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sildenafil (Liqrev)

✓ Approved

CMP Pharma, Inc. · PDE5A · 小分子

什么是 sildenafil？

sildenafil 是一种小分子，由CMP Pharma, Inc.研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Liqrev
公司CMP Pharma, Inc.
药物类别小分子
分子靶点PDE5A
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, CMP Pharma, Inc.

作用机制

分子靶点

sildenafil 作用于 1 个分子靶点：

PDE5Aphosphodiesterase 5A (PDE5, CGB-PDE)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

sildenafil 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Respiratory, thoracic and mediastinal disordersPulmonary hypertension✓ Approved

相关研究文献

PubMedMusculoskeletal care2026-06-13

Profile of Patients With Chronic Musculoskeletal Pain Waiting for Physiotherapy in Secondary Health Care: A Cross-Sectional Study.

Schubert Bruno André Ney BAN, Siqueira Bruna Pereira BP, Cardoso Faria Ana Alice AA, Waclawovsky Aline J AJ et al.

Chronic musculoskeletal pain (CMP) is a major cause of disability, with biopsychosocial effects that may be worsened by long waiting times for care. This study aimed to describe the profile of patients with CMP on the waiting list for physiotherapy. We conducted a cross-sectional study using an online survey distributed via telephone. Participants' information was obtained from the Municipal Health Department. The survey assessed data on clinical, physical and psychosocial characteristics. Overall, we contacted 1208 individuals, and 134 completed the survey. The most common pain sites were the right shoulder (44.0%), lower back (42.5%), right hand (38.8) and right knee (38.8). Nearly half of the participants reported pain in 4 or more pain sites in the last seven days (49.3%) and use of antidepressants (48.5%) or analgesics (45.5%). Symptoms of anxiety and depression were present in 45.5% and 35.8% of participants, respectively. One out of five participants reported being unable to work in the last 30 days due to their health conditions. Only 23.9% had previously received physiotherapy care, and among these, 68.7% waited one year or longer for treatment. Patients on the waiting list for physiotherapy commonly report pain, psychosocial symptoms and functional disability. Strategies to improve timely access for physiotherapy are needed to reduce the burden of CMP.

PMID 42285916
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PubMedAuris, nasus, larynx2026-06-13

Stepwise surgical management of severe dysphagia in multiple system atrophy.

Ogawa Yumiko Y, Ueha Rumi R, Goto Takao T, Ramos Miguel Limbert ML et al.

Multiple system atrophy (MSA) is a rapidly progressive neurodegenerative disorder in which dysphagia progressively worsens over time. We report a 70-year-old man with MSA who had previously undergone laryngeal suspension and tracheostomy, allowing continued oral intake while preserving phonation. However, disease progression led to recurrent aspiration pneumonia, severe secretion retention, and transient ventilatory dependence. Reassessment revealed severe saliva pooling, silent aspiration, impaired laryngeal sensation, and upper esophageal sphincter (UES) dysfunction on high-resolution manometry. Given the patient's frailty, colonization with extended-spectrum beta-lactamase-producing organisms, and strong desire to resume oral intake, subglottic laryngeal closure combined with bilateral cricopharyngeal myotomy was performed through a minimally invasive surgical field. Postoperatively, aspiration was successfully prevented, UES opening improved, and partial oral intake was resumed without recurrent aspiration pneumonia. This case highlights the importance of individualized and stage-specific surgical decision-making for severe dysphagia in progressive neurodegenerative disease.

PMID 42284998
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PubMedJournal of medical case reports2026-06-13

The youngest reported oropharyngeal leech infestation: severe anemia without airway obstruction in a 6-month-old Ethiopian infant: a case report.

Oljira Amanuel Mesfin AM, Kelbessa Samuel Kefiyalew SK, Shorro Boka Imiru BI, Mekonen Bekele Abera BA et al.

Infestation of the oropharynx by a leech is uncommon, especially in young children, and can cause major bleeding because leech saliva contains the anticoagulant hirudin. This case, which presents oropharyngeal leech infestation causing severe anemia without obstruction of the airway in a 6-month-old infant, is the youngest ever documented. Parents from rural Ambo brought in an Oromo male infant of 6 months of age, complaining of oral bleeding, decreased oral intake, hematemesis, dark stool, and agitation that had occurred throughout the previous two days. Although there was no respiratory distress, a physical examination revealed blood-stained oral mucosa and a dark brown substance in the oropharynx; a complete blood test showed severe anemia (Hb 7.3 g/dL). The bleeding immediately stopped after removal of a 2.5 cm long leech by Magill forceps from the oropharyngeal wall under direct visualization with a rigid laryngoscope. Blood transfusions, antibiotics, and an iron suspension were given, and the patient's complete recovery was confirmed by an outpatient follow-up after discharge. In environments with limited resources, this case highlights the importance of preventing such rare but dangerous infestations by improving water sanitation, adhering to safe feeding practices, and quickly suspecting parasitic causes in infants exhibiting unexplained bleeding.

