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sumatriptan (Alsuma autoinjector / sumatriptan, King / Alsuma)

✓ Approved

US WorldMeds, LLC · HTR1D · 小分子

什么是 sumatriptan？

sumatriptan 是一种小分子，由US WorldMeds, LLC研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Subcutaneous Injection。

药物档案

商品名Alsuma autoinjector, sumatriptan, King, Alsuma
公司US WorldMeds, LLC
药物类别小分子
分子靶点HTR1D
给药途径Injectable (Others), Subcutaneous Injection
状态Approved
来源： ClinicalTrials.gov, US WorldMeds, LLC

作用机制

分子靶点

sumatriptan 作用于 1 个分子靶点：

HTR1D5-hydroxytryptamine receptor 1D (HTR1DA, HT1DA)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

sumatriptan 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Nervous system disordersMigraine✓ Approved

相关研究文献

PubMedPoultry science2026-08-04

Dietary metabolizable energy and crude protein affect growth, serum indices, and fecal metabolomics in early-weaned gray-feathered King pigeon squabs.

Li Yuanhao Y, Li Xiaobin X, Yang Huiguo H, Li Haiying H et al.

This study evaluated the effects of dietary metabolizable energy (ME) and crude protein (CP) levels on growth performance, serum traits, and fecal metabolomics in early-weaned gray-feathered King pigeon squabs. A 3 × 3 factorial design was used with three ME levels (11.9, 12.2, and 12.5 MJ/kg) and three CP levels (18, 19, and 20%), producing nine treatments. A total of 216 healthy 15-D-old squabs were randomly allocated to the nine treatments, with eight replicates per treatment and three squabs per replicate, for a 28-d trial. Growth performance, body measurements, and serum biochemical, immune, and antioxidant traits were determined. Based on preliminary body-weight records available at sample selection and contrasting dietary nutrient structures, the 18% CP + 12.5 MJ/kg ME and 20% CP + 11.9 MJ/kg ME treatments were selected for untargeted fecal metabolomics. Dietary ME and CP significantly affected growth performance, some body measurements, and multiple serum variables, and significant interaction effects were detected for some traits. In the overall phenotypic assessment, responses to dietary energy-protein combinations were trait-specific, and the 20% CP + 12.2 MJ/kg ME treatment showed a favorable growth trend. Untargeted metabolomics revealed clear separation between the 18% CP + 12.5 MJ/kg ME and 20% CP + 11.9 MJ/kg ME groups in both electrospray ionization negative mode (ESI-) and positive mode (ESI+). Differential metabolites were mainly annotated as lipids and lipid-like molecules, organic acids and their derivatives, and organic heterocyclic compounds, and were mainly associated with sphingolipid metabolism, porphyrin-related metabolism, cofactor metabolism, and central carbon metabolism. Correlation analysis further indicated broad statistical associations between several key fecal differential metabolites and serum biochemical, immune, and antioxidant variables. Overall, dietary ME and CP jointly affected growth, serum physiological status, and representative fecal metabolic characteristics in early-weaned gray-feathered King pigeon squabs.

PMID 42546431
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PubMedAmerican journal of health promotion : AJHP2026-08-04

Prototyping a Methodology for Estimating the Economic Externalities Resulting From Commercial Products' Influence on the Health of Their Users.

Downs Stephen J SJ, Singer Sara J SJ, Passarelli Carol C, Golez Inah I et al.

PurposeDetermine feasibility of estimating economic externalities associated with influences that products of individual corporations have on their customers' health behaviors.DesignOur methodology included four steps: (1) model influence of company product(s) on user behavior at the population level; (2) calculate relative risks of developing selected diseases/conditions associated with product use; (3) estimate the number of cases of selected disease/conditions that could be attributed to the company's influence; and (4) summarize annual cost of attributable cases.SettingUnited States.SampleThree companies: Burger King, Netflix and Niantic Labs.MeasuresAnnual US healthcare costs associated with the use of commercial products and services by adults.AnalysisWe estimated costs and benefits (costs avoided) by linking product use and population exposure with relative risks of major chronic conditions, as established in dose-response meta-analysis studies, to calculate population attributable fractions and then linking potentially attributable cases to annual healthcare costs.ResultsAnnual cost potentially attributable to Burger King was $4.9 billion and Netflix $32.4 billion; annual benefit attributable to Niantic Labs was $322 million.ConclusionWe demonstrated a methodology for estimating economic externalities that could be associated with the use of different commercial products/services.

PMID 42547091
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PubMedSultan Qaboos University medical journal2026-08-04

Temporary Blood Donor Deferrals: Analysing their impact on donor retention and future re-donations.

