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simvastatin + triflusal (IRIST stent)

✓ Approved

Palau Pharma · HMGCR · 小分子

什么是 simvastatin + triflusal?

simvastatin + triflusal 是一种小分子,由Palau Pharma研发。该药已获批,用于治疗相关适应症,给药途径:Surgical Implantation。

药物档案

商品名IRIST stent
公司Palau Pharma
药物类别小分子
分子靶点HMGCR, PDE4A, PDE4B, PDE4C, PDE4D, PTGS1, PTGS2
给药途径Surgical Implantation
状态Approved

作用机制

分子靶点

simvastatin + triflusal 作用于 7 个分子靶点:

HMGCR3-hydroxy-3-methylglutaryl-CoA reductase (LDLCQ3, MYPLG)
PDE4Aphosphodiesterase 4A (PDE4, DPDE2)
PDE4Bphosphodiesterase 4B (PDEIVB, DPDE4)
PDE4Cphosphodiesterase 4C (DPDE1, PDE21)
PDE4Dphosphodiesterase 4D (PDE43, STRK1)
PTGS1prostaglandin-endoperoxide synthase 1 (PCOX1, COX3)
PTGS2prostaglandin-endoperoxide synthase 2 (PHS-2, GRIPGHS)
需要更深入的分析?Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

simvastatin + triflusal 针对 1 个适应症,涉及 1 个治疗领域。

治疗领域疾病/病症分期
Injury, poisoning and procedural complicationsRestenosis✓ Approved

相关研究文献

PubMedFrontiers in surgery2026-08-04

Case Report: Ureteral double-J stent placement: a rare case of ureteral perforation complicated by periureteral abscess.

Zhou Tao T, Yao Lei L

This case report presents the first documented instance of ureteral perforation complicated by a periureteral abscess following double-J stent placement. The diagnostic and therapeutic experience is summarized herein. An 83-year-old female with type 2 diabetes mellitus and ureteral calculi underwent ureteral stent insertion for stone-induced obstruction. Subsequently, she developed ureteral perforation accompanied by a periureteral abscess. Management involved stent removal, left percutaneous nephrostomy, ultrasound-guided abscess drainage, and targeted antibiotic therapy. Eventually, the patient's symptoms resolved, the abscess was completely absorbed, and no recurrence was observed during follow-up. Double-J ureteral stent insertion can lead to numerous life-threatening complications. Improper stent placement may result in ureteral perforation and subsequent periureteral abscess formation. This risk is particularly elevated in elderly diabetic patients with chronic infection due to ureteral calculi, as the ureteral wall is fragile and prone to perforation during retrograde catheterization. Percutaneous nephrostomy may represent a more appropriate strategy for relieving obstruction in such cases. If stent insertion is performed, forceful maneuvers must be avoided during the procedure, the procedure should be performed under fluoroscopic guidance and early postoperative CT imaging is recommended to confirm proper stent positioning. Ureteral perforation typically heals spontaneously without surgical repair. Once a periureteral abscess develops, prompt percutaneous drainage is essential, as antibiotic therapy alone has limited efficacy.

PMID 42548624
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PubMedNetherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation2026-08-04

Optical coherence tomography-guided orbital atherectomy for calcified coronary lesions: rationale and design of the CROWN study.

Ntantou Eleni E, Siskos Alexandros A AA, van Mieghem Nicolas M NM, Daemen Joost J et al.

The Orbital Atherectomy System (OAS) has demonstrated high procedural success, with excellent stent deliverability and low complication rates. The effects of orbital atherectomy (OA) and its impact on calcified coronary plaques are not yet fully understood, highlighting the need for a larger and more comprehensive study. Calcium Reduction by Orbital Atherectomy in Western Europe (CROWN) is an ongoing study that aims to evaluate the effects of OA in treating de novo, severely calcified coronary lesions before stent placement using optical coherence tomography (OCT), and to assess stent expansion by measuring the OCT-derived minimum stent area (MSA). The CROWN study is a prospective, multicenter, international, single-arm observational study. We will enroll 100 patients with severely calcified coronary lesions undergoing OCT-guided orbital atherectomy and stent placement. All patients will undergo peri-procedural OCT imaging, with assessments conducted before and after OA, as well as following stent placement. Patients will be enrolled at a maximum of 6 sites in the Netherlands, Germany, and Italy. The primary endpoint is to assess the proportion of patients achieving stent expansion, defined as an OCT-derived MSA ≥ 5.5 mm2. The CROWN study will evaluate the impact of OA on calcified plaques, potentially refine operator practices, and provide additional insights on device selection for treating severely calcified lesions (clinicaltrials.gov NCT06035783).

PMID 42550426
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PubMedAnnals of vascular diseases2026-08-04

Stent Grafting for a Saccular Aneurysm of Cryopreserved Homograft after Implantation for Infectious Abdominal Aortic Aneurysm.

Yanase Yosuke Y, Matsuda Yuka Y, Sakata Junichi J, Nakamura Masanori M

An 82-year-old man underwent surgical repair of an infectious abdominal aortic aneurysm using a cryopreserved homograft. Twelve years later, a pseudoaneurysm at the right iliac anastomosis was treated with a stent-graft limb. Sixteen years after the initial surgery, a saccular aneurysm developed in the mid-portion of the homograft without signs of infection. Endovascular aortic repair using an AFX2 stent graft (Endologix, Irvine, CA, USA) was performed to cover the entire graft. Postoperative CT showed no endoleaks or aneurysm enlargement. Although homografts are considered infection-resistant, late degenerative complications may occur, requiring lifelong follow-up.

PMID 42548605
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PubMedJACC. Case reports2026-08-04

IVUS-Guided Orbital Atherectomy and Intravascular Lithotripsy for Severely Calcified Coronary Lesions.

Sahoo Saroj Kumar SK, Vijayvergiya Rajesh R, Barik Ramachandra R, Kadiyala Vikas V et al.

Severely calcified coronary lesions complicate percutaneous coronary intervention (PCI) by impairing device delivery and stent expansion, often necessitating advanced plaque-modification strategies. Three patients with calcified left anterior descending artery disease underwent intravascular ultrasound (IVUS)-guided PCI with orbital atherectomy (OA), intravascular lithotripsy (IVL), and balloon dilation. In patient 1, a balloon-uncrossable lesion was treated with OA, followed by IVL when balloon dog-boning suggested residual deep calcium. In patient 2, OA-related dissection and slow flow were managed with provisional stenting, followed by IVL for persistent proximal calcium-related resistance. In patient 3, Ellis type III coronary perforation during postatherectomy balloon dilation was sealed with a covered stent, followed by IVL for proximal lesion preparation. Angiographic and IVUS assessments showed stent expansion and apposition in patients, with no adverse events during the 5-month follow-up. These cases illustrate the feasibility of an IVUS-guided escalation strategy for resistant calcified coronary lesions. This case series suggests that a stepwise, IVUS-guided multimodality strategy may facilitate successful outcomes and aid optimal stent deployment in complex calcified PCI.

PMID 42550118
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PubMedJACC. Cardiovascular imaging2026-08-04

Optimize the Stent to Optimize the Future When Stenting Calcified Coronary Lesions: Novel Insights From ILUMIEN IV.

Young Laura L, Puri Rishi R

PMID 42547198
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PubMedEuropean heart journal. Cardiovascular pharmacotherapy2026-08-04

Authors' reply to: "Stent-Free Is Not Risk-Free: Risk-Defined DAPT After DCB-Only PCI in ACS".

Håkansson Anton A, von Koch Sacharias S, Dahlgren Axel A, Reitan Christian C et al.

PMID 42547055
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