若生智能
Drug Database
EQ

equine antithymocyte globulin (Thymogam)

✓ Approved

Bharat Serums and Vaccines Limited · 多克隆抗体 · 多克隆抗体

什么是 equine antithymocyte globulin？

equine antithymocyte globulin 是一种多克隆抗体，由Bharat Serums and Vaccines Limited研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)。

药物档案

商品名Thymogam
公司Bharat Serums and Vaccines Limited
药物类别多克隆抗体, 抗体
给药途径Injectable (Others), Intravenous (IV)
状态Approved
来源： ClinicalTrials.gov, Bharat Serums and Vaccines Limited

治疗适应症

equine antithymocyte globulin 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Blood and lymphatic system disordersAplastic anaemia✓ Approved
Immune system disordersSolid organ transplant rejection✓ Approved

相关研究文献

PubMedTherapeutic advances in rare disease2026-08-05

First bone marrow transplantation for mucopolysaccharidosis type I in Vietnam: a case report.

Nguyen-Ngoc-Quynh Le L, Can-Thi-Bich Ngoc N, Dang-Anh Duong D, Dang-Thi Ha H et al.

Mucopolysaccharidosis type I (MPS-I) is an inherited lysosomal storage disorder characterized by alpha-L-iduronidase deficiency, leading to progressive multi-organ damage and fatal complications. Early treatment is crucial to improve outcomes, particularly in patients with severe phenotypes. We present the first case of successful allogeneic bone marrow transplantation (BMT) for MPS-I in Vietnam. A 10-month-old girl experienced coarse facial features, congenital dermal melanocytosis spots, kyphoscoliosis developmental delay. Laboratory analyses revealed reduced alpha-L-iduronidase activity and elevated urinary glycosaminoglycans, genetic mutations identified two heterozygous mutations in the IDUA gene, confirmed the diagnosis of MPS-I. At 3 years old, she underwent allogeneic BMT from an HLA-matched sibling donor following conditioning regimen with busulfan, cyclophosphamide, antithymocyte globulin. Neutrophil engraftment was achieved on day +24, and platelet engrafted on day +32. The post-transplant course was complicated by respiratory deterioration requiring 5 days of mechanical ventilation, which was promptly managed and resolved. No graft-versus-host disease occurred. Post-transplant chimerism showed 95.77% donor-derived cells on day +30 and remained stable at 100% from 2 months. The patient demonstrated improvement in clinical symptoms, accompanied by alpha-L-iduronidase activity returned to normal range, urinary glycosaminoglycan levels decreased and remained stable during follow-up. At 12 months, she demonstrated complete immune reconstitution. This case suggests that allogeneic BMT may be a therapeutic approach for patients with MPS-I in resource-limited settings.

PMID 42553443
阅读全文 →
PubMedEquine veterinary journal2026-08-05

Clinical outcomes of a novel flowable calcium silicate cement in equine endodontic treatment.

Jackson Kirsten K, Faulkner Josephine J, Staszyk Carsten C, Ha William W et al.

Orthograde endodontic treatment of equine cheek teeth is performed infrequently with variable success rates of obturation with calcium hydroxide paste (CHP). A novel flowable calcium silicate cement (eCSC) formulated for use as an obturation material in equine teeth has demonstrated acceptable canal filling volumes and evidence of dentinal tubule penetration. However, clinical outcomes of eCSC-obturated equine teeth have not been reported. To report the clinical outcomes of orthograde endodontic treatment using eCSC. Retrospective case series. Horses that underwent orthograde endodontic treatment using eCSC at a single referral centre between October 2020 and March 2026 and had ≥12 months follow-up were included in the study. Seven horses, with endodontic treatments on six cheek teeth and one incisor were included. The success rate of eCSC was 6 of 7 cases, with up to 5.5 years of follow-up. One eCSC case demonstrated healing of a draining tract to the paranasal sinus on CT and histologically showed no evidence of periapical infection or inflammation 16 months after treatment. The singular failed eCSC-treated tooth demonstrated incomplete cleaning and obturation of one pulp canal on histological examination. Small case numbers, heterogeneous follow-up, and a single operator limit the generalisability of these findings. Orthograde endodontic treatment of equine teeth using eCSC can result in long-term clinical success. CT and histopathological findings available for one case support biological healing in successfully treated eCSC cases. A prospective, multi-centre study with standardised follow-up is warranted to establish the predictability and indications of eCSC as an obturation material for equine endodontics.