PMID 42286657
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PubMedCarbohydrate polymers2026-06-13

The rheological behavior, particle properties and supramolecular structure of low acyl gellan gum fluid gels: impact of the calcium concentration before fluid gel formation.

D'Oria Gabriele G, Zhu Yanshen Y, Limbach Hans Joerg HJ, Hartmann Christoph C et al.

Fluid gels are jammed microgel suspensions obtained by shearing a gelling hydrocolloid during its sol-gel transition. This study focused on calcium-induced low acyl gellan gum (LAGG) fluid gels and investigated the impact of calcium concentration before fluid gel formation on the resulting rheological behavior, fluid gel particle properties, and supramolecular structure. The elasticity and yield stress of fluid gels and quiescently cooled gels reached a maximum when the calcium concentration was increased from 0.78 to (approx.) 30 mmol/kg. Small angle X-ray scattering (SAXS) of fluid gels revealed a progressive increase in gel network connectivity up to the calcium concentration where the peak in rheological properties was observed followed by a less interconnected network at calcium concentrations above the peak. Furthermore, rheological measurements supplemented with free calcium and zeta-potential measurements, support that the decrease after the peak in rheological response is due to the combination of fluid gel particle softening with a decrease in surface charge. The results of this study enable to establish clearer links between rheological behavior, particle properties and supramolecular structure of calcium-induced LAGG fluid gels. This work enables a more effective design of fluid gel properties for different applications from food to pharma and biomaterials.

PMID 42285681
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PubMedBMC oral health2026-06-13

Latent class analysis of oral frailty among community-dwelling older adults: functional profiles and associated factors.

Li Yulian Y, Zhu Qian Q, Zheng Feng F, Guo Jialing J et al.

Oral frailty, characterized by multidimensional declines in oral function, perception, and behavior, has emerged as an important concern in geriatric oral health. However, population heterogeneity in oral frailty among community-dwelling older adults remains insufficiently understood. This study aimed to identify latent oral frailty subtypes using latent class analysis (LCA) and to examine factors associated with class membership. A cross-sectional survey was conducted among 252 community-dwelling older adults aged ≥ 60 years in Fujian Province, China. Oral frailty was assessed using the Oral Frailty Index (OFI-8). Latent class analysis(LCA) was applied to item-level OFI-8 responses to identify oral frailty subgroups. Multivariable multinomial logistic regression was used to examine sociodemographic, behavioral, nutritional, and psychosocial factors associated with latent class membership. Latent class analysis identified three distinct oral frailty classes based on item-level OFI-8 responses: Severe Multidomain Oral Frailty (17.0%), Masticatory-Dryness Impairment (42.1%), and Minimal Oral Deficits/Preserved Function (41.3%). Multinomial logistic regression showed that older age, current smoking, poorer oral health-related quality of life (lower GOHAI scores), lower oral health self-efficacy, and poorer nutritional status (lower MNA scores) were independently associated with membership in more severe oral frailty classes. Compared with the Minimal Oral Deficits/Preserved Function class, never smokers had significantly lower odds of membership in the Severe Multidomain Oral Frailty and Masticatory-Dryness Impairment classes. Chronic conditions were more prevalent in more severe classes in univariate analyses but were not independently associated with class membership after multivariable adjustment. Substantial heterogeneity in oral frailty exists among community-dwelling older adults. The identified latent classes represent distinct oral functional profiles with differing associated risk patterns, underscoring the importance of class-specific prevention and intervention strategies. Early identification of individuals with masticatory and dryness-related impairments may provide an opportunity for timely intervention in individuals at greater risk of severe oral functional impairment.

PMID 42286611
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PubMedAAPS PharmSciTech2026-06-13

Twin-Screw Melt Granulation with Mannitol: High-Drug-Loaded Immediate-Release Tablets of Caffeine.

Buczkowska Elzbieta Maria EM, Kukuls Kirils K, Horváth Zoltán Márk ZM, Frolova Alīna Jaroslava AJ et al.

High drug-loaded immediate-release formulations can be produced using a solvent-free and continuous melt-granulation method with a twin-screw extruder. Known and widely used high-molecular-weight and hydrophobic melt-binders result in weak tablets and negatively influence the disintegration and dissolution of tablets. Thus, this work aimed to probe mannitol as a melt-binder at a concentration of 30 wt.% and to investigate the effect of twin-screw melt granulation processing temperature and screw speed on the preparation of high drug-loaded immediate-release caffeine tablets with superior mechanical properties. A two-level design of experiment with three center points was used for the screening of the effect of barrel temperature and screw speed on granules and tablets properties. Model drug caffeine was mixed with mannitol (Parteck® M100), while a Pharma 11 extruder with helix feed screw elements and without a nozzle was used for twin-screw melt granulation. Processing conditions were found to significantly influence the solid state of ingredients and the quality of granules. Mannitol, as a melt-binder at a concentration of 30 wt.% at given processing conditions, was proven as an efficient melt-binder for high drug-loaded immediate-release tablets with superior mechanical properties.

PMID 42286306
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