若生智能
Drug Database
TE

teriparatide (Xinfutai)

✓ Approved

Shenzhen Salubris Pharmaceuticals Co., Ltd. · PTH1R · 重组蛋白

什么是 teriparatide？

teriparatide 是一种重组蛋白，由Shenzhen Salubris Pharmaceuticals Co., Ltd.研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Subcutaneous Injection。

药物档案

商品名Xinfutai
公司Shenzhen Salubris Pharmaceuticals Co., Ltd.
药物类别重组蛋白
分子靶点PTH1R
给药途径Injectable (Others), Subcutaneous Injection
状态Approved
来源： ClinicalTrials.gov, Shenzhen Salubris Pharmaceuticals Co., Ltd.

作用机制

分子靶点

teriparatide 作用于 1 个分子靶点：

PTH1Rparathyroid hormone 1 receptor (PTHR, EKNS)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

teriparatide 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Musculoskeletal and connective tissue disordersOsteoporosis✓ Approved

相关研究文献

PubMedRSC advances2026-08-05

Functional enhancement of cantaloupe rind powder by enzymatic treatment and its application in fiber-enriched cookies.

Nguyen Thi Quynh Ngoc TQN, Dong Thi Ho Thanh THT, Tran Le Trong Nghia LTN, Nguyen Hai Duong HD et al.

Elevated postprandial blood glucose is a key contributor to metabolic disorders, including type 2 diabetes. Although dietary fiber is known to modulate glucose absorption and improve glycemic response, its intake remains below recommended levels in many populations. This has driven interest in fiber fortification of widely consumed foods such as cookies. This study investigated the effects of cellulase-xylanase treatment of cantaloupe rind powder on its composition and functional properties, and evaluated cookies formulated with 20% enzyme-treated cantaloupe rind powder (ETCP) substitution against those made with untreated cantaloupe rind powder (UTCP) and control formulations. The ETCP exhibited higher soluble dietary fiber level, increased water- and oil-holding capacities, improved glucose and cholesterol adsorption capacities, while promoting the enhanced growth of Lactobacillus acidophilus, along with a more porous microstructure. However, the total phenolic content and antioxidant capacity decreased. The ETCP-fortified dough showed improved viscoelasticity (higher G', lower tan δ) and greater hardness than the UTCP counterpart. Both ETCP and UTCP increased dietary fiber, antioxidant properties, and hardness of cookies, but UTCP showed a stronger effect. Although both powders reduced overall sensory acceptability relative to the control, the ETCP resulted in a milder decline. Importantly, both formulations reduced the estimated glycemic index (eGI), with ETCP showing a greater reduction. These findings demonstrate that enzymatic modification can valorize cantaloupe rind into a functional ingredient for fiber-enriched cookies with improved glycemic response.

PMID 42553662
阅读全文 →
PubMedGut microbiome (Cambridge, England)2026-08-05

A Lactobacillus delbrueckii subsp. bulgaricus fermented skimmed milk powder has limited effects on gastrointestinal health in healthy individuals with mild-to-moderate gastrointestinal symptoms: results from a randomised controlled trial.

Rooney Martina M, Ní Chonnacháin Clíona C, Finnerty Bernadette B, Bennett Grace G et al.

