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hydroxyprogesterone caproate (Makena SQ / 17P / Makena)

✓ Approved

Lumara Health · PGR

什么是 hydroxyprogesterone caproate？

hydroxyprogesterone caproate 是一种治疗药物，由Lumara Health研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intramuscular (IM) Injection、Subcutaneous Injection。

药物档案

商品名Makena SQ, 17P, Makena
公司Lumara Health
分子靶点PGR
给药途径Injectable (Others), Intramuscular (IM) Injection, Subcutaneous Injection
状态Approved
来源： ClinicalTrials.gov, Lumara Health

作用机制

分子靶点

hydroxyprogesterone caproate 作用于 1 个分子靶点：

PGRprogesterone receptor (NR3C3, PR)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

hydroxyprogesterone caproate 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Pregnancy, puerperium and perinatal conditionsPremature labour✓ Approved

相关研究文献

PubMedResearch square2026-06-12

Metabolomic signatures of the steroid biosynthesis driving sex differences in clinical asthma subtypes.

Dairo Gbenga G, Sharma Rinku R, Kelly Rachel S RS, Mendez Kevin K et al.

Background Asthma is a heterogeneous disease with well-documented sex differences in prevalence. However, the sex-specific and pubertal effects of inhaled corticosteroids on endogenous steroid metabolites and their relationship with asthma-related clinical outcomes remain poorly understood. Methods Targeted whole-blood plasma profiling of the steroid biosynthesis pathway was generated by Precion Inc. (NC, USA). Sixteen metabolites from the steroid biosynthesis pathway were quantified at baseline and end-of-trial in children with asthma from the Childhood Asthma Management Program (CAMP; n = 1,041), aged 5-12 years. Linear mixed models and generalized linear models were used to evaluate sex-specific longitudinal and endpoint responses of steroid metabolites and clinical outcomes with inhaled corticosteroid (ICS) use, adjusting for age, sex, race, height, and body mass index. Results ICS use in males was associated with significantly lower cortisol and cortisone levels at Year 4 (end of trial). In females, cortisol and cortisone showed more stable trajectories with ICS use, which resulted in a non-significant reduction at year 4. Males receiving ICS showed suggestive positive longitudinal associations for 17α-hydroxyprogesterone, estrone, and testosterone, while females showed a suggestive positive trajectory for androstenedione. ICS exposure modified the associations between metabolites and clinical outcomes (FEV1, FVC, eosinophils, and airway hyperresponsiveness) in a pathway- and sex-specific manner. Overall, ICS attenuated longitudinal associations between endogenous steroids and clinical outcomes, particularly in females, while selected relationships from the androgen-lung function associations were preserved at the end of the trial. Conclusion We identify sex-specific differences in ICS-associated metabolite profiles and clinical outcomes, supporting the need for further investigation into sex-informed approaches to corticosteroid use in pediatric asthma. Trial registration: Clinicaltrials.gov: NCT00000575; registered 1999-10-27.

PMID 42282026
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PubMedBiophysical chemistry2026-06-08

Probing the interactions between bovine hemoglobin and three berberine saturated fatty acid salts by multi-spectral techniques, conductimetry and molecular docking.

