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Microspheres

✓ Approved

TTY Biopharm · 治疗药物

什么是 Microspheres？

Microspheres 是一种治疗药物，由TTY Biopharm研发。该药已获批，用于治疗相关适应症，给药途径：Unknown。

药物档案

公司TTY Biopharm
给药途径Unknown
状态Approved
来源： ClinicalTrials.gov, TTY Biopharm

治疗适应症

Microspheres 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Surgical and medical proceduresOral appliance application✓ Approved

相关研究文献

PubMedRegenerative medicine2026-08-04

Two-layered electrospun nanofibrous mat loaded chitosan nanoparticles, growth factors and hair follicle bulge stem cells can promote wound healing in rat.

Moghaddam Asma A, Orazizadeh Mahmoud M, Bayati Vahid V, Nejaddehbashi Fereshteh F

Wound healing remains a demanding medical problem despite significant advances in regenerative medicine. Mesenchymal, hair follicle and pluripotent stem cells are candidate populations for therapeutically relevant applications. Hair follicle bulge stem cells with scaffolds and growth factors can promote the healing of wounds. This study explores a dual-layer electrospun nanofibrous wound dressing composed of PCL/SSD and PCL/COLL, enhanced with chitosan nanoparticles loaded with EGF and bFGF growth factors. Hair follicle bulge stem cells were seeded onto the scaffold and transplanted into rat skin wounds. FE‑SEM confirmed that the chitosan microspheres were uniformly spherical, ranging from nanoscale to ~1 µm. Thermal analysis showed a 28% weight loss up to 250°C and major degradation between 230°C and 450°C, indicating good thermal stability. About 50% of the encapsulated EGF and bFGF (6.5 ng from 2 mg microspheres) was released within 24 h, followed by sustained release. Biological assays demonstrated strong cell attachment, enhanced collagen deposition, and rapid tissue remodeling, with complete skin regeneration achieved by day 14. These findings suggest that a two-layered electrospun nanofibrous mat incorporating chitosan nanoparticles, growth factors, and hair follicle bulge stem cells significantly enhances wound healing in a rat model.

PMID 42549962
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PubMedAdvanced materials (Deerfield Beach, Fla.)2026-08-04

Durable Seawater Electrolysis Enabled by Spherical Electrostatic Repulsion and Catalyst-Support Interaction.

Gao Hanqing H, Zeng Jinjue J, Yang Yifei Y, Sun Wei W et al.

The electrolysis of seawater driven by renewable energy for hydrogen production represents a promising strategy toward net-zero emissions. The high concentration of chloride ions (Cl-) in seawater not only competes with the oxygen evolution reaction (OER) at the anode but also causes corrosion of the catalyst material. The construction of electrostatic shielding via anions on the catalyst surface can repel Cl-. However, studies on regulating anion distribution through designed geometries to maximize such repulsion remain limited. Herein, a sphere-like catalyst, constructed with a heterojunction of carbonate-intercalated nickel-iron layered double hydroxides in situ grown on malachite microspheres (MM), exhibits enhanced catalytic durability and activity. The spherical electrostatic field induced by carbonate anions protects the catalyst, and the catalyst-support interaction (CSI) tunes the electronic structure of active sites to boost OER. Finally, the assembled electrolyzer demonstrates outstanding durability over 1000 h and a voltage of 1.83 V at a current density of 1 A per cm2. This spherical geometrical design of electrostatic protection offers insights into catalyst optimization for seawater electrolysis.

PMID 42550129
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PubMedMikrochimica acta2026-08-04

Dual-mode electrochemiluminescence and colorimetric detection of malathion based on a bifunctional rGO@ZnO/Zn-Fe3O4 nanozyme.

Wang Wenzhuo W, Lu Juan J, Jiang Hanyue H, Han Pengfei P et al.

A dual-mode sensing platform has been developed for ultrasensitive malathion (MAT) detection based on bifunctional rGO@ZnO/Zn-Fe3O4 composites (reduced graphene oxide-supported ZnO nanorods and Zn-doped Fe3O4 microspheres). The rGO@ZnO/Zn-Fe3O4 nanozyme is fabricated via a one-pot hydrothermal strategy and integrates favorable electrochemiluminescence (ECL) emission and intrinsic peroxidase-mimicking activity to realize dual-signal readout. In the K2S2O8 ECL system, Au NPs@UiO-66 serves as a coreactant booster to further magnify the ECL intensity of the composite. Meanwhile, the nanozyme catalyzes the H2O2-mediated oxidation of 3,3',5,5'-tetramethylbenzidine (TMB) to produce a colorimetric response. MAT suppresses both ECL and colorimetric responses by occupying Fe2+/Fe3+ catalytic sites and scavenging of reactive radicals. The sensor achieves limits of detection as low as 2.8 × 10-13 mol/L under ECL mode and 1.32 × 10-6 mol/L under colorimetric mode. In practical testing of MAT-spiked vegetable samples, the sensor exhibits acceptable recoveries and low relative standard deviations, demonstrating its practicability for field food safety supervision and rapid pesticide residue screening.