Fermented dairy foods offer potential to improve gastrointestinal symptoms due to their functional characteristics (e.g., presence of potentially health-promoting microorganisms, and/or bioactives), which may improve quality of life (QoL). This study examined the effect of a Lactobacillus delbrueckii subsp. bulgaricus fermented skimmed milk powder (FSMP) on gastrointestinal health in healthy individuals with mild-to-moderate gastrointestinal symptoms. Subjects received 20 g/day of either the FSMP, skimmed milk powder (SMP), or maltodextrin for 8 weeks. QoL, faecal calprotectin, gut transit time, gas evacuations, stool consistency, dietary intake, and anthropometry were all assessed. Eighty-four participants (62% female, 34.9 ± 5.9 years) completed the trial. SMP improved anxiety (P = 0.015), discomfort (P = 0.002), and global (P = 0.010) domain scores vs. maltodextrin. Similarly, SMP improved discomfort (P = 0.007) and global (P = 0.023) domain score relative to FSMP. No other differences between groups post-intervention were observed (P > 0.05). Sub-analyses indicated those with more severe symptoms at baseline had more normal stool consistency (P = 0.016) and fewer gas evacuations (P = 0.008) in response to FSMP relative to maltodextrin. Overall, this exploratory analysis found an L. delbrueckii subsp. bulgaricus FSMP had limited effects on gastrointestinal health in this cohort.

PMID 42553209
阅读全文 →
PubMedChemistry (Weinheim an der Bergstrasse, Germany)2026-08-05

Amino-Rich Microporous Organic Network Composite Membranes for Efficient Extraction of Domoic Acid From Complex Matrices.

Tan Fang F, Zhang Wenmin W, Zhu Shiping S, Yu Qidong Q et al.

Microporous organic networks (MONs) have attracted considerable attention because of their high porosity, modifiable structure and excellent stability. However, their rigid structure makes it difficult to form membranes, leading to limited separation applications. MONs' powder suffers from issues of dusting and severe aggregation, leading to difficulties in separation and recycling. Herein, MONs' powder was converted into flexible and reusable membranes via phase inversion. The membranes were applied to enrich and extract domoic acid (DA, an algal toxin) from complex matrices. The adsorption performance and mechanism of three MONs membranes with different amino content were investigated and compared. The results indicate that the adsorption energy of the membranes for DA is positively correlated with the number of amino groups. Under optimized conditions, by combining syringe filter-based membrane micro-solid-phase extraction (SF-M-µSPE), with high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS), the developed method showed a low detection limit (0.5 pg mL-1), a wide linear range (1.5∼1000.0 pg mL-1, R ≥ 0.9999) and good repeatability (RSD ≤ 3.8%, n = 6). The membranes were successfully used to extract DA from seafood. There was trace DA (9.4 pg mL-1) found in oyster samples. This work demonstrates the great potential of MONs membranes in sample pretreatment.

PMID 42554504
阅读全文 →
PubMedVeterinary medicine and science2026-08-05

Harnessing of Tomato (Solanum lycopersicum) Pomace Powder on Growth Response and Haematological Indices of Sonali Chickens.

Habib Md Ahsan MA, Halder Manish M, Salma Ummay U, Amin Md Nurul MN et al.

Tomato pomace, a processing by-product rich in lycopene and polyphenols, has not yet been systematically evaluated as a functional dietary supplement for Sonali chickens in Bangladesh. This study assessed the dose-dependent effects of dried tomato pomace powder (TPP) as a dietary additive on the growth performance, feed efficiency, carcass traits, haematological indices and economic returns of Sonali chickens under tropical conditions in Bangladesh. A total of 180, one day-old Sonali chicks were randomly allocated to four dietary treatments, T0 (basal diet), T1 (basal diet + 2% TPP), T2 (basal diet + 4% TPP) and T3 (basal diet + 6% TPP), with three replicates of 15 birds each, and reared for 63 days at the Central Poultry Farm, HSTU, Dinajpur, Bangladesh. The T3 group achieved the highest final live body weight, the greatest weight gain and the most efficient feed conversion, followed by T2, T1 and T0 (p < 0.05). Carcass weight and breast, thigh and drumstick yields were significantly higher in T3. Blood analysis showed significantly lower total cholesterol and LDL together with higher HDL in the T3 group. The economic analysis indicated that T3 generated the highest net profit per bird, differing significantly from T0 (p < 0.05). Supplementing the diet with dried TPP at 6% significantly improved growth performance, carcass quality, lipid metabolism and financial returns in Sonali chickens, indicating that it is a viable, low-cost functional feed supplement for tropical poultry production systems.