Zhang Mengwei M, Yan Zhenning Z, Hu Liuyang L, Wen Xiangli X

The clinical application of berberine is limited by its poor bioavailability. To overcome this, berberine-saturated fatty acid salts have been developed, yet their interaction mechanism with hemoglobin, a key transport protein, remains unclear. This study aims to comprehensively investigate the interactions between bovine hemoglobin (BHb) and three berberine mid-chain saturated fatty acid salts ([BBR][FAs], specifically berberine caproate ([BBR][CAP]), berberine heptylate ([BBR][HEP]), berberine octanoate ([BBR][OCT])) by various experimental and molecular docking methodologies. UV-visible and fluorescence spectroscopic analyses demonstrate that [BBR][FAs] can bind to BHb with 1:1 stoichiometry and quench its fluorescence intensity through a static quenching mechanism. According to the evidence of synchronous fluorescence, three-dimensional fluorescence and FT-IR spectrometry, it was found that the microenvironment and secondary structure of BHb undergo alterations upon binding with [BBR][FAs]. Based on Förster resonance energy transfer analysis, the binding distance between [BBR][FAs] and BHb was determined to be within the range of 2.98 to 3.15 nm. This binding is associated with an increase in the esterase-like activity of BHb. The aggregation behavior of [BBR][FAs] in BHb aqueous solution was investigated from conductivity measurement. The critical aggregation concentration of [BBR][FAs] exhibited a positive correlation with increasing concentrations of BHb. Molecular docking data confirmed that the binding of [BBR][FAs] to BHb was principally mediated by hydrophobic interaction, hydrogen bonding and van der Waals force. Furthermore, this work systematically compared the chain length-dependent binding affinity between [BBR][FAs] and BHb, and observed the order of binding strength as: [BBR][CAP] ˂ [BBR][HEP] ˂ [BBR][OCT]. These findings provide quantitative structure-affinity relationship data.

PMID 42258961
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PubMedCase reports in endocrinology2026-06-08

21-Hydroxylase Deficient Congenital Adrenal Hyperplasia Due to Maternal Uniparental Isodisomy.

Kluge Michelle L ML, Schema Lynn L, Schroepfer Katy K, Thoreson Emily K EK et al.

Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD CAH) is an autosomal recessive genetic condition that results from pathogenic variants in the CYP21A2 gene. Noncarrier parents are found in a small percentage of cases, typically due to de novo variants. However, uniparental disomy (UPD) should also be considered. UPD is generally suspected when an individual with an autosomal recessive condition is found to be homozygous for a rare pathogenic variant and consanguinity has been ruled out. However, UPD in CYP21A2 may be hard to recognize because homozygous genotypes are not uncommon. We present the case of a 19-month-old male born preterm who presented to pediatric endocrinology after a positive newborn screen for CAH. He was small for gestational age, with a history of adrenal crisis and elevated 17-hydroxyprogesterone (17-OHP). Genetic testing revealed homozygosity for two common pathogenic CYP21A2 variants: c.293-13C >G and c.1360C >T (p.Pro454Ser), both variants were found in the heterozygous state in the mother while the father's CYP21A2 molecular testing was negative. UPD testing was pursued and the results were consistent with the patient having maternal isodisomy of chromosome 6. In cases of patients with CAH due to homozygous CYP21A2 variants, suspicion for UPD may be increased if the child also presents with intrauterine growth restriction (IUGR), or transient neonatal diabetes (TNDM) mellitus, associated with maternal and paternal UPD of chromosome 6, respectively.

PMID 42256322
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PubMedBioresource technology2026-06-07

Hydrogen supplementation improves glucose-based n-caproate production in Caproiciproducens galactitolivorans with reverse β-oxidation-associated redox remodeling.

Nair Pranav Sasidharan PS, Kim Hyunjin H, Kang Seongcheol S, Jeon Byoung Seung BS et al.

Medium-chain carboxylic acids, such as n-caproate, are attractive sustainable platform chemicals. However, their microbial production is often limited by electron availability and low product selectivity. This study investigated the effect of hydrogen supplementation on glucose-based n-caproate production by Caproiciproducens galactitolivorans. Batch fermentation was performed under various hydrogen pressures (0 to 600 kPa). At 600 kPa hydrogen,n-caproate reached 8.0 g L-1, accompanied by a 66% increase in n-caproate selectivity and a tenfold increase in the intracellular redox-cofactor ratio, consistent with enhanced redox-cofactor turnover. Multi-omics analysis indicated metabolic remodeling under hydrogen-enriched conditions, including the increased abundance of key enzymes in the reverse β-oxidation pathway and redox-associated functions. In contrast, although fatty acid biosynthesis genes were transcriptionally induced, this transcriptional increase was not reflected at the protein level, suggesting a metabolic response more consistent with reverse β-oxidation-supported n-caproate synthesis than with fatty acid biosynthesis. These results support the use of hydrogen as a clean external reducing agent for improving n-caproate yield and redox efficiency in defined microbial systems. This study provides mechanistic insights into redox-driven metabolic control and selective n-caproate production in a defined microbial chain elongation system.

