若生智能
Drug Database
YY

YY-3110 (YY 3110 / YY3110)

✓ Approved

YuYu Pharma · 小分子 · 小分子

什么是 YY-3110？

YY-3110 是一种小分子，由YuYu Pharma研发。该药已获批，用于治疗相关适应症，给药途径：Unknown。

药物档案

商品名YY 3110, YY3110
公司YuYu Pharma
药物类别小分子
给药途径Unknown
状态Approved
来源： ClinicalTrials.gov, YuYu Pharma

治疗适应症

YY-3110 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Vascular disordersThrombosis✓ Approved

相关研究文献

PubMedPoultry science2026-06-06

The gut-brain axis in avian appetite regulation: Integrating peripheral signals with central neurocircuitry.

Mahdavi Kimia K, Zendehdel Morteza M, Ghashghaei Elham E, Lin Hai H

The precise regulation of energy homeostasis is essential for sustainable poultry production. Dysregulation of the avian gut-brain axis (GBA) contributes to metabolic disorders such as ascites and sudden death syndrome, impaired feed efficiency, and welfare problems in high-yield broilers. The avian GBA is a specialized bidirectional network that integrates hormonal, neural, and microbial signals to match feeding behavior with acute nutrient availability and long-term metabolic demands. Unique avian traits include a simplified gustatory system, lack of a functional T1R2 sweet receptor, a divergent leptin system, and distinct microbiota composition; these traits necessitate a species-specific framework for appetite control. This narrative review synthesizes current knowledge on how peripheral signals from the gastrointestinal tract, pancreas, liver, adipose tissue, and microbiota are encoded and conveyed to central command centers to regulate feed intake in poultry. We first outline nutrient sensing and gut-derived hormones with complex or divergent actions in birds (ghrelin, peptide YY, somatostatin), then summarize canonical satiety peptides (cholecystokinin, proglucagon-derived peptides, amylin, bombesin-like peptides, and neuromedin U) and long-term metabolic cues (leptin, insulin, insulin-like growth factors, liver-expressed antimicrobial peptide-2). At the central level, we describe how arcuate neuropeptide Y/agouti-related peptide (NPY/AgRP) and pro-opiomelanocortin/cocaine- and amphetamine-regulated transcript (POMC/CART) neurons, downstream hypothalamic nuclei, and brainstem relays integrate these inputs into a dynamic balance between opposing orexigenic and anorexigenic neurochemical effector pathways. Finally, we link these mechanistic insights to potential practical strategies for improving feed conversion, reducing metabolic disease, and enhancing resilience to environmental stressors. These strategies include dietary and microbiota-targeted interventions, receptor-level modulation, and the use of divergent genetic lines.

PMID 42247765
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PubMedJournal of applied genetics2026-06-03

Genomic diversity, inbreeding, and selection signatures in duroc, landrace, and yorkshire pigs from a long-term closed breeding system.

Tang Huangyi H, Mulim Henrique A HA, Chen Shi-Yi SY, Schinckel Allan P AP et al.

Duroc (DD), Landrace (LL), and Yorkshire (YY) are among the most widely used commercial pig breeds, having undergone intense long-term selection within closed breeding systems. This study presents a comprehensive genomic analysis of genetic diversity, inbreeding patterns, and selection signatures in DD, LL, and YY populations that have been subject to close breeding for over 15 years. Genomic and pedigree data were available for 1,088 animals (DD = 348, LL = 276, YY = 464), genotyped using the GenoBaits® Porcine 100 K SNP panel. Principal component analysis and genetic diversity metrics revealed distinct population structures among the three breeds. Pairwise genetic differentiation supported this pattern, with DD showing the greatest divergence from LL (0.34 ± 0.24) and YY (0.33 ± 0.24), while LL and YY were more closely related (FST = 0.22 ± 0.19). Linkage disequilibrium (LD) analysis further confirmed these differences, as DD exhibited the highest average r² (0.34), followed by LL (0.28) and YY (0.25). Within-breed genetic diversity metrics, including observed heterozygosity (HO: 0.37 in DD, 0.39 in LL, 0.38 in YY), expected heterozygosity (HE: 0.36 in DD, 0.37 in LL, 0.38 in YY), and minor allele frequency (MAF: 0.27 in DD, 0.28 in LL, 0.29 in YY), indicated greater genetic variability in LL and YY compared to DD. Runs of homozygosity (ROH) analyses revealed different patterns of autozygosity, with DD exhibiting more long ROH indicative of recent inbreeding, while YY harbored a higher number of short ROH, suggestive of more ancient demographic events. ROH-based inbreeding coefficients (FROH) consistently exceeded pedigree-based estimates (FPED) across all breeds, highlighting the presence of recent or unrecorded inbreeding that pedigree data may not fully capture. According to Generation Proxy Selection Mapping (GPSM), 17, 1, and 12 significant SNPs were detected in DD, LL, and YY, respectively. Functional annotation of ROH islands and GPSM-significant loci revealed both breed-specific and overlapping QTLs related to traits such as growth, reproduction, and carcass. In general, the findings of this study contribute to a deeper understanding of the genomic consequences of long-term closed breeding and provide reference information to support consideration of breeding strategies that balance continued selection for productivity with the maintenance of genetic diversity in modern commercial pig populations.

