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colistimethate sodium (ColiFin / ColiFinair)

✓ Approved

EnBiotix · 治疗药物

什么是 colistimethate sodium？

colistimethate sodium 是一种治疗药物，由EnBiotix研发。该药已获批，用于治疗相关适应症，给药途径：Inhaled。

药物档案

商品名ColiFin, ColiFinair
公司EnBiotix
给药途径Inhaled
状态Approved
来源： ClinicalTrials.gov, EnBiotix

治疗适应症

colistimethate sodium 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsPneumonia pseudomonal✓ Approved

相关研究文献

PubMedJournal of dairy science2026-06-13

Effects of sodium hyaluronate with different molecular weights on whey protein-sodium hyaluronate complexes and emulsion gels, and their application in yogurt.

Zhang Herui H, Tao Ran R, Liu Meitong M, Li Yang Y

Whey protein is widely used in yogurt, fermented milk, and other formulated dairy products, but its applications are often limited by phase separation, weak gel structure, and insufficient stability during processing and storage. This study evaluated the effects of sodium hyaluronate with different molecular weights and concentrations on whey protein-sodium hyaluronate complexes, emulsion gels, and their application in yogurt. Sodium hyaluronate interacted with whey protein through noncovalent forces, including electrostatic interactions and hydrogen bonding, and altered protein conformation and interfacial characteristics. Among the tested concentrations, 0.8% sodium hyaluronate provided the best interfacial performance and was selected for subsequent emulsion-gel and yogurt experiments. The resulting emulsion gels showed predominantly elastic behavior and shear-thinning properties, and their viscosity, gel strength, and network-forming capacity increased with sodium hyaluronate molecular weight. When incorporated into yogurt, these emulsion gels improved texture and water-holding capacity, with the greatest improvement obtained from sodium hyaluronate with a molecular weight of 800 to 1,500 kDa. Under the formulation and processing conditions tested, these results demonstrate that regulating sodium hyaluronate molecular weight can improve the structure, gel functionality, and yogurt application performance of whey protein-based dairy systems.

PMID 42285487
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PubMedLymphatic research and biology2026-06-13

23Na-MRI Measures Tissue Sodium in Human Leg Lymphedema.

Taylor Shannon L SL, Crain Vanessa N VN, Chen Sheau-Chiann SC, Pridmore Michael D MD et al.

There are few objective tools to quantify lymphatic disease changes in anatomy and physiology of affected tissues. Tissue sodium could be a relevant physiological indicator of lymphatic disease. However, the importance of sodium to lymphatic physiology in humans has not been well-characterized nor exploited for clinical applications due to a lack of imaging methods to observe sodium and lymphatics together in vivo. The purpose of this study was to apply 23Na-MRI to measure tissue sodium content (TSC) in human subjects with or without lower extremity lymphedema (LEL) and investigate the relationship between lymphatic dysfunction and tissue sodium. A prospective, cross-sectional observational clinical trial enrolled participants with LEL and controls without lymphedema. 23Na-MRI measured standardized TSC in the mid-calf. For each leg with lymphedema, clinical stage was determined by a licensed clinician, and lymphedema severity was determined by radiology assessment of noncontrast hydrogen (1H)-magnetic resonance lymphangiography (MRL). Linear mixed-effects models determined differences in TSC between cases and controls and measured the association of TSC with clinical stage and lymphedema severity. Image subregions were analyzed to observe spatial patterns of TSC involvement. Results found that TSC was nearly 50% higher in lymphedema (n = 52 legs) in the skin (1.51-fold) and adipose tissue (1.47-fold) compared with controls (n = 31 legs; p < 0.001) and was directly related to both clinical stage and lymphedema severity by 1H-MRL in the skin (p < 0.001) and adipose tissue (p < 0.001). TSC accumulated in patterns in the anterior subcutaneous adipose tissue, increasing with disease severity. 23Na-MRI demonstrates that standardized TSC is distinctly elevated in lymphedema, sensitive to lymphedema disease severity, and a potential objective imaging tool for evaluating lymphedema in future clinical trials.

