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calcitonin (Fortical)

✓ Approved

Unigene · CALCR · 重组蛋白

什么是 calcitonin？

calcitonin 是一种重组蛋白，由Unigene研发。该药已获批，用于治疗相关适应症，给药途径：Inhaled。

药物档案

商品名Fortical
公司Unigene
药物类别重组蛋白
分子靶点CALCR
给药途径Inhaled
状态Approved
来源： ClinicalTrials.gov, Unigene

作用机制

分子靶点

calcitonin 作用于 1 个分子靶点：

CALCRcalcitonin receptor (CT-R, CTR)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

calcitonin 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Musculoskeletal and connective tissue disordersOsteoporosis✓ Approved

相关研究文献

PubMedArchive of clinical cases2026-08-05

Extranodal NK/T-cell lymphoma, nasal type, presenting as a necrotic palatal ulcer.

Zarei Mahdiyeh M, Tonkaboni Arghavan A, Sabouri Parastoo P

Extranodal natural killer/T-cell lymphoma (ENKTL), nasal type, is an aggressive Epstein-Barr virus (EBV)-associated lymphoma that predominantly involves the nasal cavity and upper aerodigestive tract. Primary oral manifestations are rare and may clinically mimic benign inflammatory or infectious conditions, resulting in delayed diagnosis. This report presents a rare case of ENKTL initially manifesting as a rapidly progressive necrotizing palatal ulcer. A 44-year-old man presented with a three-week history of a necrotic ulcer on the posterior hard palate. Imaging revealed extensive midfacial destruction, including palatal perforation, nasal septal erosion, turbinate destruction, ethmoidal involvement, and medial orbital wall extension. Histopathologic examination demonstrated atypical large lymphoid cells with extensive necrosis and infiltration into adipose and muscle tissue. Immunohistochemical staining demonstrated diffuse expression of LCA and CD3, focal expression of CD30, absence of CD20, ALK, and CD56 expression, and a high proliferative activity, as evidenced by a Ki-67 index of approximately 90%. Based on the histomorphologic and immunophenotypic features, extranodal NK/T-cell lymphoma was suspected. Chromogenic in situ hybridization (CISH) for Epstein-Barr virus-encoded RNA (EBER) demonstrated strong nuclear positivity in atypical lymphoid cells, confirming the diagnosis of ENKTL, nasal type. The patient achieved complete remission after chemotherapy; however, eight months later, the patient developed a systemic relapse that was diagnosed as peripheral T-cell lymphoma. This case highlights the diagnostic complexity of ENKTL presenting as a destructive palatal lesion. Comprehensive histopathologic evaluation, detailed immunophenotyping, and EBV confirmation by EBER are essential for accurate diagnosis and timely oncologic management. ENKTL should be considered in the differential diagnosis of rapidly progressive oral necrotic lesions unresponsive to conventional therapy.

PMID 42553625
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PubMedLaryngoscope investigative otolaryngology2026-08-05

Impact of Topical Steroid Nasal Irrigation Adherence on Chronic Rhinosinusitis and Allergic Rhinitis Patient Outcomes.

He Clifford Jiajun CJ, Baker Omer O, LaMonte Olivia O, Verpukhovskiy Philipp P et al.

High volume steroid nasal rinses are often prescribed for chronic rhinosinusitis and allergic rhinitis. Although the general importance of medication adherence is well established, the specific relationship between objectively measured adherence to topical steroid irrigation and patient-reported clinical outcomes has not been previously demonstrated. This study aims to investigate the effect of topical steroid nasal rinse adherence on patient outcomes. This prospective longitudinal study recruited 97 patients with chronic rhinosinusitis or allergic rhinitis. All patients were prescribed twice-daily high-volume budesonide isotonic saline sinus rinses. Objective adherence data through quantified medication usage were collected over 8 weeks. Patient outcomes were assessed via the 22-item Sino-Nasal Outcome Test (SNOT-22), a sinus discomfort visual analog scale (VAS, 0-100), and patient-perceived surgery need. Generalized estimating equations were used to analyze the impact of adherence on symptom outcomes. Higher adherence was significantly associated with improvement in both VAS (β = -0.18, p < 0.001) and SNOT-22 (β = -0.10, p = 0.024) but was not associated with increased surgery desire. Median adherence was overall 47.5%, higher in patients with recent sinus surgery (< 3 months: 55.6%) and higher baseline symptom severity (SNOT-22 ≥ 20: 51.6%), with correspondingly larger improvements in clinical outcomes. Objective adherence to budesonide sinus irrigation significantly associates with improved patient-reported outcomes, with the strongest benefit seen in patients with higher baseline symptoms and in the early postoperative period. Targeting adherence interventions may yield clinically meaningful improvements in sinonasal quality of life. 2.

