若生智能
Drug Database
DI

didanosine (didanosine EC / Videx EC)

✓ Approved

Bristol-Myers Squibb · · 小分子

什么是 didanosine？

didanosine 是一种小分子，由Bristol-Myers Squibb研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名didanosine EC, Videx EC
公司Bristol-Myers Squibb
药物类别小分子
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Bristol-Myers Squibb

作用机制

分子靶点

didanosine 作用于 1 个分子靶点：

gag-pol, HIV-1 (gag-pol)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

didanosine 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsAcquired immunodeficiency syndrome✓ Approved

相关研究文献

PubMedNature medicine2026-06-13

Efficacy and target engagement of dopamine agonist pramipexole for anhedonic depression: a randomized placebo-controlled trial.

Ventorp Filip F, Asp Marie M, Olsson Sofia S, Lindahl Jesper J et al.

Anhedonia is a core and disabling symptom of mood disorders with limited treatment options. We evaluated the efficacy and safety of the dopamine agonist pramipexole in patients with mood disorders characterized by clinically significant anhedonia. In this single-center, randomized, double-blind, placebo-controlled trial, adults with major depressive disorder, dysthymia or bipolar depression and elevated Snaith-Hamilton Pleasure Scale (SHAPS) scores were assigned (1:1) to flexible dose, once-daily oral pramipexole as add-on treatment or placebo for 9 weeks. The primary outcome was change in SHAPS score from baseline to week 9. Analyses were conducted in the modified intention-to-treat population. Eighty-five participants were randomized, and 82 were included in the analysis. The primary outcome was met: pramipexole was associated with a greater reduction in SHAPS scores compared to placebo (mean difference: -4.04, 95% confidence interval: -6.89 to -1.18, P = 0.006, Hedges' g = 0.62). Exploratory analyses indicated that pramipexole was associated with increased light physical activity and relative preservation of reward-related ventral striatal activation. Improvements in anhedonia were sustained during a 6-month open-label extension. Pramipexole was generally well tolerated compared to placebo. Pramipexole significantly improved anhedonia and showed a favorable safety profile, supporting its potential as an augmentation strategy in mood disorders. ClinicalTrials.gov identifiers: NCT05355337 and NCT05825235 .

PMID 42286321
阅读全文 →
PubMedAmerican journal of respiratory and critical care medicine2026-06-13

Patient versus surrogate decision making for life sustaining treatment and terminal care intensity.

Oh Tak Kyu TK, Song In-Ae IA

Physician Orders for Life-Sustaining Treatment (POLST) and Advance Directives (AD) aim to honor patient autonomy. However, the impact of the signatory's identity-whether the patient or a surrogate-on clinical trajectories in the intensive care unit (ICU) remains poorly characterized. To evaluate the association between signatory identity and terminal care intensity and hospitalization costs among adult patients in the ICU. This nationwide population-based cohort study utilized the South Korean National Health Insurance Service database, including 1,189,042 adult ICU admissions between 2020 and 2023. Statistical analyses employed high-dimensional fixed-effects models to account for institutional variability across 417 hospitals. Among 1,189,042 patients, surrogate-determined POLST (SD-POLST) was more than three times as prevalent as patient-determined POLST (PD-POLST). Among 90-day decedents, PD-POLST was associated with significantly reduced odds of invasive terminal care (OR, 0.43; 95% CI, 0.43-0.54). Conversely, SD-POLST more than doubled the odds (OR, 2.16; 95% CI, 1.98-2.35). Notably, even patients with proactive ADs experienced increased care intensity once a surrogate signed the final order (OR, 1.69; 95% CI, 1.51-1.89), indicating a phenomenon of "AD erosion." SD-POLST was also associated with significantly higher daily hospitalization costs (cost ratio, 1.04; 95% CI, 1.02-1.06) compared with no documentation. The clinical efficacy of POLST in limiting non-beneficial care depends fundamentally on the signatory. Surrogate-led decisions were associated with paradoxically higher care intensity and costs, potentially overriding prior patient wishes. These findings highlight the critical importance of early, patient-led discussions to ensure goal-concordant end-of-life care in the ICU.

PMID 42286341
阅读全文 →
PubMedPhysical review letters2026-06-13

SENSEI: A Search for Diurnal Modulation in Sub-GeV Dark Matter Scattering.

