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naloxone HCl (REZENOPY)

✓ Approved

Scienture Inc. · OPRM1

什么是 naloxone HCl？

naloxone HCl 是一种治疗药物，由Scienture Inc.研发。该药已获批，用于治疗相关适应症，给药途径：Inhaled。

药物档案

商品名REZENOPY
公司Scienture Inc.
分子靶点OPRM1
给药途径Inhaled
状态Approved
来源： ClinicalTrials.gov, Scienture Inc.

作用机制

分子靶点

naloxone HCl 作用于 1 个分子靶点：

OPRM1opioid receptor mu 1 (MOR1, LMOR)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

naloxone HCl 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Injury, poisoning and procedural complicationsToxicity to various agents✓ Approved

相关研究文献

PubMedCanadian family physician Medecin de famille canadien2026-06-13

Impact of virtual case conferences between primary care clinicians and an interdisciplinary chronic pain clinic.

Jorgenson Derek J DJ, Halpape Katelyn K, Marwah Radhika R, Siton Michael M

To assess the impact of virtual case conferences on referring primary care clinician knowledge, prescribing, and patient care practices. Paper-based postal survey. The USask Chronic Pain Clinic (UCPC) in Saskatoon, Sask. All referring health professionals who participated in a USask Chronic Pain Clinic case conference between July 2023 and December 2024 were included. Participants included family physicians (87.3%, n=48 of 55) and nurse practitioners (12.7%, n=7 of 55). The questionnaire collected data regarding participant demographic characteristics and various aspects of participants' chronic pain management knowledge, prescribing, and chronic pain care practices. A total of 168 questionnaires were mailed and the response rate was 32.7% (n=55 of 168). Most participants found case conferences to be a useful resource to their practices (94.5%) and reported that the service helped them with the management of their patients (92.7%). Many respondents reported improved knowledge about safe opioid prescribing (70.9%) and the process for opioid tapering (49.1%). Most agreed the knowledge they acquired from the case conference had been applied to additional patients in their practice (74.5%). Many respondents also felt more confident managing chronic pain (74.5%), more confident prescribing buprenorphine-naloxone for chronic pain (41.8%), and more willing to prescribe buprenorphine-naloxone for chronic pain (36.4%). Some had even prescribed buprenorphine-naloxone for chronic pain for the first time because of the case conference (30.9%). Case conferences between UCPC interdisciplinary chronic pain team members and referring primary care clinicians may be a valuable service to support referring providers in the care of their patients and to increase the capacity of the primary care system to manage chronic pain.

PMID 42285727
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PubMedAddiction (Abingdon, England)2026-06-12

The association between naloxone distribution, buprenorphine treatment and retention and incident high-risk opioid prescribing with opioid overdose death in Kentucky, Massachusetts, New York and Ohio, United States: An exploratory community-level cohort study of data from the HEALing Communities Study.

Walley Alexander Y AY, Cheng Debbie M DM, Vandergrift Nathan N, Larochelle Marc M et al.

