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cefaclor (Raniclor / Raniclor)

✓ Approved

Ranbaxy Laboratories Limited · 小分子 · 小分子

什么是 cefaclor？

cefaclor 是一种小分子，由Ranbaxy Laboratories Limited研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Raniclor, Raniclor
公司Ranbaxy Laboratories Limited
药物类别小分子
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Ranbaxy Laboratories Limited

治疗适应症

cefaclor 针对 6 个适应症，涉及 3 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsLower respiratory tract infection✓ Approved
Infections and infestationsOtitis media✓ Approved
Infections and infestationsTonsillitis✓ Approved
Infections and infestationsUrinary tract infection✓ Approved
Respiratory, thoracic and mediastinal disordersTonsillar inflammation✓ Approved

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相关研究文献

PubMedFoods (Basel, Switzerland)2026-06-12

Formulation-Driven Rational Architectonic Design of Pomelo (Citrus maxima) Peel-Derived Lignocellulosic Fibre-Enriched Chewable Tablets: Spectroscopic and Morphological Characterization of Structure-Function Relationships.

Ahmad Saadullah Arslan SA, Wang Lufeng L, Arshad Atif A

Dietary fibre deficiency remains a global nutritional concern, and the development of fibre-enriched functional foods is increasingly important. Fruit processing by-products, such as pomelo (Citrus maxima) peel, represent a sustainable source of dietary fibre with potential techno-functional applications. In this study, a fibre-enriched chewable tablet was developed using pomelo (Citrus maxima) peel fibre (CPF) as a functional ingredient and structural matrix. The formulation was prepared through direct compression and systematically evaluated in terms of powder flow behaviour, structural characteristics (FTIR, XRD, and SEM), hydration-related functionality, and tablet quality attributes. The CPF-based powder blend exhibited good flowability and compressibility, with an angle of repose of 26.62°, Carr's index of 8.9%, and a Hausner ratio of 1.22, indicating suitability for tablet processing. Structural characterisation demonstrated the formation of a semi-crystalline matrix with a porous fibrous morphology. CPF incorporation significantly improved water-holding capacity (9.84 g/g) and oil-holding capacity (2.97 g/g), indicating enhanced hydration functionality. The developed tablets exhibited uniform weight (560 ± 9.5 mg), consistent dimensions, and acceptable disintegration behaviour (168 ± 15 s), demonstrating satisfactory physical quality. Overall, these findings suggest that pomelo peel fibre can be effectively utilised in chewable delivery systems, providing a feasible strategy for the valorisation of citrus by-products in functional food applications.

PMID 42279686
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PubMedJournal of International Society of Preventive & Community Dentistry2026-06-08

Microbial and Mycotoxin Contamination in Packaged and Unpackaged Smokeless Tobacco and Non-tobacco Chewing Products in India.

Mahesh Shakila S, Jain Meena M, Srivastava Roomani R, Saleem Adeeba A

Smokeless tobacco (SLT) and non-tobacco chewable products such as Gutka, Khaini, and Pan Masalas are widely consumed in India but are rarely assessed for microbial safety, despite the presence of toxin-producing microorganisms that may increase carcinogenic risk. The study was aimed to investigate bacterial and fungal contamination and quantify aflatoxin B1 (AFB1) levels in commercially available chewable products. Cross-sectional laboratory-based study analyzing SLT and non-tobacco products collected from North, South, West, and East India. Fourteen samples, including Gutka, Khaini, Pan Masalas, Loose Tobacco, and Areca Nut mixes, were assessed. Bacillus spp. were identified using HiCrome™ Bacillus Agar and API 50CHB/E profiling. Fungal contaminants were characterized by colony morphology and lactophenol cotton blue microscopy. AFB1 levels were measured in duplicate using competitive ELISA. Median and interquartile ranges (IQR) for AFB1; Kruskal-Wallis H test with Dunn's post hoc test and Bonferroni correction (P < 0.05). Bacillus licheniformis was the most frequently isolated bacterium, followed by Bacillus subtilis/amyloliquefaciens and Bacillus pumilus. Nitrate-reducing activity suggested potential nitrosamine formation. Fungal contaminants included Aspergillus flavus, A. niger, Penicillium spp., Mucor spp., and Rhizopus spp., with colony counts ranging from 1.2 × 104 to 5.5 × 104 colony-forming units (CFU)/g. AFB1 was detected in 13 of 14 samples (0.085-0.459 ng/mL), with pan masala with tobacco (0.456 ng/mL, IQR 0.455-0.458) and gutka (0.400 ng/mL, IQR 0.341-0.450) showing the highest levels, whereas Khaini exhibited the lowest contamination (0.088 ng/mL, IQR 0.087-0.090). Non-tobacco pan masalas also showed notable contamination. Both SLT and non-tobacco chewable products harbor microbial and aflatoxin hazards, challenging assumptions about the safety of non-tobacco products. These findings highlight the need for product-specific microbial and mycotoxin regulations under FSSAI regulations, along with market surveillance and public awareness initiatives.