PMID 42553421
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PubMedSaudi journal of anaesthesia2026-08-05

A comparative study to assess the efficacy of atomized versus drops administration of intranasal midazolam as premedication in pediatric patients undergoing elective surgery under general anesthesia-A prospective randomized double-blind study.

Mandaknalli Parag P, Sholapur Imran I, Kori Rachana Shivanand RS

Preoperative anxiety is one of the major challenges in perioperative care of pediatric surgical patients. Intranasal midazolam is a preferred route of drug administration owing to its ease of administration, non-invasive delivery, and rapid absorption through the highly vascular nasal mucosa, but the method of administration affects the efficacy. To compare the efficacy of atomized versus drop administration of intranasal midazolam (0.3 mg/kg) as a premedication in pediatric patients aged 2-6 years undergoing elective surgery under general anesthesia. This prospective double-blind study was conducted in 60 pediatric patients randomly allocated into the Atomized Group or the nasal drops group. Drug acceptance by a 4-point Medicine Acceptance Scale, Sedation, anxiolysis at the time of shifting, assessed by the Parental Separation Anxiety Scale (PSAS), and adverse events. Drug acceptance was superior in the atomized group compared to the nasal drops group (56.7% vs 3.3%; P < 0.001). The atomized group demonstrated statistically significantly higher sedation scores (2.53 ± 0.776 vs. 1.93 ± 0.583; P = 0.001) at 5 mins, indicating faster onset of sedation. PSAS scores were better in the atomized group (1.17 ± 0.592 vs. 1.53 ± 0.629; P = 0.024). Incidence of adverse events was comparable between both groups (P = 0.379), and no respiratory depression or hemodynamic instability was noted. Atomized intranasal midazolam via mucosal atomization device is superior to conventional nasal drops in achieving higher drug acceptance, faster sedation, and better parental separation anxiolysis in pediatric patients.

PMID 42553955
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PubMedAnimal cells and systems2026-08-05

De novo whole transcriptome sequencing reveals differentially expressed messenger RNA and MicroRNA in hepatopancreas of Pandalus hypsinotus.

Lee Du Hyeong DH, Kim Woo Ryung WR, Shin Hae Jin HJ, Kim Jung-Min JM et al.

Pandalus hypsinotus (P. hypsinotus), also known as coonstripe shrimp, has high economic value and is widely distributed in Alaska, the Bering Sea and the East Sea of Korea. However, owing to the low catch rates and patchy spatial distribution, transcriptome-based studies on this species remain limited. Transcriptome analyses using PacBio Iso-Seq and Illumina RNA sequencing techniques were performed to establish a de novo unigene set of P. hypsinotus and identify differentially expressed genes (DEGs) in the hepatopancreas compared to the tail muscle. A search of all the unigenes against Gene Ontology (GO), KEGG, Pfam, BLASTN, and UniProt resulted in 46,703 annotated unigenes. A comparison of the sequences in the two tissue-derived libraries revealed 9,429 DEGs in the hepatopancreas. We also investigated the small RNAomes of P. hypsinotus using the Illumina small RNA sequencing technology. Because miRNAs are highly sensitive to stress responses and pathogen infections, they serve as effective indicators of the immune status, thereby acting as crucial tools for enhancing productivity and disease control in the aquaculture industry. The 130 identified microRNA (miRNA) candidates were classified into 32 orthologous and 98 novel miRNAs using BLASTN and miRBase. Through GO analysis and direct interactions between miRNAs and genes, the differentially expressed miRNAs (DEMs) and DEGs related to immune responses showed regulatory relationships based on their sequences. These findings provide a valuable resource for future studies on novel gene detection, gene mapping and biological pathways that may be regulated by miRNAs unique to P. hypsinotus.