We evaluated whether community-level naloxone distribution, medication for opioid use disorder treatment and retention and incident high-risk opioid prescribing rates were associated with opioid overdose death rates. Observational cohort conducted using 2019 to 2023 community-level data as an exploratory analysis of the HEALing (Helping to End Addiction Long-term®) Communities Study (HCS). Exposures included: (1) community-level naloxone distribution, past 12-months, categorized as ≤1000 units per 100 000 population vs. 1001-3000 units per 100 000 population vs. >3000 units per 100 000 population; (2) individuals treated with buprenorphine per 100 000 adult population in the current quarter; (3) individuals retained on buprenorphine for ≥ 180 days per 100 000 adult population in the current quarter; and (4) incident high-risk opioid prescribing per 100 000 adult population in the current quarter. Population-based study of 67 communities with 8.2 million adults in Kentucky, Massachusetts, New York and Ohio, USA, with required annual opioid overdose death rates of > 25 per 100 000 adult population and at least 30% rural. Across the 67 communities participating in the HCS, the adult population was 31% 18-34 years, 31% 35-54 years, 38% 55 years and over, 52% female, 73% non-Hispanic White, 15% non-Hispanic Black and 7.4% Hispanic. Quarterly community-level opioid overdose death rates from 2020 through 2023. The 2019 annual rates were 40.4 opioid overdose deaths, 1287 naloxone rescue units distributed, 977.7 people received buprenorphine treatment, 546.3 people retained for more than 180 days on buprenorphine and 1266.7 high-risk opioid prescribing incidents per 100 000 population. In models adjusted for state, community age, sex, race/ethnicity, rurality, HCS intervention group assignment, 2019 rates of opioid overdose death, naloxone distribution, buprenorphine and high-risk opioid prescribing, and the ratio of opioid overdose deaths involving fentanyl, an increase in 100 people treated with buprenorphine per 100 000 population was associated with a decrease of 0.92 [95% confidence interval (CI) = -1.30 to -0.55] in the quarterly opioid overdose death rate, while an increase of 100 people retained on buprenorphine for more than 180 days per 100 000 population was associated with a decrease of 1.3 (95% CI = -1.8 to -0. 76). There were no statistically significant associations between naloxone distribution or incident high-risk opioid prescribing with change in quarterly opioid overdose death rates. In this exploratory analysis, increases in both buprenorphine treatment and retention were statistically significantly associated with decreases in opioid overdose death rates, after adjusting for baseline rates of buprenorphine treatment and retention.

PMID 42283399
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PubMedLeukemia & lymphoma2026-06-12

Real-world treatment and outcomes in hairy cell leukemia: a multicenter retrospective cohort including BRAF inhibitor therapy.

Fradin James J JJ, Rein Lisa L, Szabo Aniko A, Carlson Karen-Sue KS et al.

Hairy cell leukemia (HCL) is a rare B-cell malignancy traditionally treated with purine analogue-based regimens. Although BRAF inhibitors are established in relapsed or refractory disease, their role as first-line therapy remains incompletely defined. We conducted a multicenter retrospective study evaluating real-world treatment of adults with classic HCL. A total of 110 patients were included. First-line therapies were cladribine (64%), cladribine plus rituximab (11%), rituximab (9%), and vemurafenib-based regimens (9%). Overall, response rate to first-line therapy was 80% (complete response rate of 65%). Median overall survival was 24.4 years. Patients treated first-line with vemurafenib-based regimens achieved an overall response rate of 80%, similar to purine analogue-based therapy. Hospitalization rates were similar across treatment groups. Vemurafenib-based therapy and rituximab monotherapy were preferentially used in older patients with greater baseline anemia. This study provides early insight into BRAF inhibitor use in HCL, highlighting encouraging responses in a limited number of patients.

PMID 42281276
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PubMedLangmuir : the ACS journal of surfaces and colloids2026-06-12

Multifaceted Regulation of Water Autodissociation Species on Interfacial Evolution and Methane Adsorption under Nanoconfinement.

Liu Shu S, Li Xijian X, Cai Junjie J, Chen Shoukun S

This study investigates the disturbance effects of H2O, H3O+, and OH- on CH4 adsorption-desorption and interfacial stability, which is of great scientific significance for optimizing material properties and revealing competitive adsorption and hydrogen-bond-mediated interfacial stress in coal pores. Using molecular simulations and experiments, we introduced these species into coal micro-nanopores to regulate the medium environment and surface charge and analyzed the hydrogen-bond network, CH4 adsorption and diffusion, and mechanical response of coal. The results show that H3O+ is more mobile than OH- in single systems, while the reverse occurs in mixed systems due to ion interference in hydrogen-bond networks. The H2O-dominated system shows a compact hydrogen-bond network and strong CH4 adsorption, followed by the mixed system, whereas H3O+- or OH--dominated systems present fragmented hydrogen bonds and weaker CH4 adsorption. Additionally, charge heterogeneity in mixed systems induces severe local structural damage in coal. HCl treatment damages coal mechanically, reducing micropore adsorption but enhancing macropore adsorption, while NaOH generates new micropores via alkali etching for gas storage. Consequently, the HCl system shows higher overall CH4 adsorption, but the NaOH system exhibits greater CH4 uptake in micropores, verifying that OH--dominated media favor higher CH4 adsorption and binding energy than H3O+-dominated ones. This work enables effective regulation of coal structure and gas adsorption performance, providing new approaches for clean and efficient coal utilization.