PMID 42253915
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PubMedBMC oral health2026-06-07

Influence of two pediatric multivitamin forms on surface characteristics and color stability of single-shade composite, nanofilled composite, and glass ionomer cement: an in vitro study.

Elbatanony Mai M MM, El Shahawi Amal M AM, Zaki Dalia Y DY

Gummy and chewable pediatric multivitamin formulations commonly contain citric acid and ascorbic acid, yielding pH values that may fall below the critical erosive threshold of 5.5. These organic acids can degrade restorative materials through proton-mediated surface dissolution and chelation of matrix cations. Despite widespread use, evidence on their long-term effect on contemporary restorative materials remains limited. This study aimed to assess the effect of gummy and chewable forms of pediatric multivitamin supplements on the surface hardness, roughness, and color stability of glass ionomer cement (Medifil), universal single-shade resin composite (Omnichroma), and a nanofilled composite resin (Filtek Z350 XT). Specimens (n = 135) of Omnichroma composite, Filtek Z350 XT composite, and Medifil glass ionomer cement were prepared and assigned to three subgroups (n = 15): (1) artificial saliva (control), (2) HerbaL Gummies dissolved in artificial saliva, and (3) Centrum chewable tablets dissolved in artificial saliva. After 6-month daily in vitro immersion cycles (69 s/day at 37 °C), surface hardness (VHN), roughness (Sa via AFM), and color change (ΔE) were evaluated. Data were analyzed using a two-way ANOVA with a 3 × 3 factorial design, followed by Tukey's HSD post hoc test. Two-way ANOVA revealed significant main effects of material and immersion medium, and significant material×medium interactions for all outcomes (all p ≤ 0.001). Both solutions significantly reduced hardness and increased roughness vs. control. Glass ionomer cement was the most susceptible material for surface hardness and roughness (lowest VHN and highest Sa across all conditions; p < 0.001 vs. both composites), while Filtek Z350 XT was the least affected. HerbaL Gummies produced greater hardness reduction than Centrum in glass ionomer and Filtek Z350 XT, while Omnichroma responded comparably to both. Omnichroma exhibited the greatest color change across all conditions (ΔE = 3.13), though all ΔE values remained clinically acceptable (ΔE < 3.3). Daily in vitro exposure to acidic pediatric multivitamin supplements adversely affected the surface hardness, roughness, and color stability of all tested restorative materials under simulated oral conditions, with material- and formulation-specific degradation patterns. HerbaL Gummies demonstrated greater erosive potential than Centrum chewable tablets for most material outcome combinations. Clinicians should account for supplement acidity when selecting restorative materials and should advise parents to administer supplements with meals and rinse with water immediately afterward.

PMID 42251354
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PubMedObesity surgery2026-06-06

Chewable or Swallowable? Patient-Reported Adherence and Satisfaction with Post Metabolic and Bariatric Surgery Supplements in Routine Practice.

