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Hep A-Vi (ViATIM / ViVAXIM)

✓ Approved

Sanofi S.A · 疫苗 · 疫苗

什么是 Hep A-Vi？

Hep A-Vi 是一种疫苗，由Sanofi S.A研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intramuscular (IM) Injection。

药物档案

商品名ViATIM, ViVAXIM
公司Sanofi S.A
药物类别疫苗, 大分子
给药途径Injectable (Others), Intramuscular (IM) Injection
状态Approved
来源： ClinicalTrials.gov, Sanofi S.A

治疗适应症

Hep A-Vi 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsTyphoid fever✓ Approved
Surgical and medical proceduresAntiviral prophylaxis✓ Approved

相关研究文献

PubMedScientific reports2026-06-13

Luminescent heparin-functionalized carbon dots with potential applications in nanoparticle-protein interactions and cell imaging.

Sen Ipsita Kumar IK, Hossain Maidul M, Bhattacharya Debesh Chandra DC, Kumar Anoop A et al.

In this study, we report the synthesis and comprehensive characterization of heparin-capped carbon dots (Hep-C-dots) prepared using D-glucose as a carbon precursor and heparin, a negatively charged polysaccharide belonging to the glycosaminoglycan family, as a capping and stabilizing agent. The obtained Hep-C-dots exhibited a uniform nanoscale size distribution with an average diameter of 2.5 ± 0.5 nm and a high negative surface charge (- 36.8 mV). Full characterization of as-synthesized Hep-C-dots has been done by several state-of-the-art analytical techniques, such as transmission electron microscopy (TEM), X-ray diffraction (XRD), UV-visible spectroscopy, Fourier-transform infrared (FTIR) spectroscopy, and zeta potential analysis. The interactions between Hep-C-dots and key human proteins, namely human methemoglobin (HB) and human serum albumin (HSA), were investigated via fluorescence spectroscopy, demonstrating significant binding affinities with Ksv values of 2.61 ± 0.5 × 107 M- 1 for HSA and 1.83 ± 0.4 × 107 M- 1 for HB. Cytotoxicity assays performed on A549 lung cancer cells revealed that Hep-C-dots exhibit slightly higher toxicity compared to bare carbon dots (C-dots), with IC50 values of 176.21 µg/mL and 200.4 µg/mL, respectively. Moreover, hemolysis assessment using bovine red blood cells (RBCs) showed that Hep-C-dots induce negligible hemolysis (0.002% at 200 µg/mL), confirming their excellent hemocompatibility. These findings suggest that Hep-C-dots hold promise as biocompatible nanomaterials for biomedical applications.

PMID 42286005
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PubMedJournal of hazardous materials2026-06-13

Respiration-coupled redox metabolism supports Cr(VI) reduction by an indigenous Bacillus in soil-groundwater systems.

Gu Decheng D, Cao Xian X, Wang Dong D, Chen Dong D et al.

Reliable in situ remediation of Cr(VI)-contaminated soil-groundwater systems remains challenging because introduced microorganisms often show poor persistence, competitiveness, and functional stability under site-specific subsurface conditions. Indigenous microorganisms may provide a more adaptable alternative, yet how their respiratory metabolism, ecological fitness, and community interactions support sustained Cr(VI) reduction and immobilization under field-relevant conditions remains insufficiently understood. Here, an indigenous Cr(VI)-reducing strain GS was isolated and evaluated in aqueous batch cultures, soil microcosms, and a pilot-scale in situ trial, supported by multi-omics and microbiome analyses. Strain GS maintained high Cr(VI) reduction across wide temperature and pH ranges in aqueous cultures. In soil microcosms (100-1000 mg kg-1 Cr(VI)), strain GS bioaugmentation achieved 66-77% Cr(VI) reduction and shifted chromium from labile pools to more stable solid-phase fractions, indicating effective immobilization. Transcriptomic and metabolomic profiling indicated that Cr(VI) stress activated a respiration-coupled redox response, characterized by enhanced heme/porphyrin metabolism, increased respiration-associated redox activity, and strengthened carbon/redox metabolism. Community analyses identified Bacillus as a key taxon associated with Cr(VI) reduction. A 180-day field trial achieved rapid Cr(VI) depletion in soil and groundwater within 30-120 days and showed no rebound over 180 days. These findings support indigenous Bacillus-based in situ bioremediation as a sustainable strategy for Cr(VI)-contaminated soil-groundwater systems.

PMID 42284780
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PubMedChemico-biological interactions2026-06-13

Effect of glycometabolism disorder mediated by TIGAR/PFKFB3 on liver damage in mice exposed to Cr(VI).

Zhu Yiran Y, Liu Wenhui W, Chen Peng P, Wang Wenchen W et al.

Various studies have shown that the harm of hexavalent chromium (Cr(VI)) to animals covers all aspects of the body, while glucose metabolism disorder is one of its hazard factors. In this study, the possible mechanism underlying Cr(VI) exposure on liver glycometabolism and damage was investigated. A mouse model was established by intragastrical administration of Cr(VI) for 5 days; liver tissues were collected and used to detect liver glycometabolism and balance between autophagy and apoptosis. Expose liver cells to a high dose of Cr(VI) significantly increased the levels of alanine aminotransferase, aspartate aminotransferase, malondialdehyde and reactive oxygen species production, suppressed glutathione peroxidase and superoxide dismutase release, upregulated 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3) expression, inhibited tp53-induced glycolysis and apoptosis regulator (TIGAR) expression and promoted liver glycometabolism disorder. Moreover, the pathway network of glycometabolism has been analysised, showing that 21 differential metabolites levels were decreased and 6 increased. Carbohydrate metabolism pathways closely related to glycometabolism disorder were significantly enriched after Cr(VI) exposure. TIGAR/PFKFB3 inhibited the interactions between Beclin1/BAX and Bcl-2 via Bcl-2 regulated the balance between autophagy and apoptosis. Overall, Cr(VI) can lead to glycometabolism disorder through TIGAR/PFKFB3 imbalance and result in liver injuries in mice.

