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alternaria allergen SLIT

✓ Approved

HAL Allergy Group · 治疗药物

什么是 alternaria allergen SLIT？

alternaria allergen SLIT 是一种治疗药物，由HAL Allergy Group研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)、Sublingual (SL)/Oral Transmucosal。

药物档案

公司HAL Allergy Group
给药途径Oral (PO), Sublingual (SL)/Oral Transmucosal
状态Approved
来源： ClinicalTrials.gov, HAL Allergy Group

治疗适应症

alternaria allergen SLIT 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Immune system disordersHypersensitivity✓ Approved

相关研究文献

PubMedInternational journal of biological macromolecules2026-08-04

Protein extraction strategies shape shellfish allergen landscapes: Implications for seafood safety, allergy diagnosis and risk management.

Iddagoda Janitha J, Chin Renee R, Karnaneedi Shaymaviswanathan S, Nugraha Roni R et al.

Shellfish is a leading cause of life-threatening food anaphylaxis. Protein extraction is a critical step in allergenic protein (allergen) detection and quantification. This study evaluates the impact of protein extraction strategies on allergen detection in the two most widely consumed shellfish species, black tiger prawn (Penaeus monodon) and white leg prawn (Litopenaeus vannamei). Proteins were extracted from raw and boiled muscle tissues in four different buffers: urea-based, sodium dodecyl sulphate (SDS)-based, SDS-based with reducing agent, and phosphate-buffered saline (PBS), the most commonly used buffer in allergy investigations. Protein abundances were analysed using SDS-PAGE and label-free liquid chromatography-tandem mass spectrometry. Allergenicity was predicted using AllerCatPro and subsequently evaluated for antibody-based immunoreactivity. Protein extraction strategies significantly influenced proteome coverages, IgE-antibody binding, allergen diversities and relative abundances. Although PBS-based extracts yielded the highest overall relative allergen abundances (~84-95%), they generated the lowest allergen diversities and reduced relative abundances of key allergens, including tropomyosin and myosin light chain from raw tissues and arginine kinase from boiled tissues. In contrast, denaturing extracts enabled broader allergen representation, with urea-based extracts from boiled tissues generating the most comprehensive allergen repertoire. In addition to well-characterised allergens, up to 72 low-abundant proteins with strong bioinformatic evidence of allergenicity were identified, with their relative recovery varying across extraction strategies. Optimised protein extraction improves allergen detection workflows, supporting the discovery of underreported and low-abundant candidate allergens for future immunological validation, and facilitating more comprehensive risk assessment strategies.

PMID 42546940
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PubMedAllergy, asthma & immunology research2026-08-04

Trajectory Analysis of Pediatric Longitudinal Allergen Sensitization Patterns From Real World Data.

Kim Sungyun S, Lee Minjeong M, Park Ji Soo JS, Gung Jaehee J et al.

To explore the relationship between allergen sensitization patterns and allergic disease diagnosis, with a particular focus on longitudinal sensitization trajectories. Using a large pediatric and young adult cohort from a common data model (CDM)-formatted clinical database, we applied unsupervised learning techniques to identify both static and dynamic sensitization clusters. We developed a predictive model to assess how early sensitization profiles contribute to developing allergic disease later in life. We conducted a single-center, retrospective cohort study using electronic health records from the Seoul National University Hospital CDM. Patients who underwent a skin prick test, multiple allergen simultaneous test, or ImmunoCAP between 2002 and 2021 were included if they were tested in 2 or more age groups. Seventeen allergen categories were analyzed. Latent class analysis identified cross-sectional sensitization clusters, and Gaussian mixture models were used to derive longitudinal trajectories. A Categorical Boosting multilabel classification model was used to predict allergic diagnoses with interpretability enhanced by SHapley Additive exPlanations. A total of 1,656 patients were analyzed. Four cross-sectional clusters were identified (house dust mite [HDM]-dominant, HDM + food, polysensitization, and multiple inhalant clusters). Nine longitudinal trajectories showed a developmental shift from food sensitization to aeroallergen sensitization. Early HDM sensitization was strongly associated with subsequent asthma, whereas eczema and food allergies are linked to food or polysensitization trajectories. Rhinitis was common across aeroallergen clusters. The prediction performance was robust for asthma (F1 score, 0.73; area under the curve, 0.80), moderate for eczema and food allergies, and limited for rhinitis. Longitudinal sensitization trajectories, particularly early HDM dominance, were predictive of asthma development, whereas the predictive values for eczema, food allergies, and rhinitis were weaker. Modeling sensitization history using machine learning may enable the early identification of high-risk children and inform personalized strategies for allergy prevention.