Bloch Itay M IM, Botti Ana M AM, Cababie Mariano M, Cancelo Gustavo G et al.

Dark matter particles with sufficiently large interactions with ordinary matter can scatter in the Earth's atmosphere and crust before reaching an underground detector. This Earth-shielding effect can induce a directional dependence in the dark matter flux, leading to a sidereal daily modulation in the signal rate. We perform a search for such a modulation using data from the SENSEI experiment, targeting MeV-scale dark matter. We achieve nearly an order-of-magnitude improvement in sensitivity over previous direct-detection bounds for dark-matter masses below ∼1  MeV, assuming the standard halo model with a Maxwell-Boltzmann velocity distribution, and restrict the amplitude of a general daily modulation signal to be below 6.8  e/g/d.

PMID 42285076
阅读全文 →
PubMedEnvironment international2026-06-13

Extreme temperature potentially triggers eye disease in children: a multicity hospital-based study in China.

Zou Xiaojie X, Gu Zhengyu Z, Song Xia X, Zhao Desheng D et al.

Extreme temperature is a major health threat worldwide and multiple organs including eyes are particularly vulnerable. However, knowledge is limited regarding the association between extreme temperature and eye disease. We aimed to investigate the association between extreme temperature and childhood eye disease, and to explore differences in the effects of daytime and nighttime extreme temperature. We collected daily data on 572,970 eye disease outpatient visits for children under 18 years old from hospitals of nine cities across China from 2010 to 2023. Daily temperature data were obtained from the ERA5-land database. A space-time-stratified case-crossover design was employed to examine the short-term associations of eye disease with temperature exposure of whole-day, during the daytime and nighttime periods. There was a U-shaped association between temperature and childhood eye disease over lag 0-7 days, suggesting an increased risk of eye disease on hot and cold days. Using the minimum morbidity temperature as the reference, extremely high temperature (95th percentile of daily temperature distribution) was associated with 15 % (95 %CI: 12 %-18 %) risk increase in childhood eye disease, which was significantly greater than extremely low temperature (5th percentile of daily temperature distribution) with the risk increase of 10 % (95 %CI: 7 %-14 %). In addition, the association of eye disease with daytime and nighttime temperature was obviously different, with a significantly stronger association with high and low temperatures at night than during the day. Under high humidity, the effect of extremely high temperature was significantly higher than extremely low temperature, while no difference was observed for low humidity. This multi-city study suggests that high and low temperatures could increase the risk of eye disease in children, with differences in the effects of daytime and nighttime temperature. Our findings may have public and medical implications in safeguarding children's eye health in the context of climate change.

PMID 42284688
阅读全文 →
PubMedSoins; la revue de reference infirmiere2026-06-13

[Screening for iron deficiency and pneumococcal vaccination: What role do they play in community cardiology?]

Vulliet-Chappaz Céline C

This article presents a single-center, cross-sectional, descriptive epidemiological field study evaluating the screening for iron deficiency and pneumococcal prevention by community cardiologists in patients with heart failure. In total, 90% of the practitioners surveyed reported being familiar with the European Society of Cardiology's recommendations regarding iron deficiency screening, but only 60% perform it at least once a year. In contrast, 90% do not assess the patient's pneumococcal vaccination status. Nearly all respondents stated they are willing to collaborate with an advanced practice nurse.

PMID 42285596
阅读全文 →
PubMedCurrent opinion in cell biology2026-06-13

I did it my way: the origins of lipid droplet heterogeneity.

Bohnert Maria M

Intracellular lipid storage is mediated by lipid droplets. Once considered inert lipid inclusions, these structures are now recognized as ubiquitous, multifunctional organelles at the core of cell biological control of metabolism. Lipid droplet dysfunctions are linked to a range of metabolic diseases including obesity, diabetes, steatohepatitis, and lipodystrophy. Intriguingly, not all lipid droplets are the same. Striking structural and functional differences are regularly observed between the lipid droplets of different tissues and cell types, and even within the lipid droplet pool of a single cell. Here, we discuss the current views on the molecular mechanisms that create and maintain this high degree of lipid droplet heterogeneity.

PMID 42284967
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多didanosine