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thrombin (ThrombiRAAS)

✓ Approved

Shanghai RAAS Blood Products Co., Ltd. · F2 · 细胞治疗

什么是 thrombin？

thrombin 是一种细胞治疗，由Shanghai RAAS Blood Products Co., Ltd.研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名ThrombiRAAS
公司Shanghai RAAS Blood Products Co., Ltd.
药物类别细胞治疗
分子靶点F2
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Shanghai RAAS Blood Products Co., Ltd.

作用机制

分子靶点

thrombin 作用于 1 个分子靶点：

F2coagulation factor II, thrombin (THPH1, PT)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

thrombin 针对 2 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Vascular disordersExtravasation blood✓ Approved
Vascular disordersHaemorrhage✓ Approved

相关研究文献

PubMedFrontiers in oncology2026-08-05

Machine learning to develop and validate a model for predicting the risk of lymph node metastasis in colorectal cancer patients.

Xia Changhe C, Liu Fang F, Xia Changjiang C, Wang Yimin Y et al.

The presence of lymph node metastasis (LNM) serves as a critical determinant of prognosis in colorectal cancer (CRC), often correlating with markedly unfavorable clinical outcomes. Consequently, this investigation sought to construct and rigorously validate a machine learning (ML) algorithm capable of estimating LNM probability within the CRC population. Through the application of logistic regression analysis, six independent predictors were identified: extramural vascular invasion (EMVI), T stage, fibrinogen (FIB), systolic blood pressure (SBP), thrombin time (TT), and alpha-fucosidase (AFU). Subsequently, diverse ML architectures were generated and assessed utilizing receiver operating characteristic (ROC) curves, calibration plots, and decision curve analysis (DCA). Among the evaluated algorithms, the stochastic gradient boosting (gbm) model exhibited superior discriminatory power, yielding area under the curve (AUC) metrics of 0.815 in the training cohort and 0.733 in the external validation set. Calibration assessments revealed a robust concordance between projected probabilities and actual observed events. Notably, the xgbTree algorithm also demonstrated commendable predictive efficacy. We successfully established and verified an ML-based framework designed to forecast LNM risk in individuals with CRC. These computational tools offer clinicians a refined mechanism for the precise identification of nodal involvement, thereby laying the groundwork for formulating personalized therapeutic regimens.

PMID 42553131
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PubMedMicrosurgery2026-08-05

Relationship Between Preoperative Coagulation Parameters and Risk of Flap Pedicle Thrombosis Following Free Flap Breast Reconstruction.

Zhu Liwen L, Xu Boyang B, Liu Wenyue W, Li Shangshan S et al.

Flap pedicle thrombosis is a frequent cause of flap compromise, which is a major complication following free flap breast reconstruction. This study aims to investigate the relationship between preoperative coagulation parameters and the risk of postoperative flap pedicle thrombosis, providing guidance for preoperative assessment and perioperative management. A retrospective analysis was conducted on all patients who underwent free flap breast reconstruction at our institution between January 2021 and August 2025. Patient demographics, surgical details, preoperative coagulation test results (including prothrombin time, activated partial thromboplastin time, fibrinogen, thrombin time, and D-dimer) and outcomes were recorded. Patients were categorized according to their preoperative coagulation test results. Demographics, surgical information, and incidence of flap pedicle thrombosis were compared between groups. Furthermore, patients were divided according to the occurrence of flap pedicle thrombosis. Preoperative coagulation parameters were compared between the two groups, and a multivariate logistic regression was performed to identify potential risk factors. A total of 154 patients (160 breasts) were included. Fifty-two breasts (32.5%) were categorized to the asymptomatic hypercoagulable group, and 108 breasts (67.5%) to the non-hypercoagulable group. Postoperative flap pedicle thrombosis occurred in nine breasts (5.6%), including two arterial thromboses and seven venous thromboses. No significant difference in postoperative flap pedicle thrombosis was observed between the two groups (9.6% vs. 3.7%, p = 0.152). Multivariate logistic regression indicated that immediate flap breast reconstruction might be an independent risk factor (p = 0.028). This study suggested no significant association between preoperative coagulation parameters (including PT, APTT, FIB, TT, and D-dimer) and flap pedicle thrombosis following free flap breast reconstruction.

PMID 42554436
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PubMedCureus2026-08-04

Hybrid Repair of a Giant Postcatheterization Femoral Pseudoaneurysm Using Dual Long-Balloon Occlusion: A Case Report.

