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superoxide dismutase (orgotein, Isnardi / Interceptor / SOD, Isnardi)

✓ Approved

Sanofi S.A · 治疗药物

什么是 superoxide dismutase？

superoxide dismutase 是一种治疗药物，由Sanofi S.A研发。该药已获批，用于治疗相关适应症。

药物档案

商品名orgotein, Isnardi, Interceptor, SOD, Isnardi
公司Sanofi S.A
状态Approved
来源： ClinicalTrials.gov, Sanofi S.A

治疗适应症

superoxide dismutase 针对 4 个适应症，涉及 3 个治疗领域。

治疗领域疾病/病症分期
Eye disordersGlaucoma✓ Approved
Hepatobiliary disordersHepatitis✓ Approved
Skin and subcutaneous tissue disordersSkin disorder✓ Approved
Skin and subcutaneous tissue disordersDermatosis✓ Approved

相关研究文献

PubMedSmall (Weinheim an der Bergstrasse, Germany)2026-08-05

Modulating the Optical and Enzymatic Properties of Polydopamine via Valence Engineering of Tungsten Affording NIR-II Photoacoustic Imaging and Targeted Therapy of Atherosclerosis.

Luo Yanni Y, Huang Lixian L, Zhao Jingjin J, Ma Yuzhen Y et al.

Atherosclerosis (AS) is a risk factor for various cardiovascular diseases (CVD), and early diagnosis and plaque removal are challenges in the management of AS and CVD. To address these challenges, we designed a tungsten‑doped polydopamine nanoparticle (W-PDA NPs). The near-infrared (NIR) optical absorption and enzymatic properties of W-PDA were tuned by adjusting the ratio of W6+ to PDA. It was found that the W-PDA NPs contain a mixture of W6+ and W5+, which generated large amounts of free electrons, thus conferring both second near-infrared (NIR-II) light absorption capability and superoxide dismutase (SOD)- and catalase (CAT)-like activities. Plaque-targeting was conferred by appending an anti-osteopontin antibody via coordination between carboxyl moieties of the antibody with W6+ ions on the W-PDA surface. The NIR-II light absorption ability can be utilized for photoacoustic diagnosis of AS, while the SOD- and CAT-like activities facilitate the conversion of superoxide into H2O2 and subsequently O2, thereby clearing reactive oxygen species and mitigating inflammation, enabling therapy of AS. Thus, the proposed theranostic agent not only can dynamically report the progression of AS but also can effectively treat AS plaques. This strategy holds broad application prospects in the early and accurate diagnosis and treatment of AS.

PMID 42554113
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PubMedCancer management and research2026-08-05

Astragalin Suppresses Colorectal Carcinogenesis by Targeting Proliferation, Oxidative Stress, and Inflammation.

Shareef Suhayla Hamad SH, Nanakaly Haween Toufiq HT, Ahmed Salam Adil SA, Gheni Noor Ali NA et al.

Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide. This study evaluated astragalin's (AST) anti-proliferative and chemopreventive effects on CRC. AST's effects were assessed in vitro on Caco-2 and HT-29 cells and in vivo on azoxymethane (AOM)-induced aberrant crypt foci (ACF) in rats. Rats received AST (50 or 100 mg/kg, 60 days) or 5-fluorouracil (5-FU) (35 mg/kg, 5 days). AST inhibited Caco-2 and HT-29 cell growth (IC50: 20.15-34.50 µg/mL). In AOM-induced rats, AST reduced ACF formation, improved colon histology, downregulated β-catenin, and upregulated Bax. AST also enhanced superoxide dismutase (SOD) and catalase (CAT) activities, reduced malondialdehyde (MDA) levels, and modulated tumor necrosis factor alpha (TNF-α), interlukin-6 (IL-6), and IL-10 levels. AST demonstrated chemopreventive activity against CRC by exerting antiproliferative, antioxidant, and anti-inflammatory effects, supporting its potential as a therapeutic agent.

PMID 42553650
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PubMedPhytotherapy research : PTR2026-08-05

Allium cepa And Its-Associated Phytochemicals: Evidence From in Vitro, in Vivo, and Human Studies on Antioxidant Effects.

Boustani Mohammad Salar MS, Eshaghi Ghalibaf Mohammad Hossein MH, Beigoli Sima S, Ghadimi Narges N et al.

