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S-amlodipine gentisate (Nexad / Nexad TAb)

✓ Approved

SK Chemicals · CACNA1C · 小分子

什么是 S-amlodipine gentisate？

S-amlodipine gentisate 是一种小分子，由SK Chemicals研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Nexad, Nexad TAb
公司SK Chemicals
药物类别小分子
分子靶点CACNA1C
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, SK Chemicals

作用机制

分子靶点

S-amlodipine gentisate 作用于 1 个分子靶点：

CACNA1Ccalcium voltage-gated channel subunit alpha1 C (CACNL1A1, CACNA1C-IT2)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

S-amlodipine gentisate 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Cardiac disordersAngina pectoris✓ Approved
Vascular disordersHypertension✓ Approved

相关研究文献

PubMedScientific reports2026-06-13

Pan-genome cloning and expression analysis of S-RNase homologous gene in SI and SC of different tomato species.

Li Chunwei C, Zhao Panfeng P

Flowering plants encode polymorphic ribonucleases (S-RNases) that determine the self-incompatibility (SI) phenotype of the style. The pan-genome cloning and expression analysis of the S-RNase homologous genes in SI and self-compatibility (SC) lines of different tomato species have not been reported. In this study, partial sequences of cDNA and DNA of the S-RNase homologous gene (designated ZS) were obtained from S. pimpinellifolium, S. Lycopersicum, S. habrochaites and S. chilense which included SI lines and SC lines. Tissue-specific expression of the S-RNase gene was detected using semi-quantitative RT-PCR and quantitative real-time PCR. We selected 6 ZS genes (two come from the SI lines and four come from SC lines) which come from different tomato species mentioned in this paper to research. ZS genes were exclusively in styles and there were significant differences in expression level of the different tomato species. The expression level of the ZS genes in the styles of the SI tomato clade S. chilense was higher than that in the SC tomato clades S. pimpinellifolium and S. lycopersicum. And, the SC tomato clade S. habrochaites, in which the expression level of the ZS genes was even higher than that in the SI tomato clade S. chilense. The outcomes presented in this research provide the basis for future deeper investigation of the molecular mechanism of SI in tomato.

PMID 42286102
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PubMedAdvanced materials (Deerfield Beach, Fla.)2026-06-13

Synergistic Dual Modulation of Li2S Redox Kinetics and Anode Stability Enabled by a High-Efficiency Organodisulfide Mediator in Anode-Free Lithium-Sulfur Batteries.

Nie Kunlun K, Ni Zhiwei Z, Li Yuan Y, Zhang Qi Q et al.

Lithium sulfide (Li2S) is pivotal for high-energy-density lithium-sulfur (Li─S) batteries due to its high theoretical capacity, abundant sulfur resources, and compatibility with anode-free architectures. However, its application is hindered by its intrinsically insulating nature and sluggish redox kinetics. Furthermore, traditional 1,3-dioxolane/1,2-dimethoxyethane electrolytes cannot withstand high voltages and pose safety hazards due to low flash points. Herein, we propose a synergistic strategy by introducing diisopropyl dithiocarbonate disulfide (DIP) as a multifunctional redox mediator into a high-flash-point, high-voltage-tolerant tetraethylene glycol dimethyl ether electrolyte system. DIP directly converts Li2S to lithium polysulfides, decreasing the activation voltage of the first charge to 2.48 from 3.18 V. Simultaneously, DIP facilitates the formation of an organosulfur-rich solid electrolyte interface on the lithium surface, effectively suppressing lithium dendrite formation and growth. Crucially, this system enables stable cycling in anode-free Cu||Li2S batteries for 160 cycles at 0.3 mAh cm-2. Standard Li||Li2S cells also demonstrate superior durability, achieving an extremely low per-cycle decay rate of 0.037% at 1C. Moreover, this strategy holds promise for other metal-sulfur systems, such as Na─S, K─S, Ca─S, Mg─S, and Zn─S batteries, providing a feasible path for safe, next-generation energy storage.

PMID 42285919
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PubMedBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie2026-06-13

20(S)-hydroxycholesterol, a natural allosteric agonist of Smoothened, exerts neuroprotective effects associated with angiogenesis and vascular plasticity following ischemia.

Li Haowen H, Fu Cong C, Fan Junwan J, Liu Tianrui T et al.