Kashif Ambreen A, Hasanato Rana R

Temporary blood donor deferral can be a challenge in retaining donors and to maintain a stable blood supply. This study aimed to analyse the pattern of temporary donor deferral and its impact on their future return for donation. This retrospective study included deferred blood donors from the Blood Bank department of King Khaled University Hospital, Riyadh, Saudi Arabia, and included data from January 2021 till December 2023 with subsequent donors follow up till August 2025 were recorded. Effect of demographics, causes of temporary deferrals and gender wise distribution were compared between new and regular blood donors and their return for future re-donations. A total of 47,522 whole blood donors were included in this study; 5,182 donors were deferred, of whom 97.3% experienced temporary deferral. Among these, 46.8% were new and 53.1% were regular donors. The leading causes of deferral were low haemoglobin/haematocrit (Hb/Hct; 45.9%), recent medication use (9.3%) and low blood pressure (8.8%). Donors deferred due to low Hb/Hct demonstrated lower return rates compared to those deferred for low blood pressure or medication use. Return rates among new donors ranged from 0-40%, whereas among regular donors it ranged from 37.5-100%, depending on the deferral category. Overall, the return rate was significantly lower in new donors and female donors (P <0.001 each). Temporary donor deferral has an effect on the future donations of the donor. This study highlights the need for stronger interventions, particularly donor education, reminder messages and follow-up to encourage the deferred donors to return, thereby supporting a consistent supply of safe blood for patients.

PMID 42549309
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PubMedFrontiers in oral health2026-08-04

Oral mucosal lesions among dental outpatients in Al-ahsa, Saudi Arabia: prevalence, clinical patterns and associated determinants: a cross-sectional study.

AlSleem Mousa Haney MH, Alghafli Hussain Adel HA, Alasafirah Abdullah Othman AO, Alkhames Hussain Mohammed HM et al.

Oral mucosal lesions (OMLs) are common worldwide and can disrupt daily activities by affecting chewing, swallowing and speech. This study aimed to determine the prevalence of OMLs among Saudis attending a dental clinic in Al-Ahsa, Saudi Arabia, identify their clinical patterns and examine associated determinants. This cross-sectional study was conducted between May and September 2023. All Saudis the King Faisal University dental complex were invited to participate. OMLs were diagnosed based on clinical features, and well-trained, calibrated examiners carried out the assessments. A total of 462 patients participated, including 282 (61%) males, with a mean age of 23.01 ± 15.39 years (SD). The majority were older than 18 years (272, 58.9%). OMLs were identified in 214 participants (46.3%). Just over half of those affected had a single lesion (54.7%), while 42.5% presented with two lesions. The most common lesions observed were linea alba (41, 19.2%), melanin pigmentation (40, 18.7%) and bone exostosis (22, 10.3%). OMLs were more prevalent among males (148, 69.2%) and participants older than 18 years (183, 85.5%; p ≤ 0.01). The binary logistic regression model indicated that age, educational level and occupation were significant predictors (p < 0.05). Participants aged ≤ 18 years had significantly lower odds of OMLs than those older than 18 years (OR = 0.06, CI: 0.034-0.111, p ≤ 0.001). For educational level, illiterate individuals had 6.1 times higher odds of having OMLs (OR = 6.11, CI: 1.17-32.02, p < 0.03). Regarding occupation, employed individuals had 2.2 times higher odds of OMLs than unemployed individuals (OR = 2.22, CI: 1.13-4.37, p ≤ 0.02). OMLs were observed in 46.3% of dental attendees, with the most frequently noted types being linea alba, oral melanin pigmentation and bone exostosis. These lesions were more common among males, adults, individuals with lower literacy and employed participants. These findings indicate the common occurrence of benign oral mucosal conditions in this population and suggest that clinicians should maintain regular vigilance during dental examinations.

PMID 42548739
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PubMedFrontiers in oncology2026-08-04

Outcomes of infantile leukemia in a Saudi multicenter cohort: patterns of treatment response, treatment failure, relapse, and survival.

Abdulrahman Abdulmajeed A, Ghemlas Ibrahim I, Al-Saedi Hawazen H, Al-Ahmari Ali A et al.