Ishibashi Kazuyuki K, Motokawa Mamika M, Islam Shariful S, Ahmed Aslam A et al.

Femoral artery pseudoaneurysm is a well-recognized complication of arterial catheterization. While ultrasound-guided thrombin injection and endovascular interventions are increasingly employed, open surgical repair remains mandatory for large, symptomatic, or complicated lesions. However, obtaining surgical vascular control can be extremely challenging in giant pseudoaneurysms that extend beyond the inguinal ligament and distort the femoral bifurcation anatomy. A 60-year-old woman on maintenance hemodialysis presented with severe pain and tense swelling in her right groin two months after undergoing cardiac catheterization via a right femoral approach. Computed tomography revealed a giant pseudoaneurysm with a maximum diameter of 8 cm, extending proximally above the inguinal ligament and distally into the upper thigh. The pseudoaneurysm neck originated near the bifurcation of the superficial femoral artery (SFA) and profunda femoris artery (PFA). Due to signs of impending rupture, including excruciating pain and overlying skin discoloration, emergency surgery was indicated. Because conventional surgical exposure for proximal and distal clamping was deemed hazardous due to the massive size and anatomical complexity of the lesion, a hybrid approach was adopted. Through a contralateral femoral approach, dual-balloon occlusion of both the SFA and PFA was performed to control systemic inflow and retrograde collateral backflow. Immediate surgical incision of the pseudoaneurysm sac under a completely bloodless operative field allowed for precise identification and direct suture closure of the neck. The patient's postoperative course was uneventful, and she was discharged on postoperative day 3. At the two-month outpatient follow-up, she remained asymptomatic with no clinical evidence of recurrent pseudoaneurysm or wound-related complications. Dual-balloon occlusion combined with open surgical repair represents a highly effective and safe hybrid strategy for treating giant femoral pseudoaneurysms when conventional vascular control is technically demanding or unsafe. This technique provides excellent visualization, facilitates precise neck closure, and minimizes surgical invasiveness in anatomically complex lesions.

PMID 42548644
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PubMedChemical & pharmaceutical bulletin2026-08-03

Photoaffinity Electrophoretic Mobility Shift Assay for Analyzing the Binding Specificity of DNA Aptamers to α-Thrombin.

Sadakane Yutaka Y, Tsubokura Akari A, Kasai Mitsuki M, Ito Yuka Y et al.

DNA aptamers are attractive alternatives to antibodies and advances in selection technologies have yielded several candidate sequences, creating a strong need for efficient methods to evaluate their binding specificity. We previously established a photoaffinity electrophoretic mobility shift assay (EMSA) for analyzing DNA-protein interactions. In this study, we investigated whether this method can be applied to assess the binding specificities of α-thrombin-binding DNA aptamers. The binding specificities of a 15-mer and a 29-mer aptamer were evaluated via photoaffinity EMSA using reaction mixtures enriched in zymogen prethrombin-2, whose structure closely resembles α-thrombin but lacks fibrinogen-clotting activity. Photoaffinity EMSA enabled quantification of the relative binding strengths of α-thrombin and prethrombin-2 resolved in the same sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis (PAGE) lane, revealing that the specificity for α-thrombin was approximately 2.5-3.5-fold higher than that for prethrombin-2 for both aptamers. In the case of the 15-mer aptamer, introducing the photoreactive group at the 9th nucleotide reduced its binding specificity for α-thrombin. This finding indicates that the position of the modification affects aptamer-protein recognition and offers clues about the structural basis of binding. Photoaffinity EMSA also enabled us to distinguish the binding sites of the 15-mer and 29-mer aptamers on α-thrombin using competition experiments with dabigatran and heparin, while allowing selective detection of α-thrombin in human plasma. Together, these results demonstrate that photoaffinity EMSA is a simple and informative approach that can evaluate the binding specificities of multiple DNA aptamers for a target protein in a single SDS-PAGE-based assay.

PMID 42543604
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PubMedZhongguo shi yan xue ye xue za zhi2026-08-03

[Prognostic Factors in Children with Hemophagocytic Lymphohistiocytosis: A Retrospective Cohort Study].

Liu Yan Y, Luo Xin X, Liu Hong H, Gu Chun-Ming CM et al.

