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miriplatin hydrate (miriplatin hydrate / SMP 11355 / Miripla)

✓ Approved

Sumitomo Pharma Co., Ltd. · 小分子 · 小分子

什么是 miriplatin hydrate？

miriplatin hydrate 是一种小分子，由Sumitomo Pharma Co., Ltd.研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intraarterial Injection。

药物档案

商品名miriplatin hydrate, SMP 11355, Miripla
公司Sumitomo Pharma Co., Ltd.
药物类别小分子
给药途径Injectable (Others), Intraarterial Injection
状态Approved
来源： ClinicalTrials.gov, Sumitomo Pharma Co., Ltd.

治疗适应症

miriplatin hydrate 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Hepatic cancer✓ Approved

相关研究文献

PubMedCommunications chemistry2026-06-12

Discovery of a low-density filled-ice phase in nitrogen hydrate at high pressure.

Berni Selene S, Espert Sophie S, Poręba Tomasz T, Di Cataldo Simone S et al.

Nitrogen, Earth's most abundant atmospheric component, in the presence of water, is known to form clathrate hydrates, that are relevant to model the evolution of water-rich planets and satellites. Here, we map the high-pressure phase diagram of nitrogen hydrate up to 16 GPa at room temperature by combining neutron diffraction, Raman spectroscopy, and crystal structure prediction. We reveal a rich sequence of structural transformations, from sI/sII clathrates to hexagonal (sH) and tetragonal (sT) phases, culminating in a previously unknown orthorhombic filled-ice structure above 1.8 GPa. This new phase cannot be indexed to any known ice frameworks and exhibits a density approximately 30% lower than that of stable ice VII, pointing to distinctive water-nitrogen interactions. Our results refine the understanding of nitrogen hydrate behavior under extreme conditions and demonstrate the propensity of N2 and H2O to form stable filled-ice structures up to 16 GPa, with important implications for planetary science.

PMID 42277331
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PubMedNature communications2026-06-12

In-situ ceramic nanoparticle assembly within wood microstructure for strong, tough, and resilient ceramic wood.

Du Fengyin F, Tian Yanpei Y, Niu Zhenyuan Z, Cai Kangyi K et al.

Increasingly extreme environmental conditions demand structural materials that combine mechanical robustness with sustainability. Natural wood is renewable and mechanically adaptable but suffers from high porosity and hydrophilicity, leading to moisture absorption, fire vulnerability, and environmental degradation. Ceramics provide high stiffness, thermal stability, and chemical resistance but are inherently brittle. Here we report ceramic wood, a composite formed by integrating a natural wood scaffold with uniformly distributed ceramic nanoparticles. A calcium silicate precursor infiltrates the aligned nanofluidic channels of wood and undergoes in-situ self-assembly into calcium silicate hydrate nanoparticles under room-temperature conditions. The resulting ceramic network fills micropores and forms strong interfacial bonding within the wood scaffold. Ceramic wood exhibits high compressive strength, enhanced toughness, excellent fire resistance, and improved durability against moisture, fungi attack, and alkaline environments. CO₂ uptake further reduces the carbon footprint, highlighting ceramic wood as a sustainable structural material for extreme environments.

PMID 42277026
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PubMedMolecules (Basel, Switzerland)2026-06-12

Isoxazole-Thiazole Hybrids: Synthesis, Structural Characterisation, Carbonic Anhydrase Inhibition, and Molecular Docking Studies.

Berber Nurcan N, Türkeri Özge Nur ÖN, Başoğlu Faika F, Çıkrıkcı Kubra K et al.

A new series of isoxazole-fused thiazole-oxazole derivatives (11a-n) was rationally designed and synthesised with the aim of developing potent carbonic anhydrase (CA) I and II inhibitors. The synthesis was achieved in five steps starting from 4-bromoacetophenone, involving key intermediates such as hydroxylamine hydrochloride, hydrazine hydrate, thioisocyanate, and various phenacyl bromide derivatives, using ethanol, triethylamine, tetrahydrofuran (THF), and dimethylformamide (DMF) as solvents. The synthetic route included the formation of a β-ketoester, isoxazole ester, hydrazine adduct, thiourea derivative, and, ultimately, a thiazole ring. The structures of the final compounds were confirmed by 1H-NMR, 13C-NMR, IR spectroscopy, and elemental analysis. All compounds were examined as inhibitors of human carbonic anhydrase (hCA) I and II, and all of them inhibited hCA I and hCA II. Kinetic investigation results revealed that these compounds inhibited hCA I and hCA II in a non-competitive manner. To further explore the molecular basis of their inhibitory activity, in silico studies, including molecular docking and 300 ns molecular dynamics (MD) simulations, were carried out against both CA I and CA II isoforms. These simulations provided detailed insights into the dynamic behaviour, stability, and key binding interactions of the compounds within the enzyme active sites, supporting their potential as promising carbonic anhydrase inhibitors.

PMID 42280128
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PubMedSensors (Basel, Switzerland)2026-06-12

Ambient Music Decreases EEG Burst-Suppression Ratio During General Anesthesia in Rats.

Morozan Vlad-Petru VP, Stancu Mihai M, Pâslaru Alexandru-Cătălin AC, Pavel Bogdan B et al.

