superoxide dismutase (bSOD, OXIS / Orgotase / Peroxinorm)

✓ Approved

什么是 superoxide dismutase？

superoxide dismutase 是一种治疗药物，由GT Biopharma, Inc.研发。该药已获批，用于治疗相关适应症。

药物档案

商品名	bSOD, OXIS, Orgotase, Peroxinorm
公司	GT Biopharma, Inc.
状态	Approved

来源： ClinicalTrials.gov, GT Biopharma, Inc.

治疗适应症

superoxide dismutase 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域	疾病/病症	分期
Nervous system disorders	Amyotrophic lateral sclerosis	✓ Approved
Musculoskeletal and connective tissue disorders	Arthritis	✓ Approved

相关研究文献

PubMedJournal of materials chemistry. B2026-08-04

Glucose-derived ultra-small carbon nanozymes for treating inflammatory bowel disease.

Wang Huibo H, Li Hao H, Guo Jiaqing J, Song Jun J et al.

Inflammatory bowel disease (IBD) encompasses a group of common inflammatory intestinal disorders that are currently challenging to cure. Nanozymes, as an emerging class of therapeutics, hold significant promise in treating IBD. In this study, an ultrasmall, metal-free carbon nanozyme (GNZ) was synthesized from glucose through a one-step hydrothermal method. GNZ exhibited quantitatively characterized superoxide dismutase (SOD)-mimicking catalytic activity and broad-spectrum antioxidant capacity against multiple reactive oxygen and nitrogen species. In LPS-stimulated macrophages, GNZ reduced intracellular oxidative stress and the expression of pro-inflammatory markers while promoting an anti-inflammatory macrophage phenotype. Moreover, oral administration of GNZ alleviated disease symptoms, increased colon length, and reduced colonic tissue injury in DSS-induced colitis mice. These findings demonstrate the potential of glucose-derived GNZ as an orally administered antioxidant nanozyme for alleviating intestinal inflammation.

PMID 42549496

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PubMedEnvironmental science and pollution research international2026-08-04

Ofloxacin impairs photosynthetic efficiency, oxidative homeostasis, and growth in Azolla pinnata.

Chaudhary Hari Dev HD, Mishra Aditi A, Bhatt Upma U, Soni Vineet V

The widespread occurrence of the fluoroquinolone antibiotic ofloxacin (OFL) in freshwater ecosystems poses an emerging threat to non-target aquatic macrophytes. This study investigated the concentration-dependent phytotoxic effects of OFL (0.25-10.0 µg L-1) on Azolla pinnata by integrating biochemical biomarkers with chlorophyll a fluorescence (OJIP) analysis. OFL exposure caused progressive morphological deterioration, reduced relative growth rate, and significant chlorophyll (Chl) loss, accompanied by elevated H2O2 and malondialdehyde accumulation, indicating enhanced oxidative stress. Superoxide dismutase and catalase activities showed an initial stimulation at lower concentrations followed by suppression at higher doses, reflecting antioxidant system failure under severe stress. ChlF and JIP-test analyses revealed impaired PSII photochemistry, reduced electron transport, reaction centre inactivation, and increased energy dissipation. Multivariate analyses confirmed strong negative associations between oxidative stress and photosynthetic performance. Overall, OFL disrupted redox homeostasis and photosynthetic efficiency, demonstrating that A. pinnata is a sensitive bioindicator for assessing antibiotic-induced ecological risks in freshwater ecosystems.

PMID 42547709

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PubMedPlant physiology and biochemistry : PPB2026-08-04

Phenotypical, physiological and molecular identification in Bougainvillea × buttiana 'Miss Manila' leaves by radiation stress.

Wu Kunlin K, Lin Hongling H, Wang Jiameng J, Chen Jinhui J

The beautiful bract coloration of Bougainvillea × buttiana 'Miss Manila' renders it significant for both landscaping and as a key source material for betaine extraction. To understand its response to gamma rays irradiation, we exposed cuttings to varying doses of 60Co-γ radiation and integrated physiological assessments and transcriptome profiling. The results demonstrated that radiation significantly altered the physiological and biochemical characteristics of the leaves. The median lethal dose value is 30-38 Gy, with the highest relative mutation rate observed at a radiation dose of 30 Gy. Antioxidant enzyme activities responded differentially: superoxide dismutase (SOD) activity decreased, while catalase (CAT) activity increased with rising radiation dose. Transcriptome analysis revealed 2211 differentially expressed genes, including 1288 up- and 923 down-regulated, enriched in pathways related to antioxidant defense, osmotic regulation, and DNA repair. qRT-PCR results further confirmed the significant upregulation of antioxidant-related gene IMT1 and DNA repair-related genes CARP1, PBP1, among others. These results not only uncover the physiological and molecular mechanisms underpinning radiation tolerance, but also provide a foundational molecular framework for gamma rays mutation breeding in Bougainvillea.

PMID 42546607

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PubMedVeterinary immunology and immunopathology2026-08-04

Efficacy of intraperitoneal and oral administration of a lectin-adjuvanted microencapsulated scaffold vaccine on immune response in Nile tilapia (Oreochromis niloticus) infected with Streptococcus iniae.

