Factor VIII (HemoRel)

Lack of Inhibitor Development in Previously Treated People With Haemophilia Switching Factor Products-Final Results of Athn 2: Factor Switching Study.

Cockrell Erin E, Chandler Martin M, Chrisentery-Singleton Tammuella T, Croteau Stacy E SE et al.

Further validation of the Role Strain Scale for Male Nursing Students in Taiwan: Confirmatory factor analysis and multiple sources of validity evidence.

Yu Hsing-Yi HY, Chin Yen-Fan YF, Huang Chun-Hsia CH, Shen Yung-Chao YC et al.

To conduct a confirmatory psychometric evaluation of the Role Strain Scale for Male Nursing Students (RSS-MNS), examining its factor structure, reliability, and convergent, discriminant, and concurrent validity. Role strain among male nursing students may hinder recruitment and retention. Existing measures often lack confirmatory validation and omit key contextual stressors. A cross-sectional online survey was conducted from August 2024 to March 2025 using convenience and snowball sampling of 250 male nursing students in Taiwan. Confirmatory factor analysis was used to test a correlated four-factor model. Reliability (Cronbach's α), convergent validity (standardized loadings, composite reliability, average variance extracted), discriminant validity (inter-factor correlations and collinearity diagnostics), and concurrent validity were examined. The four-factor model demonstrated acceptable fit and broadly consistent item-factor relations. Reliability and convergent validity were satisfactory for the Medical Personnel, Patient, and Classmate and Teacher domains but weakest for the Family and Friend domain. Discriminant validity was partially supported. Higher Family and Friend, Classmate and Teacher, and Medical Personnel Role Strain scores were modestly and significantly associated with lower intention to enter the nursing workforce, whereas Patient Role Strain was not significantly related. The RSS-MNS showed an acceptable four-factor structure and modest concurrent associations with career-entry intention. The Family and Friend Role Strain subscale showed comparatively weaker performance, and evidence for discriminant validity was partial; therefore, this subscale should be prioritized for further refinement. Overall, the scale demonstrates practical utility for screening and monitoring role strain among male nursing students to inform timely support or referral.

Prognostic stratification in a diabetic kidney disease trial using plasma concentrations of soluble tumor necrosis factor receptor 1.

Petrovic Vladimir V, Malkov Vladislav A VA, Billin Andrew N AN, Patel Uptal D UD et al.

Concentration of circulating soluble tumor necrosis factor receptor 1 is associated with faster progression in patients with diabetic kidney disease based on data obtained from large longitudinal cohort studies. A cutpoint of 4.3 ng/mL baseline plasma concentration was identified to stratify patients and predict clinical outcome. We set out to test the prognostic utility of this cutpoint in a randomized clinical trial. Soluble tumor necrosis factor receptor 1 concentration was measured across plasma samples from Joslin cohort and selonsertib trial cohort. Estimated glomerular filtration rate slope was calculated using a patient-specific linear regression model based on serum creatinine concentration and compared between the cohorts. Kidney-related events were plotted using Kaplan-Meier estimates for both cohorts. Participants from both the clinical study cohort and the observational cohort showed an inverse relationship between baseline plasma concentrations of tumor necrosis factor receptor 1 and estimated glomerular filtration rate. When stratified based on baseline soluble tumor necrosis factor receptor 1 cutpoint, higher probability of experiencing a clinical event was found in patients with levels of soluble tumor necrosis factor receptor 1 exceeding 4.3 ng/mL in either of the cohorts. We demonstrated the prognostic utility of plasma concentrations of circulating soluble tumor necrosis factor receptor 1 in identifying individuals with diabetic kidney disease at an elevated risk of progressive kidney function decline in a randomized clinical study setting. This data supports previous findings from large observational cohorts and supports the use of this marker as a reliable predictor of disease outcome.

Psychometric evaluation of the Pittsburgh Sleep Quality Index among South African women participating in the Bukhali trial: Healthy Life Trajectories Initiative.

Alcock Stephanie S, Beukes Johanna J, Hart Claire C, Scheuermaier Karine K et al.

We examined the psychometric properties of the Pittsburgh Sleep Quality Index (PSQI) in a large sample of young women in Soweto, South Africa, to assess its reliability and structural validity in this context. Data were collected from 7182 women enrolled in the Bukhali randomized controlled trial, part of the Healthy Life Trajectories Initiative (HeLTI). Sociodemographic information and PSQI data were collected through interviewer-administered surveys. Internal consistency was assessed using Cronbach's alpha, McDonald's omega and item-level correlations. Confirmatory factor analysis (CFA) evaluated the original one-factor and established two- and three-factor multidimensional models. Model fit was examined using Root Mean Square Error of Approximation (RMSEA), Comparative Fit Index (CFI), and Tucker-Lewis Index (TLI). Most women (57.4%) reported good sleep quality (PSQI ≤ 5). Poor sleep quality was associated with higher household socioeconomic status (assets score), higher education, and single relationship status. Average sleep was 7.8 hours, characterized by prolonged onset latency and high fragmentation, suggesting that continuity disruptions rather than opportunity shortage drove poor sleep. The PSQI had modest internal consistency (α = .57; ω = .57; item-total r = .33 - .65). The one-factor model demonstrated poor fit (χ2(14) = 1677.70; CFI = .65; TLI = .48; RMSEA = .13) whereas fit was good for the two-factor (χ2(13) = 291.46; CFI = .94; TLI = .91; RMSEA = .05) and three-factor models (χ2(11) = 285.21; CFI = .94; TLI = .89; RMSEA = .06). The PSQI showed a multidimensional structure in this population. While both multidimensional models performed well, the two-factor model showed slightly better fit and is recommended for use in this population. Interpreting PSQI components rather than the global score offers more meaningful insight into sleep quality and highlights the need for context-specific psychometric validation in diverse settings. The Pittsburgh Sleep Quality Index is widely used, but prior evidence shows its reliability and factor structure vary across populations, settings, and sex. Young women in under-resourced urban South African settings may experience sleep disruption shaped by psychosocial stress, safety concerns, caregiving demands, and environmental factors, yet the PSQI had not been evaluated in this population. In this large Soweto cohort, sleep problems appeared driven more by fragmented sleep and continuity disruptions than by insufficient sleep opportunity. The PSQI performed better as a multidimensional measure, particularly a parsimonious two-factor structure, than as a single global score. The findings support using component- or factor-informed PSQI interpretation and highlight the need for context-specific validation of sleep measures in diverse populations.