The Hedgehog signaling pathway has played a key role promoting angiogenesis and neurogenesis in ischemic stroke. To harness the therapeutic potential of Hedgehog signaling in stroke, we investigated the function and potential clinic applications of 20(S)-hydroxycholesterol, a natural small-molecule agonist of Smoothened in the Hedgehog pathway, with respect to its capacity to promote post-stroke neuroprotection, angiogenesis, and cerebrovascular plasticity. In vitro, hypoxia conditions were simulated in brain microvascular endothelial bEnd.3 cells using an oxygen-glucose deprivation/reoxygenation (OGD/R) model. Cell migration capability was evaluated by scratch assay and transwell assay. Endothelial cell angiogenic capacity was evaluated through tube formation assays. Male C57BL/6 J mice were subjected to middle cerebral artery occlusion (MCAO) to establish an ischemic stroke animal model. Neurological deficits were evaluated using the mNSS method. Cerebral infarct volume was measured using TTC staining. The expression levels of Hedgehog signaling pathway and angiogenesis-related proteins were evaluated by immunofluorescence. Our findings demonstrated that 20(S)-hydroxycholesterol enhanced cell viability, cell migration and tube formation capacity of bEnd.3 cells under OGD/R treatment. In addition, 20(S)-hydroxycholesterol up-regulated the expression of Smoothened and activated Gli transcription factors activity as well as angiogenesis-related genes including Angpt1, Efna5, and Cd31. Moreover. we discovered that 20(S)-hydroxycholesterol significantly reduced cerebral infarct volume and neurological deficits in MCAO model mice. 20(S)-hydroxycholesterol activates the Hedgehog signaling pathway in ischemic models. It exhibits neuroprotection functions after stroke associated with neuronal angiogenesis and vascular plasticity. This study highlights the therapeutic potential of 20(S)-hydroxycholesterol as a novel agent for ischemic stroke recovery.

PMID 42284885
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PubMedJournal of economic entomology2026-06-13

Selective feeding behavior of Spissistilus festinus (Hemiptera: Membracidae) among Fabaceae and Vitaceae plants identified by choice assays.

Hoyle Victoria V, McGinnity Schneider Elliot E, Loeb Gregory G, Fuchs Marc M

The treehopper Spissistilus festinus [Say, 1830] (Hemiptera: Membracidae) is not a direct pest of winegrapes (Vitis vinifera) but poses a threat to vineyards as a vector of grapevine red blotch virus (GRBV). While previous no-choice assays suggested a preference for Fabaceae for feeding and reproduction, recent gut content analyses revealed frequent feeding of S. festinus on Vitaceae, particularly free-living V. californica and its hybrids, within northern California vineyards. To better understand host selection and feeding behaviors of S. festinus, we conducted choice assays using excised leaves of Fabaceae (snap bean, alfalfa) and Vitaceae (winegrape, V. californica, V. californica hybrid). In two-choice assays, S. festinus more often visited snap bean, though Vitis species were also attractive when present. In four-choice contexts, snap bean remained a preferred host, followed by V. californica and winegrapes. These results confirmed the polyphagous tendencies of S. festinus and provided new insights into the feeding behaviors of this treehopper species.

PMID 42286446
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PubMedPhysical review letters2026-06-13

Effective Density Matrix for Vacua in Asymptotically Flat Gravity.

He Temple T, Mitra Prahar P, Zurek Kathryn M KM

We explicitly construct the density matrix associated to the vacuum state of a large spherically symmetric causal diamond of area A in four-dimensional asymptotically flat gravity. We achieve this using the soft effective action, which characterizes the low-energy gravitational degrees of freedom that arise in the long-distance limit of the Einstein-Hilbert action and consists of both the soft graviton mode and the Goldstone mode arising from the spontaneous breaking of supertranslation symmetry. Integrating out the soft graviton mode, we obtain an effective action for purely the Goldstone mode, from which we extract the density matrix and therefore the modular Hamiltonian K[over ^]_{s} associated to the vacuum state. As a corollary, we explicitly compute the mean and variance of K[over ^]_{s}, finding ⟨ΔK[over ^]_{s}^{2}⟩=A/ε_{UV}^{2}, with ε_{UV} being a length-scale UV cutoff on the celestial sphere.

PMID 42285067
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PubMedFood chemistry2026-06-13

A novel sandwich immunoassay for Staphylococcus aureus using horseradish peroxidase-conjugated trivalent nanobody.

Su Na N, Yang Chunxu C, Zhu Lei L, Song Heyang H et al.

Nanobodies (Nbs), owing to their lack of the fragment crystallizable region, are a promising alternative to conventional antibodies for the specific and efficient detection of pathogenic bacteria by minimizing nonspecific interactions. This study reports a trivalent nanobody (3Nb156) targeting Staphylococcus aureus (S. aureus) engineered via multivalent design and directly conjugated with horseradish peroxidase (HRP). A sandwich enzyme-linked immunosorbent assay (TNb-sELISA) was developed using Nb55 as the capture antibody and HRP-3Nb156 as the detection probe. The TNb-sELISA achieved a detection limit of 2.84 × 104 CFU/mL, representing a 3.2-fold improvement in sensitivity over the monovalent nanobody-based ELISA. The assay demonstrated high specificity and excellent reproducibility. In spiked milk and chicken samples diluted 10-fold, recoveries ranged from 89.49% to 110.37%. After 6 h of enrichment, 10 CFU of S. aureus was detectable in real samples. This study establishes a rapid, sensitive, and reliable platform for detecting S. aureus in complex food matrices.

PMID 42284895
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