PMID 42547467
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PubMedFrontiers in immunology2026-08-04

Integrated airway epithelial signaling networks linking allergen-driven inflammation to airway remodeling in asthma.

Park Shin-Young SY

Asthma is a chronic inflammatory airway disease characterized by persistent immune activation, airway hyperresponsiveness, and progressive structural remodeling. The airway epithelium functions as the primary sensor of inhaled allergens and actively orchestrates both innate and adaptive immune responses through alarmin and chemokine release, while directly driving structural changes via epithelial-mesenchymal transition and profibrotic mediator production. Upon allergen challenge, exemplified by house dust mite, airway epithelial cells activate an integrated network of signaling pathways, including epidermal growth factor receptor, mitogen-activated protein kinase, PI3K/protein kinase B, nuclear factor kappa B (NF-κB), Janus kinase/signal transducer and activator of transcription (STAT), and transforming growth factor-β/SMAD, which converge on key transcription factors, including NF-κB/RelA, AP-1, STAT6, SMAD2/3, and CCAAT/enhancer-binding protein beta, to coordinately induce the production of acute inflammatory factors, including alarmins (thymic stromal lymphopoietin (TSLP), interleukin (IL)-33, IL-25), and chemokines (C-C motif chemokine ligand 20, C-X-C motif chemokine ligand 8), as well as chronic cellular remodeling, including goblet cell hyperplasia, subepithelial fibrosis, and smooth muscle expansion. This review provides a comprehensive, network-centered synthesis of these mechanisms, with a particular focus on the molecular basis of asthma endotype heterogeneity, amplifying role of viral exacerbations, epigenetic regulation of epithelial inflammatory programs, and signaling basis of corticosteroid resistance. Further, we map the mechanistic basis of the phenotypic heterogeneity across eosinophilic, neutrophilic, and mixed asthma endotypes onto specific network configurations and then discuss therapeutic implications spanning approved biologics, kinase inhibitors, barrier-restoration strategies, and combinatorial approaches.

PMID 42548510
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PubMedAllergy, asthma & immunology research2026-08-04

Impact of Allergen-Specific Subcutaneous Immunotherapy on 12-Month Health-Related Quality of Life in Children and Their Parental Caregivers.

Zhou Wenjing W, Guo Xingyu X, Ding Bo B, Li Yaqin Y et al.

Respiratory allergies impair children's health-related quality of life (HRQoL) and increase caregiver burden. While allergen-specific subcutaneous immunotherapy (SCIT) is known to improve clinical outcomes, its short-term impact on HRQoL in children and their parental caregivers remains underexplored. We aimed to evaluate the 12-month impact of SCIT on HRQoL, identify the determinants of HRQoL, and assess the correlation between symptom improvements and HRQoL gains. This prospective study enrolled children with allergic rhinitis and/or asthma receiving either SCIT or standard pharmacotherapy, alongside their parental caregivers. Validated generic and disease-specific HRQoL instruments were administered at baseline and the 12-month follow-up. HRQoL changes were analyzed using paired t-tests and Cohen's d effect sizes (ESs). Factors influencing HRQoL were identified using multivariable regression, and correlations between symptom changes and HRQoL gains were examined. After 12 months, children in the SCIT group (n = 132) showed significantly greater improvements in HRQoL than those receiving standard pharmacotherapy (n = 120) (ESs: 0.52-1.34 vs. 0.21-1.05), particularly in the domains of "usual activities" and "pain/discomfort." Caregivers in the SCIT group also experienced greater improvements in HRQoL (ESs: 0.54-0.60 vs. 0.23-0.26), particularly in the domains of "exhaustion," "anxiety," and "day-to-day activities." Multivariable regression analysis identified significant factors influencing HRQoL for both children and caregivers, including coexisting allergic conditions, disease control status, SCIT, and caregiver burdens. Symptom improvements with SCIT showed moderate-to-strong correlations with HRQoL gains. Over a 12-month period, SCIT was associated with significantly greater improvements in HRQoL for children with respiratory allergies and their parental caregivers compared with standard pharmacotherapy. Generic HRQoL instruments demonstrated good sensitivity to short-term treatment-related changes, supporting their utility as complementary outcome measures in SCIT evaluation. ClinicalTrials.gov Identifier: NCT06535087.