During deep anesthesia, the EEG becomes discontinuous. Burst-suppression is often an intended target during deep sedation or medically induced coma. Within this state, anesthetic depth is commonly monitored by the suppression ratio (SR), which expresses the fraction of time spent in suppression. However, accumulating evidence suggests that SR remains reactive to external stimulation. We tested whether ambient music commonly played in operating theaters alters the SR in male Wistar rats under sevoflurane, chloral hydrate, or isoflurane anesthesia. To this end, the first 60 s of the Stayin' Alive audio track by the Bee Gees were played to examine auditory-induced burst-suppression reactivity in an experimental model previously established for intermittent photic stimulation. SR and the burst-suppression reactivity index (BSRi, derived as the decrease in SR during stimulation normalized to pre-stimulation SR) were measured in repeated trials. Auditory stimulation transiently decreased SR under all three anesthetics. This was associated with an increase in the rate of burst occurrence without increased burst duration. The BSRi changes depended on the anesthetic type, comparable to photic stimulation. Our experimental data suggest that the suppression ratio used to monitor targeted burst-suppression reflects both anesthetic depth and the level of ambient stimulation. Ambient sound in the operating theater or intensive care settings could influence EEG-based measures used for anesthesia monitoring.

PMID 42281042
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PubMedMaterials (Basel, Switzerland)2026-06-12

Sustainable Concrete Production Using Granodiorite, Alkali Feldspar Granite, and Mafic Metavolcanic Rock Powders as Supplementary Cementitious Materials.

Faried A Serag AS, Fathy Nourhan N, Morsi W M WM, Dawoud Maher M et al.

This study aims to explore the effect of using three distinct silicate- and aluminate-rich rock powders-granodiorite (GDP), alkali-feldspar granite (AFGP), and mafic metavolcanic (MMVP)-sourced from Egypt's largely unexploited Eastern Desert geological resources, as supplementary cementitious materials (SCMs) in concrete production. Rock samples were processed into ultrafine powders (1.4-1.5 μm average particle size) and utilized as partial cement replacements at 3%, 6%, 9%, and 12% by weight. These rock powders were confirmed to meet ASTM C618 requirements for natural pozzolans, qualifying them as viable SCMs. Pozzolanic activity was confirmed through Strength Activity Index (SAI) testing, with values of 79%, 82%, and 76% for GDP, AFGP, and MMVP, respectively, all exceeding the 75% minimum threshold required by ASTM C618. Fresh concrete workability decreased progressively with increasing rock powder content. Mechanical testing demonstrated optimal replacement levels of 9% for GDP and AFGP, and 6% for MMVP, achieving 28-day compressive strength improvements of 14.1%, 16.0%, and 14.9%, respectively, compared to plain Portland cement concrete without any rock powder replacement (control mix). Splitting tensile strength increased by 14.7%, 12.7%, and 16.3% at optimal dosages. Microstructural analysis via SEM revealed enhanced matrix densification and reduced porosity through physical filler effects and pozzolanic reactions. Energy-dispersive X-ray spectroscopy (EDX) confirmed reduced Ca/Si ratios, indicating enhanced calcium silicate hydrate (C-S-H) gel formation with superior binding characteristics. Results demonstrate that these previously unexploited rock powders effectively function as sustainable SCMs, reducing cement consumption by up to 12%, offering significant environmental benefits through reduced CO2 emissions and efficient utilization of natural geological resources in sustainable construction practices.

PMID 42279847
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PubMedMaterials (Basel, Switzerland)2026-06-12

Effect of Water-Solid Ratio on the Performance, Microstructure Evolution, and Low-Carbon Characteristics of Multi-Solid-Waste-Based Flowable Stabilized Soil.

Ni Jiaojiao J, Jiang Qing Q, Zhan Qiwei Q, Hu Haitao H et al.

To promote the high-value utilization of industrial solid wastes and address the disposal of excavated soils, a novel low-carbon composite cementitious material, solid waste-based geopolymer cement (SGPC), was developed, consisting of soda residue (SR), granulated blast furnace slag (GGBS), phosphogypsum (PG), and ordinary Portland cement (PC) in a mass ratio of 10:81:9:25, with industrial solid wastes accounting for 80% of the binder. The effects of water-to-solid ratio (W/S = 0.41-0.49) on the workability, mechanical performance, and microstructural evolution of SGPC-stabilized soil were systematically investigated to provide a sustainable alternative to conventional cement-based stabilizers. The results indicate that the optimum water-to-solid ratio is 0.43 (SGPC43), with a 28-day unconfined compressive strength of 1450 kPa, exceeding the engineering requirement of 0.8 MPa and reaching over 85% of that of a pure cement system (C43). The flowability remained 163 mm after 60 min, with initial and final setting times of 43 h and 58 h, respectively. Microstructural analysis revealed that the alkalinity provided by soda residue promotes the hydration of slag and phosphogypsum, forming interwoven calcium (alumino) silicate hydrate (C-(A)-S-H) and ettringite (AFt), which fill pores and form a dense structure, thereby enhancing mechanical performance. Environmental and economic assessments show that the CO2 emission of SGPC43 per ton of binder decreases from 930 kg CO2-e/t to 235 kg CO2-e/t (approximately 74.7% reduction), while the material cost decreases from 110 USD/t to 53 USD/t (approximately 51.8% reduction). A simplified uncertainty analysis indicates that the carbon reduction remains at 70% ± 5% and the cost reduction at 50% ± 5%, confirming the robustness of the results. Overall, SGPC43 demonstrates excellent engineering performance, environmental benefits, and economic feasibility, highlighting its potential as a low-carbon and sustainable stabilizing material.

PMID 42279901
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