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tramadol (Qdolo)

✓ Approved

Athena Bioscience, LLC · 小分子 · 小分子

什么是 tramadol？

tramadol 是一种小分子，由Athena Bioscience, LLC研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Qdolo
公司Athena Bioscience, LLC
药物类别小分子
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Athena Bioscience, LLC

治疗适应症

tramadol 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Gastrointestinal disordersAbdominal pain✓ Approved

相关研究文献

PubMedPain medicine case reports2026-08-04

Ultrasound-Guided Stellate Ganglion and Interscalene Blocks for Refractory Pediatric Parsonage-Turner Syndrome: A Case Report and Clinical Implications.

Laraib Warda W, Abbas Adeel A, Habib Insha I, Fareh Zohad Z et al.

Parsonage-Turner syndrome (PTS) is an uncommon inflammatory brachial plexopathy; pediatric and bilateral cases are rare, and evidence for managing refractory pediatric pain is limited. A previously healthy 6-year-old girl developed sudden severe left upper-limb pain with progressive wrist-drop in August 2023; by October, the right arm was affected. Nerve conduction studies/electromyography confirmed brachial plexopathy and magnetic resonance imaging showed diffuse thickening of left C5-C7. Laboratory tests were unremarkable, except for an isolated anti-glycosphingolipid monosialo-2 antibody. Oral corticosteroids, tramadol, and 2 intravenous immunoglobulin doses produced limited benefit, and corticosteroids caused mood disturbance. In October 2023, ultrasound-guided stellate ganglion (C6) and interscalene (C5-C6) blocks with 4-6 mL of 0.25% bupivacaine under general anesthesia were performed. At one week, she reported ~85% pain relief; analgesics were reduced to paracetamol. In refractory pediatric bilateral PTS, regional stellate ganglion and interscalene blocks provided rapid, substantial analgesia; prospective studies should define indications and long-term outcomes.

PMID 42550561
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PubMedEuropean journal of pain (London, England)2026-08-03

Trends and Characteristics of Opioid Use During Pregnancy Between 2010 and 2023: A French Nationwide Drug Utilization Study.

Chouchana Laurent L, Herlemont Philippe P, Jourdain Hugo H, Miranda Sara S et al.

While opioid use during pregnancy has raised concerns worldwide, population-based data in Europe remain limited. In France, little is known about opioid use in the context of pregnancy. We conducted a nationwide drug utilization study using the French EPI-MERES Registry, derived from the National Health Data System (SNDS), including pregnancies ≥ 22 weeks from 2010 to 2023. Exposure to weak and strong opioids was assessed before, during and after pregnancy, and according to calendar years. Exposure characteristics included the number of dispensations, prescriber type and oral morphine equivalents. Maternal sociodemographic and clinical characteristics associated with opioid exposure were analysed using multivariable logistic regression models. Among 9.9 million pregnancies, 548,881 (5.5%) were exposed to weak opioids and 12,501 (0.13%) to strong opioids. Weak opioid exposure increased sharply until 2016 (+120%) before stabilizing; diverging trends were observed thereafter: codeine exposure declined to 3.6% in 2023, whereas tramadol exposure continued to rise (+170% during study period) reaching 2.5%. Opioid exposure substantially decreased after conception and remained low throughout pregnancy. Weak opioid prescriptions were not refilled across trimesters in 85%-95% of exposed pregnancies. Opioid exposure was positively associated with maternal socioeconomic deprivation, chronic diseases and psychiatric disorders, with stronger associations observed for strong opioids. In France, opioid use in the context of pregnancy is not infrequent and almost exclusively driven by short-term use of weak opioids. It is strongly associated with maternal vulnerability and low-income status. Although overall opioid exposure stabilized since 2016, the continuous rise in tramadol use warrants further monitoring. Population-based evidence on opioid use during pregnancy is scarce in Europe and has been lacking in France. This nationwide study provides the first comprehensive analysis of prescription opioid use in pregnancy in France over a 14-year period, identifying prescribing patterns and populations most likely to be exposed. After a marked increase at the beginning of the study period, overall opioid exposure is stable. In the most recent years, one in 16 pregnant women is exposed to an opioid, almost exclusively a weak opioid, and we observed a sustained rise in tramadol exposure throughout the study period. These findings establish a benchmark for future surveillance.