PMID 42234283
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PubMedACS sensors2026-06-03

Modular Input-Output Biosensor Design Using De Novo Protein Switches.

Wang James J, Chen Julie Yi-Hsuan JY, Xi Chenggang C, Arteage-Organiz Estrella E et al.

Protein-based biosensors offer unique advantages over conventional analytical methods by enabling real-time detection of target analytes with minimal sample preparation. However, efficiently coupling molecular recognition to a reliable output signal remains a key challenge in biosensor design. Here, we present a plug-and-play strategy using the de novo switch platform, LOCKR, which enables direct transduction of a binding event into a defined signal output. The LOCKR architecture supports modular reconfiguration: the recognition domain can be swapped to detect a desired analyte, while the reporter module can be interchanged to tune the output format. We expand the range of LOCKR-compatible readouts beyond split luciferase to include ratiometric Förster-type resonance energy transfer and β-lactamase-based colorimetry. By integrating computationally designed high-affinity binders as interchangeable recognition elements, we demonstrate sensitive detection of glucagon, neuropeptide Y, and peptide YY with limits of detection in the picomolar range. Together with the expanding landscape of de novo designed binders and reporters, the LOCKR platform bridges the gap between molecular recognition and signal generation, enabling versatile biosensor development tailored for user-defined applications.

PMID 42233743
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PubMedInternational journal of obesity (2005)2026-06-03

Associations of body composition and resting metabolic rate with homeostatic and hedonic components of appetite.

Alruwaili Arwa A, Trotman Hannah H, Haenebalcke Laure L, Chuen Adrian Sia Jin ASJ et al.

While fat-free mass (FFM), fat mass (FM), and resting metabolic rate (RMR) influence energy intake, their specific roles as homoeostatic and hedonic drivers of eating-and factors moderating these relationships-are uncertain. This study examined associations of FFM, FM, and RMR with a comprehensive set of appetite-related outcomes in adults. 130 participants (58% male; age: 25.0 ± 8.5 years; BMI: 24.0 ± 3.7 kg/m²; mean ± SD) completed assessments of RMR (indirect-calorimetry), body composition (air-displacement plethysmography), energy intake (laboratory-based), appetite-related hormones (fasted and meal-stimulated), appetite (visual analogue scales), food reward (Leeds Food Preference Questionnaire [LFPQ]), food cravings (Control of Eating Questionnaire), taste and smell perception. GLM examined associations between exposure and outcome variables, controlling for demographic and lifestyle factors. Effect modification was assessed via interaction terms and stratified analyses with median splits for continuous variables. RMR was positively associated with energy intake (P < 0.001), while FFM and FM were not. The positive RMR-energy intake association was stronger in individuals who were younger, more active, smokers, and with lower BMI (P ≤ 0.020). FFM was positively associated with postprandial peptide-YY (PYY) and hunger, craving control and smell sensitivity (P ≤ 0.026). FM was positively associated with fasting PYY and leptin, and inversely associated with postprandial PYY and hunger, craving control, and taste sensitivity (P ≤ 0.047). RMR was inversely associated with fasting ghrelin (P < 0.001). No consistent associations were observed between body composition, RMR and food reward (LFPQ). Several associations were moderated by age, sex, BMI, physical activity and smoking. RMR is a key driver of energy intake, with sex, BMI, physical activity and smoking status moderating the relationship. Body composition (FFM and FM) is linked to distinct variations in homoeostatic and hedonic components of appetite, particularly gut hormone responses, craving control and taste perception.

PMID 42230984
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PubMedAnimal : an international journal of animal bioscience2026-05-30

Cross-population meta-analysis and colocalisation analysis reveal novel and pleiotropic genes associated with rib and teat number in pigs.