PMID 42550268
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PubMedInternational journal of biological macromolecules2026-08-03

Construction of butyrylated starch film-coated microspheres for colon-targeted delivery of Akkermansia muciniphila postbiotics.

Li Jiahao J, Zhang Zengjiang Z, Zeng Xixi X, Xie Fengwei F et al.

Emerging evidence suggests that Akkermansia muciniphila postbiotics show promising potential in promoting metabolic health. Nevertheless, their bioactivity and colonic availability can be compromised during upper gastrointestinal transit. To address this limitation, a colon-targeted delivery system was developed, based on butyrylated starch (BS) film-coated microspheres (BSFCMs). BS with a tunable degree of substitution was synthesized. Films fabricated from BS exhibited enhanced hydrophobicity and digestion resistance, with the optimal performance observed at DS = 1.79. Under in vitro simulated gastrointestinal conditions, microspheres with 14% coating weight gain showed under 30% cumulative release in simulated gastric and intestinal fluids. Furthermore, tuning the postbiotic loading ratio increased the colon-targeted delivery of representative postbiotic-derived small molecules to about 50%-70%. Collectively, these findings support the feasibility of using DS-tunable BS films as robust coating materials for constructing microsphere systems to mitigate premature release of A. muciniphila postbiotics during gastrointestinal transit and improve oral delivery efficiency for colonic applications.

PMID 42543095
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PubMedChemical biology & drug design2026-08-03

Curcumin-Loaded GelMA Microspheres Alleviate Osteoarthritis: Transcriptomic Evidence for Immune Microenvironment Remodeling and ECM Homeostasis Restoration.

Jiang Bin B, Jiang Xin X, Li Shaobo S, Niu Hao H et al.

Osteoarthritis (OA) progression is driven by inflammatory mediators and immune dysregulation within the joint. Curcumin (Cur) possesses multi-target therapeutic potential. However, its clinical application is limited by poor solubility and a short half-life. In this study, we developed injectable Cur-loaded GelMA microspheres (Cur-MS) and evaluated their effects in IL-1β stimulated chondrocytes, cartilage organoids, and a monosodium iodoacetate (MIA) induced rat OA model, complemented by public transcriptomic analysis (GSE114007). The Cur-MS demonstrated uniform size distribution, favorable biocompatibility, and sustained curcumin release. Treatment with Cur-MS significantly reduced chondrocyte apoptosis, reactive oxygen species levels, and hypertrophic markers; restored COL-II and ACAN synthesis; and downregulated MMP13 and inflammatory gene expression. In vivo, Cur-MS improved joint space, alleviated pain, decreased synovial CD68 positive macrophage infiltration and levels of IL-6 and TNF-α, and enhanced chondrogenic gene expression. Public transcriptomic data corroborated these findings, revealing upregulation of MMP13 and downregulation of SOX9 in OA cartilage, consistent with our experimental targets. Collectively, this study provides the first multi-model evidence combined with transcriptomic validation, demonstrating that Cur-MS not only directly protects chondrocytes and restores extracellular matrix homeostasis but also modulates the joint inflammatory immune microenvironment. These findings suggest that Cur-MS represents a promising locally sustained-release therapeutic strategy for OA.

PMID 42543780
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PubMedSmall (Weinheim an der Bergstrasse, Germany)2026-08-03

Non-Stoichiometric Click Polymerization for Size-Controlled and Mild Encapsulation of Cells.

Pan Yao-Yu YY, Wang Fu-Bing FB, Zhu Wei W, Shen Ai-Guo AG et al.

Artificial cell shells can achieve protection, identification, measurement, and manipulation of cells, but most cell encapsulation methods fail to control shell thickness, directly limiting the shell function in practical applications. The in-situ polymerization method has the potential to control the encapsulation shell but lacks chemical driving forces to enable shell thickness from nanoscale to micrometer-scale. The micrometer-scale shell can enhance the functionality in cell encapsulation and extend its applications to broader fields. In this work, we utilized the efficient and mild thiol-alkene click reaction to construct a micrometer-scale shell and encapsulate microbial cells into large-sized polymer microspheres. The encapsulated microbial cells are larger than the coexisting emulsion colloids and particulate impurities, thereby achieving "Convert microbial cell detection to polymer particle counting" and providing a new perspective for the application of micrometer-scale artificial cell shells.

PMID 42543798
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