To investigate the factors associated with prognosis in children diagnosed with hemophagocytic lymphohistiocytosis (HLH). A retrospective analysis was conducted on clinical data from 75 pediatric patients diagnosed with HLH at Guangdong Women and Children Hospital between January 2018 and December 2022. Patients were categorized into survival and death groups according to clinical outcomes. Demographic characteristics, clinical manifestations, and laboratory findings were compared between the two groups. Univariate and multivariate logistic regression analysis were performed to identify independent prognostic factors, while receiver operating characteristic (ROC) curve analysis was employed to assess the discriminative performance of individual markers and a combined predictive model. A total of 75 HLH cases were included, with an overall mortality rate of 32% (24/75). Compared to the survival group, children in the death group were younger, with significantly elevated levels of aspartate aminotransferase (AST), lactate dehydrogenase (LDH), activated partial thromboplastin time(APTT), prothrombin time (PT), and thrombin time (TT), while total protein (TP), albumin (ALB), triglycerides (TG), and fibrinogen (FBG) were significantly reduced (P<0.05). Multivariate logistic regression revealed that age (OR=0.661, 95%CI: 0.460-0.949, P=0.025), APTT(OR=1.082, 95%CI: 1.032-1.136, P=0.001), and FBG levels (OR=0.376, 95%CI: 0.148-0.959, P=0.041) were independent prognostic factors for children with HLH. ROC curve analysis demonstrated that the combination of age, APTT, and FBG exhibited superior predictive accuracy for adverse outcomes compared to any single marker, yielding an area under the curve (AUC) of 0.880 (95%CI: 0.789-0.971), with a sensitivity of 91.67% and specificity of 78.43%. Younger age, prolonged APTT, and decreased FBG level are significant predictors of poor prognosis in pediatric HLH patients, and their integration into a combined model can improve prediction performance.

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PubMedZhongguo shi yan xue ye xue za zhi2026-08-03

[Integrative Multi-omics Analysis of the Tnf-Pnpla2-Rictor-Nr1d1 Network Underlying the Hemostatic Action of Bletilla Striata].

Yang Tao T, Xiong Yan Y, Yang Ling L, Wang Xing-Gang XG et al.

By integrating transcriptomics and network pharmacology, we systematically investigated the potential hemostatic mechanism of Bletilla striata (BS). Thirty SPF-grade Kunming mice were randomly divided into three groups (n =10 per group): Control group, Model group, and BS group. The BS group was orally administered Bletilla striata extract (2.48 g/kg) for 7 consecutive days, while the Control and Model groups received an equal volume of 0.5% sodium carboxymethyl cellulose (CMC-Na) solution. On day 7, the Model and BS groups were injected via the tail vein with heparin sodium (0.8 U per mouse) to inducesystemic bleeding. The bleeding time (BT) was measured by tail tip amputation, and coagulation parameters including prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), and plasma fibrinogen (FIB) were measured using a semi-automaticcoagulation analyzer. Liver tissues were collected for total RNA extraction and transcriptome sequencing to identify differentially expressed genes (DEGs) related to coagulation pathways. Network pharmacology was used to construct aprotein-protein interaction (PPI) network, screen hub genes, and perform molecular docking to evaluate the binding affinity between the active component militarineand key target proteins. Compared with the Model group, preventive treatment with BS significantly shortened BT and CT (P <0.01), and reversed coagulation parameters: APTT, PT, and TT were significantly reduced (P <0.01), while FIB levels were significantly elevated P <0.001). Transcriptome analysis showed that the hepatic gene expression profile in the BS group was closer to that of the Control group. Network pharmacologyidentified Tnf, Rictor, Nrld1 , and Pnpla2 askey hub genes involved in the hemostaticprocess, all of which exhibited favorable binding affinity with militarine. Compared to the control group, the Model group showed a significant decrease in hepatic Tnf expression but significant increases in Rictor, Nr1d1 , and Pnpla2. After preventive intervention with Bletilla striata , the hepatic Tnf expression in the mice was significantly increased compared to the Model group, while Rictor, Nr1d1 , and Pnpla2 significantly decreased. These findings were further validated by RT-PCR and molecular docking analyses. This study reveals that the hemostatic effect of BS is potentially mediated through multi-target synergistic regulation of coagulation factor transcription, coupled with modulations in lipid metabolism and circadian rhythms. It provides a theoretical basis for developing novel hemostatic agents.

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