PMID 42554133
阅读全文 →
PubMedHealth science reports2026-08-05

The Role of Research, Quality Improvement, and Training in Achieving Medicines Security in Nigeria: A Cross-Sectional Exploration of Stakeholders' Perspectives.

Adigwe Obi Peter OP, Onavbavba Godspower G, Alabi Toluwalope Folashade TF, Uzuh Nwakaego Rosemary NR

Equitable access to medicines remains a challenge in Nigeria with issues such as sub-optimal national pharmaceutical production capacities and the need to improve relevant quality standards. Thus, in order to identify context-specific solutions to this challenge, this study aimed to assess the perspectives of stakeholders in the healthcare value chain on the role of quality improvement and capacity-building strategies relevant to expediting medicines security in Nigeria. A national cross-sectional survey was conducted in Nigeria using a multistage sampling technique. A pretested questionnaire was administered to relevant stakeholders in the health sector. Descriptive and inferential statistical analyses were undertaken using Statistical Package for Social Sciences (SPSS) software version 25. A total of 416 questionnaires were retrieved. Just over a third of the study participants (37.9%) surveyed were actively employed in the pharmaceutical manufacturing sector. Nearly all the participants (94.8%) believed regulatory authorities should ensure the stringent implementation of Good Manufacturing Practices to sustain consistency in the quality of medicines. Similarly, over three-quarters of the study cohort (86.1%) indicated that the pharmaceutical sector, as well as relevant agencies in the industry, should be prioritised by the government, as this was critical in achieving medicines security. Also, a strong majority of the participants indicated that attaining the World Health Organization pre-qualification status was necessary to ensure access to high-quality medicines. There was a significant association between the participants' sociodemographic characteristics and key study variables. A higher proportion of the respondents with more than 5 years of experience agreed that investment in research and development was important to improve the quality of medicines, and this was statistically significant (p = 0.009). This cross-sectional study highlights strategic areas based on stakeholders' perceptions where interventions and reforms can be channelled to support efforts towards expediting the achievement of medicines security in Nigeria.

PMID 42553489
阅读全文 →
PubMedJournal of toxicology and environmental health. Part A2026-08-05

Effects of early-life exposure to Venlafaxine in Caenorhabditis elegans.

Alves Carla C, Tamagno Wagner Antonio WA, Pompermaier Aline A, Barcellos Leonardo José Gil LJG

Improper disposal of contaminants in wastewater may adversely impact organisms across multiple biological levels, including exposure to pharmaceutical and personal care products (PPCPs). Venlafaxine (VFX), a frequently prescribed antidepressant, is a drug of concern due to its potential environmental and neurotoxic effects. The concentrations of VFX used in this study were selected to span a range relevant to both acute toxicological testing and higher-end environmental contamination scenarios. Higher concentrations may occur in wastewater effluent, hospital discharge, or pharmaceutical manufacturing waste streams. This study investigated the effects of early-in-life (pre-and neonatal) VFX exposure on Caenorhabditis elegans at concentrations of 0, 9.37, 18.75, 28.12, or 37.5 mg/L. Neurobehavioral and cholinergic endpoints were assessed at the L4 stage to assess long-term neurotoxicity. Data demonstrated that worms exposed to the highest concentration exhibited increased locomotor activity, while pharyngeal pumping was elevated at both 9.37 and 37.5 mg/L. Acetylcholinesterase (AChE) activity was decreased at 9.37 and 28.12 mg/L. Early-life VFX exposure also altered social feeding behavior, with worms showing a preference for bacterial lawn border (18.75 and 37.5 mg/L) and enhanced group feeding (28.12 and 37.5 mg/L). These results indicate that neonatal VFX exposure induces behavioral and neurochemical changes in C. elegans, associated with disruption of the cholinergic system.

PMID 42553005
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多teriparatide