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Purethal Mites (Purethal Mites)

✓ Approved

HAL Allergy Group · 治疗药物

什么是 Purethal Mites？

Purethal Mites 是一种治疗药物，由HAL Allergy Group研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Subcutaneous Injection。

药物档案

商品名Purethal Mites
公司HAL Allergy Group
给药途径Injectable (Others), Subcutaneous Injection
状态Approved
来源： ClinicalTrials.gov, HAL Allergy Group

治疗适应症

Purethal Mites 针对 3 个适应症，涉及 3 个治疗领域。

治疗领域疾病/病症分期
Respiratory, thoracic and mediastinal disordersRhinitis allergic✓ Approved
Immune system disordersAllergy to animal✓ Approved
Eye disordersConjunctivitis allergic✓ Approved

相关研究文献

PubMedFrontiers in allergy2026-08-05

Challenges of using the Occupational Asthma-specific job exposure matrix to assess occupational exposure and hand eczema.

Brands Marjolein J MJ, Loman Laura L, Bültmann Ute U, Schuttelaar Marie L A MLA

General population-based studies addressing the association between occupational exposure to irritants and allergens and hand eczema (HE) are limited, or only focus on specific occupations using self-reported exposure data. To assess the association between occupational exposure to irritants and allergens and moderate-to-very severe HE, by using the Occupational Asthma-specific job exposure matrix (OasJEM) within the Dutch general population, and to address the applicability of this approach. Within the Lifelines Cohort Study, participants with moderate-to-very severe HE at worst in the past year vs. no HE in lifetime were identified based on self-reports. The OasJEM was used to link occupations with occupational exposure to irritants and sensitizers, relying on expert-based classification. In total, 56,978 (41.9%) participants were included. The multivariate binary logistic regression analyses showed associations between occupational exposure to irritants [Odds ratio (OR): 1.19 (95% CI: 1.06-1.33)], high molecular weight sensitizers [OR: 1.20 (95% CI: 1.06-1.36)], mites [OR: 1.41 (95% CI: 1.16-1.73)] and disinfectants and cleaning products [1.25 (95% CI: 1.11-1.42)], and moderate-to-very severe HE. While associations between several irritants and allergens and HE were found by applying the OasJEM, which may provide insights into occupational exposure patterns and highlight the general relevance of occupational exposure in relation to HE and its prevention, several methodological and conceptual challenges must be acknowledged. A JEM not specifically designed for HE, like the OasJEM, may not fully capture the complex interplay between occupational exposure and HE, particularly in reflecting direct skin contact, the primary exposure route relevant for HE. However, in the absence of widely available and reliable HE-specific exposure assessment tools, the use of non-HE-specific JEMs may be considered a pragmatic alternative, while acknowledging certain limitations. Future studies should focus on task-based and HE-specific exposure data, providing more accurate insights into occupational exposure and HE.

PMID 42553221
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PubMedImmunotherapy2026-08-04

Impact of sublingual immunotherapy with dust mite drops on ECP, TARC, VCAM-1 inflammatory status in patients with allergic rhinitis.

Deng Bangyu B, Zhao Yunxia Y, Liu Jisheng J

To evaluate the effect of sublingual immunotherapy with dust mite drops on serum eosinophil cationic protein (ECP), thymus and activation-regulated chemokine (TARC), vascular cell adhesion molecule-1 (VCAM-1) levels and symptom improvement in allergic rhinitis (AR) patients. A prospective randomized controlled trial enrolled 300 AR patients sensitized to dust mites, randomly assigned to control group (conventional treatment, n = 150) and research group (conventional treatment plus sublingual dust mite drops, n = 150) for 6 months. Compared with controls, the research group showed significantly greater reductions in interleukin-4 (IL-4), interleukin-17 (IL-17), ECP, TARC, VCAM-1, lower adverse reaction rates, improved pulmonary function including forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), peak expiratory flow (PEF), FEV1/FVC ratio, and small airway function including maximal mid-expiratory flow (MMEF), expiratory flow rate at 50% of FVC (MEF50), expiratory flow rate at 25% of FVC (MEF25), as well as reduced symptom scores (all p < 0.05). Sublingual immunotherapy with Dust mite drops appears effective in suppressing systemic inflammation, minimizing treatment-related adverse events, enhancing both small airway and pulmonary function, and easing the clinical manifestations of allergic rhinitis.

PMID 42550205
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PubMedJournal of the science of food and agriculture2026-08-04

Phytochemical profiling and insecticidal activity of Moricandia sinaica across growth stages: experimental and molecular docking insights.

Zatout Roukia R, Benslama Ouided O, Zatout Chaima C, Kacem Chaouche Noreddine N et al.

Stored food products are highly vulnerable to infestation by insects and mites, resulting in significant postharvest losses worldwide. Plant-derived bioactive compounds represent promising eco-friendly alternatives to synthetic pesticides. This study investigated the phytochemical composition of Moricandia sinaica at different growth stages and evaluated its insecticidal activity against Plodia interpunctella larvae, complemented by molecular docking analysis. Gas chromatography-mass spectrometry analysis revealed clear stage-dependent variations in volatile composition. At the flowering stage, hexahydrofarnesylacetone, 1,8-cineole, and α-thujene were predominant, whereas mature plants were characterized mainly by hexahydrofarnesylacetone, α-pinene, and dihydroactinidiolide. Fatty acid analysis showed that palmitic acid remained the dominant component, although it decreased, while oleic and stearic acids increased at maturity. Insecticidal bioassays showed concentration- and time-related increases in larval mortality against P. interpunctella larvae. Molecular docking suggested that major fatty acids may interact with residues located within the carbohydrate-recognition region of β-1,3-glucan-binding protein 3 (GNBP3), providing a predictive hypothesis that requires further experimental validation. The results highlight Moricandia sinaica as a promising source of bioactive compounds with potential applications in environmentally friendly pest management strategies for stored products. © 2026 The Author(s). Journal of the Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

PMID 42548019
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PubMedJournal of experimental botany2026-08-03

An herbivorous mite protein triggers plant defense and promotes resistance to herbivores.