Various pharmacological properties and therapeutic effects were shown for Allium cepa L. (Liliaceae), (A. cepa) or onion and its derivatives including their effects on oxidative stress in different conditions. In this article, an update and comprehensive review of antioxidant effects of A. cepa and A. cepa-associated phytochemicals as well as the underlying molecular mechanisms are provided. The literature on antioxidant effects of A. cepa published between 2015 and the end of July 2025 was searched on database like PubMed, WOS, Science direct and Scopus. A. cepa and its constituents showed antioxidant in various conditions such as cardiovascular, endocrine and metabolic, gastrointestinal and liver, immunological, hematological and autoimmune, urogenital, neurologic and respiratory disorders as well as cancer and neoplasia. The antioxidant effects of A. cepa and its derivatives were achieved by decreasing lipid peroxidation (LPO), malondialdehyde (MDA), nitric oxide (NO), and endothelial nitric oxide synthase (eNOS), inhibiting NADPH oxidase (NOX) activity but enhancing antioxidants such as superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), glutathione peroxidase (GSH-Px), glutathione peroxidase omega (GSPO), thioredoxin reductase (TrxR), glutathione-S-transferase (GST) and glutathione reductase (GR) activities and thiol levels. Therefore A. cepa and A. cepa-associated phytochemicals showed potent antioxidant effects indicating their possible therapeutic value for treatment of disorders associated with oxidative stress.

PMID 42552658
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PubMedBMC plant biology2026-08-05

Multi-trait assessment of Meloidogyne incognita resistance in developed Cucumis spp. inbred lines: horticultural, physiological, biochemical, and histological insights.

El-Remaly Eman E, El-Eslamboly Ahmed Asa AA

This study aimed to develop nematode-resistant inbred lines from Cucumis sativus, C. sativus var. hardwickii, and C. metuliferus, and to elucidate their resistance mechanisms against Meloidogyne incognita. Three parental genotypes were self-pollinated across five generations, with simultaneous selection for superior horticultural traits and nematode resistance. Resistance levels were assessed based on root gall index, gall number, egg mass, and egg count per root system. To investigate the underlying mechanisms, histological, biochemical, and molecular analyses were conducted, focusing on salicylic acid (SA) content and the expression of SA pathway genes (PR1-1A, PR3, and LOX1). Based on the coefficient of variation (CV%) for horticultural traits, three inbred lines were selected from C. sativus (Cs), three from C. sativus var. hardwickii (Ch), and five from C. metuliferus (Cm). Among these, Cs-L1, Ch-L2, Cm-L1, and Cm-L2 exhibited superior horticultural traits, whereas Cs-L1, Ch-L3, Cm-L4, and Cm-L5 showed the lowest nematode infection parameters. Histological examination revealed localized necrosis and cellular degeneration in the resistant lines, suggesting a hypersensitive response (HR)-like mechanism that likely contributes to nematode containment and developmental arrest. Biochemical assays further demonstrated greater induction of defense-related enzymes, including peroxidase (POD), polyphenol oxidase (PPO), and superoxide dismutase (SOD), in the roots of resistant lines. Notably, SA levels increased significantly upon infection in all resistant roots, particularly in C. metuliferus, compared with the susceptible control (Barracuda F1). This elevated SA accumulation correlated with the upregulated expression of PR1-1A, PR3, and LOX1. Overall, resistance in the selected inbred lines is multifaceted, encompassing reduced nematode development, HR-associated necrosis, enhanced antioxidant enzyme activity, and coordinated SA-mediated gene upregulation. These responses most pronounced in C. metuliferus play a crucial role in mitigating root-knot nematode damage and provide valuable targets for breeding nematode-resistant cucumber genotypes.

PMID 42552517
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PubMedReproduction in domestic animals = Zuchthygiene2026-08-05

Effects of Anethole on Meiotic Resumption and Oxidative Balance During in Vitro Maturation of Ovine Oocytes.

de Andrade Anderson Nascimento AN, Martins Solano Dantas SD, Ferreira Alesandro Silva AS, Sá Naiza Arcângela Ribeiro de NAR et al.

