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PT-003

✓ Approved

Pediatrix Therapeutics · 未知 · 未知

什么是 PT-003？

PT-003 是一种未知，由Pediatrix Therapeutics研发。该药已获批，用于治疗相关适应症，给药途径：Unknown。

药物档案

公司Pediatrix Therapeutics
药物类别未知
给药途径Unknown
状态Approved
来源： ClinicalTrials.gov, Pediatrix Therapeutics

治疗适应症

PT-003 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Immune system disordersHypersensitivity✓ Approved

相关研究文献

PubMedDiscover oncology2026-06-13

Target trial emulation of survival outcomes for clinically localized prostate cancer treatments.

An Min Ho MH, Kim Chungsoo C, Min Kyungchan K, Yi Kyu-Ho KH et al.

The ProtecT randomized trial found similar survival between active surveillance (AS), radiotherapy (RT), and radical prostatectomy (PT) in localized prostate cancer (PC), but observational studies yielded conflicting results. This study aims to emulate ProtecT by comparing survival outcomes of men with localized PC undergoing PT or RT versus AS/watchful waiting (WW). This target trial emulation study used the Korean Nationwide Health Insurance, Cancer Registry, and Death Registry linkage data (2012-2020). We included men (50-69 years) diagnosed with a first malignant localized PC. Primary outcome was PC-specific death, and secondary outcomes were all-cause death, metastasis, and antidepressant initiation. Two cohorts (PT vs. AS/WW and RT vs. AS/WW) were analyzed using Cox regression to estimate hazard ratios (HRs) with 95% confidence intervals (CIs). Among 8,036 localized PC patients, 1,191 PT vs. 1,191 AS/WW and 428 RT vs. 428 AS/WW individuals were identified. During a mean follow-up of 4.4 years, PC-specific death occurred in 2 men (0.2%) in PT and 2 men (0.2%) in AS/WW, and 3 men (0.7%) in RT with 1 man (0.2%) in AS/WW. AS/WW showed comparable risks of PC-specific and all-cause death and metastasis as PT and RT. Compared to AS/WW, PT and RT showed lower risks of antidepressant initiation (HR [95% CI] 0.73 [0.58-0.93] for PT and HR 0.38 [0.24-0.61] for RT, respectively). In this target trial emulation study, AS/WW showed similar risks of mortality and metastasis as PT and RT, while PT and RT showed favorable outcomes with antidepressant initiation in Asian men with localized PC.

PMID 42286375
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PubMedChiropractic & manual therapies2026-06-13

Effects of percussive therapy dosages on recovery from acute exercise-induced muscle damage: a systematic review and meta-analysis.

Zhu Yang Y, Yang Lele L, Liu Tao T, Yao Fuya F et al.

Percussive therapy (PT) is increasingly used for post-exercise recovery, but its effects and dose-related responses after exercise-induced muscle damage remain uncertain. This review evaluated the effects of PT on neuromuscular performance, muscle soreness, and biochemical markers after acute exercise. The study adhered to PRISMA guidelines. A comprehensive search was conducted across PubMed, Embase, Web of Science, the Cochrane Library, and CNKI for Randomized Controlled Trials (RCTs) published through November 26, 2025. Risk of bias, methodological quality, and certainty of evidence were assessed using RoB 2, PEDro, and GRADE. Data analysis was performed using Stata-MP 18.0 software. Twelve RCTs were included. PT improved countermovement jump recovery compared with control (k = 13, g = 0.78, 95% CI 0.26 to 1.29, p < 0.01; low certainty) and reduced creatine kinase levels (k = 7, g = - 0.87, 95% CI - 1.57 to - 0.17, p = 0.02; very low certainty). PT did not clearly improve maximum voluntary contraction recovery (k = 8, g = 0.12, 95% CI - 0.10 to 0.34, p = 0.28; moderate certainty) or delayed onset muscle soreness (k = 17, g = 0.14, 95% CI - 0.19 to 0.48, p = 0.40; very low certainty). Exploratory analyses suggested that longer treatment (> 5 min per muscle group) was associated with larger countermovement jump effects, whereas 2.5-5 min protocols at higher frequency (≥ 50 Hz) were associated with creatine kinase reduction. Longer treatment was also associated with higher delayed onset muscle soreness scores. PT may improve explosive performance recovery and reduce early creatine kinase levels, but current evidence does not support clear benefits for maximum strength recovery or soreness relief. Dose-related findings are preliminary and should not be interpreted as prescriptive thresholds.

PMID 42286692
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PubMedHealth communication2026-06-13

The Reward of Virtue: Examining Roles of Patient Gratitude, Physician Affect, and Physician Rumination in Linking Patient-Centered Communication and Physician Turnover.