PMID 42285245
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PubMedJournal of hazardous materials2026-06-13

Spider-web-inspired phosphorylated aerogel engineered via Schiff base linkages for efficient uranium capture.

Ma Mingyang M, Li Hongyan H, Luo Qunyin Q, Han Ruidong R et al.

With the increasing global utilization of nuclear energy, the accumulation of uranium-containing wastewater has become a critical environmental concern, which has consequently led to significant attention being attracted to the development of high-performance adsorbents for efficient uranium separation. Herein, a phosphorylated biosorbent, P-gelatin/G2.0, was developed by integrating phosphorylated polyamidoamine (PAMAM) dendrimers (G2.0) with eco‑friendly gelatin via a spider‑web‑inspired strategy that mimics the hierarchical web architecture of spider webs, coupled with Schiff base crosslinking, yielding effective uranium capture from aqueous media. The biosorbent exhibited exceptional uranium adsorption performance, reaching a maximum capacity of 1103.20 mg·g-1 at pH 6.0, as evidenced by the Langmuir isotherm and pseudo-second-order kinetics. Thermodynamic investigations indicated a spontaneous adsorption mechanism. XPS spectra revealed that phosphate groups played a dominant role in U(VI) coordination, synergistically interacting with amino and hydroxyl groups. The P-gelatin/G2.0 biosorbent demonstrated outstanding selectivity in multi-ion systems and maintains 84.94% adsorption efficiency after five regeneration cycles, revealing its robust reusability. The DFT study confirms that the phosphorylation introduces phosphate groups which dominate the uranyl ion coordination, thereby elucidating the fundamental adsorption mechanism. This study displays the potential of P-gelatin/G2.0 as a sustainable, high-capacity material for uranium recovery in nuclear wastewater treatment and environmental remediation applications.

PMID 42284785
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PubMedEnvironmental entomology2026-06-13

Occurrence patterns of Myllocerinus aurolineatus (Coleoptera: Curculionidae) and histological observation of adult female tissues.

Sun Qinyu Q, Niu Tingting T, Lin Qiaoling Q, Lian Wenxu W et al.

From March 2023 to December 2024, a comprehensive study was conducted on the field population dynamics, developmental duration, life history, and ovarian development of Myllocerinus aurolineatus (M.aurolineatus). The study combined systematic field surveys, laboratory rearing, and ovarian dissection. The results indicated that M. aurolineatus has one generation year. The temporal dynamics varied slightly between years. In 2023, adult emergence began in early May, with a population increase in late May and a peak density in early June. In 2024, emergence occurred earlier (late April); the population abundance increased in mid-May, reaching maximum abundance by late May. The developmental duration of M. aurolineatus varied markedly, with the larval stage lasting the longest (281.71 d) and the egg stage the shortest (13.49 d). Oviposition peaked between mid-June and early July. Larvae began hatching in mid-June and inhibited the soil until the subsequent April. Pupation occurred in mid-April, marking the onset of adult emergence in late April. The ovarian development process could be divided into 6 grades, from grade I to grade VI. Field sampling revealed that by late May, adults at the oviposition peak grade (grade IV) had already appeared, and subsequently collected adults were all sexually mature. Taken together, the analyses of population dynamics and ovarian development indicate that the optimal time for controlling M. aurolineatus is before late May, when the adult population has reached peak abundance but females have not yet oviposited, thereby providing valuable guidance for its management.

PMID 42285562
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PubMedEuropean journal of cardiovascular nursing2026-06-13

Practical guidance for researchers on onboarding participants to digital platforms: key considerations when designing and conducting mHealth studies in acute care.

William Scott S, John Reejamol R, Allida Sabine M SM, Downie Anne A et al.

Onboarding participants to mobile health (mHealth) studies in acute cardiovascular care is a complex process that requires thoughtful planning, skilled communication, and technological know-how. Drawing on insights from the INFORM-AF II pilot randomized controlled trial, this Methods Corner paper outlines practical considerations for optimizing onboarding processes when engaging hospitalized adults in digital health research. Onboarding in acute care is uniquely shaped by clinical uncertainty, fluctuating patient capacity, and varying levels of digital health literacy. Researchers must balance ethical, logistical, and technological factors while ensuring recruitment and informed consent remain patient-centred and culturally responsive. Seven key considerations are outlined: (i) adequate and transparent communication; (ii) specific technology considerations required for participation in the intervention; (iii) design and user friendliness of the intervention; (iv) effective recruitment and screening strategies; (v) prioritization of privacy and data security; (vi) securing adequate infrastructure and connectivity; and (vii) providing tailored support for participants with lower digital literacy. These elements are important for reducing participant burden, enhancing engagement, and mitigating attrition. Practical strategies, including the use of flowcharts, teach-back methods, QR-code-facilitated app installation, and personalized bedside assistance, are outlined as essential to onboarding. Given the exponential growth in mHealth interventions in cardiovascular nursing research, transparent reporting of onboarding procedures is needed. The onboarding procedure should be described as a core component of complex, nurse-delivered mHealth interventions. The guidance presented offers practical advice to cardiovascular researchers on strengthening the design, implementation, and reporting of onboarding processes in mHealth trials conducted within acute hospital settings.

PMID 42287025
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