PMID 42544881
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PubMedMedical science monitor : international medical journal of experimental and clinical research2026-08-02

Ultrasound-Guided Pericapsular Nerve Group Block vs Suprainguinal Fascia Iliaca Block for Analgesia in Hip Fracture Surgery: A Prospective Comparative Observational Study.

Dedeoğlu Andaç A, Acil Fatma F, Andıç Okan O, Uzundere Osman O et al.

BACKGROUND Hip fractures cause severe perioperative pain, increased opioid use, and delayed recovery. The ultrasound-guided pericapsular nerve group (PENG) and suprainguinal fascia iliaca (SIFI) blocks are regional techniques targeting hip innervation. This study aimed to compare the effects of ultrasound-guided PENG and SIFI blocks on perioperative analgesia and clinical outcomes in hip fracture surgery. MATERIAL AND METHODS This prospective observational study included patients undergoing hip fracture surgery under spinal anesthesia. Patients received either an ultrasound-guided PENG block or a suprainguinal fascia iliaca block as part of routine clinical practice. The primary outcome was perioperative pain intensity measured using the numerical rating scale (0-10), including baseline pre-block assessments, pain during spinal positioning, and postoperative pain scores. All other variables, including ease of spinal positioning, hemodynamic parameters, cumulative 24-hour postoperative tramadol consumption, time to first analgesic requirement, range of motion of the affected limb, patient satisfaction, and adverse events, were evaluated as secondary outcomes. RESULTS A total of 67 patients were included (PENG, n=34; SIFI, n=33). The SIFI group had significantly lower pain scores in the neutral position (P=0.004), during limb elevation (P<0.001), and at 2 to 8 hours postoperatively (P<0.001). The 24-hour consumption of tramadol was lower (P=0.011), and active hip flexion at 8 hours was greater (P=0.001) in the SIFI group. Other outcomes were similar. CONCLUSIONS Both the PENG and SIFI blocks provided effective perioperative analgesia. SIFI was associated with lower pain scores at selected intervals and reduced opioid consumption; however, these findings represent time-specific associations rather than definitive superiority.

PMID 42542564
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PubMedJournal of anaesthesiology, clinical pharmacology2026-08-02

Comparison of patient-controlled lumbar erector spinae plane block with patient-controlled epidural block for postoperative analgesia in patients undergoing surgery for fracture femur.

Saini Suman S, Manu K A KA, Gupta Anju A

Lumbar erector spinae plane block (LESPB) is a promising technique for providing analgesia during hip surgery; however, its efficacy in femur shaft fracture surgery has not been well studied. Furthermore, patient-controlled LESPB has not been compared with patient-controlled epidural analgesia (PCEA). Eighty patients aged 18-65 years undergoing unilateral femur fracture surgery were randomly divided to receive either ultrasound-guided patient-controlled LESPB (Group A; n = 40) or PCEA (Group B; n = 40) preoperatively, and a catheter was placed. Thereafter, 3 mL of 0.5% hyperbaric bupivacaine with 10 μg of fentanyl was administered via a subarachnoid block. We compared the cumulative numeric rating scale (NRS) score at 24 h. The secondary objectives included the total local anesthetic (LA) boluses consumed, rescue analgesia required, and patient satisfaction over 24 h in each group. NRS at 2 and 4 h was significantly higher in Group A (P = 0.023 and 0.015, respectively); however, the cumulative NRS at 24 h was comparable (P = 0.380). The mean (SD) paracetamol requirement [0.22 (0.42) vs. 0.12 (0.33) g; P = 0.245], tramadol consumption [2.50 (11.04) vs. 1.25 (7.91); P = 0.569], and time to first rescue analgesia [0.78 (0.67) vs. 1.00 (1.26) h; P = 1.00] were comparable. The median (interquartile range) LA boluses were comparable between the groups [3 (2-4) vs. 3 (2-3); P = 0.243]. The hemodynamic variables and patient satisfaction were similar. Our results indicate that patient-controlled LESPB is as efficacious as PCEA in patients undergoing femur fracture surgery in terms of cumulative pain scores over 24 h, rescue analgesia requirements, and patient satisfaction. Although there were transiently higher pain scores, its potential relative safety profile compared with epidural analgesia suggests that LESPB is a promising alternative for managing pain in this patient population.