The aim of this study was to evaluate the effect of anethole addition to the ovine oocyte in vitro maturation (IVM) medium on viability and chromatin configuration, intracellular production of reactive oxygen species (ROS), enzymatic activity of superoxide dismutase (SOD) and catalase (CAT), as well as the levels of reduced thiols in IVM medium, in addition to its antioxidant potential (DPPH and ABTS). Cumulus-oocyte complexes (COCs) were randomly matured in IVM medium in the absence (control group, CTRL) or presence of anethole at concentrations of 30 (AN30), 300 (AN300), and 2000 μg/mL (AN2000). COCs were matured in groups under mineral oil at 39°C in a humidified atmosphere containing 5% CO2 in air for 24 h. At the end of IVM, part of the COCs was used to assess viability and chromatin configuration using Hoechst 33,342. The remaining COCs were used to assess intracellular ROS levels using the fluorescent probe H2DCFDA. Furthermore, the IVM medium was collected to evaluate antioxidant status (SOD, CAT, and reduced thiols). Finally, the antioxidant potential of different anethole concentrations was evaluated using DPPH and ABTS assays. It was observed that AN300 promoted higher meiotic resumption rates compared to the other treatments (p < 0.05) and a lower rate of oocyte degeneration compared to AN30 (p < 0.05). However, regarding the proportion of oocytes at MII, it was observed that only AN2000 was lower than AN300 (p < 0.05). Moreover, AN30 resulted in lower ROS levels compared to AN300 and AN2000 (p < 0.05). SOD activity was lower in AN2000 compared to the other treatments (p < 0.05). AN2000 also showed the highest antioxidant capacity in the DPPH and ABTS assays among the anethole concentrations, although it was lower than the control group. In conclusion, anethole supplementation during IVM positively affected oocyte meiotic progression in sheep.

PMID 42554084
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PubMedVeterinary medicine and science2026-08-05

Effects of Topical Administration of Bupivacaine HCl to the Ovarian Pedicle on Postoperative Pain, Antioxidant Enzyme Activity and Inflammatory Cytokines in Dogs Undergoing Laparoscopic Ovariectomy.

Çiplak Alper Yasin AY, Polat Bülent B

Laparoscopic ovariectomy (LOE) is a common procedure for elective sterilization in dogs and is associated with less tissue trauma than open techniques. However, manipulation of the ovarian pedicle may still induce nociceptive stimulation and contribute to perioperative inflammatory responses and changes in antioxidant enzyme activity. Topical administration of local anaesthetic to the ovarian pedicle may improve perioperative analgesia in minimally invasive surgery. To evaluate the effects of topical administration of bupivacaine HCl to the ovarian pedicle on postoperative pain, serum antioxidant enzyme activity and systemic pro-inflammatory cytokines in dogs undergoing LOE. Twenty-four clinically healthy, American Society of Anaesthesiologists (ASA) Class I female dogs were enrolled in a prospective, randomized, controlled trial. The dogs were allocated to receive either a total dose of bupivacaine HCl at 2.2 mg/kg (BPLOVE, n = 12), divided between the two ovarian pedicles, or an equivalent volume of isotonic saline (LOVE, n = 12), applied using the same topical technique. Standardized anaesthesia and surgical protocols were implemented. Postoperative pain was assessed using the University of Melbourne Pain Scale (UMPS) at 0, 2 and 4 h after surgery. Serum samples collected preoperatively, intraoperatively, and at 0, 2 and 4 h postoperatively were analysed for superoxide dismutase (SOD), catalase (CAT), interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α). Data were analysed using repeated-measures ANOVA and non-parametric tests (p < 0.05). All dogs completed the study without experiencing any major complications or requiring intraoperative rescue analgesia. UMPS scores were significantly lower in the BPLOVE group at all postoperative time points (p < 0.05). Significant group and time effects were observed in SOD and CAT activities, with higher antioxidant enzyme activity detected in bupivacaine-treated dogs (p < 0.05). Cytokine outcomes showed no consistent between-group differences; IL-6 was numerically lower in the BPLOVE group across time points, with a significant difference detected only at 4 h postoperatively. Topical administration of bupivacaine HCl to the ovarian pedicle during LOE was associated with improved early postoperative analgesia and higher serum SOD and CAT activities, without consistent short-term changes in systemic pro-inflammatory cytokine concentrations. These findings support the potential value of ovarian pedicle bupivacaine administration as part of multimodal analgesia in canine laparoscopic surgery and indicate changes in antioxidant enzyme activity during the early perioperative period.

PMID 42554136
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