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Gensci-004 (PEG rhGH / Gensci 004 / PEG Somatropin)

✓ Approved

GeneScience Pharmaceuticals Co., Ltd. · GHR · 小分子

什么是 Gensci-004？

Gensci-004 是一种小分子，由GeneScience Pharmaceuticals Co., Ltd.研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Subcutaneous Injection。

药物档案

商品名PEG rhGH, Gensci 004, PEG Somatropin
公司GeneScience Pharmaceuticals Co., Ltd.
药物类别小分子, 重组蛋白
分子靶点GHR,
给药途径Injectable (Others), Subcutaneous Injection
状态Approved
来源： ClinicalTrials.gov, GeneScience Pharmaceuticals Co., Ltd.

作用机制

分子靶点

Gensci-004 作用于 2 个分子靶点：

GHRgrowth hormone receptor (GHBP, GHIP)
(TERG_01127)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

Gensci-004 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Endocrine disordersGrowth hormone deficiency✓ Approved

相关研究文献

PubMedJournal of acquired immune deficiency syndromes (1999)2026-06-13

Comparing clinical and cytokine profiling of genital inflammation as predictors of HIV acquisition in women.

Osman Farzana F, Yende-Zuma Nonhlanhla N, Zewotir Temesgen T, Naicker Nivashnee N et al.

Inflammation in the female genital tract (FGT) is a key risk factor for HIV acquisition, but it remains unclear whether clinical or immunological measures best predict risk. We aimed to prospectively compare HIV acquisition among women with clinically and/or immunologically defined inflammation. HIV-uninfected women enrolled in the CAPRISA 004 tenofovir gel randomized controlled trial in South Africa were followed for up to 34 months. We analyzed data from 889 women, with cytokine measurements available for 774 participants. Clinical genital abnormalities were assessed at scheduled visits, and 48 cytokines were measured in cervicovaginal lavage samples. HIV incidence was compared across categories of clinical and immunological inflammation using time varying Cox proportional hazards models, adjusting for relevant covariates. Immunological inflammation, defined as ≥9 elevated cytokines, was present in 18% (140/774) of women. Among specific clinical signs, abnormal genital discharge (aHR: 2.67, 95% CI: 1.14-6.23, p=0.024) and cervicitis (aHR: 10.34, 95% CI: 2.46-43.65, p=0.001) were significantly associated with increased HIV acquisition. Women with both clinical and immunological inflammation had the highest risk of HIV acquisition, with adjusted hazard ratios of 2.08 (95% CI: 1.10-3.91, p=0.022) and 2.46 (95% CI: 1.21-5.03, p=0.013), respectively. Clinical and immunological definitions of inflammation were each independently associated with increased HIV acquisition risk and combined they reflected greater susceptibility. These findings highlight the important role of genital inflammation in women's HIV susceptibility, suggesting that clinical signs may provide practical early indicators of risk even as cytokine profiles provide a more sensitive measure of underlying inflammation.

PMID 42285049
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PubMedBMC primary care2026-06-13

Predictors of diabetes self-management and glycemic control among patients with diabetes mellitus in conflict-affected Palestine.

Farajalla Fuad F, Halahla Abd-Alrahman AA, Abuejheisheh Ashraf Jehad AJ, Salameh Ayman A et al.

Poor glycemic control and inadequate self-management drive the global diabetes mellitus (DM) burden. In conflict-affected Palestine, structural barriers worsen outcomes, yet diabetes management self-efficacy (DMSE) remains understudied. To assess diabetes management self-efficacy and glycemic control, their interrelationship, and the independent predictors of each among patients with diabetes mellitus in conflict-affected Palestine. A cross-sectional study was conducted among 418 adults with type 1 or type 2 DM attending governmental diabetes clinics in the Hebron governorate, West Bank, Palestine. Data were collected using the Arabic-validated Diabetes Management Self-Efficacy Scale (DMSES) and a structured clinical questionnaire. Non-parametric tests and two multiple linear regression models were applied to identify independent predictors, with HbA1c and DMSE scores specified as the two dependent variables. Glycated hemoglobin (HbA1c) was suboptimal (median = 7.50, IQR = 2.30), while DMSE was moderate (median = 3.45/5, IQR = 1.10). Blood glucose management was the strongest subdomain, whereas physical exercise was the weakest. Former smoking (β = 0.202, 95% CI: 0.430, 1.494, p < .001), lower physical activity frequency (β = 0.156, 95% CI: 0.098, 0.455, p = .003), and diabetes-related complications (β =-0.154, 95% CI: -1.132, - 0.210, p = .004) independently predicted higher HbA1c. Lower physical activity (β =-0.177, 95% CI: -0.208, - 0.060, p < .001), longer disease duration (β =-0.135, 95% CI: -0.177, - 0.021, p = .013), lower income (β = 0.163, 95% CI: 0.081, 0.348, p = .002), and lower education (β = 0.127, 95% CI: 0.018, 0.227, p = .022) independently predicted lower DMSE. Clinical, behavioral, and socioeconomic factors independently predicted glycemic control and self-efficacy. The DMSE-HbA1c disconnect indicates structural barriers impede self-management behavior. Integrating clinical education with economic and structural support is essential to improve diabetes outcomes in conflict-affected settings.

