powder and 257 served as controls. Infection occurred in 3.1% of the vancomycin group versus 8.6% of controls, representing a 64% reduction in infection risk (RR = 0.36; 95% CI: 0.17-0.77). No adverse events related to vancomycin were observed. CSF leak was the strongest independent predictor of infection, with 26.9% of patients with a leak developing SSI versus 4.6% without (RR = 6.14; 95% CI: 2.8-13.5). Reintervention was also a significant predictor, increasing infection risk by 2.53 times (RR = 2.53; 95% CI: 1.5-4.12). Drain use showed an association in chi-square analysis (RR of 2.17; 95% CI: 1.25-3.75). Operative duration, emergency surgery, and hospital stay were not significantly associated. Intrawound vancomycin was significantly associated with reduced postoperative SSIs in cranial and spinal neurosurgery.

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