Infantile leukemia is a rare and aggressive form of pediatric leukemia associated with high rates of treatment failure, relapse, and mortality. Despite advances in leukemia therapy, evidence from Saudi Arabia remains limited, particularly regarding treatment response and survival outcomes among infants with acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). This study aimed to describe treatment response, treatment failure, relapse, overall survival, and event-free survival among infants with acute leukemia treated at two tertiary referral centers in Saudi Arabia, and to explore outcome differences according to leukemia subtype. A retrospective multicenter observational cohort study was conducted at King Faisal Specialist Hospital and Research Centre in Riyadh and Jeddah. The study included 41 patients diagnosed with infantile leukemia between January 2012 and December 2021. Data were extracted from medical records using a structured data collection form. Demographic, clinical, treatment-response, relapse, treatment-failure, and survival outcomes were summarized using descriptive statistics. Comparisons between ALL and AML were performed using Fisher's exact test where appropriate because of small cell counts. Overall survival and event-free survival were estimated using Kaplan-Meier analysis and compared using the log-rank test. Of the 41 patients, 24 (58.5%) had ALL and 17 (41.5%) had AML. At last follow-up, 22 patients (53.7%) were alive and 19 (46.3%) had died. Among patients evaluable after first-line therapy, 20 of 26 (76.9%) achieved first complete remission. Disease reactivation or relapse occurred in 11 patients (26.8%), death in remission in 6 (14.6%), and treatment failure or refractory disease in 6 (14.6%). Median overall survival was not reached for the total cohort, while median event-free survival was 23.27 months. No statistically significant differences were observed between ALL and AML in overall survival, log-rank p = .930, or event-free survival, log-rank p = .778. Infantile leukemia was associated with considerable adverse outcomes in this Saudi multicenter cohort, including relapse, death in remission, treatment failure, and mortality. Leukemia subtype alone was not significantly associated with survival or adverse outcome patterns. These findings should be interpreted as descriptive and hypothesis-generating because of the small sample size and limited statistical power.

PMID 42548506
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PubMedFrontiers in public health2026-08-04

Association of prior interstitial lung disease awareness with knowledge, attitudes, and practices in Saudi Arabia: a national cross-sectional study.

Althobiani Malik A MA, Alahmadi Husam I HI, Almaghlouth Fatma F, Zafir Turky T et al.

Interstitial lung diseases (ILDs) are a heterogeneous group of diffuse parenchymal lung disorders, including idiopathic interstitial pneumonias, connective-tissue-disease-associated ILD and sarcoidosis. Patients often experience prolonged diagnostic delays and non-specific symptom profiles that overlap with more prevalent conditions. While these delays are well documented, the contribution of low public awareness to these delays is not well described in the Middle East. We aimed to determine the prevalence of ILD awareness in Saudi Arabia and evaluate its independent association with knowledge, attitudes, and care-seeking practices. We conducted a cross-sectional study of adults (≥18 years) across Saudi Arabia between May and October 2025. The study was reported in accordance with the Strengthening the Reporting of Observational Studies in Epidemiology guideline (STROBE). Data were collected using a validated knowledge, attitudes, and practices questionnaire, developed with reference to World Health Organisation guidance and the Theory of Planned Behaviour. Factors associated with prior ILD awareness were assessed using multivariable logistic regression. KAP domain scores, Knowledge (0-8), Attitude (1-5), and Practice (1-5) were compared between awareness groups using Mann-Whitney U tests and analysed using multivariable linear regression with standard errors, adjusting for demographics and healthcare background. p Values were adjusted for multiple comparisons using the Benjamini Hochberg false discovery rate procedure. Ethical approval was obtained from King Abdulaziz University. Of 830 individuals who initiated the survey, 628 (75.7%) provided complete responses and were included in the analysis. Of 628 participants, 116 (18.5%) reported prior ILD awareness. Healthcare providers had 6.45-fold higher odds of awareness (95% CI 3.12-13.32; p < 0.001), and other demographic factors showed no independent association. After adjustment, prior awareness was associated with higher knowledge (β = 3.27, 95% CI 2.77-3.77; p < 0.001) and higher practice scores (p < 0.001). Attitude differences were small and were not statistically significant after full adjustment (p = 0.051). Lack of awareness was reported as a care-seeking barrier by 81% (413/512) of unaware and even by 78% (90/116) of aware participants. Unaware participants prioritised symptom information (65% vs. 53%), whereas aware participants prioritised specialist centre access (53% vs. 43%). ILD awareness in Saudi Arabia is low (18.5%), concentrated among healthcare providers, with knowledge gaps across both the public and healthcare professionals. The persistence of perceived knowledge deficits, even among those aware demonstrates unmet educational needs. Findings support targeted public campaigns emphasising symptom recognition and primary care education to support earlier recognition, diagnosis, and timely specialist referral.

PMID 42548753
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