Nandhakumar, Jimsha E E, Wangkahart Eakapol E, Elumalai Preetham P

Streptococcus iniae, an emerging pathogen, significantly impacts the productivity of marine and freshwater aquaculture by causing streptococcosis. Vaccination is a promising strategy to address this challenge. This study investigates an innovative vaccination approach utilizing a biomaterial-based scaffold encapsulated with a lectin adjuvant to combat S. iniae in Nile tilapia (Oreochromis niloticus). The scaffold was prepared via ion gelation using chitosan and alginate, and it was adjuvanted with lectin. The fish were administered with both injection and oral routes, by the formulated vaccine. Both the i.p. and oral vaccinated groups exhibited significantly higher levels of lysozyme, myeloperoxidase, and superoxide dismutase compared to the control group (P < 0.05). Furthermore, increased levels of specific antibody Immunoglobulin M (IgM) were observed, along with notable fold changes in adaptive immune genes in the spleen and head kidney. The treatment group vaccinated with the encapsulated vaccine adjuvanted with lectin demonstrated high survival rates in both routes. These findings highlight the potential of this scaffold-based vaccine delivery and adjuvant for its long-term efficacy both i.p. and oral administration as a novel and effective approach for aquaculture. This strategy could also be applied for the delivery of other vaccines and therapeutics in aquatic species.

PMID 42546425

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PubMedNutricion hospitalaria2026-08-04

Sechium edule var. nigrum spinosum consumption has a hypoglycemic and antioxidant effect in Mexican older people with type 2 diabetes mellitus.

Rosado-Pérez Juana J, Barroso-Pérez Laura Daniela LD, Gavia-García Graciela G, Hernández-Álvarez David D et al.

to determine the hypoglycemic and antioxidant effect of Sechium edule var. nigrum spinosum consumption in older Mexican adults with type 2 diabetes. a quasi-experimental study was conducted in 33 older adults with diabetes: 1) placebo group (PG; n = 14); 2) experimental group (EG; n = 19). The EG consumed 1.5 g of S. edule per day (three 500 mg capsules) for three months, and the PG consumed three placebo capsules of equal appearance for three months. Glycated hemoglobin (HbA1c), lipid peroxides (LPO), protein carbonylation (PC), total oxidative status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), and the activity of the enzymes superoxide dismutase, glutathione peroxidase, and catalase were measured before and after the intervention in both groups. the EG showed a statistically significant decrease in HbA1c (EG: baseline, 8.9 ± 2.2; post. 7.8 ± 2.0), as well as in LPO, PC, TOS and OSI (LPO: baseline, 0.243 ± 0.067; post. 0.222 ± 0.050; PC: baseline, 29.4 ± 10; post. 19.2 ± 6; TOS: baseline, 6.0 ± 2.6; post. 3.1 ± 1.8; OSI: baseline, 5.7 ± 3.1; post 2.0 ± 1.1); along with a significant increase in TAS (baseline, 0.94 ± 0.29; post. 1.22 ± 0.28), changes that were not observed in the CG. the results suggest that S. edule has hypoglycemic and antioxidant effects.

PMID 42549866

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PubMedClinical and experimental reproductive medicine2026-08-04

Ameliorative effects of date palm (Phoenix dactylifera L.) fruit extract on sperm quality, DNA integrity, and oxidative stress in a busulfan-induced model in rats.

Akbari Hakimeh H

This study examined the potential protective role of date palm fruit extract (DPFE) and its underlying mechanisms against busulfan-induced sperm damage and infertility. Sixty male Wistar rats were allocated to control, busulfan alone (10 mg/kg), DPFE alone (4 mg/kg), and busulfan+DPFE co-treatment groups for a period of 56 days. Semen parameters were evaluated along with DNA fragmentation, assessed using the sperm chromatin dispersion test, and protamine deficiency, detected by chromomycin A3 staining. Testicular oxidative stress was assessed by measuring malondialdehyde (MDA) levels as well as superoxide dismutase (SOD) and catalase (CAT) activities. Phytochemical analysis confirmed the high polyphenolic and flavonoid content of DPFE. Busulfan significantly induced testicular oxidative stress, as evidenced by increased MDA levels and reduced SOD and CAT activities. These alterations were accompanied by significant declines in sperm motility and viability, deterioration of sperm morphology, and marked increases in protamine deficiency and DNA fragmentation. Co-administration of DPFE significantly counteracted these adverse effects by normalizing testicular oxidative status, reflected by decreased MDA levels and restoration of SOD and CAT activities. Consequently, DPFE improved sperm motility and morphology and, importantly, reduced the proportion of sperm exhibiting high DNA fragmentation and protamine deficiency. Antioxidant-rich DPFE exerts a significant protective effect against busulfan-induced testicular toxicity, with its mechanism strongly linked to attenuation of testicular oxidative injury, thereby improving conventional sperm quality and, critically, preserving sperm chromatin structure and DNA integrity.

PMID 42547297

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superoxide dismutase (bSOD, OXIS / Orgotase / Peroxinorm)

什么是 superoxide dismutase？

药物档案

治疗适应症

相关研究文献

Glucose-derived ultra-small carbon nanozymes for treating inflammatory bowel disease.

Ofloxacin impairs photosynthetic efficiency, oxidative homeostasis, and growth in Azolla pinnata.

Phenotypical, physiological and molecular identification in Bougainvillea × buttiana 'Miss Manila' leaves by radiation stress.

Efficacy of intraperitoneal and oral administration of a lectin-adjuvanted microencapsulated scaffold vaccine on immune response in Nile tilapia (Oreochromis niloticus) infected with Streptococcus iniae.

Sechium edule var. nigrum spinosum consumption has a hypoglycemic and antioxidant effect in Mexican older people with type 2 diabetes mellitus.

Ameliorative effects of date palm (Phoenix dactylifera L.) fruit extract on sperm quality, DNA integrity, and oxidative stress in a busulfan-induced model in rats.

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