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saxagliptin (Bessin)

✓ Approved

Sino Biopharmaceutical Co., Ltd · DPP4 · 小分子

什么是 saxagliptin？

saxagliptin 是一种小分子，由Sino Biopharmaceutical Co., Ltd研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Bessin
公司Sino Biopharmaceutical Co., Ltd
药物类别小分子
分子靶点DPP4
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Sino Biopharmaceutical Co., Ltd

作用机制

分子靶点

saxagliptin 作用于 1 个分子靶点：

DPP4dipeptidyl peptidase 4 (CD26, DPPIV)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

saxagliptin 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Metabolism and nutrition disordersType 2 diabetes mellitus✓ Approved

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The feasibility of remotely delivered Tai Chi (TC) interventions and their potential influence on 24-h movement behaviors (physical activity, sedentary time, and sleep) to promote health is limited. Thus, this study tested the feasibility of a remote TC program among community-dwelling older adults and examined its preliminary effects on 24-h movement behavior outcomes. A crossover randomized controlled trial enrolled 44 older adults assigned to either the AB sequence (12 weeks of remotely delivered TC followed by a 2-week washout and 12 weeks of usual care), or the BA sequence (the reverse order). Study feasibility was assessed by recruitment and retention rates, whereas intervention feasibility included intervention adherence, fidelity, and acceptability. The 24-h movement behaviors were tracked by a wearable sensor. Forty-one participants (mean age = 70.8 ± 5.6; 78% women) completed the study and were included in the data analysis. Recruitment and retention rates were 76% and 93%, respectively. Results showed that 85% of participants completed ≥18 of 24 TC sessions, and 94% reported the acceptability of TC as "good" or "excellent". The linear mixed-effects models using period-level change scores showed no statistically significant treatment effects for steps, sleep time, sedentary time, lightly active time, or active time. The findings demonstrate that a remotely delivered TC program is feasible, acceptable among community-dwelling older adults. Future larger trials with rigorous wearable sensor data are needed to determine whether remotely delivered TC can improve 24-h movement behavior patterns.

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Recent advances for the pharmaceutical production of highly attenuated poxviruses as viral vector platforms.

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