Drug Database
TE

teriparatide (Xinfutai)

✓ Approved

Shenzhen Salubris Pharmaceuticals Co., Ltd. · PTH1R · 重组蛋白

什么是 teriparatide?

teriparatide 是一种重组蛋白,由Shenzhen Salubris Pharmaceuticals Co., Ltd.研发。该药已获批,用于治疗相关适应症,给药途径:Injectable (Others)、Subcutaneous Injection。

药物档案

商品名Xinfutai
公司Shenzhen Salubris Pharmaceuticals Co., Ltd.
药物类别重组蛋白
分子靶点PTH1R
给药途径Injectable (Others), Subcutaneous Injection
状态Approved

作用机制

分子靶点

teriparatide 作用于 1 个分子靶点:

PTH1Rparathyroid hormone 1 receptor (PTHR, EKNS)
需要更深入的分析?Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

teriparatide 针对 1 个适应症,涉及 1 个治疗领域。

治疗领域疾病/病症分期
Musculoskeletal and connective tissue disordersOsteoporosis✓ Approved

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Highly attenuated poxviruses serve as potent viral vectors, oncolytic agents, and therapeutic vaccines. They can accommodate and stably maintain a large genomic payload of foreign inserts. Their limited replication in human cells provides an excellent safety profile, but it concomitantly necessitates higher doses of infectious particles for full therapeutic efficacy. We review recent advances in bioprocesses for the pharmaceutical production of poxvirus-based vectors, focusing mainly on the vaccinia virus and the Orf virus. These include upstream processing using highly permissive cell substrates, optimized feeding strategies, and a virus phenotype that facilitates downstream processing. The study explores ongoing challenges and identifies strategies to adapt the downstream process to intensified upstream processes in order to achieve an economic end-to-end production. For notably increased virus yields of up to 2 log after amplification, we propose to replace classic adsorption chromatography by a collective and continuous purification platform for separating the virus from process-related impurities. Filtration operations facilitate process scalability while reducing volumes, which is beneficial for a flow-through polishing to meet pharmaceutical quality attributes. Combined with artificial intelligence modeling, these advancements alleviate financial pressures on healthcare systems and accelerate the production of novel vaccine candidates for clinical use.

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Cement is one of the most used materials in the construction industry. Its production contributes about 8% to the global emissions. This study explores the use of eggshell powder (ESP) that contains over 80% calcium carbonate (CaCO3) as a partial substitute for ordinary Portland cement (OPC), such as Types B and D, to substitute limestone within the cement matrix. The physical (consistency and setting time), compressive strength, and chemical (Scanning Electron Microscope with Energy Dispersive Spectroscopy, (SEM-EDS), and X-ray Diffraction (XRD), X-ray fluorescence (XRF)) properties were evaluated against British, Indian, and established standards in the literature. The results showed that cement consistency (31-35%) and setting times were within acceptable limits according to BS EN 197-1 (initial ≥ 60 min) and IS 8112 (initial ≥ 30 min, final ≤ 600 min). The mechanical strength of the samples exceeded the required strength (42.5 N/mm2) recommended by the British Standards, except for samples B10N and D10N, which showed strength reductions of 8.4% and 12.3%, respectively. The SEM-EDS and XRD analyses confirmed a high CaCO3 content in the samples. The study suggests that incorporating ESP into OPC should not exceed 5% by weight, as higher proportions could negatively impact the cement's physical and strength properties. This approach will promote environmental sustainability by using agro-waste while ensuring the cement remains suitable for construction.

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A novel, sensitive, and environmentally sustainable spectrofluorimetric method was developed for lisinopril quantification based on Erythrosin B fluorescence quenching. The method exploits static quenching through ground-state ion-pair complex formation between dianionic Erythrosin B and dicationic lisinopril at pH 6.0. Comprehensive mechanistic investigation employing temperature-dependent Stern-Volmer analysis, thermodynamic studies, Job's method, and PM3 semi-empirical quantum mechanical calculations confirmed the static quenching mechanism driven by electrostatic interactions with binding energy of -6.90 kcal/mol (-28.87 kJ/mol). Under optimized conditions (pH 6.0, 15 μg/mL Erythrosin B, excitation/emission, 533/555 nm), the method exhibited excellent linearity over 0.01-3.0 μg/mL (r = 0.9998) with high sensitivity (LOD, 3.1 ng/mL; LOQ, 9.2 ng/mL). Validation according to ICH Q2(R2) guidelines demonstrated excellent accuracy (99.8 ± 1.119%), precision (RSD < 1.63%), robustness, and selectivity. The method was successfully applied to pharmaceutical tablets (100.02 ± 1.079% recovery) and spiked human plasma (96.19%-105.72% recovery). Comprehensive sustainability assessment using RGB12 (whiteness, 88.0/100) and EPPI (total score, 83.8) confirmed the method's superior environmental sustainability and ideal green profile. The developed method offers significant advantages including commercially available reagents, elimination of derivatization or nanomaterial synthesis, and simple instrumentation, representing an environmentally friendly alternative for routine lisinopril determination in pharmaceutical quality control and bioanalytical applications.

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