PMID 42286467
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PubMedJournal of applied gerontology : the official journal of the Southern Gerontological Society2026-06-12

Relationship Between Mental and Physical Health Among Frequent 9-1-1 Callers: A Preliminary Report.

VanderWerf Jessica A JA, Peterson Lindsay J LJ, Clapp Jonathan D JD, Veal Britney B

BackgroundOlder adults with complex health needs frequently utilize emergency medical services (EMS), reflecting gaps in community-based support systems. Community paramedicine, in which EMS professionals operate in expanded support roles, offers interventions to address multiple domains of wellbeing. However, research on the relationship between mental and physical health suggests it is important to better understand both domains.ObjectiveThis exploratory study assessed baseline data collected by the Pinellas Park, Florida, CARES (Community Assistance Resources, Education, and Safety) program, with the goal of better understanding the needs of frequent 9-1-1 callers to guide future interventions.MethodsPinellas Park Fire Department staff identified frequent 9-1-1 callers and developed a survey concerning their needs and resources. Staff administered the survey during a home visit with those who agreed to participate. Data were analyzed using Fisher's exact test to evaluate the relationship between participants' mental health and other variables.ResultsA Fisher's Exact Test indicated an association between mental and physical health (p = .004, Φ = .62). Specifically, 76.2% of participants who reported better mental health also reported better physical health. Similarly, 90% of those reporting better mental health endorsed that their life had purpose (p = .005, Φ = .66).ConclusionThe association between physical and mental health aligns with existing literature on the relationship between these domains in older adults. Future EMS interventions may benefit from addressing callers' mental health and psychosocial factors.

PMID 42281410
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PubMedHospital pediatrics2026-06-12

Effect of Opt-Out HIV Testing for Adolescent Patients on a Pediatric Hospital Medicine Service.

Sadler Annie A, Mukherjee Gargi G, Bryant Jordan E JE, Cameron Melissa M et al.

In 2023, our emergency department, serving a region with one of the highest rates of new HIV infection, implemented Centers for Disease Control and Prevention-recommended universal, opt-out HIV screening for adolescents. However, few patients admitted to the pediatric hospital medicine service (PHM) were tested. To address this gap, we aimed to expand universal, opt-out HIV testing to PHM and evaluate screening implementation. In this pre-postintervention study, we compared HIV testing rates for patients admitted to PHM aged 13 years or older during 5 months preimplementation and postimplementation (February to June 2024 and July to November 2024). Clinicians received regular education on HIV screening guidelines and opt-out language and were encouraged to incorporate screening in confidential psychosocial assessments. If the inpatient team did not offer testing, HIV navigators counseled adolescents, regardless of parental presence. Testing rates were compared with chi-square and Welch's t-test. There was a 38% increase in HIV screening from the preimplementation to postimplementation periods (preimplementation, 12.4%; postimplementation, 17.1%; P = .04). Postimplementation, 533 adolescents were eligible for HIV screening; 148 were approached, and 91 HIV tests were ordered (17.1% of eligible; 64% girls; mean age 16 ± 1.8 years), identifying one adolescent with HIV (>1% seroprevalence; 3% for boys). Adolescents were significantly more likely to be tested when approached by an HIV navigator than during a confidential interview (P = .004). Parental presence did not negatively impact adolescent participation. Adopting universal, opt-out HIV screening with HIV navigators in the inpatient setting significantly increased testing rates. Further studies on the most effective and sustainable approach to screening are needed.

PMID 42276548
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PubMedJournal of fluency disorders2026-06-12

Stuttering representation on Arabic-language Instagram: Who speaks and what gains visibility.

