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Drug Database
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Oxalyt-C

✓ Approved

Rottapharm Madaus · 小分子 · 小分子

什么是 Oxalyt-C？

Oxalyt-C 是一种小分子，由Rottapharm Madaus研发。该药已获批，用于治疗相关适应症。

药物档案

公司Rottapharm Madaus
药物类别小分子
状态Approved
来源： ClinicalTrials.gov, Rottapharm Madaus

治疗适应症

Oxalyt-C 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Renal and urinary disordersCalculus urinary✓ Approved

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A total of 558 fecal samples from beef cattle were collected across five counties in Xinjiang, China, and tested for Cryptosporidium using nested PCR targeting the small subunit (SSU) rRNA gene. The overall infection rate of Cryptosporidium was found to be 20.6% (115/558). Notably, the highest infection rate, 32.8% (43/131), was observed in post-weaned calves, followed by pre-weaned calves at 29.0% (38/131), juvenile cattle at 16.5% (21/127), and adult cattle at 7.7% (13/169). Four species of Cryptosporidium were identified: C. parvum (n = 21), C. bovis (n = 62), C. ryanae (n = 17), and C. andersoni (n = 15). Sequence analysis of the gp60 gene revealed two subtypes of C. parvum, specifically IIdA19G1 (n = 2) and IIdA16G1 (n = 11). Additionally, five subtype families of C. bovis were identified: XXVIa (n = 7), XXVIb (n = 5), XXVIc (n = 6), XXVId (n = 7), and XXVIf (n = 8). For C. ryanae, three subtype families were identified: XXIc (n = 1), XXIf (n = 1), and XXIg (n = 8). Phylogenetic analysis indicated that the identified C. parvum subtypes clustered within a subclade alongside sequences from both domestic and international sources, as well as from various hosts. The subtype sequences of C. bovis and C. ryanae were found to group into larger clades with subtype sequences from cattle in different regions of China, demonstrating no significant genetic evolutionary divergence. To our knowledge, this is the first report of the subtype IIdA16G1 of C. parvum in cattle within China. These findings underscore the high genetic diversity of Cryptosporidium spp. in beef cattle in Xinjiang, thereby enriching the understanding of the population genetic structure of Cryptosporidium spp. in this region.

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Effects of gelling and drying temperatures on the network structure and physicochemical properties of κ-carrageenan films and rehydrated hydrogels.

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This study investigated the regulation mechanism of gelling and drying temperatures on the network structure and physicochemical properties of κ-carrageenan films and rehydrated hydrogels. Microstructure observation revealed that films gelled at 10 °C and dried at 40 °C exhibited an ordered network structure with a smooth surface, whereas those dried at 60 °C or 80 °C showed extensive aggregates and surface salt precipitation. Moreover, films gelled at 10 °C showed the highest tensile strength (81.66 MPa), melting transition temperature (146.10 °C), and swelling ratio (3974.25%). In contrast, films dried at 80 °C exhibited the highest elongation at break (32.40%). In conclusion, appropriate gelling combined with drying promoted an ordered network in κ-carrageenan films, allowing direct use for food packaging and rehydration into highly transparent culture media. These findings lay a foundation for the structural regulation, performance optimization and multi-functional application.

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Familial hypercholesterolemia (FH) is a genetic disorder characterised by elevated low-density lipoprotein cholesterol (LDL-C) and increased risk of premature atherosclerotic cardiovascular disease. In Denmark, general practitioners (GPs) play a key role in identifying and referring patients with suspected FH, yet referral rates remain low. To assess GPs' awareness of FH among patients with LDL-C values above guideline-based thresholds and examine how individual patient factors influence awareness. We conducted a retrospective audit of 304 patient records from 14 general practices in the Central Denmark Region. Audit inclusion criteria were LDL-C ≥5.0 mmol/L, or ≥4.0 mmol/L if aged <40 years, and a recorded consultation in primary care. Full-text medical records were reviewed, and systematic keyword searches identified documentation related to FH. Data was extracted using a structured audit form aligned with national guidelines, capturing demographics, LDL-C levels, treatments, and referral status. The median age was 58 years (IQR 51-65) and 54.6% were females. Median first LDL-C above threshold was 5.3 mmol/L. FH awareness was documented in 29% of records, despite all patients having LDL-C values above guideline-based thresholds. Referral rates to lipid clinics were 18% overall, varying by clinic affiliation. FH awareness rates were higher among patients with higher LDL-C values and younger age at presentation. The first LDL-C value also influenced subsequent statin initiation. GPs' awareness and referral rates for FH were low. FH awareness, LDL-C value, and age influenced management and referral rates, highlighting the need for improved support in identifying FH in primary care.

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Luminescent heparin-functionalized carbon dots with potential applications in nanoparticle-protein interactions and cell imaging.

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Ultrasound treatment of maize starches with varying amylose and gelatinisation state.

Zhu Minqian M, Xiong Weiyan W, Kumar Gaurav G, Liu Xingxun X et al.

To elucidate how ultrasound affects starch architecture, starches with varying amylopectin/amylose ratios and pre-gelatinised states were systematically investigated. Waxy maize starch (WMS, 1% amylose), normal maize starch (NMS, 26% amylose), and Gelose 80 (G80, 80% amylose) were pre-conditioned to non- (A: 50 °C), semi- (B: 65 °C/85 °C), and fully gelatinised (C: 95 °C/140 °C) states prior to sonication (20 kHz, 1 h, 2250 J/cm3). Multi-scale structural characterization, spanning granular to molecular levels, was performed using mastersizer, polarised light microscopy, scanning electron microscopy (SEM), differential scanning calorimetry (DSC), X-ray diffraction (XRD), small-angle X-ray scattering (SAXS), Nuclear Magnetic Resonance (NMR) and size-exclusion chromatography (SEC). Ultrasound promoted granule disruption and amylopectin dispersion, accompanied by significant reductions in gelatinization enthalpy (ΔH), relative crystallinity (RC), SAXS peak intensity (q ≈ 0.07 Å-1), and double-helix content. In contrast, crystalline polymorphism, single-helix content, and molecular size distribution remained largely unchanged. These findings reveal selective ultrasound-induced modulation primarily targeting amylopectin double helices, with structural susceptibility dictated by amylopectin architecture and granule integrity.

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