PMID 42250817
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PubMedBioresource technology2026-06-07

Enhancing ethanol-driven chain elongation via iron speciation: impacts on metabolic flux and dual FAB/RBO pathway activation.

Liu Yuhao Y, Qian Zhikuan Z, Peng Yaxin Y, Zhang Tongli T et al.

Anaerobic chain elongation (CE) has emerged as a promising technology for upgrading low-value organic substrates into high-value medium-chain fatty acids (MCFAs); however, achieving targeted metabolic flux and efficient electron transfer remains challenging. To address this, this study explores the role of iron speciation in enhancing chain elongation (CE) driven by ethanol. Two iron-modified activated carbons, Fe3O4@AC and ZVI@AC, were evaluated to assess their impact on microbial metabolic networks. Results revealed that Fe3O4@AC significantly enhanced caproate production (4600.0 mg/L) and electron transfer efficiency (87.0 %), while ZVI@AC triggered a diversion towards alcohol production (940.61 mg/L n-butanol). The superior performance of Fe3O4@AC was attributed to its semiconductive properties, which facilitated interspecies electron transfer (potentially via DIET-like mechanisms) and balanced electron flow, promoting the activation of both fatty acid biosynthesis (FAB) and reverse β-oxidation (RBO) pathways. Metagenomic analysis revealed a shift in microbial community composition, with Massilibacterium enrichment under Fe3O4@AC, highlighting the importance of tailored material design for targeted MCFA production. These findings provide insights into optimizing microbial metabolism for enhanced CE efficiency.

PMID 42250818
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PubMedScottish medical journal2026-06-06

Association of inflammation with sex hormones and vitamin D in women: Findings from NHANES (2021-2023).

Abu-Zaid Ahmed A, Baradwan Saeed S, Adly Heba M HM, Saleh Saleh A K SAK et al.

ObjectiveTo examine associations between systemic inflammation, sex hormones, and vitamin D levels in U.S. women.MethodsA cross-sectional study was conducted using NHANES 2021-2023 data from 3179 women aged 18-80 years. Participants were grouped by high-sensitivity C-reactive protein (hs-CRP) quartiles. Demographic, anthropometric, lifestyle, dietary, and clinical variables were analyzed. Serum biomarkers included hs-CRP, sex hormones, lipid parameters, and 25-hydroxyvitamin D3 (25OHD3). Multivariable linear regression assessed independent associations between hs-CRP and endocrine markers after adjustment for confounders.ResultsWomen in the highest hs-CRP quartile had higher age, body weight, waist circumference, body mass index, and prevalence of hypertension and diabetes than those in the lowest quartile. Higher hs-CRP levels were associated with lower concentrations of 17α-hydroxyprogesterone, androstenedione, anti-Müllerian hormone (AMH), dehydroepiandrosterone sulfate, follicle-stimulating hormone (FSH), sex hormone-binding globulin, and 25OHD3. After adjustment, hs-CRP remained positively associated with AMH (β = 0.212, p = 0.007), estrone (β = 0.142, p = 0.048), low-density lipoprotein cholesterol (β = 0.241, p = 0.002), and total cholesterol (β = 0.224, p = 0.001), and inversely associated with FSH (β = -0.194, p = 0.039) and luteinizing hormone (β = -0.191, p = 0.019).ConclusionSystemic inflammation was associated with reproductive hormones and lipid profiles, while many associations weakened after adjustment for adiposity. These findings highlight complex links between inflammation, endocrine function, and cardiometabolic health, influenced by obesity-related factors.

PMID 42249749
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