Zheng Yu Y, Yang Shu S, Liu Piper Liping PL

Increasing physician turnover poses challenges to healthcare institutions worldwide. Patient-centered communication (PCC), which increases patient-physician communication quality and physician work experiences, is considered a potential solution. Nonetheless, little is known about its actual effects and underlying mechanisms on healthcare providers themselves. Drawing on an integrated framework based on affective event theory and affect theory of social exchange, this study proposes and tests a pathway model linking PCC and physician turnover intention. Analyzing survey data collected from Chinese physicians (N = 600) with the structural equation model technique, the findings show that PCC is negatively associated with turnover intention. Particularly, this association is sequentially mediated by 1) receipt of patient gratitude, positive affect after consultations and positive work rumination (β = -.002, 95%CI[-.006, -.0002]), 2) receipt of patient gratitude, positive affect after consultations and negative work rumination (β = -.003, 95%CI[-.007, -.0004]), 3) receipt of patient gratitude, negative affect after consultations and positive work rumination (β = -.003, 95%CI[-.007, -.0004]), and 4) receipt of patient gratitude, negative affect after consultations and negative work rumination (β = -.002, 95%CI[-.006, -.0002]). On this basis, this study contributes to the literature by elucidating how PCC benefits physicians through their active elicitation of positive affective events.

PMID 42287068
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PubMedNature materials2026-06-13

Polar nano-regions enable large spin Hall conductivity in metallic PtCoO2.

Ji Guiping G, Zheng Yi Y, Zhang Yuejie Y, Liang Yuhan Y et al.

Spin-source materials for spintronic devices are required to convert charge currents into spin currents efficiently and maintain minimal electrical losses. However, conventional strategies to enhance charge-spin conversion often come at the cost of increasing ohmic dissipation. Here we demonstrate that introducing polar lattice distortions into a highly conductive metal can overcome this trade-off. We report the discovery of polar displacements in PtCoO2 and show that these displacements enhance charge-spin conversion by two orders of magnitude compared with its non-polar phase. The coexistence of polarity and metallicity yields a room-temperature spin Hall conductivity of 1.6 × 107ℏ/2e (Ω m)-1. Electron ptychography reveals that the inversion-symmetry breaking originates from local polar nano-regions. Polar PtCoO2 drives efficient spin-orbit torque switching with substantially reduced switching voltage and power compared with Pt-based control devices, and is compatible with silicon substrates, establishing a strategy for designing highly efficient spin-source materials.

PMID 42286108
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PubMedJournal of computational chemistry2026-06-13

Quantitative Assessment of Metal-Ligand Bonding in Halide-Containing Terpyridine Pincer Complexes of Group 10 Metals.

Gholiee Yasin Y

This study investigates metal-ligand bonding in planar pincer complexes [(tpy)M(X)]+, where M is Ni(II), Pd(II), or Pt(II) and X is a halide, using DFT and energy decomposition analysis. It shows that electrostatic interactions dominate the overall stability, while interaction strength decreases from fluoride to iodide. Orbital interactions contribute significantly (44.4%-50.2%) to the total attraction and are analyzed in detail under C2v symmetry through a1, a2, b1, and b2 components, revealing different metal-ligand overlap patterns. σ-type interactions are the main orbital contribution (62.7%-76.1%), followed by π interactions (19.4%-29.6%), including in-plane and out-of-plane components. δ-type interactions are minor (4.8%-7.7%) but arise from metal-ligand π* overlap. Charge transfer trends from ligand to metal correlate well with both electrostatic and total interaction energies, supporting a consistent bonding description across the series.

PMID 42286940
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PubMedBiology direct2026-06-13

Autochthonous dengue transmission in Europe: epidemiology, mechanisms, and modelling insights.

Campinopoli Giulia G, Caro Antonino Di AD, D'Alise Alessandra A, Conventi Francesco F et al.

Dengue is the most rapidly expanding arboviral infection globally, with rising incidence and widening geographic distribution driven by urbanisation, climate change, vector expansion, and global mobility. Although traditionally confined to tropical and subtropical regions, dengue is increasingly emerging in temperate settings, including Europe. Recent outbreaks in Italy, Spain, and France, together with evidence of under-recognised transmission, indicate a transition from sporadic importation to recurrent autochthonous infection. This shift is facilitated by the establishment of Aedes albopictus, increasing climatic suitability, an increase in case importation from endemic areas and delays in clinical recognition and public health response. In non-endemic regions, dengue presents distinct challenges, including low population immunity, limited clinical awareness, and diagnostic constraints that may hinder early detection. While advances in vaccines, particularly TAK-003, and novel vector control strategies such as Wolbachia-based interventions offer new opportunities, their role in Europe remains context-specific and complementary to strengthened surveillance and preparedness systems. Modelling approaches provide valuable decision support but are constrained by data limitations in emerging settings. The emergence of dengue in Europe should be viewed as an early signal of broader changes in vector-borne disease dynamics. Proactive investment in integrated surveillance, diagnostics, vector control, and targeted vaccination strategies will be essential to mitigate future risk and prevent sustained transmission in non-endemic regions.

PMID 42286757
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