PMID 42541212
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PubMedSalud publica de Mexico2026-07-31

López-Brambila Miguel Ángel MÁ, Fleiz-Bautista Clara C, Cruz-Martín Del Campo Silvia Lorenia SL, Cruz-López Miguel Bencomo MB et al.

Identificar los medicamentos con potencial psicoactivo y uso indebido en la población mexicana. Material y métodos. Se utilizaron datos de la Encuesta Nacional de Consumo de Drogas, Alcohol y Tabaco 2025, la muestra incluyó a 555 personas que reportaron uso indebido de medicamentos psicoactivos alguna vez en la vida, y representan a 2.4 millones de personas. El medicamento más reportado fue el tramadol (86.8%), sustancia clasificada como opioide. Le siguieron el clonazepam (76.5%) y el diazepam (15.1%), ambos tranquilizantes. En tercer lugar, se encontró el metilfenidato (37.8%), considerado un estimulante de uso médico. Otros medicamentos fueron mencionados con muy baja frecuencia, entre ellos morfina, fentanilo, alprazolam, flunitrazepam, clobenzorex, fentermina, anfetamina, fenobarbital y pregabalina. Conclusión. La regulación del uso indebido de medicamentos psicoactivos en México requiere fortalecer los mecanismos de coordinación, supervisión y vigilancia, así como promover estrategias de prevención e impulsar la educación en salud.

PMID 42536901
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PubMedJournal of maxillofacial and oral surgery2026-07-30

Tramadol hydrochloride vs. lignocaine hydrochloride in the extraction of anterior teeth: a randomised comparative study.

Agarwal Srishti S, Lakshmanan Saravanan S, Krishnan Murugesan M, Arularasan Gidean G

Tramadol hydrochloride (T-HCL) has shown potential local anesthetic properties but its efficacy in dental extraction remains unclear. This study aimed to compare the local anesthetic effect of tramadol with that of lignocaine hydrochloride (L-HCL) in the extraction of maxillary anterior teeth. It was a randomized, double-blind, controlled trial. Patients aged 18-60 years, requiring extraction of one or more maxillary anterior teeth were included in the study. The patients were assigned into two groups: Group A received 1.8 ml of 5% T-HCL and Group B received 1.8 ml of 2% L-HCL without adrenaline, respectively. Amount of anesthesia administered, onset of anesthesia, and intraoperative pain were evaluated using unpaired t tests. Forty patients were enrolled. The study results revealed that the amount of anesthesia required was higher in the tramadol group than in the lignocaine group. The onset of anesthesia was faster in the tramadol group (4.5 ± 0.88 min) compared to the lignocaine group (5.35 ± 0.87 min) Intraoperative pain, measured using the Visual Analog Scale (VAS), was slightly higher in the tramadol group (0.85 ± 0.78 min) compared to the lignocaine group (0.5 ± 0.4 min). Tramadol has less potent, higher dose is required for the desired anesthetic property which cannot be recommended as a first-line anesthetic. However, it can be considered as alternative drug for patients who are allergic to lignocaine or other conventional local anesthetics.

PMID 42528899
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