Adem Hisham H

Social media platforms play an increasing role in how stuttering is represented in public discourse. In Arabic-speaking contexts, little is known about the stuttering-related content available online, including who produces it, what types of advice circulate, and how engagement differs across sources. This study examined Arabic-language stuttering discourse on Instagram, focusing on associations among source identity, advice type, and post-level engagement (likes and comments). A structured content analysis was conducted on 500 Arabic-language Instagram posts related to stuttering collected over seven months. Posts were coded for source identity, advice type, and valence. Associations between source identity, advice type, and engagement (likes and comments) were modeled using logistic and negative binomial regression. Qualitative contextual coding was used to interpret recurrent narrative patterns underlying quantitative associations. Intercoder reliability was assessed using Krippendorff's alpha, and sensitivity analyses were conducted to evaluate the robustness of model estimates. Non-clinical sources, including special educators and digital content creators, produced the majority of posts (77.4%). Advice type varied significantly by source identity, χ²(8, N = 500) = 102.81, p < .001, Cramér's V = .45, with several non-clinical sources showing substantially higher odds of posting non-evidence-based advice (e.g., AORs ≈ 4.9-7.2). Engagement also differed by source and advice type. Non-evidence-based posts were associated with higher rates of likes (RR = 1.46, p = .004) and comments (RR = 1.39, p = .027), with the highest engagement observed for non-evidence-based posts authored by digital creators. Intercoder reliability ranged from Krippendorff's α = .72-.88 across coded variables. Qualitative contextual coding identified recurring narrative patterns centered on self-acceptance, perseverance, and claims of fluency change, alongside content with varying alignment with clinical perspectives. Arabic-language Instagram reflects a discourse environment in which stuttering-related information is produced largely by non-clinical sources and engagement does not consistently correspond to clinical expertise. Visibility appears influenced by content characteristics, structural and cultural contexts, and platform dynamics. These findings point to a hybrid credibility system in which professional and experiential perspectives intersect and highlight considerations for digital health communication about stuttering in Arabic-speaking contexts. They also contribute to broader discussions of how health-related information circulates within digital environments.

PMID 42276025
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PubMedAnimals : an open access journal from MDPI2026-06-12

Dietary L-Citrulline Supplementation Promotes Rumen Development and Modulates the Microbiota-Metabolome Axis in Suckling Hu Lambs.

Tang Zhen Z, Zhang Shuoyi S, Xu Peiyao P, Tang Honggang H et al.

The suckling phase is the critical window for rumen functional maturation, yet amino-acid-based interventions tailored to this stage remain scarce. L-citrulline (L-cit) bypasses hepatic first-pass metabolism, is converted to L-arginine peripherally, and resists ruminal microbial degradation, making it a candidate functional additive for early-life ruminants. This study evaluated whether dietary L-cit at 2 g·lamb-1·d-1 would improve rumen development and metabolic function in suckling Hu lambs. Twenty male Hu lambs were randomly assigned to a control (CON) or L-cit group (n = 10/group) and reared for 45 d (3 d adaptation + 42 d treatment). Growth and starter intake were assessed in all lambs; six lambs per group (n = 6) were subsequently slaughtered for rumen morphometry, gas chromatography-flame ionization detection (GC-FID) volatile fatty acid (VFA) quantification, 16S rRNA gene sequencing, and liquid chromatography-mass spectrometry (LC-MS) untargeted metabolomics. L-cit increased average daily starter intake by 25.96% (p = 0.036) and produced a 20.00% numerical but non-significant increase in average daily gain (ADG) (p = 0.203; Cohen's d = 0.58). Rumen weight, volume, and papillary length, width, density, and epithelial thickness were all elevated (p < 0.05), whereas muscular thickness was unaffected (p = 0.162). Total VFA, acetate, propionate (+37.64%, p < 0.001), and butyrate were higher in the L-cit group; the molar proportion of propionate rose from 21.41% to 24.75%, and the acetate-to-propionate ratio declined from 2.90 to 2.44 (p = 0.005). Microbial richness (Chao1, Observed species) increased without altered evenness, and linear discriminant analysis effect size (LEfSe) identified L-cit-driven enrichment of propionate-generating and fiber-degrading genera, including Prevotellaceae_UCG-004, Ruminobacter, and the NK4A214_group. Of 539 differential metabolites (147 of which were annotated to the Kyoto Encyclopedia of Genes and Genomes (KEGG) database), KEGG enrichment highlighted linoleic acid metabolism and purine metabolism as the biologically interpretable targets. Microbiota-metabolite correlations linked L-cit-enriched genera to up-regulated metabolites such as adenine. Dietary L-cit at 2 g·lamb-1·d-1 enhances starter intake, promotes rumen epithelial development, promotes a shift toward enhanced propiogenic fermentation within an acetate-dominant profile, and remodels the microbiota-metabolome axis, supporting its application as a functional additive during the suckling phase of ruminants. Because epithelial barrier integrity, oxidative stress, and inflammatory markers were not directly measured, these findings should be interpreted as morphological and association-based evidence, and further functional validation is required.

PMID 42278158
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