PMID 42554364
阅读全文 →
PubMedExperimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation2026-08-04

Rabbit Anti-Thymocyte Globulin Versus Basiliximab in Spousal Kidney Transplant: Early Immunological and Clinical Outcomes.

Şafak Adem A, Karakaya Emre E, Uslu Ahmed A, Çekmen Nedim N et al.

Spousal living donor kidney transplant is commonly performed; however, the optimal induction immunosuppression strategy in recipients with low immunological risk remains unclear. We compared the early clinical and immunological outcomes of low -dose rabbit anti -thymocyte globulin and basiliximab in low -risk spousal kidney transplant recipients. We retrospectively analyzed 43 recipients with low immunological risk who underwent spousal living donor kidney transplant and received induction therapy with either rabbit anti -thymocyte globulin (n = 20 ) or basiliximab (n = 23 ). Low immunological risk was defined as first -time transplant with negative panel reactive antibody and negative complement -dependent cytotoxicity crossmatch. Primary endpoints were early graft function, as assessed by serum creatinine trends, and biopsy -proven acute rejection within the first 2 postoperative months. Secondary endpoints included perioperative lymphocyte dynamics and documented infections, including cytomegalovirus and urinary tract infections. Peripheral blood lymphocyte counts were significantly lower in the group treated with rabbit anti -thymocyte globulin on postoperative day 1 and day 7 versus the basiliximab -treated group (P < .001 ). In contrast, no significant differences were observed between groups in early graft function trajectories (P = .71 ) or the incidence of biopsy-proven acute rejection (rabbit anti -thymocyte globulin, 3 of 20; vs basiliximab, 2 of 23; P > .05 ). All documented urinary tract infections (n =3 ) and the single cytomegalovirus infection occurred in the group treated with rabbit anti -thymocyte globulin; however, these differences were not statistically significant (P > .05 ). In spousal kidney transplant recipients with low immunological risk, low -dose rabbit anti -thymocyte globulin (4.5 mg /kg ) and basiliximab provide comparable early graft function and similar protection against acute rejection. Although rabbit anti -thymocyte globulin induces more pronounced lymphocyte depletion, this observation does not translate into superior early clinical outcomes in this patient population.

PMID 42549789
阅读全文 →
PubMedVeterinary immunology and immunopathology2026-08-04

The equine mesenchymal stromal cell (MSC) secretome modulates neutrophils and monocyte-derived macrophages and extracellular vesicles (EVs) impact macrophage viability.

Rajesh Aarthi A, Harman Rebecca M RM, Van de Walle Gerlinde R GR

Neutrophil chemotaxis and phagocytosis are critical for protection against bacteria, but can be compromised by methicillin-resistant Staphylococcus aureus (MRSA). MRSA can also circumvent macrophage surveillance by affecting polarization and reactive oxygen species (ROS) production. We previously demonstrated that the secretome of equine mesenchymal stromal cells (MSCs), comprised of all secreted bioactive factors and collected as conditioned medium (CM), reduces the growth of MRSA both in vitro and in vivo. This study aimed to determine if the equine MSC secretome has additional anti-MRSA properties by studying its effects on equine neutrophil and macrophage functions in vitro. Transwell assays demonstrated that CM from adipose tissue- and bone marrow-, but not peripheral blood-, derived MSCs significantly enhanced neutrophil migration. In addition, CM from all three MSC sources significantly reduced the phagocytic capacity of neutrophils but did not alter ROS production. MSC CM from all three tissue sources promoted macrophage polarization toward both CD86-positive (M1-like) and CD206-positive (M2-like) phenotypes, but did not change phagocytic capacity or ROS production. Further experiments showed that the complete CM, rather than the soluble and extracellular vesicle (EV) subfractions, was responsible for the increased neutrophil chemotaxis. Additionally, the primary effect of EVs on macrophages was cell death, possibly through autophagy, which can be beneficial if tissue damaging inflammation is diminished with decreased numbers of viable macrophages. Collectively, our findings show that the equine MSC secretome modulates various innate immune responses in vitro and may have therapeutic potential for managing dysregulated inflammation associated with bacterial diseases in vivo.

