Rottapharm Madaus · 小分子 · 小分子
Oxalyt-C 是一种小分子，由Rottapharm Madaus研发。该药已获批，用于治疗相关适应症。
| 公司 | Rottapharm Madaus |
| 药物类别 | 小分子 |
| 状态 | Approved |
Oxalyt-C 针对 1 个适应症，涉及 1 个治疗领域。
| 治疗领域 | 疾病/病症 | 分期 |
|---|---|---|
| Renal and urinary disorders | Calculus urinary | ✓ Approved |
Machado Emerson Fernando Garcia EFG, Linhares Josiane Aparecida JA, Dugonski Maria Eduarda ME, Cazarote Helena Bianchi HB et al.
HLA-C*12:475 differs from HLA-C*12:03:01:01 by a nonsynonymous substitution in exon 1.
Li Zeda Z, Zhu Biqiong B, Chen Kui K, Long Xiangdang X et al.
While the associations of low-density lipoprotein cholesterol (LDL-C) and the triglyceride-to-high-density lipoprotein cholesterol ratio (TG/HDL-C) with carotid atherosclerosis are known, their age-varying trajectories remain unclear. This study aimed to characterize the age-specific heterogeneity in these associations using a large Chinese health check-up cohort. We retrospectively enrolled 23,058 adults undergoing carotid ultrasonography. After exclusions, 21,227 participants were included. Multivariate logistic regression evaluated the independent associations of LDL-C and TG/HDL-C with carotid plaque. Age-stratified analyses (<40, 40-49, 50-59, 60-69, ≥70 years) and interaction tests were performed. Sensitivity analyses included substituting non-HDL-C for LDL-C and the triglyceride-glucose index (TyG index) for TG/HDL-C. Associations with hypoechoic plaques were also assessed. The carotid plaque detection rate was 31.4% (6,657/21,227). Both LDL-C (OR = 1.12, 95% CI: 1.08-1.17, P < 0.001) and TG/HDL-C (OR = 1.11, 95% CI: 1.07-1.15, P < 0.001) were independently associated with plaque. However, their age patterns diverged significantly. The association of LDL-C was strongest in participants aged <40 years (OR = 1.51, 95% CI: 1.30-1.76) but attenuated with age, becoming non-significant in those ≥60 years (P for interaction <0.001). Conversely, the TG/HDL-C association remained stable across age groups, with the numerically highest ORs observed in the <40 and 50-59 age groups (OR = 1.20 and 1.15, respectively), though the age interaction was not significant (P = 0.544). Within the plaque population, LDL-C correlated with hypoechoic plaques (OR = 1.23, 95% CI: 1.16-1.30), while the TyG index did not. LDL-C and TG/HDL-C exhibit distinct age-modified patterns of association with carotid plaque. The LDL-C association is most pronounced in younger individuals, whereas the TG/HDL-C association remains relatively stable across age strata. These cross-sectional findings generate the hypothesis that age-specific lipid assessment strategies may warrant prospective evaluation.
Siegel Ruby J RJ, Hacke Katrin K, Gebhart Catherine L CL, Franz Brian J BJ et al.
HLA-C*07:1268 differs from HLA-C*07:02:01:01 by one nucleotide substitution in exon 3.
Karale Bhagyashri B, Tambe Manisha M, Rajak Jyoti J, D'Silva Selma Zenia SZ
HLA-C*06:02:01:117 differs from HLA-C*06:02:01:01 by single nucleotide change in the 5'UTR at position gDNA -149.
Karale Bhagyashri B, Tambe Manisha M, Rajak Jyoti J, D'Silva Selma Zenia SZ
HLA-A*33:03:01:32 and HLA-C*04:01:01:205 differ from HLA-A*33:03:01:01 and HLA-C*04:01:01:01 by a single nucleotides within introns respectively.
Chu Zhuding Z, Shu Lishan L, Liu Yu Y, Jiang Pengcheng P et al.
Addressing the conflict between rising sludge production and its resource utilization, this study evaluated environmental risks and resource potential of sludge-derived biochar. The nutrients and heavy metals in sludge and biochar were systematically analyzed based on mixed industrial-domestic sludge and purely domestic sludge, produced at pyrolysis temperatures from 350°C to 800°C. Results indicated that sludge source critically determined its resource utilization pathway. For mixed sludge, pyrolysis at 550-650°C concentrated total nutrients by 77-82% (peaking at 13-14.5%), whereas domestic sludge retained available nitrogen best at < 450°C, limiting nitrogen loss to < 50%. Pyrolysis reduced environmental risks by stabilizing heavy metals. For mixed sludge at 650°C, residual fractions of Cu, Cr, and Pb exceeded 80%, reducing potential ecological risks (RI) to mild pollution levels (38.98 and 21.14). For domestic sludge at 450°C, Cd and Zn leaching toxicity was effectively passivated to below 0.001 mg/kg and 2 mg/kg, respectively, meeting safety standards. This study confirms that a temperature-based strategy based on source differentiation can simultaneously optimize the nutrient efficiency and environmental safety of sludge-derived biochar, providing important insights and theoretical framework for fertilizer use in future studies.
注册免费账户还可查看另外 9996 篇文献
免费注册查看全部文献 →