PMID 42553694
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PubMedNigerian medical journal : journal of the Nigeria Medical Association2026-08-05

The Rating of Nigerian Neurosurgical Facilities Based on the Availability of Sub-Specialty Services in 2024.

Emejulu Jude Kennedy Chinedu JKC, Nkwerem Sunday Patrick Uzomaka SPU

Nigerian neurosurgery is striving to catch up with emerging sub-specialties, in accordance with international best practices. The study aims to profile the available sub-specialty services in Nigerian neurosurgery and rate the facilities based on their capacities. A cross-sectional study involving all centres with full-time neurosurgical services in Nigeria. Data collection was done electronically with questionnaires, WhatsApp, and short message services (SMS), from practising and resident neurosurgeons per centre. Clarifications on equivocal responses were sought by direct phone interviews. The rating of facilities was based on the availability of 7 major sub-specialty services - Spine instrumentation / C-Arm, operative microscopy, trans-sphenoidal/-nasal cranial procedures, neuroendoscopy, aneurysmal clipping, neuronavigation and aneurysmal coiling. Scores and ratings were done based on the number of available services. A total of 44 neurosurgery facilities were profiled, 38 (86.4%) being government-owned, and 6 (23.6%), privately-owned. Of the 38 government facilities, 30 are federal. The modal available service is spine instrumentation/C-Arm fluoroscopy (78%), then operative microscopy (58.5%) and trans-sphenoidal/-nasal cranial procedures (51.2%). The mean subspecialty services are as follows: spine instrumentation/C-arm 0.8, operative microscopy 0.6, transsphenoidal/nasal procedure 0.5, neuroendoscopy 0.4, aneurysm clipping 0.4, neuronavigation 0.1, aneurysm coiling 0.04. Amongst the top-10 facilities, 7 are government and 3 privately-owned, but amongst the top-3 facilities, 2 are privately-owned. All 10 lowest-ranked facilities are government-owned. Spine surgery and operative microscopy are more readily available in Nigeria, while aneurysmal clipping and coiling and neuroendoscopy services are poor in Nigeria. Despite the government-owned institutions being in the lead, the privately-owned institutions have massive future prospects.

PMID 42553941
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PubMedSaudi journal of anaesthesia2026-08-05

Comparative efficacy of high-flow nasal cannula versus conventional oxygen delivery during procedural sedation for ovum pickup in assisted reproductive technology.

Mohan Vishal V, Hooda Bhavna B, Singh Shalendra S, Dwivedi Deepak D et al.

Procedural sedation during ovum pickup (OPU) is often associated with transient hypoxemia and airway interventions. High-flow nasal cannula (HFNC) therapy may improve oxygenation during sedated procedures, but evidence in assisted reproductive techniques remains limited. This study compares HFNC with conventional low-flow oxygen (CFO) in maintaining oxygenation during OPU. In this randomized controlled trial, 220 women undergoing OPU under propofol sedation were allocated to either CFO (Group C; n = 110) or HFNC (Group H; n = 110). The outcomes assessed included desaturation events, hemodynamic parameters, depth of sedation, airway interventions, and adverse events. Hemodynamic and respiratory parameters remained stable and comparable between groups throughout the procedure and recovery. Desaturation events were more frequent in Group C (P = 0.161), and the need for rescue escalation of oxygen therapy was significantly higher in this group compared with the group H (13.6% vs. 5.5%; P = 0.03). Total Propofol consumption, procedure duration, recovery time, and adverse events were similar, with high patient and physician satisfaction in both groups. HFNC provides a safe and effective alternative to CFO therapy during procedural sedation for OPU, significantly reducing the need for oxygen escalation without affecting hemodynamic stability, sedation depth, or recovery. Its routine use may enhance respiratory safety in sedated reproductive procedures.

PMID 42553875
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