PMID 42546424
阅读全文 →
PubMedJournal of chromatography. B, Analytical technologies in the biomedical and life sciences2026-08-04

Development and validation of a liquid chromatography-tandem mass spectrometry method for the quantification of twenty-five steroids in equine serum.

Ledeck Joy J, Dubrowski Thomas T, Peeters Stéphanie S, Le Goff Caroline C et al.

Steroids are potential biomarkers for monitoring equine pregnancy. However, immunoassays currently used for their quantification suffer from cross-reactivity and limited specificity, thus requiring more accurate methods. This study reports the development and validation of a robust liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for simultaneous quantification of 25 steroids covering the main biosynthetic pathways of progestogens, corticosteroids, androgens, and estrogens. Steroids were extracted by protein precipitation followed by evaporation, derivatization, and reconstitution before LC-MS/MS analysis. A surrogate matrix was used for calibration and validation to avoid endogenous interference. Validation was performed according to and partly adapted from Clinical and Laboratory Standards Institute guidelines (CLSI), including linearity, trueness, precision, limits of detection and quantification, measurement uncertainty, recovery, matrix effects, carryover, selectivity, and stability. Calibration curves were fitted using the best-performing weighted linear or quadratic regression model, yielding excellent linearity (R2 > 0.990), trueness between -9.0% and 2.3%, and intra- and inter-day precision <6.3%. Lower limits of quantification ranged from 2.07 to 2250 pg/mL depending on physiological analytes concentration. Extraction recovery averaged 24.3-114.9%, matrix effects were acceptable, and accuracy ranged from 94.4% to 98.9%. No carryover or interferences were detected. Measurement uncertainty remained <15%. This study presents the first LC-MS/MS method partially validated per CLSI criteria for the quantification of 24 steroids in equine serum. The method offers a sensitive and specific alternative to immunoassays and provides a robust tool for equine steroid profiling with potential applications in pregnancy monitoring, placentitis diagnosis, and fetal sex determination.

PMID 42546535
阅读全文 →
PubMedJournal of equine veterinary science2026-08-04

Comparison of xylazine-ketamine-guaifenesin and xylazine-tiletamine-zolazepam protocols for constant rate infusion anesthesia in horses undergoing field castration.

Maneephan Photchanun P, Thepparat Krittima K, Suwanekkasit Benjawan B, Limrodpai Jirakarn J et al.

The common use of "triple drip" (xylazine, ketamine, and guaifenesin; XKG) is a popular protocol for constant rate infusion (CRI) in equine practice. However, due to restrictions on ketamine and guaifenesin in many countries, tiletamine-zolazepam (TZ) could serve as an alternative. To date, there have been limited studies evaluating the use of xylazine in combination with TZ (XTZ) administered via CRI to maintain surgical anesthesia in equine field practice. To compare the effectiveness and safety of XTZ infusion with the classical XKG protocol for field anesthesia. Twelve healthy stallions were randomly allocated to two groups (XKG and XTZ) for castration. All horses were premedicated with xylazine at 1 mg/kg intravenously (IV). The XKG group received ketamine at 2 mg/kg IV for induction, followed by maintenance with xylazine 1.375 mg/kg/h, ketamine 2.75 mg/kg/h and guaifenesin 68.75 mg/kg/h The XTZ group was induced with TZ at 1 mg/kg IV and maintained with xylazine 0.75 mg/kg/h and TZ 1.5 mg/kg/h RESULTS: No clinically significant differences of anesthetic effects and cardiorespiratory parameters were observed between the XTZ and XKG formulation. The preparation of the CRI XTZ might be effectively alternated the triple drip for maintaining anesthesia in equine field practice.

PMID 42546860
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多equine antithymocyte globulin