Liu Q Q, Yu J J, Yin Y Y, Chen J J et al.

Total rib number (TRN) and total teat number (TTN) are key anatomical and economic traits in pigs, linked to carcass yield and reproductive performance, respectively, and are genetically correlated. However, the shared genetic basis underlying these traits remains incompletely understood. This study aimed to dissect the genetic architecture of TRN and TTN and to identify pleiotropic genes affecting both traits. Single-population genome-wide association studies (GWASs), multi-population meta-analysis, and multi-trait meta-analysis were conducted using phenotypic and genotypic data from three pig populations: Yorkshire (YY, n = 413), Suhuai (SH, n = 655), and Landrace × Yorkshire (LY, n = 678). Significant genetic and phenotypic correlations were observed between TRN and TTN, with genetic correlations of 0.82 in YY, 0.46 in SH, and 0.35 in LY. Ten quantitative trait loci (QTLs) associated with TRN were identified, including novel loci on SSC2 (39.38-40.49 Mb), SSC3 (123.79-125.58 Mb), SSC6 (103.40-104.53 Mb), SSC12 (53.30-54.84 Mb), and SSC18 (45.29-46.91 Mb). For TTN, eight QTLs were detected, including three newly discovered regions on SSC13 (142.82-143.99 Mb), SSC14 (7.26-8.54 Mb), and SSC16 (10.19-12.18 Mb). Candidate genes were identified through functional annotation and phenome-wide association analysis. For TRN, the prioritised genes included GREB1, SMCHD1, HES7, VRTN, ABCD4, NTN1, and members of the HOX gene family, whereas for TTN, the identified genes included FRMD4A, STC1, GREB1, and ABCD4. Colocalisation analysis integrating GWAS and multi-tissue expression QTL data suggested shared genetic signals for several genes, including EMILIN2, PTGR2, PSEN1, and ABCD4 for TRN, and PTGR2 and ENSSSCG00000033037 for TTN. Notably, GREB1, PTGR2, and ABCD4 were identified as pleiotropic genes potentially regulating both traits. These results clarify the shared genetic architecture of rib and teat number and provide candidate genes for future functional validation and genetic improvement in pig breeding.

PMID 42214138
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PubMedFrontiers in bioengineering and biotechnology2026-05-29

Performance evaluation of biological safety cabinets: a real-world analysis.

Song Tao T, Yin Shaohua S, Liu Zhenlin Z, Xue Xiaoqi X et al.

Biological safety cabinets (BSCs) are essential for protecting personnel, samples, and the environment in clinical and research laboratories. Evidence on the real-world performance of Class II BSCs in China remains limited, particularly regarding differences between domestic and imported equipment. We conducted a cross-sectional evaluation of 360 Class II BSCs in Beijing using 1,803 performance testing records from 2018 to 2023. Performance indicators, including noise, illumination, cleanliness, inflow velocity, downflow velocity, HEPA filter integrity, and airflow smoke pattern were measured according to JG 170-2005, YY 0569-2011 and SN/T 3901-2014 standards. BSCs were assessed and classified as fully qualified performance (FQP) if the indicator met the standard without equaling the threshold, marginally qualified performance (MQP) if the indicator equaled the threshold, or unqualified if the standard was not met. Qualified rates were compared by manufacturing region, hospital level, using sector, and service life using χ 2 tests and non-parametric analyses. Among 360 Class II BSCs, the median service life was 7 years (IQR 5-10). The overall qualified rate was 70.4%, with no difference between domestic and imported BSCs (71.3% vs. 69.2%; χ 2 =0.909, P=0.340). Domestic BSCs showed higher FQP rate (55.4% vs. 40.5%; χ 2 =11.625, P=0.0007) and lower MQP rate (15.8% vs. 28.7%; χ 2 =15.087, P=0.0001), with similar pattern for noise, inflow velocity, and downflow velocity. The inflow velocity, downflow velocity, and illumination showed relatively lower qualified rates, with only inflow velocity having a higher qualified rate in domestic BSCs (85.5% vs. 80.9%; χ 2 =6.845, P=0.009). Imported BSCs performed slightly better in several key indicators, including inflow velocity, downflow velocity, and HEPA filter integrity, although differences were not statistically significant. These findings suggest that BSC reliability reflects an interplay between manufacturing-related characteristics and in-use performance, and that the MQP helps identify BSCs operating near minimum safety margins for proactive monitoring and timely intervention.

PMID 42212170
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