Govil Aparna A, Girkar Shamika S, Greve Jan Willem JW

Metabolic and bariatric surgery (MBS) provides durable weight loss and metabolic improvement but can also predispose patients to micronutrient deficiencies due to altered gastrointestinal anatomy. Lifelong nutrient supplementation is therefore essential; however, adherence typically declines over time. While chewable formulations are often recommended early postoperatively for presumed tolerability, real-world evidence comparing patient adherence, satisfaction, and preferences between chewable and swallowable supplements remains limited particularly in resource-constrained settings such as India, where cost, availability, and taste heavily influence long-term compliance. To compare adherence, tolerability, and satisfaction between chewable and swallowable supplements in an Indian patient cohort, and to explore factors influencing formulation choice, discontinuation, and perceived health impact. A cross-sectional survey was conducted among 110 adults at least one month post metabolic and bariatric surgery (Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG)) attending a tertiary center in Mumbai. A structured, self-administered questionnaire assessed supplement type, adherence patterns, swallowing difficulty, satisfaction (5-point Likert scale), and preference drivers (e.g., taste, cost, convenience). Associations between supplement formulation and adherence outcomes were analyzed. Participants were predominantly female (74%) with mean age 43 years; 60% had undergone RYGB. Swallowable formulations were most commonly preferred (70%). Overall, 41% had discontinued supplements after surgery, primarily due to forgetfulness (35%), cost or safety concerns (22%), and swallowing difficulty (14%). Swallowable users reported higher satisfaction (68% vs. 30%) and significantly greater current use compared with chewable/both users (93.5% vs. 75.8%, p = 0.021). Preference was mainly driven by ease of swallowing (35%), taste/mouthfeel (34%), and physician advice (23%). A majority of participants (72%) believed that supplement formulation could influence long-term health outcomes. Common improvement suggestions included fewer pills, better taste, easier swallowing, and affordability. These findings suggest that swallowable formulations may be acceptable in routine practice and highlight the importance of incorporating patient preference in long-term supplementation strategies. Despite widespread swallowing concerns, swallowable formulations were associated with higher patient satisfaction and better sustained adherence. While this study has many limitations, it provides a snapshot of patient preferences in an area that is relatively unexplored. In the Indian context, with limited specialized products and cost sensitivity, these findings highlight the need for patient centred supplement strategies emphasizing palatability, convenience, and accessibility.

PMID 42250129
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PubMedInternational immunopharmacology2026-05-29

Vagus nerve is essential for the anxiolytic effect of YL-IPA08, a potent ligand for the translocator protein (18 kDa).

Ni Han H, He Dujuan D, Duan Jingyao J, Zhao Jianing J et al.

The vagus nerve serves as a key neural pathway modulating parasympathetic activity, which plays a critical role in mood regulation and has been implicated in anxiety and depression. The translocator protein (18 kDa, TSPO) ligand YL-IPA08 has demonstrated consistent anxiolytic effects in animal studies. Using lipopolysaccharide (LPS)- or cefaclor-induced anxiety models in adult mice with or without vagotomy, we investigated the involvement of the vagus nerve in mediating the effects of YL-IPA08 and its underlying mechanisms. As anticipated, chronic YL-IPA08 administration significantly reversed anxiety-related behaviors induced by LPS or antibiotic exposure, an effect that was attenuated by vagotomy. Furthermore, vagotomy impaired YL-IPA08's ability to counteract cefaclor-induced microglial activation and inflammatory responses in the prefrontal cortex (PFC). The present study shows that YL-IPA08 exerts significant anxiolytic effects, which are associated with the vagus nerve signaling pathway, suggesting that the vagus nerve may be involved in partial regulation of these effects.

PMID 42208331
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PubMedFrontiers in veterinary science2026-05-29

Reusable gelatin-based inks for 3D printing of veterinary gabapentin tablets: a sustainable approach.

Taylor Alex A, Ketolainen Jarkko J, Paulsson Mattias M, Autenrieth Jonas J et al.

Gabapentin (GAB), an anticonvulsant, is commonly used in veterinary medicine to manage anxiety, pain, and epilepsy. Although it is widely used, achieving personalized dosing for small animals remains a significant challenge. Three-dimensional printing (3DP), particularly semi-solid extrusion (SSE), has shown promise in producing individualized dosage forms efficiently and with precision. Despite its advantages, SSE is limited by the need to freshly prepare the ink for printing and the extended post-processing times required for curing or solidifying the printed objects. This study investigated for the first time the feasibility of reusing a formulation designed for veterinary patients. The chewable tablets in this study were made using an already available proprietary gelatin-based excipient base, CuraVet®. Two formulations with varying GAB concentrations were printed using the same syringe initially and then again after 14 days of refrigerated storage. The formulation that contained a lower concentration of GAB maintained printability and dosing precision without requiring adjustments to printer settings, enabling the production of chewable tablets in under 30 min with a minimal amount of active work required. In contrast, the higher concentration formulation exhibited crystal formation, indicating instability. This proof-of-concept study demonstrated the feasibility of using reusable gelatin-based inks for on-demand 3D printing of veterinary medicines, highlighting their potential for clinical adoption in veterinary practices and pharmacies, provided that stability is carefully characterized.

PMID 42211341
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