Zhou Bin B, Cui Jia-Rong JR, Chen Ya-Xuan YX, Li Jia-Mei JM et al.

Herbivore-associated molecular patterns (HAMPs) enable plants to recognize herbivorous arthropods and help them adjust their resistance against these herbivores. In this study, we report a novel HAMP from spider mites, TeCP, that can activate defense responses in multiple plant species. TeCP interacted with and relied on the rubisco small chain (RbcS) to activate plant defense. Yeast library screening revealed two proteins interacting with RbcS8: catalase (CAT1) and fructose-1,6-bisphosphate aldolase (FBA). TeCP mediates the degradation of RbcS, thereby reducing the abundance of CAT1 and FBA proteins, which activates plant defense through negative regulation. Our results therefore reveal a novel HAMP from herbivores that enhances plant defense and resistance against herbivores, providing valuable insights for pest management.

PMID 42544632
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PubMedExperimental dermatology2026-08-03

LC-OCT for Cutaneous Lupus Erythematosus: Characterization Across Disease Subtypes and Differentiation From Rosacea.

Traini Daniele Omar DO, Palmisano Gerardo G, Ventura Rebecca R, Cannizzaro Maria Vittoria MV et al.

Cutaneous lupus erythematosus (CLE) encompasses a heterogeneous group of autoimmune skin manifestations that often overlap clinically with other inflammatory dermatoses, particularly rosacea. While histopathology remains the gold standard, its invasiveness limits routine and longitudinal use. Line-field confocal optical coherence tomography (LC-OCT) is an emerging non-invasive imaging modality capable of providing real-time, near-histological resolution of skin architecture. In this single-center cross-sectional observational study, 45 patients (30 CLE: 16 acute, 5 subacute, 9 chronic; 15 rosacea) underwent LC-OCT imaging of active lesions. Images were independently evaluated using predefined criteria reflecting histopathological features. LC-OCT identified key histopathological correlates of CLE in vivo. Interface dermatitis features (including dermoepidermal junction disruption, basal cell vacuolization and band-like inflammatory infiltrate) were highly prevalent in ACLE and SCLE, while chronic CLE was characterized by epidermal atrophy, hyperkeratosis, fibrosis and adnexal destruction. In contrast, rosacea exhibited a vascular and folliculocentric pattern with frequent peri-adnexal inflammation and Demodex infestation, without interface changes. Interobserver agreement was substantial to excellent for most criteria. In the ACLE versus rosacea comparison, interface dermatitis features like band-like DEJ infiltrate, DEJ disruption, basal vacuolization and apoptotic bodies were associated with ACLE. Conversely, rosacea exhibited a vascular-folliculocentric profile with peri-infundibular infiltrates and Demodex mites. In conclusion, LC-OCT enables non-invasive visualization of disease-specific microarchitectural patterns in CLE, reflecting both inflammatory and chronic remodelling changes. In this pilot study, it shows potential in differentiating CLE from rosacea and may support diagnosis, staging and treatment monitoring in clinical practice. Larger, multicenter studies are required to confirm the role of LC-OCT in the non-invasive diagnosis of CLE.

PMID 42544818
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PubMedVeterinary parasitology2026-08-02

Outbreak of human infestation by Ornithonyssus sylviarum associated with migratory Sturnus roseus in Bukan, Iran, 2025.

Firooziyan Samira S, Rikhtehgar Ehsan E, Tavassoli Mousa M, Gholizadeh Saber S

Migratory birds act as important dispersal hosts for parasitic mites, facilitating their spread over long geographic distances and potentially contributing to the emergence of infestations in previously unaffected areas. This study investigates an unprecedented outbreak of mite infestation among residents of two villages in northwestern Iran, in July 2025. This outbreak coincided with the arrival and nesting of migratory rosy starlings (Sturnus roseus) within or near human dwellings. A comprehensive survey and clinical examination of the affected villagers revealed that 37.6% of residents in Ebrahim Khesar and 26.3% of residents in ZavehKuh presented with skin lesions consistent with mite parasitism, with housewives representing the most affected occupational group. All itching and skin irritation occurs during the day and mainly involved the trunk and hands. The mean age of affected individuals did not differ significantly between the two villages (35.7 ± 23.1 vs. 41.0 ± 25.8 years; t = -1.111, df = 100, P = 0.269; 95% CI: -15.0-4.2). Mites were collected from live birds and their carcasses and identified as Ornithonyssus sylviarum using morphological criteria. The close association between nesting rosy starlings and human settlements facilitated direct transmission of mites to humans, resulting in widespread symptoms of pruritus and dermatitis, but no systemic disease. This study found rosy starlings introduced bird mites (O. sylviarum) to homes, causing human infestations. Successful control depends on identifying the mite species, bird/nest management, education, and surveillance. A better understanding of the factors driving these outbreaks is essential for informing prevention strategies and reducing the impact of mite infestations on vulnerable populations.

PMID 42542072
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