PMID 42286847
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PubMedCarbohydrate polymers2026-06-13

Preparation of water-soluble sodium polyglucuronates from water-insoluble glucans by NaBr-free TEMPO-catalyzed oxidation with sodium dichloroisocyanurate in water.

Chitbanyong Korawit K, Arnandan Pavitra Thevi PT, Hou Runqing R, Shibata Izumi I et al.

NaBr-free TEMPO-catalyzed oxidation with sodium dichloroisocyanurate (NaDCC) used as the consumed co-oxidant in water and room temperature was applied to water-insoluble polyglucans, such as a commercial regenerated cellulose (Bemliese), curdlan, α-(1 → 3)-glucan, corn starch, and 20% NaOH-treated/never-dried ramie. Water-soluble oxidized products with degrees of oxidation (DO) of >0.8 were obtained from Bemliese, curdlan, α-(1 → 3)-glucan, and corn starch by the TEMPO/NaDCC system at pH 9. The mass-average degrees of polymerization (DPw) of the oxidized products were higher than those prepared by the conventional TEMPO/NaBr/NaClO system at pH 10. In the case of 20% NaOH-treated and never-dried ramie, DOs were only ~0.6 and water-soluble oxidized products could not be obtained quantitatively. Consequently, the TEMPO/NaDCC system in water at pH 9 is advantageous for preparation of water-soluble oxidized products with higher DPw values from water-insoluble glucans, such as Bemliese, curdlan, α-(1 → 3)-glucan, and corn starch, by suppression of depolymerization probably because of no NaBrO present in the system. The water-soluble oxidized products or sodium polyglucuronates are possible to be used as biodegradable and metabolizable polymeric builders in laundry detergents.

PMID 42285656
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PubMedAnnals of hepatology2026-06-13

Role of spot urine analyses in patients with cirrhosis and ascites as the single first decompensation event.

Balcars Lorenz L, Wunderbaldinger Adrian A, Simonis Lucie L, Embacher Jan J et al.

Ascites is the most frequent complication in patients with cirrhosis. Although guidelines propose diuretic treatment monitoring through measuring spot urine sodium, data on its application in clinical care as well as its independent prognostic information are surprisingly scarce. We therefore aimed to evaluate the role of spot urine parameters in patients with cirrhosis and ascites. We analysed patients managed at the Medical University of Vienna between 2011 and 2024. Data on urine spot analyses were obtained within 30 days of first ascites development and longitudinally thereafter. The prognostic implication for predicting recurrent ascites within 180 days was evaluated. One-hundred and ten patients (61% male, main aetiology alcohol-related liver disease in 61%) were included. Median spot urine sodium was significantly different according to ascites severity and diuretic therapy (grade II + diuretics: 119.0 vs. grade III + diuretics: 54.5 mmol/L; grade II + no diuretics: 60.0 vs. grade III + no diuretics: 16.0 mmol/L). However, neither baseline nor longitudinal spot urine sodium provided independent prognostic information for the development of recurrent ascites within 180 days after adjustment for liver disease severity. Similarly, the spot urine sodium/potassium ratio, analysed continuously or using established cut-offs, was not independently associated with recurrent ascites. These findings remained consistent in sensitivity analyses considering recurrent ascites within 90 days and after accounting for diuretic therapy. Spot urine analyses around index ascites decompensation were not associated with the development of recurrent ascites in the current study.

PMID 42285228
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PubMedHypertension research : official journal of the Japanese Society of Hypertension2026-06-13

Response to comment on "Sodium, potassium and blood pressure in Australian schoolchildren: exploring differences by sex and weight status-a cross-sectional study".

Grimes Carley A CA, Lim Karen K, Clark Lachlan L, Woodward Mark M et al.

PMID 42286310
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PubMedJournal of endodontics2026-06-13

Application of high-performance liquid chromatography (HPLC) to quantify formaldehyde release from the chemical interaction of sodium hypochlorite (NaOCl) and ethylenediaminetetraacetic acid (EDTA).

Konstantinos Ioannidis I, Irene Katmerou K, Alexandros Nikolaidis N, Ioannis Kolokouris K et al.

PMID 42285459
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