PMID 42281467
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PubMedScientific reports2026-06-12

Influence of H+ on CO2 solubility during carbonate acidizing.

Khojastehmehr Mohammad M, Korivand Arash A, Bazargan Mohammad M, Masihi Mohsen M

Carbonate acidizing is a matrix stimulation technique used to enhance well productivity and injectivity by reacting carbonate formations with hydrochloric acid (HCl), generating carbon dioxide (CO2) in aqueous, liquid, gaseous, or supercritical phases depending on pressure, temperature, and fluid composition. Among the ions commonly present in carbonate-acid systems, the effects of calcium, magnesium, and chloride ions on CO2 solubility have been extensively studied. However, the specific impact of H+ remains poorly understood. In this study, acid flooding experiments were conducted at backpressures of 0.1, 2.7, and 8.2 MPa and injection rates of 1, 2, 4, and 8 mL/min at ambient temperature using 1 wt% HCl to investigate H+'s influence on CO2 solubility. Observed differential pressures between the core inlet and outlet suggest that CO2 solubility is influenced not only by calcium and chloride ions but also by the presence of H+. The findings also indicate that the formation of non-aqueous CO2 can contribute to increases in differential pressure, whereas the absence of such increases does not necessarily imply the absence of non-aqueous CO2, as it may be masked by other competing mechanisms. Furthermore, the results challenge the common assumption that maintaining backpressures above 6.9 MPa ensures complete CO2 dissolution. These insights underscore the need for further investigation into CO2 solubility in acidic, salt-containing systems using specialized measurement setups and support the development of improved predictive models that incorporate the role of H+ alongside pressure, temperature, and salt concentration.

PMID 42277150
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PubMedHarm reduction journal2026-06-12

Take-home naloxone (THN) ownership among a community-based cohort of sex workers who use drugs in metro vancouver: longitudinal trends and structural determinants (2017-2024).

Moreheart Sarah S, Shannon Kate K, Krüsi Andrea A, Bartels Wiebke W et al.

Sex workers who use drugs face disproportionately high overdose burden, driven by drug toxicity and intersecting structural factors in sex work and drug use environments. Given limited evidence regarding sex workers' use of overdose prevention tools, including take-home naloxone (THN), we examined period prevalence, time trends, and structural factors longitudinally associated with THN ownership among sex workers over 7 years. Data derived from An Evaluation of Sex Workers' Health Access, a prospective, community-based cohort of sex workers in Vancouver, Canada (March 2017-March 2024). Generalized linear mixed-effects modeling (GLMM) examined structural factors associated with THN ownership. Among 506 participants, 90.3% (N = 457) ever owned THN. Period prevalence of THN ownership remained high across semi-annual visits( 72.6-88.8%). In multivariable GLMM modeling, THN ownership was associated with injection drug use (Adjusted Odds Ratio [AOR] 1.70, 95% Confidence Interval [CI] 1.35-2.14), enrollment in opioid agonist therapy (AOR 1.60, 95% CI 1.29-1.98), and drug use with sex work clients (AOR 1.27, 95% CI 1.02-1.59); whereas recent homelessness was associated with lower odds of THN ownership (AOR 0.52, 95% CI 0.37-0.73). Having used sex work-specific programs was marginally associated with higher odds of THN ownership. The majority of sex workers in this study owned THN, with high prevalence sustained over time. Ownership was particularly associated with enrollment in opioid agonist therapy and drug use with clients. However, recent homelessness was a barrier to THN ownership. Findings highlight the importance of integrating THN distribution and training into sex work-specific programs, with a focus on enhancing access to treatment and addressing structural factors that impact both safety and overdose prevention. Ensuring sex workers' right to health via strengthening THN access and equity-driven harm reduction strategies that prioritize the most marginalized sex workers is recommended.

PMID 42277811
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