PMID 42547470
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PubMedBeyoglu eye journal2026-08-04

One-Year Visual, Refractive, Tomographic, and Aberrometric Outcomes of Repeat Corneal Collagen Crosslinking in Eyes with Progressive Keratoconus.

Buyuktepe Tuna Celik TC, Kılıç Burcu B, Ucakhan-Gunduz Omur O OO

To evaluate visual, refractive, tomographic and aberrometic outcomes of repeat corneal collagen crosslinking (CXL) using Dresden protocol in the management of keratoconus progression at 1-year follow-up. Charts of consecutive progressive keratoconus patients who underwent repeat corneal collagen CXL using Dresden protocol and had at least 1 year follow-up were retrospectively evaluated. Best spectacle-corrected distance visual acuity (CDVA), manifest refraction, slit lamp biomicroscopy, corneal tomography, corneal aberrometry and endothelial cell counts were evaluated before repeat CXL and at postoperative year-1. At postoperative 1-month, corneal demarcation line depth were evaluated using anterior segment optic coherence tomography. Overall, seven eyes of seven patients with the mean age of 23 (ranged 19 to 27) years were included. The interval between the initial and repeat CXL procedures was 60 (ranged 28 to 89) months. At postoperative month-1, a clear demarcation line could be observed in all patient eyes. The mean demarcation line depth was 250 (ranged 220 to 360) µm. At postoperative month-12, mean CDVA, manifest refraction, topographic indices, and aberrometric outcomes remained stable (p>0.05). Maximum keratometry was reduced more than 1D in two (28.6%) eyes, and remained stable in the remaining five (71.4%) eyes. No significant endothelial cell loss or any other sight-threatening complication was encountered in any patient eye. Repeat corneal CXL seems to be safe and effective in halting keratoconus progression at 1-year follow-up.

PMID 42549180
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PubMedJournal of tropical medicine2026-08-04

Real-Time PCR-Based Detection of Mycobacterium leprae From Multiple Clinical Samples for Molecular Diagnosis of Leprosy in Côte D'Ivoire.

Dehe Bahou Roger BR, Amon Aby Christiane AC, Ban Ouemela Venance OV, Tiemoko Gogbé Jean-Luc GJ et al.

Leprosy remains endemic in Côte d'Ivoire, with persistent Grade 2 disability cases indicating ongoing challenges in early diagnosis. Classical diagnosis relies on clinical examination and microscopy, which lacks sensitivity because Mycobacterium leprae cannot be cultured. In the context of the WHO "Zero Leprosy" strategy (2021-2030), molecular tools are needed to confirm cases, detect subclinical infections, and monitor transmission. We developed and evaluated a real-time PCR protocol targeting the M. leprae 16S rRNA gene for molecular diagnosis. Clinical specimens (slit-skin smears and nasal mucus) were collected from 20 clinically diagnosed leprosy patients in Côte d'Ivoire. DNA/RNA extraction was performed using both a semiautomated kit (NucliSENS) and a manual guanidinium thiocyanate (GuSCN) method. Real-time PCR results were compared with direct microscopy (Ziehl-Neelsen staining). The choice of GuSCN was justified by its chaotropic properties, which inactivate mycobacteria, stabilize RNA, and improve biosafety. Among 48 samples, microscopy detected only nine (18.8%) positive cases, all from multibacillary (MB) patients. In contrast, real-time PCR detected 35 (72.9%) positives using the NucliSENS kit and 31 (64.6%) using the GuSCN method. In paucibacillary (PB) patients, PCR positivity reached 59.5%, whereas microscopy was nearly negative. Ear lobe exudates provided the best diagnostic yield. Real-time PCR targeting 16S rRNA significantly improves M. leprae detection compared to microscopy, especially in PB forms. The manual GuSCN method is a reliable, low-cost alternative for endemic settings. This approach can facilitate early case confirmation, subclinical infection detection, and support leprosy control efforts in Côte d'Ivoire within the WHO Zero Leprosy framework.

PMID 42548962
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